{"id":"https://openalex.org/W2155464520","doi":"https://doi.org/10.1128/mcb.3.7.1204","title":"Recombination of Plasmids into the Saccharomyces cerevisiae Chromosome Is Reduced by Small Amounts of Sequence Heterogeneity","display_name":"Recombination of Plasmids into the Saccharomyces cerevisiae Chromosome Is Reduced by Small Amounts of Sequence Heterogeneity","publication_year":1983,"publication_date":"1983-07-01","ids":{"openalex":"https://openalex.org/W2155464520","doi":"https://doi.org/10.1128/mcb.3.7.1204","mag":"2155464520","pmid":"https://pubmed.ncbi.nlm.nih.gov/6350848","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/370111"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.3.7.1204","doi":"https://doi.org/10.1128/mcb.3.7.1204","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.3.7.1204","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/370111","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084637534","display_name":"Sarah Smolik-Utlaut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Smolik-Utlaut","raw_affiliation_strings":["Department of Biophysics and Theoretical Biology, The University of Chicago, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics and Theoretical Biology, The University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087254791","display_name":"Thomas D. Petes","orcid":"https://orcid.org/0000-0003-4890-8002","observed_orcids":["https://orcid.org/0000-0003-4890-8002"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T D Petes","raw_affiliation_strings":["Department of Microbiology, The University of Chicago, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, The University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":1.3842,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.8094466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"7","first_page":"1204","last_page":"1211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5580999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5580999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.42719998955726624,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitotic-recombination","display_name":"mitotic recombination","score":0.9440000057220459},{"id":"https://openalex.org/keywords/integrative-recombination","display_name":"integrative recombination","score":0.8539999723434448},{"id":"https://openalex.org/keywords/sequence-heterogeneity","display_name":"sequence heterogeneity","score":0.8679999709129333},{"id":"https://openalex.org/keywords/ribosomal-dna","display_name":"ribosomal DNA","score":0.9169999957084656},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8930000066757202},{"id":"https://openalex.org/keywords/recombination-fraction","display_name":"recombination frequency","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.8785059452056885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8597477674484253},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.8028841614723206},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.7800158262252808},{"id":"https://openalex.org/C135300049","wikidata":"https://www.wikidata.org/wiki/Q5426559","display_name":"FLP-FRT recombination","level":5,"score":0.7393128871917725},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6993873715400696},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.6772201657295227},{"id":"https://openalex.org/C82040048","wikidata":"https://www.wikidata.org/wiki/Q7049125","display_name":"Non-allelic homologous recombination","level":5,"score":0.6324672698974609},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6058204174041748},{"id":"https://openalex.org/C127764415","wikidata":"https://www.wikidata.org/wiki/Q6356161","display_name":"Mitotic crossover","level":4,"score":0.5961950421333313},{"id":"https://openalex.org/C85638360","wikidata":"https://www.wikidata.org/wiki/Q263090","display_name":"Autonomously replicating sequence","level":5,"score":0.5032405257225037},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.4956003427505493},{"id":"https://openalex.org/C101434241","wikidata":"https://www.wikidata.org/wiki/Q211675","display_name":"Genetic recombination","level":4,"score":0.49043771624565125},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4767782986164093},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.46644920110702515},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3932691812515259},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37467271089553833},{"id":"https://openalex.org/C58337764","wikidata":"https://www.wikidata.org/wiki/Q976651","display_name":"Origin of replication","level":4,"score":0.15082651376724243}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012331","descriptor_name":"RNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/mcb.3.7.1204","doi":"https://doi.org/10.1128/mcb.3.7.1204","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.3.7.1204","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"doi:10.1128/mcb.3.7.1204-1211.1983","doi":"https://doi.org/10.1128/mcb.3.7.1204-1211.1983","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.3.7.1204-1211.1983","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:370111","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/370111","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:6350848","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6350848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:370111","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/370111","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G251412040","display_name":"Recombination in yeast","funder_award_id":"R01GM024110","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2837947413","display_name":"Molecular and Cellular Biology Training","funder_award_id":"T32GM007183","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W588812189","https://openalex.org/W1521372450","https://openalex.org/W1525325176","https://openalex.org/W1558106087","https://openalex.org/W1586827727","https://openalex.org/W1891931254","https://openalex.org/W1981679499","https://openalex.org/W1985910275","https://openalex.org/W1988875152","https://openalex.org/W2006945555","https://openalex.org/W2016556312","https://openalex.org/W2018082807","https://openalex.org/W2022016707","https://openalex.org/W2043286136","https://openalex.org/W2049149084","https://openalex.org/W2050829890","https://openalex.org/W2058909214","https://openalex.org/W2071094953","https://openalex.org/W2074395460","https://openalex.org/W2087685644","https://openalex.org/W2130972387","https://openalex.org/W2135528144","https://openalex.org/W2301295689","https://openalex.org/W2771211701","https://openalex.org/W4253662363"],"related_works":["https://openalex.org/W2889488961","https://openalex.org/W1856658838","https://openalex.org/W2100381588","https://openalex.org/W2037879641","https://openalex.org/W1952795264","https://openalex.org/W2069348889","https://openalex.org/W2397045096","https://openalex.org/W6987836592","https://openalex.org/W97300068","https://openalex.org/W3157607323"],"abstract_inverted_index":{"As":[0],"a":[1,21],"model":[2],"system":[3],"for":[4],"studying":[5],"the":[6,12,26,51,66,77,80],"properties":[7],"of":[8,53,61,70,79],"mitotic":[9],"recombination":[10,19,55,72],"in":[11,40],"yeast":[13],"Saccharomyces":[14],"cerevisiae,":[15],"we":[16],"have":[17],"examined":[18],"between":[20],"recombinant":[22,37],"plasmid":[23],"(introduced":[24],"into":[25],"S.":[27,44],"cerevisiae":[28,45],"cell":[29],"by":[30,76],"transformation)":[31],"and":[32,68],"homologous":[33,82],"chromosomal":[34],"loci.":[35],"The":[36],"plasmids":[38],"used":[39],"these":[41,71],"experiments":[42],"contained":[43],"rRNA":[46],"genes.":[47],"We":[48],"found":[49],"that":[50],"frequency":[52,67],"integrative":[54],"is":[56],"sensitive":[57],"to":[58],"small":[59],"amounts":[60],"sequence":[62],"heterogeneity.":[63],"In":[64],"addition,":[65],"specificity":[69],"events":[73],"are":[74],"affected":[75],"lengths":[78],"interacting":[81],"DNA":[83],"sequences.":[84]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}