{"id":"https://openalex.org/W2155286629","doi":null,"title":"GABAergic and glutamatergic currents in hippocampal slices and neuronal cultures show profound differences: a clue to a potent homeostatic modulation.","display_name":"GABAergic and glutamatergic currents in hippocampal slices and neuronal cultures show profound differences: a clue to a potent homeostatic modulation.","publication_year":2010,"publication_date":"2010-08-01","ids":{"openalex":"https://openalex.org/W2155286629","mag":"2155286629","pmid":"https://pubmed.ncbi.nlm.nih.gov/20814079"},"language":"en","primary_location":{"id":"pmid:20814079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20814079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086623048","display_name":"Marcin Szczot","orcid":"https://orcid.org/0000-0002-3902-059X","observed_orcids":["https://orcid.org/0000-0002-3902-059X"]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"M Szczot","raw_affiliation_strings":["Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, Wroclaw, Poland. marcin.szczot@biofiz.am.wroc.pl","Laboratory of Neuroscience, Department of Biophysics, Wroc\u0142aw Medical University, Wroclaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, Wroclaw, Poland. marcin.szczot@biofiz.am.wroc.pl","institution_ids":["https://openalex.org/I385303915"]},{"raw_affiliation_string":"Laboratory of Neuroscience, Department of Biophysics, Wroc\u0142aw Medical University, Wroclaw, Poland","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060893993","display_name":"Tomasz W\u00f3jtowicz","orcid":"https://orcid.org/0000-0003-1128-4363","observed_orcids":["https://orcid.org/0000-0003-1128-4363"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Wojtowicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091870155","display_name":"Jerzy Wladyslaw Mozrzymas","orcid":"https://orcid.org/0000-0003-1674-1818","observed_orcids":["https://orcid.org/0000-0003-1674-1818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J W Mozrzymas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7808,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.66291146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"61","issue":"4","first_page":"501","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampal-slices","display_name":"hippocampal slices","score":0.8309999704360962},{"id":"https://openalex.org/keywords/primary-neuronal-cultures","display_name":"primary neuronal cultures","score":0.7889999747276306},{"id":"https://openalex.org/keywords/miniature-ipscs","display_name":"miniature IPSCs","score":0.6700000166893005},{"id":"https://openalex.org/keywords/miniature-epscs","display_name":"miniature EPSCs","score":0.9800000190734863},{"id":"https://openalex.org/keywords/synaptic-homeostasis","display_name":"synaptic homeostasis","score":0.6539999842643738},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.9309999942779541},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.8510000109672546},{"id":"https://openalex.org/keywords/glutamate-receptors","display_name":"glutamate receptors","score":0.9459999799728394},{"id":"https://openalex.org/keywords/model-comparison","display_name":"model comparison","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.9197343587875366},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.847065806388855},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8291792869567871},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7943117618560791},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.7826279401779175},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.5916013717651367},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.580923318862915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.558883547782898},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.5052562355995178},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5031573176383972},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.4820905029773712},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.4359997808933258},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.41447871923446655},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.39254331588745117},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2839929461479187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23021119832992554},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05673074722290039}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053444","descriptor_name":"Inhibitory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20814079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20814079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Comparative Study"},{"id":"mag:2155286629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20814079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W315090786","https://openalex.org/W800904743","https://openalex.org/W1496861555","https://openalex.org/W1514853588","https://openalex.org/W1530039133","https://openalex.org/W1869876350","https://openalex.org/W1979497358","https://openalex.org/W1993391624","https://openalex.org/W2004803686","https://openalex.org/W2013239918","https://openalex.org/W2015701831","https://openalex.org/W2047535883","https://openalex.org/W2060304640","https://openalex.org/W2066781880","https://openalex.org/W2075820187","https://openalex.org/W2080345761","https://openalex.org/W2080611091","https://openalex.org/W2082372907","https://openalex.org/W2093725075","https://openalex.org/W2098224847","https://openalex.org/W2118084082","https://openalex.org/W2119109172","https://openalex.org/W2122037734","https://openalex.org/W2130486299","https://openalex.org/W2137115884","https://openalex.org/W2168313252","https://openalex.org/W3189173254","https://openalex.org/W4321429493"],"related_works":["https://openalex.org/W940974043","https://openalex.org/W2126151396","https://openalex.org/W2033144609","https://openalex.org/W171058796","https://openalex.org/W2126568243","https://openalex.org/W2068192474","https://openalex.org/W4252793460","https://openalex.org/W1976400775","https://openalex.org/W7096824996","https://openalex.org/W2257040941"],"abstract_inverted_index":{"Acute":[0],"hippocampal":[1,99],"slices":[2,100,179],"and":[3,91,101,121,139,155,180,188,204],"primary":[4],"neuronal":[5,46,61,102,215],"cultures":[6,181],"are":[7],"often":[8],"used":[9],"with":[10,221],"a":[11,67,76],"tacit":[12],"assumption":[13],"that":[14,134,199,224],"basic":[15],"characteristics":[16],"of":[17,27,36,49,70,89,112,118,127,202],"the":[18,28,52,81,87,214,226],"two":[19,147],"models":[20],"closely":[21],"resemble":[22],"each":[23],"other.":[24],"The":[25],"use":[26],"cell":[29,103,216],"cultures,":[30],"however,":[31],"may":[32,72],"raise":[33],"controversies":[34],"because":[35],"non-physiological":[37],"conditions":[38],"resulting":[39],"from":[40,98],"e.g.":[41],"glial":[42],"cells":[43],"deficit,":[44],"random":[45],"sprouting,":[47],"lack":[48],"specificity":[50],"in":[51,60,95,130,135,158,167,175,192,213,225],"synaptic":[53,210],"connections,":[54],"impaired":[55],"homeostasis,":[56],"etc.":[57],"Importantly,":[58],"alteration":[59],"environment,":[62],"especially":[63],"when":[64,177],"occurring":[65],"over":[66],"prolonged":[68],"period":[69],"time,":[71],"give":[73],"rise":[74],"to":[75,223],"profound":[77,219],"homeostatic":[78],"modulation.":[79],"In":[80,149,194],"present":[82],"study":[83],"we":[84,196],"have":[85],"compared":[86],"properties":[88,212],"GABAergic":[90],"glutamatergic":[92],"(non-NMDA)":[93],"currents":[94,113],"pyramidal":[96],"neurons":[97,132,160],"culture.":[104],"We":[105],"show":[106,173,218],"that,":[107],"most":[108],"strikingly,":[109],"amplitude":[110,176],"ratio":[111],"elicited":[114],"by":[115],"ultrafast":[116],"applications":[117],"saturating":[119],"GABA":[120],"glutamate":[122,205],"was":[123,165,186],"nearly":[124],"one":[125],"order":[126],"magnitude":[128],"larger":[129,154],"cultured":[131,159],"than":[133],"slices.":[136,168,193],"Miniature":[137,169],"IPSCs":[138,170],"EPSCs":[140],"also":[141],"showed":[142],"substantial":[143],"differences":[144,174,220],"between":[145],"these":[146],"models.":[148],"particular,":[150],"mEPSC":[151],"amplitudes":[152],"were":[153],"more":[156,190],"frequent":[157,191],"but":[161,182],"their":[162,183],"time":[163,184],"duration":[164,185],"longer":[166],"did":[171],"not":[172],"comparing":[178],"faster":[187],"occurrence":[189],"conclusion,":[195],"provide":[197],"evidence":[198],"expression":[200],"pattern":[201],"GABA(A)":[203],"receptors":[206],"as":[207,209],"well":[208],"current":[211],"culture":[217],"respect":[222],"physiological":[227],"conditions.":[228]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}