{"id":"https://openalex.org/W2155195115","doi":"https://doi.org/10.7326/0003-4819-156-5-201203060-00004","title":"Low-Dose Prednisone Inclusion in a Methotrexate-Based, Tight Control Strategy for Early Rheumatoid Arthritis","display_name":"Low-Dose Prednisone Inclusion in a Methotrexate-Based, Tight Control Strategy for Early Rheumatoid Arthritis","publication_year":2012,"publication_date":"2012-03-06","ids":{"openalex":"https://openalex.org/W2155195115","doi":"https://doi.org/10.7326/0003-4819-156-5-201203060-00004","mag":"2155195115","pmid":"https://pubmed.ncbi.nlm.nih.gov/22393128"},"language":"en","primary_location":{"id":"doi:10.7326/0003-4819-156-5-201203060-00004","doi":"https://doi.org/10.7326/0003-4819-156-5-201203060-00004","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-156-5-201203060-00004","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021951199","display_name":"Marije F. Bakker","orcid":"https://orcid.org/0000-0002-9287-8827","observed_orcids":["https://orcid.org/0000-0002-9287-8827"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]},{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]},{"id":"https://openalex.org/I4210117957","display_name":"Flevoziekenhuis","ror":"https://ror.org/02tqqrq23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210117957"]},{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]},{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Marije F. Bakker","raw_affiliation_strings":["From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","Flevohospital, Almere, the Netherlands","From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht","Meander Medical Center, Amersfoort","St. Antonius Hospital, Nieuwegein","St. Jansdal Hospital, Harderwijk","Tergooi Hospital, Hilversum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210147058","https://openalex.org/I4210158428"]},{"raw_affiliation_string":"Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I4210117957"]},{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210106388"]},{"raw_affiliation_string":"Meander Medical Center, Amersfoort","institution_ids":["https://openalex.org/I4210158428"]},{"raw_affiliation_string":"St. Antonius Hospital, Nieuwegein","institution_ids":["https://openalex.org/I4210103448"]},{"raw_affiliation_string":"St. Jansdal Hospital, Harderwijk","institution_ids":[]},{"raw_affiliation_string":"Tergooi Hospital, Hilversum","institution_ids":["https://openalex.org/I4210147058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008286981","display_name":"Johannes W. G. Jacobs","orcid":"https://orcid.org/0000-0002-7438-3468","observed_orcids":["https://orcid.org/0000-0002-7438-3468","https://orcid.org/0000-0003-1584-6933","https://orcid.org/0000-0002-8583-7277","https://orcid.org/0009-0003-7427-5883"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]},{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]},{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]},{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Johannes W.G. Jacobs","raw_affiliation_strings":["From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210147058","https://openalex.org/I4210158428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073590530","display_name":"Paco M J Welsing","orcid":"https://orcid.org/0000-0003-2361-2803","observed_orcids":["https://orcid.org/0000-0003-2361-2803"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]},{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]},{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]},{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Paco M.J. Welsing","raw_affiliation_strings":["From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210147058","https://openalex.org/I4210158428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022863158","display_name":"Suzanne M. M. Verstappen","orcid":"https://orcid.org/0000-0001-6181-0646","observed_orcids":["https://orcid.org/0000-0001-6181-0646"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]},{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]},{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]},{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Suzanne M.M. Verstappen","raw_affiliation_strings":["From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210147058","https://openalex.org/I4210158428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039255500","display_name":"Janneke Tekstra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]},{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]},{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]},{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Janneke Tekstra","raw_affiliation_strings":["From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210147058","https://openalex.org/I4210158428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047197208","display_name":"Evelien Ton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]},{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]},{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]},{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Evelien Ton","raw_affiliation_strings":["From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210147058","https://openalex.org/I4210158428"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Monique A.W. Geurts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]},{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]},{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]},{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Monique A.W. Geurts","raw_affiliation_strings":["From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210147058","https://openalex.org/I4210158428"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jacobine H. van der Werf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]},{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]},{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]},{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jacobine H. van der Werf","raw_affiliation_strings":["From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210147058","https://openalex.org/I4210158428"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Grietje A. van Albada-Kuipers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]},{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]},{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]},{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Grietje A. van Albada-Kuipers","raw_affiliation_strings":["From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210147058","https://openalex.org/I4210158428"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zalima N. Jahangier-de Veen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]},{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]},{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]},{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Zalima N. Jahangier-de Veen","raw_affiliation_strings":["From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210147058","https://openalex.org/I4210158428"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maaike J. van der Veen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]},{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]},{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]},{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maaike J. van der Veen","raw_affiliation_strings":["From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210147058","https://openalex.org/I4210158428"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Catharina M. Verhoef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]},{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]},{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]},{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Catharina M. Verhoef","raw_affiliation_strings":["From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210147058","https://openalex.org/I4210158428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113758008","display_name":"Floris P. J. G. Lafeber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]},{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]},{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]},{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Floris P.J.G. Lafeber","raw_affiliation_strings":["From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210147058","https://openalex.org/I4210158428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063928355","display_name":"J. W. J. Bijlsma","orcid":"https://orcid.org/0000-0002-0128-8451","observed_orcids":["https://orcid.org/0000-0002-0128-8451"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]},{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]},{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]},{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Johannes W.J. Bijlsma","raw_affiliation_strings":["From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht; St. Antonius Hospital, Nieuwegein; Meander Medical Center, Amersfoort; Tergooi Hospital, Hilversum; St. Jansdal Hospital, Harderwijk; and Flevohospital, Almere, the Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210147058","https://openalex.org/I4210158428"]}]},{"author_position":"last","author":{"id":null,"display_name":"on behalf of the Utrecht Rheumatoid Arthritis Cohort Study Group*","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"on behalf of the Utrecht Rheumatoid Arthritis Cohort Study Group*","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5021951199"],"corresponding_institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448","https://openalex.org/I4210106388","https://openalex.org/I4210117957","https://openalex.org/I4210147058","https://openalex.org/I4210158428"],"apc_list":null,"apc_paid":null,"fwci":30.0467,"has_fulltext":false,"cited_by_count":322,"citation_normalized_percentile":{"value":0.99870079,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"156","issue":"5","first_page":"329","last_page":"339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-rheumatoid-arthritis","display_name":"early rheumatoid arthritis","score":0.984000027179718},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.8669999837875366},{"id":"https://openalex.org/keywords/low-dose-prednisone","display_name":"low-dose prednisone","score":0.9399999976158142},{"id":"https://openalex.org/keywords/steroid-sparing-therapy","display_name":"steroid-sparing therapy","score":0.5820000171661377},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.8069999814033508},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.8690000176429749},{"id":"https://openalex.org/keywords/physical-disability","display_name":"physical disability","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.847000002861023},{"id":"https://openalex.org/keywords/biologic-agents","display_name":"biologic agents","score":0.7620000243186951},{"id":"https://openalex.org/keywords/treatment-response-criteria","display_name":"treatment response criteria","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9460024833679199},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.8787644505500793},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7437258958816528},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.7249067425727844},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5801011919975281},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5636371374130249},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5263777375221252},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5120382905006409},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.44104307889938354},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4146210551261902},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3455427289009094},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.32472625374794006},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05020800232887268},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.045892179012298584}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.7326/0003-4819-156-5-201203060-00004","doi":"https://doi.org/10.7326/0003-4819-156-5-201203060-00004","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-156-5-201203060-00004","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:22393128","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22393128","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1556890549","https://openalex.org/W1596144660","https://openalex.org/W1953534612","https://openalex.org/W1964630882","https://openalex.org/W1982348705","https://openalex.org/W1994955363","https://openalex.org/W2006917513","https://openalex.org/W2019055944","https://openalex.org/W2046447616","https://openalex.org/W2065344034","https://openalex.org/W2096818146","https://openalex.org/W2098215027","https://openalex.org/W2098889063","https://openalex.org/W2109237866","https://openalex.org/W2110177517","https://openalex.org/W2115068422","https://openalex.org/W2119138901","https://openalex.org/W2119288715","https://openalex.org/W2119524039","https://openalex.org/W2121311666","https://openalex.org/W2122641956","https://openalex.org/W2126275861","https://openalex.org/W2131553420","https://openalex.org/W2133103918","https://openalex.org/W2134171514","https://openalex.org/W2136184915","https://openalex.org/W2136767090","https://openalex.org/W2140698836","https://openalex.org/W2146502982","https://openalex.org/W2152348310","https://openalex.org/W2154341553","https://openalex.org/W2155109530","https://openalex.org/W3006080604","https://openalex.org/W4308769923"],"related_works":["https://openalex.org/W4283524728","https://openalex.org/W2138243862","https://openalex.org/W2411121127","https://openalex.org/W2106806370","https://openalex.org/W2314544353","https://openalex.org/W4247645528","https://openalex.org/W2366611537","https://openalex.org/W2020756831","https://openalex.org/W2396165291","https://openalex.org/W2227428044"],"abstract_inverted_index":{"BACKGROUND:":[0],"Treatment":[1],"strategies":[2],"for":[3,35,125,240,264],"tight":[4,36,93,237,265],"control":[5,37,94,238,266],"of":[6,29,120,213,256],"early":[7,39,80,268],"rheumatoid":[8],"arthritis":[9],"(RA)":[10],"are":[11],"highly":[12],"effective":[13,198],"but":[14,225],"can":[15],"be":[16],"improved.":[17],"OBJECTIVE:":[18],"To":[19],"investigate":[20],"whether":[21],"adding":[22],"prednisone,":[23],"10":[24],"mg/d,":[25],"at":[26,114],"the":[27,74,111,118,146,156,170,181,211,230],"start":[28],"a":[30,152],"methotrexate":[31],"(MTX)-based":[32],"treatment":[33,107,262],"strategy":[34,95,194,239,263],"in":[38,57,73,169,180,199,222,229,259,267],"RA":[40,81,241,269],"increases":[41],"its":[42],"effectiveness.":[43],"DESIGN:":[44],"A":[45,236],"2-year,":[46],"prospective,":[47],"randomized,":[48],"placebo-controlled,":[49],"double-blind,":[50],"multicenter":[51],"trial":[52],"(CAMERA-II":[53],"[Computer":[54],"Assisted":[55],"Management":[56],"Early":[58],"Rheumatoid":[59],"Arthritis":[60],"trial-II]).":[61],"(International":[62],"Standard":[63],"Randomised":[64],"Controlled":[65],"Trial":[66],"Number:":[67],"ISRCTN":[68],"70365169)":[69],"SETTING:":[70],"7":[71],"hospitals":[72],"Netherlands.":[75],"PATIENTS:":[76],"236":[77],"patients":[78],"with":[79,97],"(duration":[82],"<1":[83],"year).":[84],"INTERVENTION:":[85],"Patients":[86],"were":[87,220],"randomly":[88],"assigned":[89],"to":[90,110,148,155,245],"an":[91,246,260],"MTX-based,":[92],"starting":[96],"either":[98],"MTX":[99,103,173,184,191,231],"and":[100,104,145,167,174,185,192,203,209,232],"prednisone":[101,175,193,233,258],"or":[102,151,215],"placebo.":[105],"Methotrexate":[106],"was":[108,131,165,195],"tailored":[109],"individual":[112],"patient":[113,271],"monthly":[115,243],"visits":[116,244],"on":[117],"basis":[119],"predefined":[121],"response":[122,142],"criteria":[123],"aiming":[124],"remission.":[126],"MEASUREMENTS:":[127],"The":[128,190],"primary":[129],"outcome":[130],"radiographic":[132],"erosive":[133],"joint":[134,160],"damage":[135,161],"after":[136,162],"2":[137,163],"years.":[138],"Secondary":[139],"outcomes":[140],"included":[141],"criteria,":[143],"remission,":[144,208],"need":[147],"add":[149],"cyclosporine":[150,214],"biologic":[153,216],"agent":[154],"treatment.":[157,217],"RESULTS:":[158],"Erosive":[159],"years":[164],"limited":[166],"less":[168,228],"group":[171,182],"receiving":[172,183],"(n":[176,187],"=":[177,188],"117)":[178],"than":[179],"placebo":[186],"119).":[189],"also":[196],"more":[197],"reducing":[200],"disease":[201],"activity":[202],"physical":[204],"disability,":[205],"achieving":[206],"sustained":[207],"avoiding":[210],"addition":[212],"Adverse":[218],"events":[219],"similar":[221],"both":[223],"groups,":[224],"some":[226],"occurred":[227],"group.":[234],"LIMITATION:":[235],"implies":[242],"outpatient":[247],"clinic,":[248],"which":[249],"is":[250],"not":[251],"always":[252],"feasible.":[253],"CONCLUSION:":[254],"Inclusion":[255],"low-dose":[257],"MTX-based":[261],"improves":[270],"outcomes.":[272],"PRIMARY":[273],"FUNDING":[274],"SOURCE:":[275],"Catharijne":[276],"Foundation.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":35},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":41},{"year":2013,"cited_by_count":44},{"year":2012,"cited_by_count":26}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
