{"id":"https://openalex.org/W2155244198","doi":"https://doi.org/10.1093/chemse/bjj021","title":"Faithful Expression of GFP from the PLC\u03b22 Promoter in a Functional Class of Taste Receptor Cells","display_name":"Faithful Expression of GFP from the PLC\u03b22 Promoter in a Functional Class of Taste Receptor Cells","publication_year":2006,"publication_date":"2006-01-04","ids":{"openalex":"https://openalex.org/W2155244198","doi":"https://doi.org/10.1093/chemse/bjj021","mag":"2155244198","pmid":"https://pubmed.ncbi.nlm.nih.gov/16394244"},"language":"en","primary_location":{"id":"doi:10.1093/chemse/bjj021","doi":"https://doi.org/10.1093/chemse/bjj021","is_oa":false,"landing_page_url":"https://doi.org/10.1093/chemse/bjj021","pdf_url":null,"source":{"id":"https://openalex.org/S8722945","display_name":"Chemical Senses","issn_l":"0379-864X","issn":["0379-864X","1464-3553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Senses","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079288585","display_name":"Joung Woul Kim","orcid":"https://orcid.org/0000-0002-0269-8081","observed_orcids":["https://orcid.org/0000-0002-0269-8081","https://orcid.org/0000-0001-5456-8820"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joung Woul Kim","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Miami Miller School of Medicine (RMSB 4040), 1600 NW 10th Avenue, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Miami Miller School of Medicine (RMSB 4040), 1600 NW 10th Avenue, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Craig Roberts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Craig Roberts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017088569","display_name":"Yutaka Maruyama","orcid":"https://orcid.org/0000-0003-4035-4885","observed_orcids":["https://orcid.org/0000-0003-4035-4885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yutaka Maruyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071666691","display_name":"Stephanie A Berg","orcid":"https://orcid.org/0000-0001-6193-5350","observed_orcids":["https://orcid.org/0000-0001-6193-5350"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie Berg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066904083","display_name":"Stephen D. Roper","orcid":"https://orcid.org/0000-0001-6049-8320","observed_orcids":["https://orcid.org/0000-0001-6049-8320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Roper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037354482","display_name":"Nirupa Chaudhari","orcid":"https://orcid.org/0000-0002-3883-5893","observed_orcids":["https://orcid.org/0000-0002-3883-5893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nirupa Chaudhari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079288585"],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":{"value":4317,"currency":"USD","value_usd":4317},"apc_paid":null,"fwci":6.1442,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.96233091,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"31","issue":"3","first_page":"213","last_page":"219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phospholipase-c-beta2","display_name":"PLC\u03b22","score":0.8859999775886536},{"id":"https://openalex.org/keywords/taste-cells","display_name":"taste cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/taste-bud-development","display_name":"taste bud development","score":0.656000018119812},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.6949999928474426},{"id":"https://openalex.org/keywords/gfp-reporter","display_name":"GFP reporter","score":0.7990000247955322},{"id":"https://openalex.org/keywords/circumvallate-papillae","display_name":"circumvallate papillae","score":0.8640000224113464},{"id":"https://openalex.org/keywords/calcium-imaging","display_name":"calcium imaging","score":0.6079999804496765},{"id":"https://openalex.org/keywords/taste-transduction","display_name":"taste transduction","score":0.7649999856948853},{"id":"https://openalex.org/keywords/bitter-taste","display_name":"bitter taste","score":0.7639999985694885},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.8664261102676392},{"id":"https://openalex.org/C2776946002","wikidata":"https://www.wikidata.org/wiki/Q202637","display_name":"Umami","level":3,"score":0.8361537456512451},{"id":"https://openalex.org/C2777687625","wikidata":"https://www.wikidata.org/wiki/Q862867","display_name":"Taste bud","level":3,"score":0.7577160596847534},{"id":"https://openalex.org/C178006227","wikidata":"https://www.wikidata.org/wiki/Q3454532","display_name":"Taste receptor","level":3,"score":0.725040853023529},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.6619983911514282},{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.6227663159370422},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6218403577804565},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5931228399276733},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5238878130912781},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4401625692844391},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41679781675338745},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24813953042030334},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18985575437545776}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054799","descriptor_name":"Phospholipase C beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/chemse/bjj021","doi":"https://doi.org/10.1093/chemse/bjj021","is_oa":false,"landing_page_url":"https://doi.org/10.1093/chemse/bjj021","pdf_url":null,"source":{"id":"https://openalex.org/S8722945","display_name":"Chemical Senses","issn_l":"0379-864X","issn":["0379-864X","1464-3553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Senses","raw_type":"journal-article"},{"id":"pmid:16394244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16394244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical senses","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life on land","id":"https://metadata.un.org/sdg/15","score":0.5600000023841858}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3006567686","display_name":"Mechanisms of sweet transduction in mammalian taste buds","funder_award_id":"R01DC006021","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G3067943600","display_name":"Signaling in Taste Cells","funder_award_id":"R01DC006308","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G4835205863","display_name":null,"funder_award_id":"DC006308","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G5077877978","display_name":null,"funder_award_id":"DC006021","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G56493949","display_name":null,"funder_award_id":"DC000374","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320309249","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1592727056","https://openalex.org/W1774637004","https://openalex.org/W1857132483","https://openalex.org/W1909865944","https://openalex.org/W1918549573","https://openalex.org/W1970250202","https://openalex.org/W2003405098","https://openalex.org/W2008264452","https://openalex.org/W2030774440","https://openalex.org/W2034583757","https://openalex.org/W2061898655","https://openalex.org/W2063934299","https://openalex.org/W2076060807","https://openalex.org/W2076395918","https://openalex.org/W2080340979","https://openalex.org/W2086339199","https://openalex.org/W2098729010","https://openalex.org/W2104228115","https://openalex.org/W2111658605","https://openalex.org/W2118268566","https://openalex.org/W2119517589","https://openalex.org/W2123477786","https://openalex.org/W2169702025","https://openalex.org/W2172096995","https://openalex.org/W2272066499","https://openalex.org/W2288400231","https://openalex.org/W4249590403"],"related_works":["https://openalex.org/W7099358478","https://openalex.org/W1971320703","https://openalex.org/W1968795590","https://openalex.org/W1975026051","https://openalex.org/W1496948115","https://openalex.org/W1968552568","https://openalex.org/W2034144407","https://openalex.org/W2119526311","https://openalex.org/W2063934299","https://openalex.org/W2082710235"],"abstract_inverted_index":{"Phospholipase":[0],"C-type":[1],"beta2":[2],"(PLCbeta2)":[3],"is":[4,17,30,85],"expressed":[5],"in":[6,19,70,77,91,121,142],"a":[7,34,139,152],"subset":[8],"of":[9,22,54,74,106,117],"cells":[10,64,107,146],"within":[11],"mammalian":[12],"taste":[13,145,153,170,176],"buds.":[14],"This":[15],"enzyme":[16],"involved":[18],"the":[20,52,55,103,118,127,155],"transduction":[21],"sweet,":[23],"bitter,":[24],"and":[25,28,65,175],"umami":[26],"stimuli":[27],"thus":[29],"believed":[31],"to":[32,58,61,88,151,165],"be":[33,89,166],"marker":[35],"for":[36,168],"gustatory":[37],"sensory":[38,172],"receptor":[39],"cells.":[40],"We":[41],"have":[42],"developed":[43],"transgenic":[44,162],"mice":[45],"expressing":[46,108],"green":[47],"fluorescent":[48],"protein":[49],"(GFP)":[50],"under":[51],"control":[53],"PLCbeta2":[56,134,160],"promoter":[57],"enable":[59],"one":[60,82],"identify":[62],"these":[63],"record":[66],"their":[67],"physiological":[68],"activity":[69],"living":[71],"preparations.":[72],"Expression":[73,116],"GFP":[75,109,119],"(especially":[76],"lines":[78,163],"with":[79,138],"more":[80],"than":[81],"copy":[83],"integrated)":[84],"strong":[86],"enough":[87],"detected":[90],"intact":[92],"tissue":[93],"preparations":[94],"using":[95],"epifluorescence":[96],"microscopy.":[97],"By":[98],"immunohistochemistry,":[99],"we":[100],"confirmed":[101],"that":[102,112],"overwhelming":[104],"majority":[105],"are":[110],"those":[111],"endogenously":[113],"express":[114],"PLCbeta2.":[115],"transgene":[120],"circumvallate":[122],"papillae":[123],"occurs":[124],"at":[125],"about":[126],"same":[128],"time":[129],"during":[130],"development":[131],"as":[132],"endogenous":[133],"expression.":[135],"When":[136],"loaded":[137],"calcium-sensitive":[140],"dye":[141],"situ,":[143],"GFP-positive":[144],"produce":[147],"typical":[148],"Ca2+":[149],"responses":[150],"stimulus,":[154],"bitter":[156],"compound":[157],"cycloheximide.":[158],"These":[159],"promoter-GFP":[161],"promise":[164],"useful":[167],"studying":[169],"transduction,":[171],"signal":[173],"processing,":[174],"bud":[177],"development.":[178]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
