{"id":"https://openalex.org/W2155474680","doi":null,"title":"Vaccination against drug-resistant HIV","display_name":"Vaccination against drug-resistant HIV","publication_year":2009,"publication_date":"2009-02-26","ids":{"openalex":"https://openalex.org/W2155474680","mag":"2155474680"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26918476","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Vaccination_against_drug-resistant_HIV/26918476","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/38217","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011504849","display_name":"Andreas Boberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andreas Boberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5011504849"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-vaccine","display_name":"HIV vaccine","score":0.8100000023841858},{"id":"https://openalex.org/keywords/drug-resistant-hiv","display_name":"drug-resistant HIV","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hiv-1-reverse-transcriptase","display_name":"HIV-1 reverse transcriptase","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hiv-1-protease","display_name":"HIV-1 protease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/epitope-selection","display_name":"epitope selection","score":0.7329999804496765},{"id":"https://openalex.org/keywords/ctl-epitopes","display_name":"CTL epitopes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/dna-vaccine","display_name":"DNA vaccine","score":0.7009999752044678},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.8360000252723694},{"id":"https://openalex.org/keywords/protein-processing","display_name":"protein processing","score":0.42100000381469727},{"id":"https://openalex.org/keywords/antiretroviral-drug-resistance","display_name":"antiretroviral resistance","score":0.6690000295639038},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6272029280662537},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6176333427429199},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5952593684196472},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5487313270568848},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5225980877876282},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2797272205352783}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:figshare.com:article/26918476","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Vaccination_against_drug-resistant_HIV/26918476","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:figshare.com:article/26925760","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Vaccination_against_drug-resistant_HIV/26925760","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/38217","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38217","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:openarchive.ki.se:10616/42360","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10616/42360","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"},{"id":"mag:2155474680","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/10616/38217/1/thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/38217","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38217","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":310,"referenced_works":["https://openalex.org/W34672287","https://openalex.org/W35389034","https://openalex.org/W43868576","https://openalex.org/W136988059","https://openalex.org/W186447518","https://openalex.org/W320510261","https://openalex.org/W1482928030","https://openalex.org/W1485596855","https://openalex.org/W1488725977","https://openalex.org/W1496518737","https://openalex.org/W1510731214","https://openalex.org/W1528520360","https://openalex.org/W1530152146","https://openalex.org/W1533770469","https://openalex.org/W1543059476","https://openalex.org/W1559556959","https://openalex.org/W1561535731","https://openalex.org/W1566941893","https://openalex.org/W1568188620","https://openalex.org/W1586015366","https://openalex.org/W1591577693","https://openalex.org/W1606321542","https://openalex.org/W1645781049","https://openalex.org/W1655510925","https://openalex.org/W1728222029","https://openalex.org/W1728915855","https://openalex.org/W1762082768","https://openalex.org/W1797402756","https://openalex.org/W1815763197","https://openalex.org/W1834473277","https://openalex.org/W1945834141","https://openalex.org/W1963570653","https://openalex.org/W1964488853","https://openalex.org/W1964819733","https://openalex.org/W1965718145","https://openalex.org/W1966286149","https://openalex.org/W1968751741","https://openalex.org/W1968895408","https://openalex.org/W1970089737","https://openalex.org/W1971321663","https://openalex.org/W1971329194","https://openalex.org/W1971923146","https://openalex.org/W1972103487","https://openalex.org/W1972139662","https://openalex.org/W1973181394","https://openalex.org/W1973215073","https://openalex.org/W1973398091","https://openalex.org/W1973711348","https://openalex.org/W1973963032","https://openalex.org/W1974138678","https://openalex.org/W1974616965","https://openalex.org/W1975807928","https://openalex.org/W1977282539","https://openalex.org/W1977726608","https://openalex.org/W1978825760","https://openalex.org/W1978928084","https://openalex.org/W1979658483","https://openalex.org/W1979967352","https://openalex.org/W1980624354","https://openalex.org/W1982769349","https://openalex.org/W1984678830","https://openalex.org/W1984811742","https://openalex.org/W1985381156","https://openalex.org/W1986152436","https://openalex.org/W1987451949","https://openalex.org/W1988106168","https://openalex.org/W1991731171","https://openalex.org/W1991834254","https://openalex.org/W1991843456","https://openalex.org/W1993529526","https://openalex.org/W1993846907","https://openalex.org/W1994048581","https://openalex.org/W1994363366","https://openalex.org/W1996464851","https://openalex.org/W1997677134","https://openalex.org/W1998415250","https://openalex.org/W1999022576","https://openalex.org/W1999119754","https://openalex.org/W1999408038","https://openalex.org/W1999628723","https://openalex.org/W1999743248","https://openalex.org/W2000677951","https://openalex.org/W2001045670","https://openalex.org/W2001213090","https://openalex.org/W2001375348","https://openalex.org/W2001897216","https://openalex.org/W2003227439","https://openalex.org/W2003272127","https://openalex.org/W2003412376","https://openalex.org/W2004773897","https://openalex.org/W2005096802","https://openalex.org/W2006549627","https://openalex.org/W2006629564","https://openalex.org/W2010294404","https://openalex.org/W2011630381","https://openalex.org/W2012139740","https://openalex.org/W2013958019","https://openalex.org/W2014954180","https://openalex.org/W2015771838","https://openalex.org/W2016468531","https://openalex.org/W2017585121","https://openalex.org/W2018155922","https://openalex.org/W2018712964","https://openalex.org/W2021445133","https://openalex.org/W2022098233","https://openalex.org/W2022661248","https://openalex.org/W2022890571","https://openalex.org/W2024213191","https://openalex.org/W2024301353","https://openalex.org/W2024557230","https://openalex.org/W2024702568","https://openalex.org/W2026444780","https://openalex.org/W2027552314","https://openalex.org/W2029353650","https://openalex.org/W2030482575","https://openalex.org/W2032722583","https://openalex.org/W2032857191","https://openalex.org/W2032898755","https://openalex.org/W2032998136","https://openalex.org/W2033953542","https://openalex.org/W2034085790","https://openalex.org/W2034207391","https://openalex.org/W2034858284","https://openalex.org/W2035570649","https://openalex.org/W2037343680","https://openalex.org/W2037345530","https://openalex.org/W2038104095","https://openalex.org/W2038917355","https://openalex.org/W2039593592","https://openalex.org/W2040066315","https://openalex.org/W2040313539","https://openalex.org/W2042021450","https://openalex.org/W2042695720","https://openalex.org/W2046341656","https://openalex.org/W2048737347","https://openalex.org/W2048809303","https://openalex.org/W2048999843","https://openalex.org/W2049432379","https://openalex.org/W2050238805","https://openalex.org/W2051731494","https://openalex.org/W2052321000","https://openalex.org/W2052701858","https://openalex.org/W2052990805","https://openalex.org/W2053612301","https://openalex.org/W2058934410","https://openalex.org/W2060382143","https://openalex.org/W2060829964","https://openalex.org/W2062096354","https://openalex.org/W2062106514","https://openalex.org/W2063150941","https://openalex.org/W2063247794","https://openalex.org/W2064882706","https://openalex.org/W2065133594","https://openalex.org/W2065329551","https://openalex.org/W2065818546","https://openalex.org/W2066033112","https://openalex.org/W2067207716","https://openalex.org/W2068619847","https://openalex.org/W2070060564","https://openalex.org/W2070316569","https://openalex.org/W2070426326","https://openalex.org/W2070558900","https://openalex.org/W2071670416","https://openalex.org/W2072375850","https://openalex.org/W2072854874","https://openalex.org/W2072965202","https://openalex.org/W2075783643","https://openalex.org/W2076120354","https://openalex.org/W2076225720","https://openalex.org/W2078494443","https://openalex.org/W2079280846","https://openalex.org/W2079542677","https://openalex.org/W2080499742","https://openalex.org/W2081746064","https://openalex.org/W2082314789","https://openalex.org/W2082927436","https://openalex.org/W2083087192","https://openalex.org/W2084529902","https://openalex.org/W2084905130","https://openalex.org/W2084956029","https://openalex.org/W2085536266","https://openalex.org/W2085919513","https://openalex.org/W2087565826","https://openalex.org/W2088146742","https://openalex.org/W2090010029","https://openalex.org/W2090433023","https://openalex.org/W2090640877","https://openalex.org/W2092234326","https://openalex.org/W2095855948","https://openalex.org/W2096211018","https://openalex.org/W2096234619","https://openalex.org/W2099025040","https://openalex.org/W2099535895","https://openalex.org/W2099782613","https://openalex.org/W2100182517","https://openalex.org/W2102551327","https://openalex.org/W2103059036","https://openalex.org/W2103182811","https://openalex.org/W2103663071","https://openalex.org/W2104043925","https://openalex.org/W2105175831","https://openalex.org/W2106628190","https://openalex.org/W2106628454","https://openalex.org/W2107303716","https://openalex.org/W2107551331","https://openalex.org/W2107683840","https://openalex.org/W2108381430","https://openalex.org/W2109000128","https://openalex.org/W2109210467","https://openalex.org/W2110287237","https://openalex.org/W2110609746","https://openalex.org/W2111949375","https://openalex.org/W2112625426","https://openalex.org/W2113331234","https://openalex.org/W2114754387","https://openalex.org/W2114977840","https://openalex.org/W2115373328","https://openalex.org/W2116364705","https://openalex.org/W2116983636","https://openalex.org/W2118894865","https://openalex.org/W2119232577","https://openalex.org/W2119690110","https://openalex.org/W2123163899","https://openalex.org/W2123324807","https://openalex.org/W2124627199","https://openalex.org/W2124969212","https://openalex.org/W2125029606","https://openalex.org/W2125927970","https://openalex.org/W2126266564","https://openalex.org/W2126332055","https://openalex.org/W2127788247","https://openalex.org/W2129114331","https://openalex.org/W2130151135","https://openalex.org/W2130642272","https://openalex.org/W2131413819","https://openalex.org/W2131609927","https://openalex.org/W2132014099","https://openalex.org/W2134961928","https://openalex.org/W2134992605","https://openalex.org/W2136347300","https://openalex.org/W2136681370","https://openalex.org/W2138205821","https://openalex.org/W2138639890","https://openalex.org/W2138820414","https://openalex.org/W2140027694","https://openalex.org/W2142470167","https://openalex.org/W2143071104","https://openalex.org/W2144882745","https://openalex.org/W2145031719","https://openalex.org/W2146074801","https://openalex.org/W2146428988","https://openalex.org/W2146486587","https://openalex.org/W2147169218","https://openalex.org/W2147413871","https://openalex.org/W2147645455","https://openalex.org/W2148044949","https://openalex.org/W2149653499","https://openalex.org/W2149951876","https://openalex.org/W2150632173","https://openalex.org/W2150756957","https://openalex.org/W2151292912","https://openalex.org/W2152640863","https://openalex.org/W2153670011","https://openalex.org/W2156414024","https://openalex.org/W2156557297","https://openalex.org/W2156643487","https://openalex.org/W2157911948","https://openalex.org/W2158240501","https://openalex.org/W2158903958","https://openalex.org/W2159465958","https://openalex.org/W2160010002","https://openalex.org/W2160925670","https://openalex.org/W2161152520","https://openalex.org/W2161255094","https://openalex.org/W2161337335","https://openalex.org/W2161420098","https://openalex.org/W2162187516","https://openalex.org/W2162632699","https://openalex.org/W2163667267","https://openalex.org/W2166782710","https://openalex.org/W2167174534","https://openalex.org/W2167521062","https://openalex.org/W2167681235","https://openalex.org/W2170240282","https://openalex.org/W2170349869","https://openalex.org/W2170525627","https://openalex.org/W2170904230","https://openalex.org/W2171499092","https://openalex.org/W2171750584","https://openalex.org/W2178503716","https://openalex.org/W2240372320","https://openalex.org/W2271871949","https://openalex.org/W2281910391","https://openalex.org/W2314893245","https://openalex.org/W2334324008","https://openalex.org/W2336069963","https://openalex.org/W2339173512","https://openalex.org/W2394868559","https://openalex.org/W2398721998","https://openalex.org/W2401545377","https://openalex.org/W2406461214","https://openalex.org/W2411895135","https://openalex.org/W2414698896","https://openalex.org/W2427608048","https://openalex.org/W2493480757","https://openalex.org/W2510625568","https://openalex.org/W2568563387","https://openalex.org/W2573090124","https://openalex.org/W2586162883","https://openalex.org/W2621219747"],"related_works":["https://openalex.org/W2034994059","https://openalex.org/W2803662744","https://openalex.org/W2068649387","https://openalex.org/W2032998136","https://openalex.org/W2046450019","https://openalex.org/W2147645455","https://openalex.org/W2034219867","https://openalex.org/W2316196841","https://openalex.org/W4313472208","https://openalex.org/W2052883886"],"abstract_inverted_index":{"As":[0],"the":[1,93,112,134,160,164,168,172,181,184,188,254,294,312,321,335,349,359,367,376],"use":[2],"of":[3,10,21,80,95,111,163,171,183,187,320,323,337,348,366,378,382,465,501],"antiretroviral":[4],"drug":[5,11,379,449],"treatment":[6],"increases":[7],"worldwide,":[8],"development":[9,377],"resistant":[12,25,149,237],"HIV":[13,96],"phenotypes":[14],"is":[15,279],"expected":[16],"to":[17,63,77,91,120,133,179,197,201,266,289,301,315,340,351,374],"increase.":[18],"The":[19,206,245,281],"frequency":[20],"drug-":[22],"or":[23],"multi-drug":[24,148],"virus":[26],"transmitted":[27],"in":[28,39,57,70,204,217,247,271,275,293,362,423],"primary":[29,150],"infections":[30],"will":[31],"consequently":[32],"be":[33,55,202,307],"more":[34],"abundant.":[35],"Logical":[36],"vaccine":[37,139,155,350,492],"targets":[38],"drug-resistant":[40,116,420,494],"strains":[41],"are":[42,118,297,329,332],"reverse":[43,97,143,483],"transcriptase":[44,98,144,484],"and":[45,51,83,99,123,152,174,194,212,249,257,273,300,342],"protease.":[46],"However,":[47],"even":[48],"though":[49],"antibodies":[50],"cell-mediated":[52],"responses":[53],"can":[54,128,306],"seen":[56],"patients,":[58],"it":[59],"has":[60],"been":[61],"difficult":[62],"develop":[64],"highly":[65],"immunogenic":[66,203,269,299],"vaccines":[67,339,418],"against":[68,419,447,493],"RT":[69,82,225,272,325],"animal":[71],"models.":[72],"This":[73,309],"motivated":[74],"novel":[75],"strategies":[76],"increase":[78,180],"immunogenicity":[79,94,182,209],"current":[81],"PR":[84,274],"immunogens.":[85],"We":[86,331],"have":[87,107],"focused":[88],"our":[89],"efforts":[90],"stimulate":[92,129,241],"protease":[100,452],"by":[101,166,177],"three":[102],"different":[103,255],"approaches.":[104],"First,":[105],"we":[106,158,175],"selected":[108,189],"specific":[109],"epitopes":[110,190,207,370],"two":[113],"proteins,":[114],"where":[115],"mutations":[117],"known":[119],"take":[121],"place,":[122],"investigated":[124],"how":[125],"well":[126],"these":[127,284,344],"an":[130,242],"immune":[131,161,243],"response":[132],"entire":[135],"protein.":[136,185],"Secondly,":[137],"DNA":[138,220,229,417,455],"constructs":[140,256],"encoding":[141],"full-length":[142,224],"were":[145,199,208,215,231],"created":[146],"from":[147,283],"isolates":[151],"tested":[153,422],"as":[154,210,228,346,371,489],"candidates.":[156],"Thirdly,":[157],"enhance":[159,311],"presentation":[162],"proteins":[165,295],"modifying":[167],"processing":[169,251],"pathway":[170],"protein":[173],"hope":[176],"that":[178,296],"Most":[186],"(both":[191],"wild":[192,368],"type":[193,223,369],"mutant":[195,238],"analogs":[196],"those)":[198],"found":[200,252],"mice.":[205],"peptides":[211],"when":[213],"they":[214],"expressed":[216,227],"multi-CTL":[218,456],"epitope":[219,453,457],"constructs.":[221],"Wild":[222],"gene":[226,258],"plasmid":[230],"weakly":[232],"immunogenic,":[233],"whereas":[234],"a":[235,372,424,448,490],"multidrug":[236],"did":[239],"not":[240],"response.":[244],"difference":[246],"expression":[248],"intracellular":[250],"between":[253],"product":[259],"may":[260,286,310],"partly":[261],"explain":[262],"this.":[263],"Furthermore,":[264],"screening":[265],"find":[267],"naturally":[268,298],"sites":[270,292],"HIV-1":[276,421,451,482],"infected":[277],"patients":[278],"ongoing.":[280],"result":[282],"studies":[285,319,356],"help":[287],"us":[288],"pick":[290],"out":[291],"which":[302],"potential":[303],"vacci":[304],"ne":[305],"targeted.":[308],"pre-existing":[313],"immunity":[314],"those":[316],"regions.":[317],"Immunogenicity":[318],"effect":[322],"fusing":[324],"with":[326],"ornithine":[327],"decarboxylase":[328],"planned.":[330],"also":[333],"investigating":[334],"efficiency":[336],"coupling":[338],"erythrocytes":[341],"using":[343,363],"cells":[345],"carriers":[347],"antigen":[352],"presenting":[353],"cells.":[354],"These":[355],"look":[357],"into":[358],"possible":[360],"advantages":[361],"drug-induced":[364],"variants":[365],"way":[373],"suppress":[375],"resistance.":[380],"List":[381],"scientific":[383],"papers":[384],"I.":[385],"Isaguliants":[386,479],"MG,":[387],"Zuber":[388,398,440],"B,":[389,441,476],"Boberg":[390,432,471],"A,":[391,433,472],"Sjostrand":[392,434],"D,":[393,435],"Belikov":[394],"SV,":[395],"Rollman":[396,436],"E,":[397,437,470],"AK,":[399],"Rechinsky":[400],"VO,":[401],"Rytting":[402],"AS,":[403],"Kallander":[404],"CF,":[405],"Hinkula":[406,438],"J,":[407,439],"Kochetkov":[408],"SN,":[409],"Liu":[410],"M,":[411],"Wahren":[412,442,475],"B":[413,443],"(2004).":[414],"Reverse":[415],"transcriptase-based":[416],"mouse":[425],"model.":[426],"Vaccine.":[427,460,496],"22(13-14):":[428],"1810-9.":[429],"https://pubmed.ncbi.nlm.nih.gov/15068865":[430],"II.":[431],"(2005).":[444,481],"Immunological":[445],"cross-reactivity":[446],"mutated":[450],"after":[454],"construct":[458],"immunization.":[459],"Sep":[461,497],"19:":[462,498],"Epub":[463,499],"ahead":[464,500],"print.":[466,502],"https://pubmed.ncbi.nlm.nih.gov/16181710":[467],"III.":[468],"Starodubova":[469],"Kashuba":[473],"EV,":[474],"Karpov":[477],"V,":[478],"M":[480],"targeted":[485],"for":[486],"proteasomal":[487],"degradation":[488],"prototype":[491],"HIV-1.":[495],"https://pubmed.ncbi.nlm.nih.gov/16181708":[503]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}