{"id":"https://openalex.org/W2155209256","doi":null,"title":"Radiolabeled amino acids: basic aspects and clinical applications in oncology.","display_name":"Radiolabeled amino acids: basic aspects and clinical applications in oncology.","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W2155209256","mag":"2155209256","pmid":"https://pubmed.ncbi.nlm.nih.gov/11337520"},"language":"en","primary_location":{"id":"pmid:11337520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11337520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108091121","display_name":"P.L. Jager","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P L Jager","raw_affiliation_strings":["Department of Nuclear Medicine, PET Center, University Hospital Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, PET Center, University Hospital Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110432047","display_name":"Willem Vaalburg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Vaalburg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017680598","display_name":"Jan Pruim","orcid":"https://orcid.org/0000-0002-8323-6187","observed_orcids":["https://orcid.org/0000-0002-8323-6187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Pruim","raw_affiliation_strings":["Guided Treatment in Optimal Selected Cancer Patients (GUTS)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guided Treatment in Optimal Selected Cancer Patients (GUTS)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061495577","display_name":"Elisabeth G.E. de Vries","orcid":"https://orcid.org/0000-0002-8949-7425","observed_orcids":["https://orcid.org/0000-0002-8949-7425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E G de Vries","raw_affiliation_strings":["Guided Treatment in Optimal Selected Cancer Patients (GUTS)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guided Treatment in Optimal Selected Cancer Patients (GUTS)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062516261","display_name":"Karl\u2010Josef Langen","orcid":"https://orcid.org/0000-0003-1101-5075","observed_orcids":["https://orcid.org/0000-0003-1101-5075"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K J Langen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112218095","display_name":"DA Piers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D A Piers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":18.6197,"has_fulltext":false,"cited_by_count":555,"citation_normalized_percentile":{"value":0.99712932,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"42","issue":"3","first_page":"432","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.7128999829292297,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.7128999829292297,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.23080000281333923,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiolabeled-amino-acids","display_name":"radiolabeled amino acids","score":0.996999979019165},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.9660000205039978},{"id":"https://openalex.org/keywords/11c-methionine","display_name":"11C-methionine","score":0.8989999890327454},{"id":"https://openalex.org/keywords/brain-tumor-imaging","display_name":"brain tumor imaging","score":0.8730000257492065},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.7129999995231628},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5730000138282776},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.855821967124939},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.5956383943557739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4995734691619873},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.484519898891449},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35701698064804077},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3260893225669861},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3223174512386322}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008781","descriptor_name":"Methyltyrosines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"pmid:11337520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11337520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.320.1190","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.1190","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/42/3/432.full.pdf","raw_type":"text"},{"id":"pmh:oai:juser.fz-juelich.de:35816","doi":null,"is_oa":false,"landing_page_url":"https://juser.fz-juelich.de/record/35816","pdf_url":null,"source":{"id":"https://openalex.org/S4306401090","display_name":"JuSER (Forschungszentrum J\u00fclich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I171892758","host_organization_name":"Forschungszentrum J\u00fclich","host_organization_lineage":["https://openalex.org/I171892758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of nuclear medicine 42, 432 - 445 (2001).","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/49076dc2-61ea-4bc4-b4e9-53696a3bb56e","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/49076dc2-61ea-4bc4-b4e9-53696a3bb56e","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jager, PL, Vaalburg, W, Pruim, J, de Vries, EGE, Langen, KJ & Piers, DA 2001, 'Radiolabeled amino acids : Basic aspects and clinical applications in oncology', Journal of Nuclear Medicine, vol. 42, no. 3, pp. 432-445.","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:rug:oai:pure.rug.nl:publications/49076dc2-61ea-4bc4-b4e9-53696a3bb56e","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/49076dc2-61ea-4bc4-b4e9-53696a3bb56e","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine, 42(3), 432 - 445. SOC NUCLEAR MEDICINE INC","raw_type":"info:eu-repo/semantics/other"},{"id":"mag:2155209256","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11337520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W37680713","https://openalex.org/W43024369","https://openalex.org/W159968795","https://openalex.org/W178996021","https://openalex.org/W181493504","https://openalex.org/W203563334","https://openalex.org/W637719622","https://openalex.org/W1498362729","https://openalex.org/W1504587557","https://openalex.org/W1519325153","https://openalex.org/W1538569506","https://openalex.org/W1551012469","https://openalex.org/W1571850773","https://openalex.org/W1579641819","https://openalex.org/W1582975705","https://openalex.org/W1756092574","https://openalex.org/W1758324074","https://openalex.org/W1777459910","https://openalex.org/W1800926115","https://openalex.org/W1834156980","https://openalex.org/W1862941952","https://openalex.org/W1880201718","https://openalex.org/W1905394398","https://openalex.org/W1906753921","https://openalex.org/W1923567073","https://openalex.org/W1924618720","https://openalex.org/W1934939379","https://openalex.org/W1950512608","https://openalex.org/W1956844386","https://openalex.org/W1959422223","https://openalex.org/W1963715209","https://openalex.org/W1964447165","https://openalex.org/W1964636040","https://openalex.org/W1965662896","https://openalex.org/W1967030982","https://openalex.org/W1967267336","https://openalex.org/W1984079023","https://openalex.org/W1984217572","https://openalex.org/W1992368266","https://openalex.org/W1992814170","https://openalex.org/W1995490493","https://openalex.org/W1996756117","https://openalex.org/W2002603548","https://openalex.org/W2008567093","https://openalex.org/W2009549758","https://openalex.org/W2012215869","https://openalex.org/W2014630881","https://openalex.org/W2020847174","https://openalex.org/W2022605882","https://openalex.org/W2029626921","https://openalex.org/W2036303858","https://openalex.org/W2036791907","https://openalex.org/W2038310765","https://openalex.org/W2042634829","https://openalex.org/W2043654346","https://openalex.org/W2047016903","https://openalex.org/W2048877583","https://openalex.org/W2049429481","https://openalex.org/W2049726712","https://openalex.org/W2051580746","https://openalex.org/W2053613471","https://openalex.org/W2056428181","https://openalex.org/W2057057993","https://openalex.org/W2057920830","https://openalex.org/W2062469473","https://openalex.org/W2074884761","https://openalex.org/W2075503794","https://openalex.org/W2076121967","https://openalex.org/W2085560035","https://openalex.org/W2085742913","https://openalex.org/W2087898563","https://openalex.org/W2093134001","https://openalex.org/W2096484020","https://openalex.org/W2099916729","https://openalex.org/W2101950700","https://openalex.org/W2102451128","https://openalex.org/W2102678706","https://openalex.org/W2114093040","https://openalex.org/W2115349819","https://openalex.org/W2120812758","https://openalex.org/W2120883486","https://openalex.org/W2124649759","https://openalex.org/W2124731509","https://openalex.org/W2125218519","https://openalex.org/W2128433644","https://openalex.org/W2135419956","https://openalex.org/W2138238285","https://openalex.org/W2140866432","https://openalex.org/W2143192486","https://openalex.org/W2147323447","https://openalex.org/W2150055347","https://openalex.org/W2150340231","https://openalex.org/W2151712814","https://openalex.org/W2152938850","https://openalex.org/W2156658337","https://openalex.org/W2159281512","https://openalex.org/W2162765770","https://openalex.org/W2165957336","https://openalex.org/W2166194370","https://openalex.org/W2182083622","https://openalex.org/W2185517781","https://openalex.org/W2186719595","https://openalex.org/W2186875060","https://openalex.org/W2187475385","https://openalex.org/W2202440279","https://openalex.org/W2240318118","https://openalex.org/W2283576054","https://openalex.org/W2285484584","https://openalex.org/W2288375875","https://openalex.org/W2293310745","https://openalex.org/W2337487609","https://openalex.org/W2404583775","https://openalex.org/W2406511218","https://openalex.org/W2409387191","https://openalex.org/W2411022273","https://openalex.org/W2417556408","https://openalex.org/W2463909153","https://openalex.org/W2476772439","https://openalex.org/W2511844880","https://openalex.org/W2519155034"],"related_works":["https://openalex.org/W7099016029","https://openalex.org/W2393447243","https://openalex.org/W3032214967","https://openalex.org/W1019316276","https://openalex.org/W2343615323","https://openalex.org/W191002237","https://openalex.org/W58957323","https://openalex.org/W3205994226","https://openalex.org/W4353028036","https://openalex.org/W2317835881"],"abstract_inverted_index":{"As":[0],"the":[1,20,68,125,133,143],"applications":[2],"of":[3,23,32,77,85,127,136,151],"metabolic":[4],"imaging":[5,88,100,139,154],"are":[6],"expanding,":[7],"radiolabeled":[8,33,128],"amino":[9,24,34,78,86,98,129,137,152],"acids":[10,130],"may":[11,71,106],"gain":[12],"increased":[13],"clinical":[14,39,93,175],"interest.":[15],"This":[16],"review":[17],"first":[18],"describes":[19,38],"basic":[21,30],"aspects":[22,31],"acid":[25,87,99,138,153],"metabolism,":[26],"then":[27],"continues":[28],"with":[29,41,111],"acids,":[35],"and":[36,54,82,91,142,172],"finally":[37],"applications,":[40],"an":[42],"emphasis":[43],"on":[44,51],"diagnostic":[45,134,144],"value.":[46],"A":[47],"special":[48],"focus":[49],"is":[50,89,101,118,131,166],"(11)C-methionine,":[52],"(11)C-tyrosine,":[53],"(123)I-iodomethyltyrosine,":[55],"because":[56],"these":[57],"have":[58],"been":[59,161],"most":[60],"used":[61],"clinically,":[62],"although":[63,115],"their":[64],"common":[65],"affinity":[66],"for":[67],"L-transport":[69],"systems":[70],"limit":[72],"generalization":[73],"to":[74],"other":[75,156],"classes":[76],"acids.":[79],"The":[80,95,148],"theoretic":[81],"preclinical":[83],"background":[84],"sound":[90],"supports":[92],"applications.":[94],"fact":[96],"that":[97],"less":[102],"influenced":[103],"by":[104],"inflammation":[105],"be":[107],"advantageous":[108],"in":[109,155,168,173],"comparison":[110],"(18)F-FDG":[112],"PET":[113],"imaging,":[114,124],"tumor":[116,123,157],"specificity":[117],"not":[119],"absolute.":[120],"In":[121],"brain":[122],"use":[126],"established,":[132],"accuracy":[135],"seems":[140,146],"adequate,":[141],"value":[145],"advantageous.":[147],"general":[149],"feasibility":[150],"types":[158],"has":[159],"sufficiently":[160],"shown,":[162],"but":[163],"more":[164],"research":[165],"required":[167],"larger":[169],"patient":[170],"series":[171],"well-defined":[174],"settings.":[176]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":29},{"year":2013,"cited_by_count":29},{"year":2012,"cited_by_count":33}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}