{"id":"https://openalex.org/W2155304812","doi":"https://doi.org/10.2217/fon.11.50","title":"A Comprehensive Review of S-1 in the Treatment of Advanced Gastric Adenocarcinoma","display_name":"A Comprehensive Review of S-1 in the Treatment of Advanced Gastric Adenocarcinoma","publication_year":2011,"publication_date":"2011-06-15","ids":{"openalex":"https://openalex.org/W2155304812","doi":"https://doi.org/10.2217/fon.11.50","mag":"2155304812","pmid":"https://pubmed.ncbi.nlm.nih.gov/21675835"},"language":"en","primary_location":{"id":"doi:10.2217/fon.11.50","doi":"https://doi.org/10.2217/fon.11.50","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fon.11.50","pdf_url":null,"source":{"id":"https://openalex.org/S174572715","display_name":"Future Oncology","issn_l":"1479-6694","issn":["1479-6694","1744-8301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027873506","display_name":"Mariela Anabel Blum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariela Blum","raw_affiliation_strings":["Baylor College of Medicine, Department of Medicine, Division of Hematology \u2013 Oncology, Houston, TX, USA","Department of Medicine, Division of Hematology - Oncology, Baylor College of Medicine, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Department of Medicine, Division of Hematology \u2013 Oncology, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Medicine, Division of Hematology - Oncology, Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101666025","display_name":"Akihiro Suzuki","orcid":"https://orcid.org/0000-0002-5825-3057","observed_orcids":["https://orcid.org/0000-0002-5825-3057"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akihiro Suzuki","raw_affiliation_strings":["The University of Texas, Anderson Cancer Center, Division of Gastrointestinal Oncology, Houston, TX, USA","UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas, Anderson Cancer Center, Division of Gastrointestinal Oncology, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044064524","display_name":"Jaffer A. Ajani","orcid":"https://orcid.org/0000-0001-9946-0629","observed_orcids":["https://orcid.org/0000-0001-9946-0629"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaffer A Ajani","raw_affiliation_strings":["The University of Texas, Anderson Cancer Center, Division of Gastrointestinal Oncology, Houston, TX, USA","GI Medical Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas, Anderson Cancer Center, Division of Gastrointestinal Oncology, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"GI Medical Oncology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5736,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.50473322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"6","first_page":"715","last_page":"726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s-1","display_name":"S-1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tegafur-uracil","display_name":"tegafur-uracil","score":0.9229999780654907},{"id":"https://openalex.org/keywords/advanced-gastric-adenocarcinoma","display_name":"advanced gastric adenocarcinoma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/oral-fluoropyrimidine","display_name":"oral fluoropyrimidine","score":0.9589999914169312},{"id":"https://openalex.org/keywords/triplet-chemotherapy","display_name":"triplet chemotherapy","score":0.5640000104904175},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cyp2a6-polymorphism","display_name":"CYP2A6 polymorphism","score":0.8899999856948853},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.722000002861023},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.39399999380111694},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8681696653366089},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6326459646224976},{"id":"https://openalex.org/C2777511904","wikidata":"https://www.wikidata.org/wiki/Q425227","display_name":"Taxane","level":4,"score":0.6245274543762207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5957105159759521},{"id":"https://openalex.org/C2777299880","wikidata":"https://www.wikidata.org/wiki/Q413370","display_name":"Tegafur","level":3,"score":0.5720301866531372},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4703669250011444},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.464977502822876},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33909183740615845},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.23949643969535828}],"mesh":[{"descriptor_ui":"D000069287","descriptor_name":"Capecitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010094","descriptor_name":"Oxonic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010094","descriptor_name":"Oxonic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010094","descriptor_name":"Oxonic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010094","descriptor_name":"Oxonic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2217/fon.11.50","doi":"https://doi.org/10.2217/fon.11.50","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fon.11.50","pdf_url":null,"source":{"id":"https://openalex.org/S174572715","display_name":"Future Oncology","issn_l":"1479-6694","issn":["1479-6694","1744-8301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Oncology","raw_type":"journal-article"},{"id":"pmid:21675835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21675835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future oncology (London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W61003746","https://openalex.org/W1875373156","https://openalex.org/W1959630789","https://openalex.org/W1974449546","https://openalex.org/W1974957356","https://openalex.org/W1980253503","https://openalex.org/W1985233531","https://openalex.org/W1994843088","https://openalex.org/W2008575122","https://openalex.org/W2018619890","https://openalex.org/W2032540605","https://openalex.org/W2035961702","https://openalex.org/W2038926895","https://openalex.org/W2039838462","https://openalex.org/W2040872961","https://openalex.org/W2053144686","https://openalex.org/W2062004184","https://openalex.org/W2065014168","https://openalex.org/W2077902459","https://openalex.org/W2092804614","https://openalex.org/W2099141426","https://openalex.org/W2100439220","https://openalex.org/W2100642935","https://openalex.org/W2107890342","https://openalex.org/W2112750298","https://openalex.org/W2117452560","https://openalex.org/W2119516652","https://openalex.org/W2122866527","https://openalex.org/W2128328462","https://openalex.org/W2131926022","https://openalex.org/W2131972171","https://openalex.org/W2133127344","https://openalex.org/W2137991416","https://openalex.org/W2138732660","https://openalex.org/W2140410892","https://openalex.org/W2152256906","https://openalex.org/W2153244200","https://openalex.org/W2154767509","https://openalex.org/W2164411042","https://openalex.org/W2168388707","https://openalex.org/W2170809431","https://openalex.org/W2171075804","https://openalex.org/W2171905219","https://openalex.org/W2229238935","https://openalex.org/W2246437066","https://openalex.org/W2339778209","https://openalex.org/W2396646859","https://openalex.org/W2402300954","https://openalex.org/W2415335061","https://openalex.org/W2430807912","https://openalex.org/W2528428498","https://openalex.org/W2606322517","https://openalex.org/W4252783112","https://openalex.org/W6716240200"],"related_works":["https://openalex.org/W2017727167","https://openalex.org/W7162668860","https://openalex.org/W2488947950","https://openalex.org/W2977848385","https://openalex.org/W2319033888","https://openalex.org/W2523657987","https://openalex.org/W2407515179","https://openalex.org/W2418437663","https://openalex.org/W2023622300","https://openalex.org/W2137991416"],"abstract_inverted_index":{"Gastric":[0,56],"cancer":[1,53,57,71],"is":[2,58,139,165,171,182,244,267],"the":[3,29,34,39,97,128,192,216,223,233,250],"fourth":[4],"most":[5],"common":[6],"malignancy":[7],"worldwide":[8],"with":[9,83,114,123,127,145,162,196],"Japan,":[10,185],"Korea,":[11],"Taiwan,":[12,187],"China,":[13,186],"Mongolia":[14],"and":[15,21,99,107,130,154,178,189,199,218,260],"many":[16],"countries":[17,208],"in":[18,54,61,88,96,103,110,158,184,205,215,240,249],"South":[19],"America":[20],"eastern":[22],"Europe,":[23],"as":[24,26,173,222,232],"well":[25],"parts":[27],"of":[28,36,143,194,257],"Middle":[30],"East,":[31],"contributing":[32],"to":[33,140,209,247],"majority":[35],"cases.":[37],"In":[38],"USA,":[40],"it":[41,174],"was":[42],"estimated":[43],"that":[44,150,265,272],"approximately":[45],"10,620":[46],"deaths":[47],"would":[48],"be":[49,121],"caused":[50],"by":[51,147],"gastric":[52,70,197],"2010.":[55],"often":[59,94],"diagnosed":[60],"its":[62],"advanced":[63,69],"stages.":[64],"Current":[65],"first-line":[66],"treatment":[67,193],"for":[68,191],"(AGC)":[72],"using":[73],"triplet":[74,118],"combination":[75],"chemotherapy":[76],"containing":[77],"a":[78,81,91,268],"platinum-based":[79],"compound,":[80],"fluoropyrimidine":[82,271],"an":[84],"anthracycline":[85],"(frequently":[86],"added":[87],"Europe)":[89],"or":[90],"taxane":[92],"(more":[93],"used":[95],"USA":[98,217],"elsewhere)":[100],"has":[101,202],"resulted":[102],"higher":[104],"response":[105],"rates":[106],"modest":[108],"improvement":[109],"overall":[111],"survival":[112],"compared":[113,126,161],"doublet":[115],"combinations.":[116],"However,":[117],"combinations":[119],"can":[120],"associated":[122],"increased":[124],"toxicity":[125],"doublets":[129],"patient":[131],"selection":[132],"becomes":[133],"important.":[134],"A":[135],"desirable":[136],"research":[137],"strategy":[138],"improve":[141],"outcomes":[142],"patients":[144,195],"AGC":[146],"identifying":[148],"treatments":[149],"are":[151],"effective,":[152],"convenient":[153,269],"safe.":[155],"The":[156,236],"interest":[157],"oral":[159,168,270],"agents":[160,164],"intravenous":[163,277],"mounting.":[166],"One":[167],"fluoropyrimidine,":[169],"S-1,":[170],"novel":[172],"combines":[175],"tegafur,":[176],"5-chloro-2,4-dihydroxypyridine":[177],"potassium":[179],"oxonate.":[180],"S-1":[181,266],"approved":[183,204],"Korea":[188],"Singapore":[190],"cancer,":[198],"more":[200],"recently":[201],"been":[203],"27":[206],"European":[207],"treat":[210],"AGC.":[211,283],"Initial":[212],"clinical":[213],"trials":[214],"Europe":[219],"observed":[220],"diarrhea":[221],"dose-limiting":[224,234],"toxicity;":[225],"however,":[226],"initial":[227],"Japanese":[228],"studies":[229],"reported":[230],"myelosuppression":[231],"toxicity.":[235],"differing":[237],"dose":[238],"tolerance":[239],"these":[241],"two":[242],"populations":[243],"likely":[245],"due":[246],"polymorphisms":[248],"CYP2A6":[251],"gene.":[252],"Based":[253],"on":[254],"our":[255],"review":[256],"Phase":[258],"II":[259],"III":[261],"studies,":[262],"we":[263],"conclude":[264],"provides":[273],"safety":[274],"advantage":[275],"over":[276],"fluorouracil":[278],"without":[279],"compromising":[280],"efficacy":[281],"against":[282]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
