{"id":"https://openalex.org/W2155554546","doi":"https://doi.org/10.1016/j.cardiores.2006.06.004","title":"Vascular smooth muscle cell senescence in atherosclerosis","display_name":"Vascular smooth muscle cell senescence in atherosclerosis","publication_year":2006,"publication_date":"2006-06-07","ids":{"openalex":"https://openalex.org/W2155554546","doi":"https://doi.org/10.1016/j.cardiores.2006.06.004","mag":"2155554546","pmid":"https://pubmed.ncbi.nlm.nih.gov/16824498"},"language":"en","primary_location":{"id":"doi:10.1016/j.cardiores.2006.06.004","doi":"https://doi.org/10.1016/j.cardiores.2006.06.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cardiores.2006.06.004","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085672714","display_name":"Isabelle Gorenne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I GORENNE","raw_affiliation_strings":["Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001887990","display_name":"Mary Meltem Kavurma","orcid":"https://orcid.org/0000-0001-7353-0932","observed_orcids":["https://orcid.org/0000-0001-7353-0932"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M KAVURMA","raw_affiliation_strings":["Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S SCOTT","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S SCOTT","raw_affiliation_strings":["Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067198585","display_name":"Martin R. Bennett","orcid":"https://orcid.org/0000-0002-2565-1825","observed_orcids":["https://orcid.org/0000-0002-2565-1825"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"M BENNETT","raw_affiliation_strings":["Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067198585"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"],"apc_list":{"value":4715,"currency":"EUR","value_usd":5329},"apc_paid":null,"fwci":0.4201,"has_fulltext":true,"cited_by_count":199,"citation_normalized_percentile":{"value":0.36258993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"72","issue":"1","first_page":"9","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9819999933242798},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":1.0},{"id":"https://openalex.org/keywords/atherosclerotic-plaque","display_name":"atherosclerotic plaque","score":0.8790000081062317},{"id":"https://openalex.org/keywords/senescence-markers","display_name":"senescence markers","score":0.9229999780654907},{"id":"https://openalex.org/keywords/senescence-mechanisms","display_name":"senescence mechanisms","score":0.8090000152587891},{"id":"https://openalex.org/keywords/plaque-macrophages","display_name":"plaque macrophages","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.9511088132858276},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.7565999627113342},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.4915953576564789},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46735408902168274},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4515860676765442},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4329811930656433},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.4285026490688324},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4226140081882477},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41032010316848755},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39442873001098633},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3184516131877899},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20202764868736267},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07815828919410706},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.056889355182647705}],"mesh":[{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.cardiores.2006.06.004","doi":"https://doi.org/10.1016/j.cardiores.2006.06.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cardiores.2006.06.004","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},{"id":"pmid:16824498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16824498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.325.8386","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.8386","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cardiovascres.oxfordjournals.org/content/72/1/9.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":108,"referenced_works":["https://openalex.org/W1029472","https://openalex.org/W3784027","https://openalex.org/W90516192","https://openalex.org/W637070445","https://openalex.org/W1806028129","https://openalex.org/W1965179405","https://openalex.org/W1966453709","https://openalex.org/W1967039991","https://openalex.org/W1969091160","https://openalex.org/W1970891016","https://openalex.org/W1972655555","https://openalex.org/W1973331210","https://openalex.org/W1974030991","https://openalex.org/W1980255413","https://openalex.org/W1983673827","https://openalex.org/W1984290310","https://openalex.org/W1987323212","https://openalex.org/W1987347555","https://openalex.org/W1989335335","https://openalex.org/W1991620357","https://openalex.org/W1992190981","https://openalex.org/W1993376880","https://openalex.org/W1997007011","https://openalex.org/W1997447547","https://openalex.org/W2001757458","https://openalex.org/W2006396854","https://openalex.org/W2012543064","https://openalex.org/W2013576756","https://openalex.org/W2013987164","https://openalex.org/W2014864029","https://openalex.org/W2015591824","https://openalex.org/W2020717634","https://openalex.org/W2023696449","https://openalex.org/W2026856852","https://openalex.org/W2027931017","https://openalex.org/W2027957140","https://openalex.org/W2030876656","https://openalex.org/W2032407757","https://openalex.org/W2035963497","https://openalex.org/W2037480531","https://openalex.org/W2037585138","https://openalex.org/W2037732138","https://openalex.org/W2039422436","https://openalex.org/W2039592355","https://openalex.org/W2041198010","https://openalex.org/W2042377388","https://openalex.org/W2044642112","https://openalex.org/W2045119323","https://openalex.org/W2047330128","https://openalex.org/W2050551830","https://openalex.org/W2050931938","https://openalex.org/W2054894653","https://openalex.org/W2057805062","https://openalex.org/W2057951424","https://openalex.org/W2058553011","https://openalex.org/W2058638257","https://openalex.org/W2070780660","https://openalex.org/W2071673220","https://openalex.org/W2072744580","https://openalex.org/W2077548365","https://openalex.org/W2081906011","https://openalex.org/W2085707549","https://openalex.org/W2087404852","https://openalex.org/W2088193327","https://openalex.org/W2088965226","https://openalex.org/W2095114292","https://openalex.org/W2100550233","https://openalex.org/W2101214961","https://openalex.org/W2102566010","https://openalex.org/W2102839588","https://openalex.org/W2104576349","https://openalex.org/W2104908670","https://openalex.org/W2105023898","https://openalex.org/W2108106334","https://openalex.org/W2108482850","https://openalex.org/W2109369265","https://openalex.org/W2109383439","https://openalex.org/W2117331734","https://openalex.org/W2118645481","https://openalex.org/W2122701592","https://openalex.org/W2126736026","https://openalex.org/W2127296141","https://openalex.org/W2127657628","https://openalex.org/W2132540714","https://openalex.org/W2135971646","https://openalex.org/W2141443485","https://openalex.org/W2143121941","https://openalex.org/W2143353478","https://openalex.org/W2143998515","https://openalex.org/W2145859123","https://openalex.org/W2147424761","https://openalex.org/W2147646689","https://openalex.org/W2149634356","https://openalex.org/W2151749258","https://openalex.org/W2152616419","https://openalex.org/W2153358400","https://openalex.org/W2157575236","https://openalex.org/W2159819769","https://openalex.org/W2160279897","https://openalex.org/W2161682643","https://openalex.org/W2164022766","https://openalex.org/W2164315464","https://openalex.org/W2165617921","https://openalex.org/W2168198236","https://openalex.org/W2315612846","https://openalex.org/W2324248025","https://openalex.org/W2328732945","https://openalex.org/W2473095060"],"related_works":["https://openalex.org/W7098276231","https://openalex.org/W2885787059","https://openalex.org/W4281639457","https://openalex.org/W2266051946","https://openalex.org/W7098070998","https://openalex.org/W397808976","https://openalex.org/W7119507368","https://openalex.org/W2417775236","https://openalex.org/W1952293023","https://openalex.org/W2885511418"],"abstract_inverted_index":{"Markers":[0],"of":[1,14,32],"cell":[2],"senescence":[3,33,47],"have":[4],"been":[5],"identified":[6],"in":[7,35,38,48],"both":[8,34],"the":[9,43,52],"blood":[10],"and":[11,37,50,54],"vessel":[12],"wall":[13],"patients":[15],"with":[16],"atherosclerosis.":[17],"In":[18],"particular,":[19],"vascular":[20],"smooth":[21],"muscle":[22],"cells":[23],"(VSMCs)":[24],"derived":[25],"from":[26],"human":[27],"plaques":[28],"show":[29],"numerous":[30],"features":[31],"culture":[36],"vivo.":[39],"This":[40],"review":[41],"summarises":[42],"evidence":[44],"for":[45],"VSMC":[46],"atherosclerosis,":[49],"outlines":[51],"mechanisms":[53],"triggers":[55],"leading":[56],"to":[57],"their":[58],"senescence.":[59]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
