{"id":"https://openalex.org/W2155238230","doi":"https://doi.org/10.1001/archderm.144.5.666","title":"Looking Older","display_name":"Looking Older","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W2155238230","doi":"https://doi.org/10.1001/archderm.144.5.666","mag":"2155238230","pmid":"https://pubmed.ncbi.nlm.nih.gov/18490597","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2887041"},"language":"en","primary_location":{"id":"doi:10.1001/archderm.144.5.666","doi":"https://doi.org/10.1001/archderm.144.5.666","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archderm.144.5.666","pdf_url":null,"source":{"id":"https://openalex.org/S115046667","display_name":"Archives of Dermatology","issn_l":"0003-987X","issn":["0003-987X","1538-3652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2887041","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086349143","display_name":"Gary J. Fisher","orcid":"https://orcid.org/0000-0002-6065-6242","observed_orcids":["https://orcid.org/0000-0002-6065-6242"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary J. Fisher","raw_affiliation_strings":["Department of Dermatology, University of Michigan, Medical Science I Bldg, R6447, 1150 W Medical Center Dr, Ann Arbor, MI 48109-0609, USA. gjfisher@umich.edu","Department of Dermatology, University of Michigan, Medical Science I Bldg, R6447, 1150 W Medical Center Dr, Ann Arbor, MI 48109-0609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Michigan, Medical Science I Bldg, R6447, 1150 W Medical Center Dr, Ann Arbor, MI 48109-0609, USA. gjfisher@umich.edu","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Dermatology, University of Michigan, Medical Science I Bldg, R6447, 1150 W Medical Center Dr, Ann Arbor, MI 48109-0609, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083589748","display_name":"James Varani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Varani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005798011","display_name":"John J. Voorhees","orcid":"https://orcid.org/0000-0003-1856-785X","observed_orcids":["https://orcid.org/0000-0003-1856-785X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John J. Voorhees","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":25.5441,"has_fulltext":false,"cited_by_count":544,"citation_normalized_percentile":{"value":0.99811368,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"144","issue":"5","first_page":"666","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11322","display_name":"Facial Rejuvenation and Surgery Techniques","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.9959999918937683},{"id":"https://openalex.org/keywords/collagen-fragmentation","display_name":"collagen fragmentation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fibroblast-adhesion","display_name":"fibroblast adhesion","score":0.765999972820282},{"id":"https://openalex.org/keywords/collagen-degradation","display_name":"collagen degradation","score":0.515999972820282},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.48500001430511475},{"id":"https://openalex.org/keywords/topical-retinoic-acid","display_name":"topical retinoic acid","score":0.9190000295639038},{"id":"https://openalex.org/keywords/carbon-dioxide-laser-resurfacing","display_name":"carbon dioxide laser resurfacing","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cross-linked-hyaluronic-acid","display_name":"cross-linked hyaluronic acid","score":0.9200000166893005},{"id":"https://openalex.org/keywords/skin-appearance","display_name":"skin appearance","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.6721049547195435},{"id":"https://openalex.org/C2909910311","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Skin Aging","level":2,"score":0.6299906969070435},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.5583711862564087},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5583182573318481},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5260605216026306},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.48901399970054626},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46003302931785583},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.45127928256988525},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.4291221499443054},{"id":"https://openalex.org/C2778005187","wikidata":"https://www.wikidata.org/wiki/Q5262669","display_name":"Dermal fibroblast","level":4,"score":0.4285157322883606},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.42329877614974976},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3360816240310669},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.259319007396698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23815837502479553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22895067930221558},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2012239694595337},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.19804280996322632},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19436711072921753},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.19157350063323975},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10909444093704224},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06282955408096313}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013472","descriptor_name":"Sunlight","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1001/archderm.144.5.666","doi":"https://doi.org/10.1001/archderm.144.5.666","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archderm.144.5.666","pdf_url":null,"source":{"id":"https://openalex.org/S115046667","display_name":"Archives of Dermatology","issn_l":"0003-987X","issn":["0003-987X","1538-3652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Dermatology","raw_type":"journal-article"},{"id":"pmid:18490597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18490597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of dermatology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2887041","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2887041","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Arch Dermatol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2887041","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2887041","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Arch Dermatol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G394509212","display_name":"Transforming Growth Factor-Beta (TGF-b) Signaling in Aged Skin","funder_award_id":"R01AG019364","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6136125887","display_name":"Collagenase degradation in extracellular matrix in aging","funder_award_id":"R01AG025186","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W25497486","https://openalex.org/W46903450","https://openalex.org/W148052990","https://openalex.org/W1529623919","https://openalex.org/W1540816832","https://openalex.org/W1551998217","https://openalex.org/W1555702256","https://openalex.org/W1616193782","https://openalex.org/W1631191622","https://openalex.org/W1975423593","https://openalex.org/W1979400692","https://openalex.org/W1981148477","https://openalex.org/W1981397830","https://openalex.org/W1982730543","https://openalex.org/W1987707948","https://openalex.org/W1994972521","https://openalex.org/W1995076534","https://openalex.org/W2000212488","https://openalex.org/W2000936610","https://openalex.org/W2011093418","https://openalex.org/W2019568643","https://openalex.org/W2026226283","https://openalex.org/W2029709403","https://openalex.org/W2034309361","https://openalex.org/W2038705000","https://openalex.org/W2044364429","https://openalex.org/W2050742799","https://openalex.org/W2051875300","https://openalex.org/W2054221638","https://openalex.org/W2055062469","https://openalex.org/W2058650920","https://openalex.org/W2060370047","https://openalex.org/W2061801043","https://openalex.org/W2071359561","https://openalex.org/W2072310852","https://openalex.org/W2077292033","https://openalex.org/W2077513585","https://openalex.org/W2085224134","https://openalex.org/W2090913089","https://openalex.org/W2095328842","https://openalex.org/W2113677341","https://openalex.org/W2117671645","https://openalex.org/W2117982366","https://openalex.org/W2136072575","https://openalex.org/W2145872218","https://openalex.org/W2146581693","https://openalex.org/W2150652632","https://openalex.org/W2159741685","https://openalex.org/W2162948580","https://openalex.org/W2313226498","https://openalex.org/W2431091373","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7169840971","https://openalex.org/W2027257898","https://openalex.org/W4292189154","https://openalex.org/W2789947828","https://openalex.org/W2113356275","https://openalex.org/W3154438694","https://openalex.org/W7100723667","https://openalex.org/W2937839953","https://openalex.org/W1983125814","https://openalex.org/W2014932693"],"abstract_inverted_index":{"Skin":[0],"appearance":[1,241],"is":[2,41,68,121,211],"a":[3,155],"primary":[4],"indicator":[5],"of":[6,21,36,65,70,79,89,106,127,140,145,176,182,187,215,220,231,244],"age.":[7],"During":[8],"the":[9,28,58,71,86,90,97,151,206,240],"last":[10],"decade,":[11],"substantial":[12,237],"progress":[13],"has":[14],"been":[15],"made":[16],"toward":[17],"understanding":[18,26],"underlying":[19],"mechanisms":[20,49],"human":[22,225],"skin":[23,52,67],"aging.":[24],"This":[25,148],"provides":[27],"basis":[29],"for":[30,123,213],"current":[31],"use":[32],"and":[33,84,95,117,129,142,173,201,203,218,242],"new":[34,191],"development":[35],"antiaging":[37,162],"treatments.":[38],"Our":[39],"objective":[40],"to":[42,48,102,189,239],"review":[43],"present":[44],"state-of-the-art":[45],"knowledge":[46],"pertaining":[47],"involved":[50],"in":[51,154,196,223],"aging,":[53],"with":[54],"specific":[55,80],"focus":[56],"on":[57],"dermal":[59,72],"collagen":[60,73,98,128,141,192,199,234],"matrix.":[61,74],"A":[62],"major":[63],"feature":[64],"aged":[66,133,224,245],"fragmentation":[69,210],"Fragmentation":[75],"results":[76],"from":[77,110,114],"actions":[78],"enzymes":[81],"(matrix":[82],"metalloproteinases)":[83],"impairs":[85],"structural":[87,216],"integrity":[88,217],"dermis.":[91],"Fibroblasts":[92],"that":[93,228],"produce":[94,137],"organize":[96],"matrix":[99],"cannot":[100],"attach":[101],"fragmented":[103],"collagen.":[104,185],"Loss":[105],"attachment":[107],"prevents":[108],"fibroblasts":[109,136,188],"receiving":[111],"mechanical":[112],"information":[113],"their":[115],"support,":[116],"they":[118],"collapse.":[119],"Stretch":[120],"critical":[122],"normal":[124],"balanced":[125],"production":[126,181,200,230],"collagen-degrading":[130,146],"enzymes.":[131,147],"In":[132],"skin,":[134],"collapsed":[135],"low":[138],"levels":[139,144],"high":[143],"imbalance":[149],"advances":[150],"aging":[152,207],"process":[153],"self-perpetuating,":[156],"never-ending":[157],"deleterious":[158],"cycle.":[159],"Clinically":[160],"proven":[161],"treatments":[163],"such":[164],"as":[165],"topical":[166],"retinoic":[167],"acid,":[168],"carbon":[169],"dioxide":[170],"laser":[171],"resurfacing,":[172],"intradermal":[174],"injection":[175],"cross-linked":[177],"hyaluronic":[178],"acid":[179],"stimulate":[180,229],"new,":[183,232],"undamaged":[184],"Attachment":[186],"this":[190],"allows":[193],"stretch,":[194],"which":[195],"turn":[197],"balances":[198],"degradation":[202],"thereby":[204],"slows":[205],"process.":[208],"Collagen":[209],"responsible":[212],"loss":[214],"impairment":[219],"fibroblast":[221],"function":[222],"skin.":[226,246],"Treatments":[227],"nonfragmented":[233],"should":[235],"provide":[236],"improvement":[238],"health":[243]},"counts_by_year":[{"year":2026,"cited_by_count":32},{"year":2025,"cited_by_count":39},{"year":2024,"cited_by_count":44},{"year":2023,"cited_by_count":36},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":36},{"year":2019,"cited_by_count":30},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":38},{"year":2015,"cited_by_count":49},{"year":2014,"cited_by_count":25},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":29}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
