{"id":"https://openalex.org/W2155199677","doi":"https://doi.org/10.1093/jac/23.6.831","title":"Ciprofloxacin, imipenem and rifampicin: in-vitro synergy of two and three drug combinations against Pseudomonas cepacia","display_name":"Ciprofloxacin, imipenem and rifampicin: in-vitro synergy of two and three drug combinations against Pseudomonas cepacia","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2155199677","doi":"https://doi.org/10.1093/jac/23.6.831","mag":"2155199677","pmid":"https://pubmed.ncbi.nlm.nih.gov/2759929"},"language":"en","primary_location":{"id":"doi:10.1093/jac/23.6.831","doi":"https://doi.org/10.1093/jac/23.6.831","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/23.6.831","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111832914","display_name":"Ashir Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ashir Kumar","raw_affiliation_strings":["Department of Pediatrics and Human Development, Michigan State University, East Lansing","aDepartment of Pediatrics and Human Development, Michigan State UniversityEast Lansing, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Human Development, Michigan State University, East Lansing","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"aDepartment of Pediatrics and Human Development, Michigan State UniversityEast Lansing, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060985071","display_name":"Roslyn Wofford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801799315","display_name":"Hurley Medical Center","ror":"https://ror.org/034npj057","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801799315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosslyn Wofford-McQueen","raw_affiliation_strings":["b Department of Pediatric Education and Research Laboratory, Hurley Medical Center Flint, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Department of Pediatric Education and Research Laboratory, Hurley Medical Center Flint, Michigan, USA","institution_ids":["https://openalex.org/I2801799315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001675373","display_name":"Ralph C. Gordon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801799315","display_name":"Hurley Medical Center","ror":"https://ror.org/034npj057","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801799315"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph C. Gordon","raw_affiliation_strings":["a Department of Pediatrics and Human Development, Michigan State University East Lansing, USA","b Department of Pediatric Education and Research Laboratory, Hurley Medical Center Flint, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Pediatrics and Human Development, Michigan State University East Lansing, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"b Department of Pediatric Education and Research Laboratory, Hurley Medical Center Flint, Michigan, USA","institution_ids":["https://openalex.org/I2801799315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111832914"],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":null,"fwci":0.9873,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.73584906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"23","issue":"6","first_page":"831","last_page":"835"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.08340000361204147,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.020899999886751175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/burkholderia-cepacia","display_name":"Burkholderia cepacia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ciprofloxacin","display_name":"ciprofloxacin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/imipenem","display_name":"imipenem","score":1.0},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":1.0},{"id":"https://openalex.org/keywords/antibiotic-synergy","display_name":"antibiotic synergy","score":0.7889999747276306},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7129999995231628},{"id":"https://openalex.org/keywords/in-vitro-antibacterial-activity","display_name":"in vitro antibacterial activity","score":0.6840000152587891},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7689999938011169},{"id":"https://openalex.org/keywords/intermediate-susceptibility","display_name":"intermediate susceptibility","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.9525355100631714},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.8789113759994507},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.8253338932991028},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7419559955596924},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6081048250198364},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.5419635772705078},{"id":"https://openalex.org/C2781463711","wikidata":"https://www.wikidata.org/wiki/Q131143","display_name":"Pseudomonas","level":3,"score":0.5057439804077148},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3837549686431885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33022457361221313},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.20878231525421143},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.10459351539611816},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002939","descriptor_name":"Ciprofloxacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011549","descriptor_name":"Pseudomonas","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013183","descriptor_name":"Sputum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015378","descriptor_name":"Imipenem","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/jac/23.6.831","doi":"https://doi.org/10.1093/jac/23.6.831","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/23.6.831","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmid:2759929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2759929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2057731460","https://openalex.org/W2020396565","https://openalex.org/W2080471742","https://openalex.org/W2057168149","https://openalex.org/W2024575387","https://openalex.org/W2119938342","https://openalex.org/W2010922557","https://openalex.org/W2354716070","https://openalex.org/W2137749172","https://openalex.org/W2077258216"],"abstract_inverted_index":{"The":[0,47,78],"in-vitro":[1,109],"activity":[2],"of":[3,21,56,64,75,95,104],"ciprofloxacin,":[4],"imipenem":[5,48,58],"and":[6,9,12,40,49,59,66,97],"rifampicin,":[7],"singly,":[8],"in":[10,101,107],"two":[11,85,96],"three":[13,68,79,92,98],"drug":[14],"combinations":[15],"was":[16,52,71],"evaluated":[17],"against":[18],"16":[19,25,65,76],"isolates":[20,26,32,86],"Pseudomonas":[22],"cepacia.":[23],"All":[24],"were":[27,33,38,88],"resistant":[28,89],"to":[29,35,45,90],"rifampicin;":[30],"nine":[31],"susceptible":[34,39],"ciprofloxacin;":[36],"six":[37],"seven":[41,63],"had":[42],"intermediate":[43],"susceptibility":[44],"imipenem.":[46],"rifampicin":[50],"combination":[51,70,81],"synergistic":[53,61,72],"for":[54,62,73],"one":[55],"16,":[57],"ciprofloxacin":[60],"the":[67],"antibiotic":[69,80],"12":[74],"isolates.":[77],"demonstrated":[82],"synergism":[83],"with":[84],"which":[87],"all":[91],"drugs.":[93],"Combinations":[94],"antibiotics":[99],"resulted":[100],"enhanced":[102],"killing":[103],"P.":[105],"cepacia":[106],"this":[108],"study.":[110]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}