{"id":"https://openalex.org/W2155458096","doi":"https://doi.org/10.1016/j.phymed.2014.04.003","title":"Assessment of genotoxicity of herbal medicinal products: Application of the \u201cbracketing and matrixing\u201d concept using the example of Valerianae radix (valerian root)","display_name":"Assessment of genotoxicity of herbal medicinal products: Application of the \u201cbracketing and matrixing\u201d concept using the example of Valerianae radix (valerian root)","publication_year":2014,"publication_date":"2014-05-15","ids":{"openalex":"https://openalex.org/W2155458096","doi":"https://doi.org/10.1016/j.phymed.2014.04.003","mag":"2155458096","pmid":"https://pubmed.ncbi.nlm.nih.gov/24837473"},"language":"en","primary_location":{"id":"doi:10.1016/j.phymed.2014.04.003","doi":"https://doi.org/10.1016/j.phymed.2014.04.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phymed.2014.04.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0944711314001482/pdf","source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0944711314001482/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070346935","display_name":"Olaf Kelber","orcid":"https://orcid.org/0000-0003-3334-5833","observed_orcids":["https://orcid.org/0000-0003-3334-5833"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olaf Kelber","raw_affiliation_strings":["Kooperation Phytopharmaka GbR, 53173 Bonn, Germany(2)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kooperation Phytopharmaka GbR, 53173 Bonn, Germany(2)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000900796","display_name":"Tankred Wegener","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tankred Wegener","raw_affiliation_strings":["Kooperation Phytopharmaka GbR, 53173 Bonn, Germany(2)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kooperation Phytopharmaka GbR, 53173 Bonn, Germany(2)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021491727","display_name":"Barbara Steinhoff","orcid":"https://orcid.org/0000-0002-4389-4572","observed_orcids":["https://orcid.org/0000-0002-4389-4572"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Steinhoff","raw_affiliation_strings":["Kooperation Phytopharmaka GbR, 53173 Bonn, Germany(2)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kooperation Phytopharmaka GbR, 53173 Bonn, Germany(2)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051303107","display_name":"Christiane Staiger","orcid":"https://orcid.org/0000-0001-8687-7687","observed_orcids":["https://orcid.org/0000-0001-8687-7687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christiane Staiger","raw_affiliation_strings":["Kooperation Phytopharmaka GbR, 53173 Bonn, Germany(2)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kooperation Phytopharmaka GbR, 53173 Bonn, Germany(2)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045898803","display_name":"Jacqueline Wiesner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123859907","display_name":"Federal Institute for Drugs and Medical Devices","ror":"https://ror.org/05ex5vz81","country_code":"DE","type":"government","lineage":["https://openalex.org/I123859907"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jacqueline Wiesner","raw_affiliation_strings":["Federal Institute for Drugs and Medical Devices (BfArM), 53175 Bonn, Germany(3)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Institute for Drugs and Medical Devices (BfArM), 53175 Bonn, Germany(3)","institution_ids":["https://openalex.org/I123859907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022730908","display_name":"Werner Kn\u00f6\u00df","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123859907","display_name":"Federal Institute for Drugs and Medical Devices","ror":"https://ror.org/05ex5vz81","country_code":"DE","type":"government","lineage":["https://openalex.org/I123859907"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Werner Kn\u00f6ss","raw_affiliation_strings":["Federal Institute for Drugs and Medical Devices (BfArM), 53175 Bonn, Germany(3)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Institute for Drugs and Medical Devices (BfArM), 53175 Bonn, Germany(3)","institution_ids":["https://openalex.org/I123859907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110623897","display_name":"Karin Kraft","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karin Kraft","raw_affiliation_strings":["Kooperation Phytopharmaka GbR, 53173 Bonn, Germany(2). Electronic address: koop.phyto.bonn@t-online.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kooperation Phytopharmaka GbR, 53173 Bonn, Germany(2). Electronic address: koop.phyto.bonn@t-online.de","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110623897"],"corresponding_institution_ids":[],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":0.2411,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.17425083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"21","issue":"8-9","first_page":"1124","last_page":"1129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.06069999933242798,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genotoxicity-assessment","display_name":"genotoxicity assessment","score":0.9240000247955322},{"id":"https://openalex.org/keywords/herbal-medicinal-products","display_name":"herbal medicinal products","score":0.9950000047683716},{"id":"https://openalex.org/keywords/valerian-root","display_name":"valerian root","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ames-test","display_name":"Ames test","score":0.7540000081062317},{"id":"https://openalex.org/keywords/drug-approval","display_name":"drug approval","score":0.6439999938011169},{"id":"https://openalex.org/keywords/extractants","display_name":"extraction solvents","score":0.8930000066757202},{"id":"https://openalex.org/keywords/phytochemical-constituents","display_name":"phytochemical constituents","score":0.7440000176429749},{"id":"https://openalex.org/keywords/traditional-herbal-medicinal-products","display_name":"traditional herbal medicinal products","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2777845490","wikidata":"https://www.wikidata.org/wiki/Q157819","display_name":"Valerian","level":2,"score":0.9385803937911987},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.7704164981842041},{"id":"https://openalex.org/C102944935","wikidata":"https://www.wikidata.org/wiki/Q4953701","display_name":"Bracketing (phenomenology)","level":2,"score":0.7400698065757751},{"id":"https://openalex.org/C2779091547","wikidata":"https://www.wikidata.org/wiki/Q287565","display_name":"Radix (gastropod)","level":2,"score":0.6869144439697266},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.35297614336013794},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2772420644760132},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2690228223800659},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.251803994178772},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003257","descriptor_name":"Consumer Product Safety","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D008519","descriptor_name":"Medicine, Traditional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009152","descriptor_name":"Mutagenicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014632","descriptor_name":"Valerian","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D028321","descriptor_name":"Plant Preparations","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D029001","descriptor_name":"Herbal Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phymed.2014.04.003","doi":"https://doi.org/10.1016/j.phymed.2014.04.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phymed.2014.04.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0944711314001482/pdf","source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},{"id":"pmid:24837473","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24837473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine : international journal of phytotherapy and phytopharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.phymed.2014.04.003","doi":"https://doi.org/10.1016/j.phymed.2014.04.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phymed.2014.04.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0944711314001482/pdf","source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317499","display_name":"Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte","ror":"https://ror.org/05ex5vz81"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2155458096.pdf","grobid_xml":"https://content.openalex.org/works/W2155458096.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W601733968","https://openalex.org/W1775749144","https://openalex.org/W1973195696","https://openalex.org/W1973879072","https://openalex.org/W1975041847","https://openalex.org/W1991954600","https://openalex.org/W1995369671","https://openalex.org/W1997572591","https://openalex.org/W2004678494","https://openalex.org/W2005156172","https://openalex.org/W2008707948","https://openalex.org/W2039711297","https://openalex.org/W2046220307","https://openalex.org/W2076605192","https://openalex.org/W2080234195","https://openalex.org/W2095007587","https://openalex.org/W2104809170","https://openalex.org/W2118050126","https://openalex.org/W2123726543","https://openalex.org/W2181351195","https://openalex.org/W2199171951","https://openalex.org/W2322641799","https://openalex.org/W2323853198","https://openalex.org/W2342574045","https://openalex.org/W6808487194"],"related_works":["https://openalex.org/W1997572591","https://openalex.org/W2118050126","https://openalex.org/W2321831745","https://openalex.org/W3082220225","https://openalex.org/W2321657089","https://openalex.org/W4405613374","https://openalex.org/W2542058716","https://openalex.org/W7133811068","https://openalex.org/W57804100","https://openalex.org/W4416634126"],"abstract_inverted_index":{"An":[0],"assessment":[1,69,97],"of":[2,12,26,70,72,98,102,112,124,144,148,156,173,184,193,199,213,229,232,262,280],"genotoxicity":[3,71,83,99,128,290],"is":[4,91,176,269],"a":[5,79,92,145,162,168,281,292],"precondition":[6],"for":[7,20,33,82,95,110,127,130,257],"marketing":[8],"authorization":[9],"respectively":[10],"registration":[11],"herbal":[13,27,37,73,114,132,164],"medicinal":[14,38,133,135],"products":[15],"(HMPs),":[16],"as":[17,19,50],"well":[18],"inclusion":[21,202,309],"into":[22],"the":[23,42,57,65,68,88,96,120,139,157,181,191,197,204,211,214,226,245,263,273,278,286,311],"'Community":[24],"list":[25],"substances,":[28],"preparations":[29,160],"and":[30,52,187,217,238,307],"combinations":[31],"thereof":[32],"use":[34,304],"in":[35,45,100,203,244,270,305,310],"traditional":[36,131],"products'":[39,136],"established":[40],"by":[41],"European":[43],"Commission":[44],"accordance":[46,271],"with":[47,138,196,272],"Directive":[48],"2001/83/EC":[49],"amended,":[51],"based":[53],"on":[54,59,67,122,180,289],"proposals":[55],"from":[56,161],"Committee":[58],"Herbal":[60],"Medicinal":[61],"Products":[62],"(HMPC).":[63],"In":[64,284],"'Guideline":[66],"substances/preparations'":[74],"(EMEA/HMPC/107079/2007)":[75],"HMPC":[76,116],"has":[77,117,298],"described":[78],"stepwise":[80],"approach":[81],"testing,":[84],"according":[85,166,248],"to":[86,141,167,177,249],"which":[87,151],"Ames":[89,246],"test":[90,125,149,247],"sufficient":[93],"base":[94],"case":[101],"an":[103],"unequivocally":[104,255],"negative":[105,256],"result.":[106],"For":[107],"reducing":[108],"efforts":[109],"testing":[111,129,143],"individual":[113],"substances/preparations,":[115],"also":[118,219],"developed":[119],"'guideline":[121],"selection":[123],"materials":[126,150],"products/herbal":[134],"(EMEA/HMPC/67644/2009)":[137],"aim":[140],"allow":[142],"standard":[146],"range":[147,216],"could":[152],"be":[153],"considered":[154],"representative":[155],"commonly":[158],"used":[159],"specific":[163],"drug":[165],"'bracketing/matrixing'":[169],"approach.":[170],"The":[171],"purpose":[172],"this":[174,185,267],"paper":[175],"provide":[178,291],"data":[179],"practical":[182],"application":[183],"bracketing":[186],"matrixing":[188],"concept":[189],"using":[190],"example":[192],"Valerianae":[194,233,296],"radix,":[195,234],"intention":[198],"facilitating":[200],"its":[201,303,308],"\"Community":[205],"list\".":[206],"Five":[207],"extraction":[208,221],"solvents,":[209,222],"representing":[210],"extremes":[212],"polarity":[215],"including":[218,236],"mid-range":[220],"were":[223,242,254],"used,":[224],"covering":[225],"entire":[227],"spectrum":[228],"phytochemical":[230],"constituents":[231],"thereby":[235],"polar":[237],"non-polar":[239],"constituents.":[240],"Extracts":[241],"tested":[243],"all":[250,258],"relevant":[251],"guidelines.":[252],"Results":[253],"extracts.":[259],"A":[260],"review":[261],"literature":[264],"showed":[265],"that":[266],"result":[268],"available":[274],"data,":[275],"thus":[276],"demonstrating":[277],"lack":[279],"genotoxic":[282,300],"potential.":[283],"conclusion":[285],"two":[287],"guidelines":[288],"practically":[293],"applicable":[294],"concept.":[295],"radix":[297],"no":[299],"potential,":[301],"supporting":[302],"HMPs":[306],"Community":[312],"list.":[313]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}