{"id":"https://openalex.org/W2155348252","doi":"https://doi.org/10.1111/j.1755-148x.2008.00508.x","title":"Retention of the cyanobacterial neurotoxin\u03b2\u2010N\u2010methylamino\u2010 l \u2010alanine in melanin and neuromelanin\u2010containing cells \u2013 a possible link between Parkinson\u2010dementia complex and pigmentary retinopathy","display_name":"Retention of the cyanobacterial neurotoxin\u03b2\u2010N\u2010methylamino\u2010 l \u2010alanine in melanin and neuromelanin\u2010containing cells \u2013 a possible link between Parkinson\u2010dementia complex and pigmentary retinopathy","publication_year":2008,"publication_date":"2008-09-11","ids":{"openalex":"https://openalex.org/W2155348252","doi":"https://doi.org/10.1111/j.1755-148x.2008.00508.x","mag":"2155348252","pmid":"https://pubmed.ncbi.nlm.nih.gov/19154235"},"language":"en","primary_location":{"id":"doi:10.1111/j.1755-148x.2008.00508.x","doi":"https://doi.org/10.1111/j.1755-148x.2008.00508.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1755-148x.2008.00508.x","pdf_url":null,"source":{"id":"https://openalex.org/S179442820","display_name":"Pigment Cell & Melanoma Research","issn_l":"1755-1471","issn":["1755-1471","1755-148X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment Cell & Melanoma Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081460832","display_name":"Oskar Karlsson","orcid":"https://orcid.org/0000-0001-8009-0015","observed_orcids":["https://orcid.org/0000-0001-8009-0015"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Oskar Karlsson","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110072364","display_name":"Cecilia Berg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Cecilia Berg","raw_affiliation_strings":["Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038818371","display_name":"Eva B. Brittebo","orcid":"https://orcid.org/0000-0003-2844-8563","observed_orcids":["https://orcid.org/0000-0003-2844-8563"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Eva B. Brittebo","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078071199","display_name":"Nils Gunnar Lindquist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Nils Gunnar Lindquist","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038818371"],"corresponding_institution_ids":["https://openalex.org/I123387679"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.5209,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.81295338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"1","first_page":"120","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.4189000129699707,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.4189000129699707,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.1949000060558319,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.05469999834895134,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmaa","display_name":"BMAA","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cyanobacterial-neurotoxins","display_name":"cyanobacterial neurotoxins","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pigmentary-retinopathy","display_name":"pigmentary retinopathy","score":0.9549999833106995},{"id":"https://openalex.org/keywords/neuromelanin","display_name":"neuromelanin","score":0.8690000176429749},{"id":"https://openalex.org/keywords/melanin","display_name":"melanin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.7480000257492065},{"id":"https://openalex.org/keywords/sepia-melanin","display_name":"sepia melanin","score":0.7369999885559082},{"id":"https://openalex.org/keywords/bioaccumulation","display_name":"bioaccumulation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C43310041","wikidata":"https://www.wikidata.org/wiki/Q1981297","display_name":"Neuromelanin","level":5,"score":0.9894849061965942},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.8702222108840942},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.638438880443573},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.5153509974479675},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.501694917678833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4890976548194885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4067719876766205},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3564663529396057},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.29037997126579285},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.15168413519859314},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.12042206525802612}],"mesh":[{"descriptor_ui":"D000087522","descriptor_name":"Cyanobacteria Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000458","descriptor_name":"Cyanobacteria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000599","descriptor_name":"Amino Acids, Diamino","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011896","descriptor_name":"Rana temporaria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018690","descriptor_name":"Excitatory Amino Acid Agonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049833","descriptor_name":"Sepia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1755-148x.2008.00508.x","doi":"https://doi.org/10.1111/j.1755-148x.2008.00508.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1755-148x.2008.00508.x","pdf_url":null,"source":{"id":"https://openalex.org/S179442820","display_name":"Pigment Cell & Melanoma Research","issn_l":"1755-1471","issn":["1755-1471","1755-148X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment Cell & Melanoma Research","raw_type":"journal-article"},{"id":"pmid:19154235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19154235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment cell & melanoma research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321033","display_name":"Svenska Forskningsr\u00e5det Formas","ror":"https://ror.org/03pjs1y45"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W63470078","https://openalex.org/W193891455","https://openalex.org/W1503853200","https://openalex.org/W1527411259","https://openalex.org/W1556657736","https://openalex.org/W1558984540","https://openalex.org/W1560879547","https://openalex.org/W1657254835","https://openalex.org/W1928197339","https://openalex.org/W1973385523","https://openalex.org/W1980046499","https://openalex.org/W1985729602","https://openalex.org/W1991468624","https://openalex.org/W1992114982","https://openalex.org/W1994010840","https://openalex.org/W2000956059","https://openalex.org/W2002692118","https://openalex.org/W2004434463","https://openalex.org/W2006191770","https://openalex.org/W2006597186","https://openalex.org/W2013473158","https://openalex.org/W2014707045","https://openalex.org/W2016196694","https://openalex.org/W2016926246","https://openalex.org/W2025541331","https://openalex.org/W2032870207","https://openalex.org/W2040058461","https://openalex.org/W2041069307","https://openalex.org/W2044186293","https://openalex.org/W2046565782","https://openalex.org/W2049255279","https://openalex.org/W2049546127","https://openalex.org/W2050337430","https://openalex.org/W2054421268","https://openalex.org/W2054684143","https://openalex.org/W2061030617","https://openalex.org/W2061183770","https://openalex.org/W2069610633","https://openalex.org/W2070253620","https://openalex.org/W2071505837","https://openalex.org/W2073505294","https://openalex.org/W2078335841","https://openalex.org/W2079554923","https://openalex.org/W2080347218","https://openalex.org/W2081647497","https://openalex.org/W2087067803","https://openalex.org/W2089339433","https://openalex.org/W2090141827","https://openalex.org/W2092469426","https://openalex.org/W2092620685","https://openalex.org/W2101065472","https://openalex.org/W2101195640","https://openalex.org/W2105896253","https://openalex.org/W2139217432","https://openalex.org/W2139856185","https://openalex.org/W2163424987","https://openalex.org/W2178105210","https://openalex.org/W2240958717","https://openalex.org/W2284752289","https://openalex.org/W2335562796","https://openalex.org/W2410258645","https://openalex.org/W2433710419","https://openalex.org/W4239927651","https://openalex.org/W4255200862"],"related_works":["https://openalex.org/W2618735307","https://openalex.org/W1968825357","https://openalex.org/W2044186293","https://openalex.org/W2087125360","https://openalex.org/W2789293490","https://openalex.org/W7029274133","https://openalex.org/W198989120","https://openalex.org/W2622563719","https://openalex.org/W2026776092","https://openalex.org/W7034979611"],"abstract_inverted_index":{"beta-N-methylamino-l-alanine":[0],"(BMAA),":[1],"a":[2,19,69,111,163],"neurotoxic":[3],"amino":[4],"acid":[5],"produced":[6],"by":[7],"cyanobacteria,":[8],"has":[9],"been":[10],"suggested":[11],"to":[12,52,95,123,128,132],"be":[13,162],"involved":[14],"in":[15,32,58,76,86,98,134],"the":[16,54,81,91,121,153],"etiology":[17],"of":[18,48,56,72,90,93,114,150,157],"neurodegenerative":[20],"disease":[21],"complex":[22,26],"which":[23],"includes":[24],"Parkinson-dementia":[25],"(PDC).":[27],"In":[28,105],"PDC,":[29],"neuromelanin-containing":[30,84,137],"neurons":[31,85],"substantia":[33],"nigra":[34],"are":[35],"degenerated.":[36],"Many":[37],"PDC":[38,167],"patients":[39],"also":[40],"have":[41],"an":[42],"uncommon":[43],"pigmentary":[44,169],"retinopathy.":[45,170],"The":[46],"aim":[47],"this":[49],"study":[50],"was":[51,74],"investigate":[53],"distribution":[55],"(3)H-BMAA":[57,73,94,115],"mice":[59],"and":[60,83,136,143,168],"frogs,":[61],"with":[62,107,116,159],"emphasis":[63],"on":[64],"pigment-containing":[65],"tissues.":[66],"Using":[67],"autoradiography,":[68],"distinct":[70],"retention":[71],"observed":[75],"melanin-containing":[77],"tissues":[78],"such":[79],"as":[80],"eye":[82],"frog":[87],"brain.":[88],"Analysis":[89],"binding":[92,103,122],"Sepia":[96],"melanin":[97,109,117,146,154,160],"vitro":[99],"demonstrated":[100],"two":[101],"apparent":[102],"sites.":[104],"vitro-studies":[106],"synthetic":[108],"revealed":[110],"stronger":[112],"interaction":[113],"during":[118],"synthesis":[119],"than":[120],"preformed":[124],"melanin.":[125],"Long-term":[126],"exposure":[127],"BMAA":[129,151,158],"may":[130,161],"lead":[131],"bioaccumulation":[133],"melanin-":[135],"cells":[138],"causing":[139],"high":[140],"intracellular":[141],"levels,":[142],"potentially":[144],"changed":[145],"characteristics":[147],"via":[148],"incorporation":[149],"into":[152],"polymer.":[155],"Interaction":[156],"possible":[164],"link":[165],"between":[166]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}