{"id":"https://openalex.org/W2155409158","doi":"https://doi.org/10.1095/biolreprod51.2.310","title":"Interleukin-1\u03b2 Stimulates Nitrite Production in the Rat Ovary: Evidence for Heterologous Cell-Cell Interaction and for Insulin-Mediated Regulation of the Inducible Isoform of Nitric Oxide Synthase1","display_name":"Interleukin-1\u03b2 Stimulates Nitrite Production in the Rat Ovary: Evidence for Heterologous Cell-Cell Interaction and for Insulin-Mediated Regulation of the Inducible Isoform of Nitric Oxide Synthase1","publication_year":1994,"publication_date":"1994-08-01","ids":{"openalex":"https://openalex.org/W2155409158","doi":"https://doi.org/10.1095/biolreprod51.2.310","mag":"2155409158","pmid":"https://pubmed.ncbi.nlm.nih.gov/7524699"},"language":"en","primary_location":{"id":"doi:10.1095/biolreprod51.2.310","doi":"https://doi.org/10.1095/biolreprod51.2.310","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod51.2.310","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109470962","display_name":"Izhar Ben\u2010Shlomo","orcid":"https://orcid.org/0000-0002-2085-0171","observed_orcids":["https://orcid.org/0000-0002-2085-0171"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Izhar Ben-Shlomo","raw_affiliation_strings":["Division of Reproductive Endocrinology, University of Maryland at Baltimore 21201","Division of Reproductive Endocrinology, University of Maryland at Baltimore, Baltimore, Maryland 21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology, University of Maryland at Baltimore 21201","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Division of Reproductive Endocrinology, University of Maryland at Baltimore, Baltimore, Maryland 21201","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085171713","display_name":"Ehud S. Kokia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ehud Kokia","raw_affiliation_strings":["Division of Reproductive Endocrinology, University of Maryland at Baltimore, Baltimore, Maryland 21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology, University of Maryland at Baltimore, Baltimore, Maryland 21201","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030900858","display_name":"Marian J. Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marian J. Jackson","raw_affiliation_strings":["Department of Obstetrics and Gynecology and Medical Biotechnology Center, University of Maryland at Baltimore, Baltimore, Maryland 21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology and Medical Biotechnology Center, University of Maryland at Baltimore, Baltimore, Maryland 21201","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086044543","display_name":"Eli Y. Adashi","orcid":"https://orcid.org/0000-0001-7730-1192","observed_orcids":["https://orcid.org/0000-0001-7730-1192"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eli Y. Adashi","raw_affiliation_strings":["Division of Reproductive Endocrinology, University of Maryland at Baltimore, Baltimore, Maryland 21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology, University of Maryland at Baltimore, Baltimore, Maryland 21201","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000028306","display_name":"Donna W. Payne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donna W. Payne","raw_affiliation_strings":["Division of Reproductive Endocrinology, University of Maryland at Baltimore, Baltimore, Maryland 21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology, University of Maryland at Baltimore, Baltimore, Maryland 21201","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000028306"],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":{"value":4605,"currency":"USD","value_usd":4605},"apc_paid":null,"fwci":6.0998,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.96761996,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"51","issue":"2","first_page":"310","last_page":"318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9290000200271606},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9300000071525574},{"id":"https://openalex.org/keywords/nitrite-accumulation","display_name":"nitrite accumulation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ovarian-function","display_name":"ovarian function","score":0.45100000500679016},{"id":"https://openalex.org/keywords/granulosa-cells","display_name":"granulosa cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/theca-interstitial-cells","display_name":"theca-interstitial cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.8610000014305115},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.7630000114440918},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.5450000166893005},{"id":"https://openalex.org/keywords/il-1-receptor","display_name":"IL-1 receptor","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C2776179834","wikidata":"https://www.wikidata.org/wiki/Q72158415","display_name":"Nitrite","level":3,"score":0.8199082612991333},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7949899435043335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6589177250862122},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6279213428497314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45415985584259033},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.41751059889793396},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41517600417137146},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41138774156570435},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40105491876602173},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33747366070747375},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2776384668","wikidata":"https://www.wikidata.org/wiki/Q182168","display_name":"Nitrate","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000594","descriptor_name":"Amino Acid Oxidoreductases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000594","descriptor_name":"Amino Acid Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009573","descriptor_name":"Nitrites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1095/biolreprod51.2.310","doi":"https://doi.org/10.1095/biolreprod51.2.310","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod51.2.310","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},{"id":"pmid:7524699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7524699","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of reproduction","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.5199999809265137}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1570420775","display_name":null,"funder_award_id":"HD-30288","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2277877828","display_name":"ARGININE SYNTHESIS AND UTILIZATION IN BRAIN","funder_award_id":"5r29ns030596-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3941151206","display_name":"INTERLEUKIN-1:  AN INTERMEDIARY IN OVULATION","funder_award_id":"5r01hd030288-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4015512316","display_name":null,"funder_award_id":"NS30596","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4891997262","display_name":null,"funder_award_id":"HD-19998","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G942357586","display_name":"SOMATOMEDIN-C/IGF-I: REGULATOR OF GRANULOSA CELLS","funder_award_id":"5r01hd019998-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1496457337","https://openalex.org/W1511098597","https://openalex.org/W1594268419","https://openalex.org/W1908877967","https://openalex.org/W1994303699","https://openalex.org/W1994389040","https://openalex.org/W1995418515","https://openalex.org/W1999376129","https://openalex.org/W2009013636","https://openalex.org/W2011574071","https://openalex.org/W2019814232","https://openalex.org/W2023170094","https://openalex.org/W2029294144","https://openalex.org/W2033379487","https://openalex.org/W2033632633","https://openalex.org/W2038098772","https://openalex.org/W2044918962","https://openalex.org/W2051031104","https://openalex.org/W2051890182","https://openalex.org/W2061078634","https://openalex.org/W2074935563","https://openalex.org/W2077824574","https://openalex.org/W2107732949","https://openalex.org/W2116591857","https://openalex.org/W2129888466","https://openalex.org/W2153491246","https://openalex.org/W2169805359","https://openalex.org/W2175413019","https://openalex.org/W2346202365"],"related_works":["https://openalex.org/W2072307928","https://openalex.org/W2158494565","https://openalex.org/W1999376129","https://openalex.org/W2146603998","https://openalex.org/W1991726045","https://openalex.org/W4254224145","https://openalex.org/W1967738557","https://openalex.org/W2112879035","https://openalex.org/W2093071785","https://openalex.org/W2292653015"],"abstract_inverted_index":{"Recent":[0],"studies":[1,299],"suggest":[2],"that":[3,186],"endogenously":[4],"generated":[5],"nitric":[6],"oxide":[7],"(NO)":[8],"may":[9],"mediate":[10],"the":[11,31,45,73,153,169,188,198,242,269,289,296,317],"effects":[12],"of":[13,18,30,34,47,57,80,85,87,106,113,128,156,175,191,197,201,213,244,254,273,288,292,309,316,320],"cytokines":[14],"in":[15,65,122,138,180,285,295],"a":[16,66,77,119,164,181,258,280],"variety":[17],"tissues.":[19],"In":[20,193],"an":[21,130,157,214,301],"effort":[22],"to":[23,149,224,262],"determine":[24],"whether":[25],"NO":[26,88,284],"generation":[27],"mediates":[28],"any":[29],"intraovarian":[32],"actions":[33,291],"interleukin-1":[35],"\u03b2":[36,59,115,159,256,294],"(IL-1":[37],"\u03b2),":[38],"we":[39],"have":[40],"looked":[41],"for":[42,271,283],"and":[43,70,171,230,276],"characterized":[44,75],"accumulation":[46,102,124,146,177,221,236],"nitrite":[48,63,101,123,145,176,220,235,311],"by":[49,76,97,125,152,184,241],"IL-1":[50,58,98,107,114,143,158,172,218,233,255,293,303],"\u03b2-treated,":[51],"cultured":[52,137],"whole":[53],"ovarian":[54,264,310],"dispersates.":[55],"Application":[56],"significantly":[60,204],"enhanced":[61,238],"basal":[62],"release":[64],"dose-,":[67],"cell":[68],"density-":[69],"time-dependent":[71],"manner,":[72],"latter":[74],"lag":[78],"time":[79],"about":[81],"20":[82],"h,":[83],"suggestive":[84],"induction":[86],"synthase":[89],"(NOS).":[90],"Cellular":[91],"NOS":[92,202],"activity":[93],"was":[94,147,209,222,237],"also":[95],"elevated":[96],"\u03b2.":[99,108],"Sustained":[100],"required":[103],"continuous":[104],"application":[105,155,212],"The":[109,252],"maximally":[110],"stimulating":[111],"dose":[112],"(50":[116],"ng/ml)":[117],"produced":[118],"10-fold":[120],"increase":[121],"96":[126],"h":[127],"culture,":[129],"effect":[131],"reduced":[132,148],"23%":[133],"when":[134],"cells":[135,278],"were":[136,178,203],"substrate":[139],"(i.e.,":[140],"arginine)-free":[141],"media.":[142],"\u03b2-stimulated":[144,173],"control":[150,170],"levels":[151,174],"simultaneous":[154],"receptor":[160],"antagonist,":[161],"thereby":[162],"suggesting":[163],"specific":[165],"receptor-mediated":[166],"effect.":[167,251],"Both":[168],"attenuated":[179],"dose-dependent":[182],"manner":[183],"inhibitors":[185,196],"favor":[187],"inducible":[189,318],"form":[190,200],"NOS.":[192,321],"contrast,":[194],"selective":[195],"constitutive":[199],"less":[205],"potent.":[206],"No":[207],"inhibition":[208],"noted":[210],"after":[211],"inactive":[215],"stereoisomeric":[216],"analogue.":[217],"\u03b2-induced":[219,234],"shown":[223],"require":[225],"cell-cell":[226],"interaction":[227],"between":[228],"granulosa":[229,275],"theca-interstitial":[231,277],"cells.":[232],"nearly":[239],"2-fold":[240],"addition":[243],"insulin,":[245],"although":[246],"insulin":[247],"alone":[248],"had":[249],"no":[250],"synergy":[253],"with":[257],"hormone":[259],"(insulin)":[260],"known":[261],"regulate":[263],"function":[265],"as":[266,268],"well":[267],"requirement":[270],"participation":[272],"both":[274],"suggests":[279],"possible":[281],"role":[282],"mediating":[286],"some":[287],"pleiotropic":[290],"ovary.":[297],"These":[298],"demonstrate":[300],"arginine-dependent,":[302],"\u03b2-":[304],"induced,":[305],"receptor-mediated,":[306],"insulin-enhanced":[307],"stimulation":[308],"accumulation,":[312],"presumably":[313],"reflecting":[314],"activation":[315],"isoform":[319]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}