{"id":"https://openalex.org/W2155402153","doi":"https://doi.org/10.1189/jlb.0907611","title":"Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics","display_name":"Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics","publication_year":2008,"publication_date":"2008-02-19","ids":{"openalex":"https://openalex.org/W2155402153","doi":"https://doi.org/10.1189/jlb.0907611","mag":"2155402153","pmid":"https://pubmed.ncbi.nlm.nih.gov/18285406"},"language":"en","primary_location":{"id":"doi:10.1189/jlb.0907611","doi":"https://doi.org/10.1189/jlb.0907611","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.0907611","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090200946","display_name":"Naoki Umemura","orcid":"https://orcid.org/0000-0002-3249-782X","observed_orcids":["https://orcid.org/0000-0002-3249-782X"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Umemura","raw_affiliation_strings":["Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan","Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine , Gifu , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan","institution_ids":["https://openalex.org/I42405503"]},{"raw_affiliation_string":"Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine , Gifu , Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041450266","display_name":"Masanao Saio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masanao Saio","raw_affiliation_strings":["Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018794808","display_name":"Tatsuhiko Suwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuhiko Suwa","raw_affiliation_strings":["Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079217250","display_name":"Yusuke Kitoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Kitoh","raw_affiliation_strings":["Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077501519","display_name":"Juncheng Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Juncheng Bai","raw_affiliation_strings":["Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kenichi Nonaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Nonaka","raw_affiliation_strings":["Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan","Department of Surgical Oncology, Gifu University Graduate School of Medicine , Gifu , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan","institution_ids":["https://openalex.org/I42405503"]},{"raw_affiliation_string":"Department of Surgical Oncology, Gifu University Graduate School of Medicine , Gifu , Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086418884","display_name":"Guan\u2010Feng Ouyang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Guan-Feng Ouyang","raw_affiliation_strings":["Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070409732","display_name":"Makoto Okada","orcid":"https://orcid.org/0009-0008-4275-5723","observed_orcids":["https://orcid.org/0009-0008-4275-5723"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Okada","raw_affiliation_strings":["Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan","Department of Neurosurgery, Gifu University Graduate School of Medicine , Gifu , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan","institution_ids":["https://openalex.org/I42405503"]},{"raw_affiliation_string":"Department of Neurosurgery, Gifu University Graduate School of Medicine , Gifu , Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103397294","display_name":"Margit Bal\u00e1zs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Margit Balazs","raw_affiliation_strings":["Department of Preventive Medicine, University of Debrecen , Hungary , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, University of Debrecen , Hungary , Japan","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040839445","display_name":"R\u00f3za \u00c1d\u00e1ny","orcid":"https://orcid.org/0000-0002-9679-6669","observed_orcids":["https://orcid.org/0000-0002-9679-6669"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Roza Adany","raw_affiliation_strings":["Department of Preventive Medicine, University of Debrecen , Hungary , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, University of Debrecen , Hungary , Japan","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103411365","display_name":"Toshiyuki Shibata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Shibata","raw_affiliation_strings":["Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine , Gifu , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine , Gifu , Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110852327","display_name":"Tsuyoshi Takami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Takami","raw_affiliation_strings":["Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Gifu University Graduate School of Medicine , Gifu , Japan","institution_ids":["https://openalex.org/I42405503"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041450266"],"corresponding_institution_ids":["https://openalex.org/I42405503"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":12.0496,"has_fulltext":false,"cited_by_count":349,"citation_normalized_percentile":{"value":0.99076861,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"83","issue":"5","first_page":"1136","last_page":"1144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.8190000057220459},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cd206","display_name":"CD206","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.796999990940094},{"id":"https://openalex.org/keywords/cx3cr1","display_name":"CX3CR1","score":0.7760000228881836},{"id":"https://openalex.org/keywords/ccr2","display_name":"CCR2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/inflammatory-monocytes","display_name":"inflammatory monocytes","score":0.7570000290870667},{"id":"https://openalex.org/keywords/cd8-t-cell-suppression","display_name":"CD8+ T cell suppression","score":0.7820000052452087},{"id":"https://openalex.org/keywords/colon-adenocarcinoma","display_name":"colon adenocarcinoma","score":0.8500000238418579},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/peritoneal-exudate-cells","display_name":"peritoneal exudate cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.6940000057220459},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C55721878","wikidata":"https://www.wikidata.org/wiki/Q15220362","display_name":"Myeloid-derived Suppressor Cell","level":4,"score":0.7781118154525757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7025308012962341},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5670092105865479},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.5427456498146057},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5188437700271606},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5082640051841736},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4940047860145569},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4779227375984192},{"id":"https://openalex.org/C2779828298","wikidata":"https://www.wikidata.org/wiki/Q4035577","display_name":"CD36","level":3,"score":0.47659772634506226},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.45978572964668274},{"id":"https://openalex.org/C2779919695","wikidata":"https://www.wikidata.org/wiki/Q4201963","display_name":"CD11c","level":4,"score":0.41122496128082275},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3914477527141571},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35525137186050415},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3055317997932434},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.301318496465683},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.22229990363121033},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.21447187662124634},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14460086822509766},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11593049764633179},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1189/jlb.0907611","doi":"https://doi.org/10.1189/jlb.0907611","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.0907611","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmid:18285406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18285406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Journal Article"},{"id":"pmh:oai:ganymedesd.lib.unideb.hu:2437/85089","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2437/85089","pdf_url":null,"source":{"id":"https://openalex.org/S4306402089","display_name":"University of Debrecen Electronic Archive (University of Debrecen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132735039","host_organization_name":"University of Debrecen","host_organization_lineage":["https://openalex.org/I132735039"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"foly\u00f3iratcikk"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G435395097","display_name":"Analysis of brain specific differentiation and maturation of tumor-infiltrating dendritic cells in glioma","funder_award_id":"18390393","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6347276406","display_name":"Development of immunotherapy for glioma utilizing cell-free protein expression system","funder_award_id":"16591437","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320306091","display_name":"American Association for Cancer Research","ror":"https://ror.org/02fnpv153"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1526617084","https://openalex.org/W1598162705","https://openalex.org/W1886267442","https://openalex.org/W1966577330","https://openalex.org/W1984673216","https://openalex.org/W1987481383","https://openalex.org/W2001717792","https://openalex.org/W2002504985","https://openalex.org/W2002801575","https://openalex.org/W2004854221","https://openalex.org/W2015904992","https://openalex.org/W2015919529","https://openalex.org/W2018794044","https://openalex.org/W2026578487","https://openalex.org/W2032118383","https://openalex.org/W2038689279","https://openalex.org/W2039183048","https://openalex.org/W2046768931","https://openalex.org/W2089270260","https://openalex.org/W2089457438","https://openalex.org/W2093705034","https://openalex.org/W2131015559","https://openalex.org/W2137798077","https://openalex.org/W2156106286","https://openalex.org/W2157962067","https://openalex.org/W2163175900","https://openalex.org/W2168669893","https://openalex.org/W2411131024"],"related_works":["https://openalex.org/W2662893324","https://openalex.org/W1995232616","https://openalex.org/W3039326014","https://openalex.org/W1489523181","https://openalex.org/W2326050263","https://openalex.org/W2313002969","https://openalex.org/W2969505681","https://openalex.org/W1995462306","https://openalex.org/W1992045882","https://openalex.org/W2894477715"],"abstract_inverted_index":{"Here,":[0],"tumor-infiltrating":[1,152,166],"CD11b(+)":[2],"myelomonocytoid":[3],"cells":[4,43,52,97],"in":[5,118],"murine":[6,11],"colon":[7],"adenocarcinoma-38":[8],"and":[9,44,55,72,80,88,103,117,123,159],"GL261":[10],"glioma":[12],"were":[13,18],"phenotypically":[14],"characterized.":[15],"Over":[16],"90%":[17],"of":[19,38,62,109,121,138,140,157],"the":[20,36,51,60],"CD11b(+)F4/80(+)":[21],"monocyte/macrophage":[22],"lineage.":[23],"They":[24,75],"also":[25,76,114],"had":[26,45],"a":[27,46,136],"myeloid-derived":[28],"suppressor":[29],"cell":[30],"(MDSC)":[31],"phenotype,":[32],"as":[33,135],"they":[34],"suppressed":[35],"proliferation":[37],"activated":[39],"splenic":[40],"CD8(+)":[41],"T":[42],"CD11b(+)CD11c(+)Gr-1(low)IL-4Ralpha(+)":[47],"phenotype.":[48],"In":[49],"addition,":[50],"expressed":[53,68,78,100],"CX(3)CR1":[54],"CCR2":[56],"simultaneously,":[57],"which":[58,83,106],"are":[59,84],"markers":[61],"an":[63,173],"inflammatory":[64],"monocyte.":[65],"The":[66,112],"MDSCs":[67,113,122,143,153,167],"CD206,":[69,102],"CXCL10,":[70],"IL-1beta,":[71],"TNF-alpha":[73],"mRNAs.":[74],"simultaneously":[77],"CXCL10":[79],"CD206":[81,163],"proteins,":[82],"typical,":[85],"classical":[86],"(M1)":[87],"alternative":[89],"(M2)":[90],"macrophage":[91],"activation":[92],"markers,":[93],"respectively.":[94],"Peritoneal":[95],"exudate":[96],"(PECs)":[98],"strongly":[99],"CD36,":[101],"TGF-beta":[104],"mRNA,":[105],"is":[107],"characteristic":[108],"deactivated":[110,149],"monocytes.":[111],"secreted":[115],"TGF-beta,":[116],"vitro":[119],"culture":[120],"PECs":[124],"with":[125],"anti-TGF-beta":[126],"antibody":[127],"recovered":[128],"their":[129],"ability":[130],"to":[131,169],"secrete":[132],"NO.":[133],"However,":[134],"result":[137],"secretion":[139],"proinflammatory":[141],"cytokines,":[142],"could":[144],"not":[145],"be":[146,170],"categorized":[147],"into":[148],"monocyte/macrophages.":[150],"Thus,":[151],"bear":[154],"pleiotropic":[155],"characteristics":[156],"M1":[158],"M2":[160],"monocytes/macrophages.":[161],"Furthermore,":[162],"expression":[164],"by":[165,172],"appears":[168],"regulated":[171],"autocrine":[174],"mechanism":[175],"that":[176],"involves":[177],"TGF-beta.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":35},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}