{"id":"https://openalex.org/W2155457768","doi":"https://doi.org/10.1002/ana.20021","title":"Involvement of medullary serotonergic groups in multiple system atrophy","display_name":"Involvement of medullary serotonergic groups in multiple system atrophy","publication_year":2004,"publication_date":"2004-02-20","ids":{"openalex":"https://openalex.org/W2155457768","doi":"https://doi.org/10.1002/ana.20021","mag":"2155457768","pmid":"https://pubmed.ncbi.nlm.nih.gov/14991820"},"language":"en","primary_location":{"id":"doi:10.1002/ana.20021","doi":"https://doi.org/10.1002/ana.20021","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.20021","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069111019","display_name":"Eduardo Elias Benarroch","orcid":"https://orcid.org/0000-0001-7968-5054","observed_orcids":["https://orcid.org/0000-0001-7968-5054"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eduardo E. Benarroch","raw_affiliation_strings":["Department of Neurology, Mayo Clinic, 811 Guggenheim Building, 200 First Street SW, Rochester, MN 55905, USA. benarroch.eduardo@mayo.edu","Mayo Clinic, Department of Neurology, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic, 811 Guggenheim Building, 200 First Street SW, Rochester, MN 55905, USA. benarroch.eduardo@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Department of Neurology, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079915472","display_name":"Ann M. Schmeichel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann M. Schmeichel","raw_affiliation_strings":["Mayo Clinic, Department of Neurology, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Department of Neurology, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047373167","display_name":"Phillip A. Low","orcid":"https://orcid.org/0000-0002-5386-4764","observed_orcids":["https://orcid.org/0000-0002-5386-4764"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip A. Low","raw_affiliation_strings":["Mayo Clinic, Department of Neurology, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Department of Neurology, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004201320","display_name":"Joseph E. Parisi","orcid":"https://orcid.org/0000-0002-0215-9643","observed_orcids":["https://orcid.org/0000-0002-0215-9643"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E. Parisi","raw_affiliation_strings":["Mayo Clinic, Department of Neurology, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Department of Neurology, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069111019"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":4.0325,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.9346351,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"55","issue":"3","first_page":"418","last_page":"422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-system-atrophy","display_name":"multiple system atrophy","score":1.0},{"id":"https://openalex.org/keywords/tryptophan-hydroxylase","display_name":"tryptophan hydroxylase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/nucleus-raphe-magnus","display_name":"nucleus raphe magnus","score":0.8920000195503235},{"id":"https://openalex.org/keywords/raphe-obscurus","display_name":"raphe obscurus","score":0.9380000233650208},{"id":"https://openalex.org/keywords/raphe-pallidus","display_name":"raphe pallidus","score":0.996999979019165},{"id":"https://openalex.org/keywords/ventrolateral-medulla","display_name":"ventrolateral medulla","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sympathetic-outflow","display_name":"sympathetic outflow","score":0.7179999947547913},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.9311702847480774},{"id":"https://openalex.org/C2777615928","wikidata":"https://www.wikidata.org/wiki/Q26261774","display_name":"Raphe","level":5,"score":0.7627514004707336},{"id":"https://openalex.org/C17291353","wikidata":"https://www.wikidata.org/wiki/Q6807308","display_name":"Medulla","level":2,"score":0.6960939168930054},{"id":"https://openalex.org/C142642502","wikidata":"https://www.wikidata.org/wiki/Q7455042","display_name":"Serotonergic cell groups","level":5,"score":0.6534243822097778},{"id":"https://openalex.org/C2777865548","wikidata":"https://www.wikidata.org/wiki/Q2061493","display_name":"Raphe nuclei","level":5,"score":0.6099473834037781},{"id":"https://openalex.org/C195121873","wikidata":"https://www.wikidata.org/wiki/Q1131385","display_name":"Medullary cavity","level":2,"score":0.5113736987113953},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48351672291755676},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.45041391253471375},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41444239020347595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3646445572376251},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35822612047195435},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35433512926101685},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.34856805205345154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2900632619857788},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014365","descriptor_name":"Tryptophan Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019578","descriptor_name":"Multiple System Atrophy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019578","descriptor_name":"Multiple System Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051843","descriptor_name":"Synucleins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ana.20021","doi":"https://doi.org/10.1002/ana.20021","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.20021","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},{"id":"pmid:14991820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14991820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of neurology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2672175028","display_name":null,"funder_award_id":"P01 NS 32352-P2","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4210312231","display_name":"AUTONOMIC DISORDERS PROGRAM PROJECT","funder_award_id":"P01NS032352","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W85157149","https://openalex.org/W1483007279","https://openalex.org/W1484357334","https://openalex.org/W1831769215","https://openalex.org/W1845449766","https://openalex.org/W1963912731","https://openalex.org/W1964996062","https://openalex.org/W1973326370","https://openalex.org/W1990720413","https://openalex.org/W1992720458","https://openalex.org/W1993275163","https://openalex.org/W2022256292","https://openalex.org/W2034998797","https://openalex.org/W2083027281","https://openalex.org/W2088999208","https://openalex.org/W2153154672","https://openalex.org/W2158717429","https://openalex.org/W2244794906","https://openalex.org/W2288664799","https://openalex.org/W2483134582"],"related_works":["https://openalex.org/W1964996062","https://openalex.org/W2068100867","https://openalex.org/W2083203593","https://openalex.org/W2140484786","https://openalex.org/W2521173803","https://openalex.org/W3087545404","https://openalex.org/W2073392849","https://openalex.org/W2253462026","https://openalex.org/W3187589441","https://openalex.org/W2018095361"],"abstract_inverted_index":{"We":[0],"sought":[1],"to":[2,78],"determine":[3],"whether":[4],"medullary":[5],"serotonergic":[6,56,74],"neurons":[7,57,75],"were":[8],"affected":[9],"in":[10,58,70,87],"multiple":[11],"system":[12],"atrophy":[13],"(MSA).":[14],"Immunostaining":[15],"for":[16],"tryptophan":[17],"hydroxylase":[18],"was":[19,51],"performed":[20],"on":[21],"serial":[22],"50":[23],"microm":[24],"sections":[25],"of":[26,29,43,55,73,81],"the":[27,59],"medulla":[28,69],"brains":[30],"obtained":[31],"at":[32],"autopsy":[33],"from":[34],"six":[35],"control":[36,80],"subjects,":[37],"eight":[38],"subjects":[39],"with":[40,47],"clinical":[41],"diagnosis":[42],"MSA,":[44],"and":[45,67,84],"four":[46],"Parkinson's":[48],"disease.":[49],"There":[50],"a":[52],"severe":[53],"depletion":[54],"nucleus":[60],"raphe":[61,63,65],"magnus,":[62],"obscurus,":[64],"pallidus,":[66],"ventrolateral":[68],"MSA.":[71,88],"Depletion":[72],"may":[76],"contribute":[77],"impaired":[79],"sympathetic":[82],"outflow":[83],"other":[85],"abnormalities":[86]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}