{"id":"https://openalex.org/W2155268390","doi":"https://doi.org/10.1111/febs.12866","title":"Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription","display_name":"Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription","publication_year":2014,"publication_date":"2014-06-09","ids":{"openalex":"https://openalex.org/W2155268390","doi":"https://doi.org/10.1111/febs.12866","mag":"2155268390","pmid":"https://pubmed.ncbi.nlm.nih.gov/24910119","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4474172"},"language":"en","primary_location":{"id":"doi:10.1111/febs.12866","doi":"https://doi.org/10.1111/febs.12866","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.12866","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.12866","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.12866","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010780653","display_name":"Bhavana Chhunchha","orcid":"https://orcid.org/0000-0001-9613-8765","observed_orcids":["https://orcid.org/0000-0001-9613-8765"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhavana Chhunchha","raw_affiliation_strings":["Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103416824","display_name":"Nigar Fatma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nigar Fatma","raw_affiliation_strings":["Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072279870","display_name":"Eri Kubo","orcid":"https://orcid.org/0000-0001-6789-9311","observed_orcids":["https://orcid.org/0000-0001-6789-9311"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eri Kubo","raw_affiliation_strings":["Department of Ophthalmology, Kanazawa Medical University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Kanazawa Medical University, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101836695","display_name":"Dhirendra P. Singh","orcid":"https://orcid.org/0000-0003-3311-2191","observed_orcids":["https://orcid.org/0000-0003-3311-2191"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dhirendra P. Singh","raw_affiliation_strings":["Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101836695"],"corresponding_institution_ids":["https://openalex.org/I59130452"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.9563,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.7394145,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"281","issue":"15","first_page":"3357","last_page":"3381"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxiredoxin-6","display_name":"peroxiredoxin 6","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/sumo1","display_name":"SUMO1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9279999732971191},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.972000002861023},{"id":"https://openalex.org/keywords/lens-epithelial-cells","display_name":"lens epithelial cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/lens-aging","display_name":"lens aging","score":0.8610000014305115},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.6230000257492065},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7519999742507935},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.8370000123977661},{"id":"https://openalex.org/keywords/senp1","display_name":"SENP1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.6679999828338623},{"id":"https://openalex.org/keywords/oxidative-stress-induced-cell-death","display_name":"oxidative stress-induced cell death","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C171350616","wikidata":"https://www.wikidata.org/wiki/Q61506","display_name":"SUMO protein","level":4,"score":0.8204119801521301},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7258124351501465},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7207098603248596},{"id":"https://openalex.org/C2780416994","wikidata":"https://www.wikidata.org/wiki/Q419462","display_name":"Peroxiredoxin","level":4,"score":0.587300181388855},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5851243138313293},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49918580055236816},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.4865669310092926},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4803256094455719},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40759381651878357},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3600538372993469},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28587228059768677},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15570953488349915},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14861860871315002},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.11334723234176636},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004794","descriptor_name":"Enzyme Repression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016329","descriptor_name":"Sp1 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016329","descriptor_name":"Sp1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025842","descriptor_name":"SUMO-1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054465","descriptor_name":"Peroxiredoxin VI","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D058207","descriptor_name":"Sumoylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/febs.12866","doi":"https://doi.org/10.1111/febs.12866","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.12866","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.12866","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:24910119","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24910119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4474172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4474172","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"FEBS J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/febs.12866","doi":"https://doi.org/10.1111/febs.12866","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.12866","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.12866","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2187481759","display_name":"Peroxiredoxin 6 and Cataractogenesis","funder_award_id":"R01EY017613","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3163500035","display_name":null,"funder_award_id":"EY013394","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3892783048","display_name":"Regulation and Function of Prdx6 in eye lens during Aging & Oxidative Stress","funder_award_id":"R01EY024589","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G4777483720","display_name":null,"funder_award_id":"EY017613","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7713909871","display_name":null,"funder_award_id":"EY0176613 and EY013394","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8162925416","display_name":"Gene Regulation by and of LEDGF","funder_award_id":"R01EY013394","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2155268390.pdf","grobid_xml":"https://content.openalex.org/works/W2155268390.grobid-xml"},"referenced_works_count":115,"referenced_works":["https://openalex.org/W95252060","https://openalex.org/W181090678","https://openalex.org/W1501564271","https://openalex.org/W1513724442","https://openalex.org/W1566467567","https://openalex.org/W1575226591","https://openalex.org/W1744223828","https://openalex.org/W1959908262","https://openalex.org/W1963961667","https://openalex.org/W1964381171","https://openalex.org/W1965226335","https://openalex.org/W1965493433","https://openalex.org/W1966728645","https://openalex.org/W1967874462","https://openalex.org/W1969165489","https://openalex.org/W1973480232","https://openalex.org/W1976554071","https://openalex.org/W1977910682","https://openalex.org/W1977959424","https://openalex.org/W1979275431","https://openalex.org/W1980018854","https://openalex.org/W1981243923","https://openalex.org/W1987480357","https://openalex.org/W1990815712","https://openalex.org/W1991189921","https://openalex.org/W1992125440","https://openalex.org/W1992576746","https://openalex.org/W1993180829","https://openalex.org/W1994218254","https://openalex.org/W1995002748","https://openalex.org/W1996760634","https://openalex.org/W1997917833","https://openalex.org/W2001341780","https://openalex.org/W2001366457","https://openalex.org/W2002022490","https://openalex.org/W2004722555","https://openalex.org/W2006971226","https://openalex.org/W2008203769","https://openalex.org/W2010576862","https://openalex.org/W2013244756","https://openalex.org/W2015868577","https://openalex.org/W2016241657","https://openalex.org/W2018686658","https://openalex.org/W2020042771","https://openalex.org/W2020050203","https://openalex.org/W2021176126","https://openalex.org/W2021618108","https://openalex.org/W2024574118","https://openalex.org/W2025960110","https://openalex.org/W2026421562","https://openalex.org/W2029189334","https://openalex.org/W2031668046","https://openalex.org/W2032172345","https://openalex.org/W2034882495","https://openalex.org/W2037845650","https://openalex.org/W2043097986","https://openalex.org/W2043137911","https://openalex.org/W2044432481","https://openalex.org/W2044559213","https://openalex.org/W2050895547","https://openalex.org/W2050935157","https://openalex.org/W2051158533","https://openalex.org/W2051166632","https://openalex.org/W2051343147","https://openalex.org/W2052495973","https://openalex.org/W2062118458","https://openalex.org/W2062250649","https://openalex.org/W2067305246","https://openalex.org/W2067463001","https://openalex.org/W2067775412","https://openalex.org/W2070270322","https://openalex.org/W2073133734","https://openalex.org/W2073148985","https://openalex.org/W2073286776","https://openalex.org/W2073983559","https://openalex.org/W2079306180","https://openalex.org/W2082629253","https://openalex.org/W2082970207","https://openalex.org/W2084117490","https://openalex.org/W2084666034","https://openalex.org/W2093877886","https://openalex.org/W2094741094","https://openalex.org/W2096098020","https://openalex.org/W2100804908","https://openalex.org/W2104079111","https://openalex.org/W2110548948","https://openalex.org/W2112441454","https://openalex.org/W2114591766","https://openalex.org/W2117909268","https://openalex.org/W2122395558","https://openalex.org/W2124296777","https://openalex.org/W2134690343","https://openalex.org/W2136956610","https://openalex.org/W2137772017","https://openalex.org/W2140709359","https://openalex.org/W2144112275","https://openalex.org/W2145722065","https://openalex.org/W2147699350","https://openalex.org/W2148205861","https://openalex.org/W2148721425","https://openalex.org/W2148914950","https://openalex.org/W2153398746","https://openalex.org/W2156503672","https://openalex.org/W2164764996","https://openalex.org/W2165445583","https://openalex.org/W2166440966","https://openalex.org/W2167536088","https://openalex.org/W2168668456","https://openalex.org/W2169627244","https://openalex.org/W2171805808","https://openalex.org/W2172298521","https://openalex.org/W2314225431","https://openalex.org/W2320634483","https://openalex.org/W2332271182","https://openalex.org/W4249588491"],"related_works":["https://openalex.org/W2568082786","https://openalex.org/W2891333775","https://openalex.org/W7125390729","https://openalex.org/W2122395558","https://openalex.org/W2140709359","https://openalex.org/W1575226591","https://openalex.org/W4224233247","https://openalex.org/W2886280474","https://openalex.org/W2899756437","https://openalex.org/W2051343147"],"abstract_inverted_index":{"Loss":[0],"of":[1,25,74,85,91,121,136,177,181,186,221,251,272],"the":[2,23,30,72,89,182,219,226,252],"cytoprotective":[3],"protein":[4,127,132,155],"peroxiredoxin":[5],"6":[6],"(Prdx6)":[7],"in":[8,71,152,161,167,217],"cells":[9,45,58,81,141,165],"that":[10,96,106,204,231],"are":[11],"aging":[12,50,64,168],"or":[13,51,223],"under":[14],"oxidative":[15,61,145,265],"stress":[16,62],"is":[17,38,98],"known":[18],"to":[19,22,144,197,262],"be":[20],"linked":[21],"pathobiology":[24],"many":[26],"age-related":[27],"diseases.":[28],"However,":[29],"mechanism":[31],"by":[32,209,241,268],"which":[33],"Prdx6":[34,97,122,193,195,207,224,239,243],"activity":[35,120,208,240,271],"goes":[36],"awry":[37],"largely":[39],"unknown.":[40],"Using":[41],"Prdx6-deficient":[42],"(Prdx6(-/-)":[43],")":[44],"as":[46,245,247],"a":[47,68,99,257,260,269],"model":[48],"for":[49,101,259],"redox":[52,162],"active":[53,163],"cells,":[54],"human/mouse":[55],"lens":[56],"epithelial":[57],"(LECs)":[59],"facing":[60],"and":[63,87,105,119,123,131,156,166,179,194,213],"lenses,":[65],"we":[66,94],"found":[67],"significant":[69,150],"increase":[70],"levels":[73,84,135],"small":[75],"ubiquitin-like":[76],"modifier":[77],"(Sumo)1":[78],"conjugates.":[79],"These":[80],"displayed":[82],"increased":[83,134,175],"Sumo1":[86,107,115,178,205],"reduced":[88,117,270],"expression":[90,118,158,176],"Prdx6.":[92,273],"Specifically,":[93],"observed":[95,160],"target":[100],"aberrant":[102,235],"sumoylation":[103,236],"signaling,":[104],"modification":[108],"reduces":[109],"its":[110,124,211,215],"cellular":[111],"abundance.":[112],"LECs":[113],"overexpressing":[114],"showed":[116],"transactivator":[125],"specificity":[126],"1":[128],"(Sp1),":[129],"mRNA":[130,157],"with":[133,174,191],"reactive":[137,232],"oxygen":[138,233],"species;":[139],"those":[140],"were":[142],"vulnerable":[143],"stress-induced":[146],"cell":[147],"death.":[148],"A":[149],"reduction":[151,171],"Prdx6,":[153],"Sp1":[154],"was":[159,172],"Prdx6(-/-)":[164],"lenses/LECs.":[169],"The":[170,228,249],"correlated":[173],"enrichment":[180],"inactive":[183],"form":[184],"(dimeric)":[185],"Sumo-specific":[187],"protease":[188],"(Senp)1.":[189],"Experiments":[190],"Sumo1-fused":[192],"promoter-linked":[196],"chloramphenicol":[198],"acetyltransferase":[199],"reporter":[200],"gene":[201],"constructs":[202],"indicated":[203],"dysregulated":[206],"reducing":[210,242],"abundance":[212],"attenuating":[214],"transcription;":[216],"contrast,":[218],"delivery":[220],"Senp1":[222],"reversed":[225],"process.":[227],"data":[229],"show":[230],"species-evoked":[234],"signaling":[237,266],"affects":[238],"abundance,":[244],"well":[246],"transcription.":[248],"findings":[250],"present":[253],"study":[254],"may":[255],"provide":[256],"foundation":[258],"strategy":[261],"repair":[263],"deleterious":[264],"generated":[267]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}