{"id":"https://openalex.org/W2155269095","doi":"https://doi.org/10.1161/atvbaha.114.302818","title":"Interacting Mechanisms in the Pathogenesis of Cardiac Allograft Vasculopathy","display_name":"Interacting Mechanisms in the Pathogenesis of Cardiac Allograft Vasculopathy","publication_year":2014,"publication_date":"2014-06-06","ids":{"openalex":"https://openalex.org/W2155269095","doi":"https://doi.org/10.1161/atvbaha.114.302818","mag":"2155269095","pmid":"https://pubmed.ncbi.nlm.nih.gov/24903097","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4324618"},"language":"en","primary_location":{"id":"doi:10.1161/atvbaha.114.302818","doi":"https://doi.org/10.1161/atvbaha.114.302818","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvbaha.114.302818","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4324618","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022235365","display_name":"Jordan S. Pober","orcid":"https://orcid.org/0000-0001-5990-1071","observed_orcids":["https://orcid.org/0000-0001-5990-1071"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan S. Pober","raw_affiliation_strings":["From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT","Jordan S. Pober From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Jordan S. Pober From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004236987","display_name":"Dan Jane\u2010wit","orcid":"https://orcid.org/0000-0001-7115-0362","observed_orcids":["https://orcid.org/0000-0001-7115-0362"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Jane-wit","raw_affiliation_strings":["From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT","Dan Jane-wit From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Dan Jane-wit From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023705448","display_name":"Lingfeng Qin","orcid":"https://orcid.org/0000-0002-5381-6826","observed_orcids":["https://orcid.org/0000-0002-5381-6826"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lingfeng Qin","raw_affiliation_strings":["From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT","Lingfeng Qin From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Lingfeng Qin From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036202065","display_name":"George Tellides","orcid":"https://orcid.org/0000-0001-7042-8190","observed_orcids":["https://orcid.org/0000-0001-7042-8190"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Tellides","raw_affiliation_strings":["From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT","George Tellides From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"George Tellides From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":2.1688,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.9019492,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"34","issue":"8","first_page":"1609","last_page":"1614"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-allograft-vasculopathy","display_name":"cardiac allograft vasculopathy","score":1.0},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/graft-loss","display_name":"graft loss","score":0.8579999804496765},{"id":"https://openalex.org/keywords/arterial-stenosis","display_name":"arterial stenosis","score":0.6669999957084656},{"id":"https://openalex.org/keywords/alloimmunity","display_name":"alloimmunity","score":0.722000002861023},{"id":"https://openalex.org/keywords/atherosclerosis-risk-factors","display_name":"atherosclerosis risk factors","score":0.9580000042915344},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.609000027179718},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cell-mediated-immunity","display_name":"T cell immunity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/b-cell-mediated-immunity","display_name":"B cell-mediated immunity","score":0.9779999852180481},{"id":"https://openalex.org/keywords/donor-specific-antibodies","display_name":"donor-specific antibodies","score":0.8679999709129333},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C2778324207","wikidata":"https://www.wikidata.org/wiki/Q4733063","display_name":"Alloimmunity","level":3,"score":0.7472847104072571},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7393190860748291},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6106464266777039},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5450600981712341},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4723083972930908},{"id":"https://openalex.org/C178596483","wikidata":"https://www.wikidata.org/wiki/Q7916472","display_name":"Vascularity","level":2,"score":0.432937890291214},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4313116669654846},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42708471417427063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18117743730545044}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007518","descriptor_name":"Isoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056724","descriptor_name":"Immunity, Humoral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064591","descriptor_name":"Allografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/atvbaha.114.302818","doi":"https://doi.org/10.1161/atvbaha.114.302818","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvbaha.114.302818","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},{"id":"pmid:24903097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24903097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, thrombosis, and vascular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4324618","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4324618","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Arterioscler Thromb Vasc Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4324618","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4324618","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Arterioscler Thromb Vasc Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1692468525","display_name":"Chronic DTH and IFN-gamma in Human Graft Arteriosclerosis","funder_award_id":"P01HL070295","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2942682031","display_name":"Regulating Anti-Endothelial T Cell Responses in Graft Arteriosclerosis","funder_award_id":"R01HL109455","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3240652374","display_name":"Human and Translational Immunology","funder_award_id":"T32AI089704","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000860819","display_name":"Immunohematology/Transfusion Medicine Research Training","funder_award_id":"T32HL007974","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W54684436","https://openalex.org/W134332809","https://openalex.org/W155025199","https://openalex.org/W282283539","https://openalex.org/W1507771178","https://openalex.org/W1523840697","https://openalex.org/W1529051001","https://openalex.org/W1563797570","https://openalex.org/W1593792120","https://openalex.org/W1663730150","https://openalex.org/W1773738593","https://openalex.org/W1946807613","https://openalex.org/W1963518447","https://openalex.org/W1963841304","https://openalex.org/W1964673612","https://openalex.org/W1965096707","https://openalex.org/W1966025802","https://openalex.org/W1970237823","https://openalex.org/W1977685314","https://openalex.org/W1981568036","https://openalex.org/W1982707127","https://openalex.org/W2004562742","https://openalex.org/W2015983803","https://openalex.org/W2023632462","https://openalex.org/W2027488189","https://openalex.org/W2028208800","https://openalex.org/W2028276026","https://openalex.org/W2029094224","https://openalex.org/W2029180052","https://openalex.org/W2031300651","https://openalex.org/W2031635155","https://openalex.org/W2036747216","https://openalex.org/W2042375257","https://openalex.org/W2049470206","https://openalex.org/W2060034277","https://openalex.org/W2061778160","https://openalex.org/W2067679957","https://openalex.org/W2076833412","https://openalex.org/W2084776016","https://openalex.org/W2088859046","https://openalex.org/W2091463791","https://openalex.org/W2104061060","https://openalex.org/W2108923719","https://openalex.org/W2110360170","https://openalex.org/W2110664624","https://openalex.org/W2118398499","https://openalex.org/W2122652084","https://openalex.org/W2123639070","https://openalex.org/W2123670089","https://openalex.org/W2127360618","https://openalex.org/W2130625143","https://openalex.org/W2132621489","https://openalex.org/W2132809216","https://openalex.org/W2133906238","https://openalex.org/W2139418412","https://openalex.org/W2143967688","https://openalex.org/W2148022096","https://openalex.org/W2152079015","https://openalex.org/W2159819332","https://openalex.org/W2160172454","https://openalex.org/W2165115566","https://openalex.org/W2166685519","https://openalex.org/W2321999138","https://openalex.org/W2413980656"],"related_works":["https://openalex.org/W1999154633","https://openalex.org/W2009811996","https://openalex.org/W7064596057","https://openalex.org/W3191105691","https://openalex.org/W618399719","https://openalex.org/W2773024392","https://openalex.org/W1972888339","https://openalex.org/W3151074749","https://openalex.org/W1980427514","https://openalex.org/W2050859884"],"abstract_inverted_index":{"Cardiac":[0,92],"allograft":[1,93],"vasculopathy":[2,94],"is":[3],"the":[4,81,117,127,133],"major":[5],"cause":[6],"of":[7,17,25,63,98,155,176],"late":[8],"graft":[9,90,112],"loss":[10,113],"in":[11,110],"heart":[12],"transplant":[13,99],"recipients.":[14],"Histological":[15],"studies":[16],"characteristic":[18],"end-stage":[19],"lesions":[20,95],"reveal":[21],"arterial":[22,85],"changes":[23],"consisting":[24],"a":[26,45],"diffuse,":[27],"confluent,":[28],"and":[29,44,83,101,105,170],"concentric":[30],"intimal":[31,67],"expansion":[32,68],"containing":[33],"graft-derived":[34,55],"cells":[35],"expressing":[36],"smooth":[37],"muscle":[38],"markers,":[39],"extracellular":[40],"matrix,":[41],"penetrating":[42],"microvessels,":[43],"host":[46],"mononuclear":[47],"cell":[48,58],"infiltrate":[49],"concentrated":[50],"subjacent":[51],"to":[52,107,148],"an":[53],"intact":[54],"luminal":[56],"endothelial":[57],"lining":[59],"with":[60,70,189],"little":[61],"evidence":[62],"acute":[64],"injury.":[65],"This":[66],"combined":[69],"inadequate":[71],"compensatory":[72],"outward":[73],"remodeling":[74],"produces":[75],"severe":[76],"generalized":[77],"stenosis":[78],"extending":[79],"throughout":[80],"epicardial":[82],"intramyocardial":[84],"tree":[86],"that":[87],"causes":[88],"ischemic":[89],"failure.":[91],"affect":[96],"\u226550%":[97],"recipients":[100],"are":[102],"both":[103],"progressive":[104],"refractory":[106],"treatment,":[108],"resulting":[109],"\u22485%":[111],"per":[114],"year":[115],"through":[116,174],"first":[118],"10":[119],"years":[120],"after":[121],"transplant.":[122],"Lesions":[123],"typically":[124],"stop":[125],"at":[126],"suture":[128],"line,":[129],"implicating":[130],"alloimmunity":[131],"as":[132],"primary":[134],"driver,":[135],"but":[136],"pathogenesis":[137],"may":[138,187],"be":[139],"multifactorial.":[140],"Here,":[141],"we":[142,180],"will":[143,181],"discuss":[144],"6":[145],"potential":[146],"contributors":[147],"lesion":[149],"formation":[150],"(1)":[151],"conventional":[152],"risk":[153],"factors":[154],"atherosclerosis;":[156],"(2)":[157],"pre-":[158],"or":[159],"peritransplant":[160],"injuries;":[161],"(3)":[162],"infection;":[163],"(4)":[164],"innate":[165],"immunity;":[166,169],"(5)":[167],"T-cell-mediated":[168],"(6)":[171],"B-cell-mediated":[172],"immunity":[173],"production":[175],"donor-specific":[177],"antibody.":[178],"Finally,":[179],"consider":[182],"how":[183],"these":[184],"various":[185],"mechanisms":[186],"interact":[188],"each":[190],"other.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
