{"id":"https://openalex.org/W2155199307","doi":"https://doi.org/10.4103/2229-5151.134150","title":"Effect of gamma-hydroxybutyrate on keratinocytes proliferation: A preliminary prospective controlled study in severe burn patients","display_name":"Effect of gamma-hydroxybutyrate on keratinocytes proliferation: A preliminary prospective controlled study in severe burn patients","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2155199307","doi":"https://doi.org/10.4103/2229-5151.134150","mag":"2155199307","pmid":"https://pubmed.ncbi.nlm.nih.gov/25024938","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4093961"},"language":"en","primary_location":{"id":"doi:10.4103/2229-5151.134150","doi":"https://doi.org/10.4103/2229-5151.134150","is_oa":false,"landing_page_url":"https://doi.org/10.4103/2229-5151.134150","pdf_url":null,"source":{"id":"https://openalex.org/S2764375788","display_name":"International Journal of Critical Illness and Injury Science","issn_l":"2229-5151","issn":["2229-5151","2231-5004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Critical Illness and Injury Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4093961/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075955953","display_name":"Anne\u2010Fran\u00e7oise Rousseau","orcid":"https://orcid.org/0000-0002-4157-6570","observed_orcids":["https://orcid.org/0000-0002-4157-6570"]},"institutions":[{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Anne-Francoise Rousseau","raw_affiliation_strings":["Intensive Care Unit and Burn Centre, University Hospital, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit and Burn Centre, University Hospital, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085184974","display_name":"L. Bargues","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136310","display_name":"H\u00f4pital d'instruction des Arm\u00e9es Percy","ror":"https://ror.org/039c2j878","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210136310"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Bargues","raw_affiliation_strings":["Burn Centre, Percy Military Teaching Hospital, Clamart, France","Burn Centre, Percy Military Teaching Hospital, Clamart, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burn Centre, Percy Military Teaching Hospital, Clamart, France","institution_ids":["https://openalex.org/I4210136310"]},{"raw_affiliation_string":"Burn Centre, Percy Military Teaching Hospital, Clamart, Belgium","institution_ids":["https://openalex.org/I4210136310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109244509","display_name":"Herv\u00e9Le Bever","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136310","display_name":"H\u00f4pital d'instruction des Arm\u00e9es Percy","ror":"https://ror.org/039c2j878","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210136310"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"HerveLe Bever","raw_affiliation_strings":["Burn Centre, Percy Military Teaching Hospital, Clamart, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burn Centre, Percy Military Teaching Hospital, Clamart, Belgium","institution_ids":["https://openalex.org/I4210136310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014398893","display_name":"Philippe Vest","orcid":"https://orcid.org/0009-0003-7878-7667","observed_orcids":["https://orcid.org/0009-0003-7878-7667"]},"institutions":[{"id":"https://openalex.org/I4210136310","display_name":"H\u00f4pital d'instruction des Arm\u00e9es Percy","ror":"https://ror.org/039c2j878","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210136310"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Vest","raw_affiliation_strings":["Clinical Chemistry, Percy Military Teaching Hospital, Clamart, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Chemistry, Percy Military Teaching Hospital, Clamart, France","institution_ids":["https://openalex.org/I4210136310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107431925","display_name":"Etienne Cavalier","orcid":"https://orcid.org/0000-0003-0947-2226","observed_orcids":["https://orcid.org/0000-0003-0947-2226","https://orcid.org/0000-0002-1480-5761"]},"institutions":[{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Etienne Cavalier","raw_affiliation_strings":["Clinical Chemistry, University Hospital, Li\u00e8ge, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Chemistry, University Hospital, Li\u00e8ge, France","institution_ids":["https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043452327","display_name":"Didier Ledoux","orcid":"https://orcid.org/0000-0002-9314-6564","observed_orcids":["https://orcid.org/0000-0002-9314-6564"]},"institutions":[{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210136310","display_name":"H\u00f4pital d'instruction des Arm\u00e9es Percy","ror":"https://ror.org/039c2j878","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210136310"]}],"countries":["BE","FR"],"is_corresponding":false,"raw_author_name":"Didier Ledoux","raw_affiliation_strings":["Intensive Care Unit and Burn Centre, University Hospital, Li\u00e8ge, Belgium","Burn Centre, Percy Military Teaching Hospital, Clamart, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit and Burn Centre, University Hospital, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I4210134544"]},{"raw_affiliation_string":"Burn Centre, Percy Military Teaching Hospital, Clamart, Belgium","institution_ids":["https://openalex.org/I4210136310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111971148","display_name":"GeraldE. Pierard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"GeraldE. Pierard","raw_affiliation_strings":["Dermatopathology, University Hospital, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatopathology, University Hospital, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I4210134544"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057237977","display_name":"Pierre Damas","orcid":"https://orcid.org/0000-0001-9598-867X","observed_orcids":["https://orcid.org/0000-0001-9598-867X"]},"institutions":[{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Pierre Damas","raw_affiliation_strings":["Intensive Care Unit and Burn Centre, University Hospital, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit and Burn Centre, University Hospital, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I4210134544"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075955953"],"corresponding_institution_ids":["https://openalex.org/I4210134544"],"apc_list":null,"apc_paid":null,"fwci":0.6311,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.68123344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"4","issue":"2","first_page":"108","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.1851000040769577,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-hydroxybutyric-acid","display_name":"gamma-hydroxybutyric acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/keratinocyte-proliferation","display_name":"keratinocyte proliferation","score":0.949999988079071},{"id":"https://openalex.org/keywords/severe-burns","display_name":"severe burns","score":0.9100000262260437},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8159999847412109},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.7129999995231628},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9860000014305115},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.5640000104904175},{"id":"https://openalex.org/keywords/continuous-infusion","display_name":"continuous infusion","score":0.6710000038146973},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ulex-europaeus-agglutinin-1","display_name":"UEA-1","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mac387","display_name":"MAC387","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8722403049468994},{"id":"https://openalex.org/C12868164","wikidata":"https://www.wikidata.org/wiki/Q1424533","display_name":"Mann\u2013Whitney U test","level":2,"score":0.6029379367828369},{"id":"https://openalex.org/C2777785397","wikidata":"https://www.wikidata.org/wiki/Q492194","display_name":"Group B","level":2,"score":0.5274396538734436},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5137994885444641},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.43677759170532227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42048153281211853},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.4124656915664673},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4024483263492584}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4103/2229-5151.134150","doi":"https://doi.org/10.4103/2229-5151.134150","is_oa":false,"landing_page_url":"https://doi.org/10.4103/2229-5151.134150","pdf_url":null,"source":{"id":"https://openalex.org/S2764375788","display_name":"International Journal of Critical Illness and Injury Science","issn_l":"2229-5151","issn":["2229-5151","2231-5004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Critical Illness and Injury Science","raw_type":"journal-article"},{"id":"pmid:25024938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25024938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of critical illness and injury science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4093961","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4093961/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Crit Illn Inj Sci","raw_type":"Text"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/168890","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/168890","pdf_url":"https://orbi.uliege.be/bitstream/2268/168890/1/IntJCritIllnInjSci_2014_4_2_108_134150.pdf","source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Critical Illness and Injury Science, 4 (2), 108-113 (2014-04)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4093961","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4093961/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Crit Illn Inj Sci","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2155199307.pdf","grobid_xml":"https://content.openalex.org/works/W2155199307.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W192698512","https://openalex.org/W1965534772","https://openalex.org/W1971032764","https://openalex.org/W1971736185","https://openalex.org/W1978645231","https://openalex.org/W1980077716","https://openalex.org/W1996988588","https://openalex.org/W2022698715","https://openalex.org/W2040677368","https://openalex.org/W2041909724","https://openalex.org/W2046248093","https://openalex.org/W2046522131","https://openalex.org/W2047566406","https://openalex.org/W2063795732","https://openalex.org/W2070787360","https://openalex.org/W2079128619","https://openalex.org/W2083513256","https://openalex.org/W2094746288","https://openalex.org/W2104298848","https://openalex.org/W2107696783","https://openalex.org/W2130271602","https://openalex.org/W2153019637","https://openalex.org/W2156239755","https://openalex.org/W2255156181","https://openalex.org/W2325918023","https://openalex.org/W2408784072","https://openalex.org/W3142972004"],"related_works":["https://openalex.org/W1965534772","https://openalex.org/W2274031610","https://openalex.org/W2281027927","https://openalex.org/W2505380350","https://openalex.org/W2065768124","https://openalex.org/W2382105918","https://openalex.org/W1990173190","https://openalex.org/W2375200220","https://openalex.org/W2422024395","https://openalex.org/W1968104911"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hypermetabolism":[1],"and":[2,136,161,248,281],"hyposomatotropism":[3],"related":[4],"to":[5,9,72,93,203,285],"severe":[6],"burns":[7],"lead":[8],"impaired":[10],"wound":[11,17],"healing.":[12],"Growth":[13],"hormone":[14],"(GH)":[15],"boosts":[16],"healing":[18],"notably":[19],"following":[20,87],"stimulation":[21],"of":[22,25,45,104,114,121,163,176,210,233,276],"the":[23,84,94,112,164,214,255],"production":[24],"insulin-like":[26],"growth":[27],"factor-1":[28],"(IGF1),":[29],"a":[30,238,250,273],"mitogen":[31],"factor":[32],"for":[33,75,99,149,194],"keratinocytes.":[34],"Gamma-hydroxybutyrate":[35],"(GHB)":[36],"stimulates":[37],"endogenous":[38],"GH":[39],"secretion.":[40],"AIM:":[41],"To":[42],"assess":[43],"effects":[44,265],"GHB":[46,96,122,234,277],"sedation":[47],"on":[48,52,144,278],"keratinocytes":[49],"proliferation":[50,280],"(based":[51],"immunohistochemical":[53],"techniques).":[54],"DESIGN:":[55],"Monocentric,":[56],"prospective,":[57],"controlled":[58],"trial.":[59],"MATERIALS":[60],"AND":[61],"METHODS:":[62],"Patients":[63],"(aging":[64],"18-65":[65],"years,":[66],"burn":[67],"surface":[68],"area":[69],">30%,":[70],"expected":[71],"be":[73,204],"sedated":[74],"at":[76,83,111,142,159,243,258],"least":[77],"one":[78],"month)":[79],"were":[80,157,170,178,186,266],"alternately":[81],"allocated,":[82],"5(th)":[85],"day":[86],"injury,":[88],"in":[89,254],"three":[90],"groups":[91],"according":[92],"intravenous":[95],"dose":[97],"administered":[98],"21":[100],"days:":[101],"Evening":[102],"bolus":[103],"50":[105],"mg/kg":[106],"(Group":[107,117,123,216],"B),":[108],"continuous":[109],"infusion":[110],"rate":[113],"10":[115],"mg/kg/h":[116],"C),":[118],"or":[119],"absence":[120],"P).":[124],"They":[125],"all":[126],"received":[127],"local":[128],"standard":[129],"cares.":[130],"Immunohistochemistry":[131],"(Ki67/MIB-1,":[132],"Ulex":[133],"europaeus":[134],"agglutinin-1":[135],"Mac":[137],"387":[138],"antibodies)":[139],"was":[140,201,235],"performed":[141,187],"D21":[143,244,259],"adjacent":[145],"unburned":[146],"skin":[147],"sample":[148],"assessing":[150],"any":[151],"keratinocyte":[152,279],"activation.":[153],"Serum":[154],"IGF1":[155,256],"levels":[156],"measured":[158],"initiation":[160],"completion":[162],"protocol.":[165],"STATISTICAL":[166],"ANALYSIS:":[167],"Categorical":[168],"variables":[169],"compared":[171],"with":[172,191,237,249],"Chi-square":[173],"test.":[174,182],"Comparisons":[175],"medians":[177],"made":[179],"using":[180,188],"Kruskal-Wallis":[181],"Post":[183],"hoc":[184],"analyses":[185],"Mann-Whitney":[189],"test":[190],"Bonferroni":[192],"correction":[193],"multiple":[195],"comparisons.":[196],"A":[197,208],"P":[198],"<":[199],"0.05":[200],"considered":[202],"statistically":[205],"significant.":[206],"RESULTS:":[207],"total":[209],"14":[211],"patients":[212],"completed":[213],"study":[215],"B:":[217],"n":[218,223,228],"=":[219,224,229,246,261],"5,":[220,225],"Group":[221,226],"C:":[222],"P:":[227],"4).":[230],"Continuous":[231],"administration":[232],"associated":[236],"significant":[239,251],"higher":[240,252],"Ki67":[241],"immunolabeling":[242],"(P":[245,260],"0.049)":[247],"increase":[253],"concentrations":[257],"0.024).":[262],"No":[263],"adverse":[264],"disclosed.":[267],"CONCLUSIONS:":[268],"Our":[269],"preliminary":[270],"data":[271],"support":[272],"positive":[274],"effect":[275],"are":[282],"encouraging":[283],"enough":[284],"warrant":[286],"large":[287],"prospective":[288],"studies.":[289]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}