{"id":"https://openalex.org/W2155490454","doi":"https://doi.org/10.1095/biolreprod25.2.353","title":"Dose Response Analysis of GnRH Stimulation of hCG Release from Human Term Placenta1","display_name":"Dose Response Analysis of GnRH Stimulation of hCG Release from Human Term Placenta1","publication_year":1981,"publication_date":"1981-09-01","ids":{"openalex":"https://openalex.org/W2155490454","doi":"https://doi.org/10.1095/biolreprod25.2.353","mag":"2155490454","pmid":"https://pubmed.ncbi.nlm.nih.gov/7030414"},"language":"en","primary_location":{"id":"doi:10.1095/biolreprod25.2.353","doi":"https://doi.org/10.1095/biolreprod25.2.353","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod25.2.353","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054633068","display_name":"Theresa M. Siler-Khodr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"T. M. Siler-Khodr","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111534597","display_name":"Gabriel S. Khodr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. S. Khodr","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054633068"],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":{"value":4605,"currency":"USD","value_usd":4605},"apc_paid":null,"fwci":2.6337,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.89513678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"25","issue":"2","first_page":"353","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":0.6779999732971191},{"id":"https://openalex.org/keywords/human-chorionic-gonadotropin","display_name":"human chorionic gonadotropin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/beta-hcg","display_name":"beta-hCG","score":0.9990000128746033},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.6940000057220459},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5199999809265137},{"id":"https://openalex.org/keywords/human-placental-lactogen","display_name":"human placental lactogen","score":0.8610000014305115},{"id":"https://openalex.org/keywords/placental-explants","display_name":"placental explants","score":0.6970000267028809},{"id":"https://openalex.org/keywords/gonadotropin-secretion","display_name":"gonadotropin secretion","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2775948956","wikidata":"https://www.wikidata.org/wiki/Q407172","display_name":"Human chorionic gonadotropin","level":3,"score":0.797160804271698},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.7824524641036987},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7354949116706848},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7161505818367004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6166234016418457},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.49892163276672363},{"id":"https://openalex.org/C3019987054","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Dose dependence","level":2,"score":0.4931149184703827},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4077508747577667},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2572893500328064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10725533962249756}],"mesh":[{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010906","descriptor_name":"Pituitary Hormone-Releasing Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1095/biolreprod25.2.353","doi":"https://doi.org/10.1095/biolreprod25.2.353","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod25.2.353","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},{"id":"pmid:7030414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7030414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of reproduction","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1527925119","https://openalex.org/W1546565855","https://openalex.org/W1676310332","https://openalex.org/W1893651774","https://openalex.org/W1993509602","https://openalex.org/W2020411797","https://openalex.org/W2021314548","https://openalex.org/W2026884349","https://openalex.org/W2027424239","https://openalex.org/W2412965617"],"related_works":["https://openalex.org/W2123782956","https://openalex.org/W2122080693","https://openalex.org/W2005081124","https://openalex.org/W1999799626","https://openalex.org/W624710857","https://openalex.org/W2041620435","https://openalex.org/W2109090550","https://openalex.org/W1929049177","https://openalex.org/W2020946333","https://openalex.org/W107546508"],"abstract_inverted_index":{"The":[0,33,101],"release":[1,67,84,103,125],"of":[2,35,48,64,85,96,104,110,126],"immunoreactive":[3],"alpha":[4],"and":[5,59,79],"beta":[6],"human":[7,27],"chorionic":[8,28],"gonadotropin":[9],"(\u03b1hCG":[10],"and\u03b2":[11],"hCG)":[12],"from":[13],"placental":[14],"explants":[15],"in":[16,22,115],"vitro":[17],"was":[18,30,53,70,87,112,128],"stimulated":[19,114],"by":[20,37,68,119],"GnRH":[21,38,69,97],"a":[23,116],"dose-response":[24,117],"fashion,":[25],"but":[26,50],"somatomammotropin":[29],"not":[31,113],"affected.":[32],"stimulation":[34,63],"\u03b1hCG":[36,105],"(1,":[39],"2,":[40,76],"or":[41],"5":[42],"\u03bcg/ml)":[43],"occurred":[44],"on":[45,56,73,89],"Days":[46,57,74],"1\u20133":[47],"culture,":[49],"this":[51],"increase":[52],"dose-related":[54,62],"only":[55],"2":[58],"3.":[60],"A":[61],"the":[65,93,107,122],"\u03b2hCG":[66,86,127],"also":[71],"observed":[72],"1,":[75],"3,":[77],"7,":[78],"8.":[80],"In":[81],"addition,":[82],"increased":[83,123],"effected":[88],"Day":[90],"4,":[91],"using":[92],"highest":[94],"dose":[95],"studied":[98],"(5":[99],"\u03bcg/ml).":[100],"cumulative":[102,124],"during":[106],"8":[108],"days":[109],"culture":[111],"fashion":[118],"GnRH,":[120],"while":[121],"dose-related.":[129]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}