{"id":"https://openalex.org/W2155359211","doi":"https://doi.org/10.1111/j.1872-034x.2012.01011.x","title":"Notch\u2010dependent expression of epithelial\u2013mesenchymal transition markers in cholangiocytes after liver transplantation","display_name":"Notch\u2010dependent expression of epithelial\u2013mesenchymal transition markers in cholangiocytes after liver transplantation","publication_year":2012,"publication_date":"2012-03-27","ids":{"openalex":"https://openalex.org/W2155359211","doi":"https://doi.org/10.1111/j.1872-034x.2012.01011.x","mag":"2155359211","pmid":"https://pubmed.ncbi.nlm.nih.gov/22594800"},"language":"en","primary_location":{"id":"doi:10.1111/j.1872-034x.2012.01011.x","doi":"https://doi.org/10.1111/j.1872-034x.2012.01011.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1872-034x.2012.01011.x","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100390774","display_name":"Xiaowei Liu","orcid":"https://orcid.org/0000-0003-3970-1309","observed_orcids":["https://orcid.org/0000-0003-3970-1309","https://orcid.org/0000-0002-7091-8031"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowei Liu","raw_affiliation_strings":["Division of Liver Transplantation, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology             Department of General Surgery, Wuhan No.\u200311 Hospital, Wuhan, China","Department of General Surgery, Wuhan No. 11 Hospital, Wuhan, China","Division of Liver Transplantation, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Liver Transplantation, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology             Department of General Surgery, Wuhan No.\u200311 Hospital, Wuhan, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]},{"raw_affiliation_string":"Department of General Surgery, Wuhan No. 11 Hospital, Wuhan, China","institution_ids":[]},{"raw_affiliation_string":"Division of Liver Transplantation, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["Division of Liver Transplantation, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Liver Transplantation, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038616728","display_name":"Jun Xiong","orcid":"https://orcid.org/0000-0003-0062-9784","observed_orcids":["https://orcid.org/0000-0003-0062-9784"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Xiong","raw_affiliation_strings":["Division of Liver Transplantation, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Liver Transplantation, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400736","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-3971-9130","observed_orcids":["https://orcid.org/0000-0002-3971-9130"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["Division of Liver Transplantation, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Liver Transplantation, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419736","display_name":"Yong Zhang","orcid":"https://orcid.org/0000-0001-8034-2446","observed_orcids":["https://orcid.org/0000-0001-8034-2446"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong Zhang","raw_affiliation_strings":["Division of Liver Transplantation, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Liver Transplantation, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102722821","display_name":"Qichang Zheng","orcid":"https://orcid.org/0000-0002-4198-9578","observed_orcids":["https://orcid.org/0000-0002-4198-9578"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qichang Zheng","raw_affiliation_strings":["Division of Liver Transplantation, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Liver Transplantation, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100419736","https://openalex.org/A5102722821"],"corresponding_institution_ids":["https://openalex.org/I47720641"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":1.2064,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.80338293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"42","issue":"10","first_page":"1024","last_page":"1038"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.31150001287460327,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8920000195503235},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":1.0},{"id":"https://openalex.org/keywords/cholangiocytes","display_name":"cholangiocytes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/jagged1","display_name":"Jagged1","score":0.7730000019073486},{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cholangiocyte-proliferation","display_name":"cholangiocyte proliferation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/gamma-secretase-inhibitors","display_name":"gamma-secretase inhibitors","score":0.7129999995231628},{"id":"https://openalex.org/keywords/biliary-fibrosis","display_name":"biliary fibrosis","score":0.6079999804496765},{"id":"https://openalex.org/keywords/cholestasis","display_name":"cholestasis","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C2780186670","wikidata":"https://www.wikidata.org/wiki/Q5104283","display_name":"Cholangiocyte","level":2,"score":0.9233174324035645},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.8121601343154907},{"id":"https://openalex.org/C2780283210","wikidata":"https://www.wikidata.org/wiki/Q18027301","display_name":"HES1","level":4,"score":0.6975825428962708},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.6537739038467407},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5332657098770142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5201383233070374},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5084484815597534},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.47509801387786865},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45995011925697327},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3987836539745331},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3170497417449951},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.27524635195732117},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24131950736045837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20053672790527344},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1998373568058014},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1872-034x.2012.01011.x","doi":"https://doi.org/10.1111/j.1872-034x.2012.01011.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1872-034x.2012.01011.x","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},{"id":"pmid:22594800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22594800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology research : the official journal of the Japan Society of Hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W101216611","https://openalex.org/W140141082","https://openalex.org/W1497663772","https://openalex.org/W1569369573","https://openalex.org/W1643497640","https://openalex.org/W1677076286","https://openalex.org/W1914626081","https://openalex.org/W1966849995","https://openalex.org/W1970076973","https://openalex.org/W1971013426","https://openalex.org/W1975000833","https://openalex.org/W1982565378","https://openalex.org/W1982577178","https://openalex.org/W1984211346","https://openalex.org/W1988338260","https://openalex.org/W1993767935","https://openalex.org/W2000773023","https://openalex.org/W2001390626","https://openalex.org/W2007117352","https://openalex.org/W2017729871","https://openalex.org/W2027497744","https://openalex.org/W2032942532","https://openalex.org/W2054962474","https://openalex.org/W2057704012","https://openalex.org/W2058473734","https://openalex.org/W2061872176","https://openalex.org/W2075519389","https://openalex.org/W2082438422","https://openalex.org/W2089491632","https://openalex.org/W2097041991","https://openalex.org/W2097466570","https://openalex.org/W2105042695","https://openalex.org/W2125227867","https://openalex.org/W2130795707","https://openalex.org/W2134116694","https://openalex.org/W2145981498","https://openalex.org/W2149914697","https://openalex.org/W2167512484","https://openalex.org/W2167808312"],"related_works":["https://openalex.org/W2771296002","https://openalex.org/W2214176511","https://openalex.org/W2060782406","https://openalex.org/W2981022665","https://openalex.org/W2326275973","https://openalex.org/W3178139368","https://openalex.org/W3199096226","https://openalex.org/W2387615726","https://openalex.org/W2473917317","https://openalex.org/W2624461109"],"abstract_inverted_index":{"AIM:":[0],"Epithelial-mesenchymal":[1],"transition":[2],"(EMT)":[3],"has":[4],"been":[5],"identified":[6],"in":[7,26,44,51,62,96,169,190],"chronic":[8],"cholestatic":[9],"liver":[10,54,58,97,170,194,227],"diseases,":[11],"which":[12],"are":[13],"characterized":[14],"by":[15,86,128,165,207],"biliary":[16,81],"proliferation":[17,220],"and":[18,67,80,93,99,105,110,122,130,137,156,172,196,201,221],"fibrosis.":[19],"Activation":[20,214],"of":[21,29,41,47,78,118,124,139,148,162,181,187,193,210,215,223],"Notch":[22,42,119,149,182,211,216],"signaling":[23,43,150,183,217],"mediates":[24],"EMT":[25,48,140,163,188,224],"a":[27,157],"variety":[28],"epithelial":[30,82],"cell":[31],"types.":[32],"In":[33],"the":[34,39,45,116,146,185,208],"present":[35],"study,":[36],"we":[37],"investigated":[38],"role":[40],"regulation":[46],"marker":[49],"expression":[50,77,138,186,222],"cholangiocytes":[52,69,125,166,174],"after":[53,74,178,226],"transplantation.":[55,75,179,228],"METHODS:":[56],"Orthotopic":[57],"transplantation":[59],"was":[60,84,167],"performed":[61],"Sprague-Dawley":[63],"rats.":[64],"Liver":[65],"tissues":[66],"isolated":[68,100,173,197],"were":[70,112,126,142,204],"collected":[71],"1":[72,176],"week":[73,177],"The":[76],"mesenchymal":[79],"markers":[83,141,164,189,225],"evaluated":[85,144],"immunohistochemistry,":[87],"quantitative":[88],"polymerase":[89],"chain":[90],"reaction":[91],"(PCR)":[92],"western":[94,106],"blotting":[95,107],"sections":[98,195],"cholangiocytes.":[101,198],"Quantitative":[102],"real-time":[103],"PCR":[104],"for":[108],"Jagged1":[109],"HES1":[111],"utilized":[113],"to":[114],"evaluate":[115],"activation":[117],"signaling.":[120,212],"Proliferation":[121],"migration":[123,136],"assessed":[127],"5-bromodeoxyuridine":[129],"transwell":[131],"assays,":[132],"respectively.":[133],"Cholangiocyte":[134,199],"proliferation,":[135],"also":[143,205],"following":[145],"inhibition":[147,209],"with":[151],"N,(N-[3,5-difluorophenacetyl]-L-alanyl)-S-phenylglycine":[152],"t-butylester":[153],"(\u03b3-secretase":[154],"inhibitor)":[155],"Jagged1-neutralizing":[158],"antibody.":[159],"RESULTS:":[160],"Expression":[161],"observed":[168],"grafts":[171],"obtained":[175],"Inhibition":[180],"prevented":[184],"bile":[191],"ducts":[192],"proliferative":[200],"migratory":[202],"capacities":[203],"suppressed":[206],"CONCLUSION:":[213],"promotes":[218],"cholangiocyte":[219]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
