{"id":"https://openalex.org/W2155172706","doi":null,"title":"Mecanismos de evasi\u00f3n y persistencia de Mycobacterium tuberculosis durante el estado de latencia y posibles estrategias para el control de la infecci\u00f3n latente","display_name":"Mecanismos de evasi\u00f3n y persistencia de Mycobacterium tuberculosis durante el estado de latencia y posibles estrategias para el control de la infecci\u00f3n latente","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2155172706","mag":"2155172706"},"language":"es","primary_location":{"id":"pmh:oai:doaj.org/article:a76f036e3b9f44c3af51a3001d79e366","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a76f036e3b9f44c3af51a3001d79e366","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"VacciMonitor, Vol 18, Iss 3, Pp 18-25 (2009)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/a76f036e3b9f44c3af51a3001d79e366","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026429668","display_name":"Nadine \u00c1lvarez","orcid":"https://orcid.org/0000-0002-9045-5740","observed_orcids":["https://orcid.org/0000-0002-9045-5740"]},"institutions":[{"id":"https://openalex.org/I4210100398","display_name":"Finlay Institute","ror":"https://ror.org/00kq7a553","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210100398"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"\u00c1lvarez, Nadine","raw_affiliation_strings":["Instituto Finlay, Ciudad de la Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Finlay, Ciudad de la Habana, Cuba","institution_ids":["https://openalex.org/I4210100398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035948331","display_name":"Reinier Borrero","orcid":"https://orcid.org/0000-0003-0679-7973","observed_orcids":["https://orcid.org/0000-0003-0679-7973"]},"institutions":[{"id":"https://openalex.org/I4210100398","display_name":"Finlay Institute","ror":"https://ror.org/00kq7a553","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210100398"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Borrero, Reinier","raw_affiliation_strings":["Instituto Finlay, Ciudad de la Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Finlay, Ciudad de la Habana, Cuba","institution_ids":["https://openalex.org/I4210100398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080674227","display_name":"F\u00e1tima Reyes","orcid":"https://orcid.org/0000-0003-3227-8739","observed_orcids":["https://orcid.org/0000-0003-3227-8739"]},"institutions":[{"id":"https://openalex.org/I4210100398","display_name":"Finlay Institute","ror":"https://ror.org/00kq7a553","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210100398"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Reyes, F\u00e1tima","raw_affiliation_strings":["Instituto Finlay, Ciudad de la Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Finlay, Ciudad de la Habana, Cuba","institution_ids":["https://openalex.org/I4210100398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005100749","display_name":"Frank Camacho","orcid":"https://orcid.org/0000-0003-2247-7160","observed_orcids":["https://orcid.org/0000-0003-2247-7160"]},"institutions":[{"id":"https://openalex.org/I4210100398","display_name":"Finlay Institute","ror":"https://ror.org/00kq7a553","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210100398"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Camacho, Frank","raw_affiliation_strings":["Instituto Finlay, Ciudad de la Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Finlay, Ciudad de la Habana, Cuba","institution_ids":["https://openalex.org/I4210100398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053969434","display_name":"Norazmi Mohd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Mohd, Norazmi","raw_affiliation_strings":["Univ. Sains Malaysia (Malaysia)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Sains Malaysia (Malaysia)","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sarmiento, Mar\u00eda Elena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100398","display_name":"Finlay Institute","ror":"https://ror.org/00kq7a553","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210100398"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Sarmiento, Mar\u00eda Elena","raw_affiliation_strings":["Instituto Finlay, Ciudad de la Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Finlay, Ciudad de la Habana, Cuba","institution_ids":["https://openalex.org/I4210100398"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065100470","display_name":"Armando Acosta","orcid":"https://orcid.org/0000-0001-5882-1360","observed_orcids":["https://orcid.org/0000-0001-5882-1360"]},"institutions":[{"id":"https://openalex.org/I4210100398","display_name":"Finlay Institute","ror":"https://ror.org/00kq7a553","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210100398"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Acosta, Armando","raw_affiliation_strings":["Instituto Finlay, Ciudad de la Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Finlay, Ciudad de la Habana, Cuba","institution_ids":["https://openalex.org/I4210100398"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":1.0},{"id":"https://openalex.org/keywords/latent-tuberculosis-infection","display_name":"latent tuberculosis infection","score":0.8600000143051147},{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.859000027179718},{"id":"https://openalex.org/keywords/tuberculosis-vaccine-development","display_name":"tuberculosis vaccine development","score":0.7409999966621399},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7200000286102295},{"id":"https://openalex.org/keywords/tuberculosis-relapse","display_name":"tuberculosis relapse","score":0.7720000147819519},{"id":"https://openalex.org/keywords/stress-tolerance","display_name":"stress tolerance","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.4517943859100342},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.18851953744888306}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:doaj.org/article:a76f036e3b9f44c3af51a3001d79e366","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a76f036e3b9f44c3af51a3001d79e366","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"VacciMonitor, Vol 18, Iss 3, Pp 18-25 (2009)","raw_type":"article"},{"id":"pmh:oai:redalyc.org:203414613004","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=203414613004","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"VacciMonitor (Cuba) Num.3 Vol.18","raw_type":"art\u00edculo cient\u00edfico"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:a76f036e3b9f44c3af51a3001d79e366","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a76f036e3b9f44c3af51a3001d79e366","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"VacciMonitor, Vol 18, Iss 3, Pp 18-25 (2009)","raw_type":"article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W223852105","https://openalex.org/W1851138068","https://openalex.org/W1864461701","https://openalex.org/W1973789730","https://openalex.org/W1976768342","https://openalex.org/W1977176428","https://openalex.org/W1978364383","https://openalex.org/W1979690999","https://openalex.org/W1984009950","https://openalex.org/W1984523365","https://openalex.org/W1998962194","https://openalex.org/W2007097682","https://openalex.org/W2008994777","https://openalex.org/W2011786720","https://openalex.org/W2013404819","https://openalex.org/W2017539316","https://openalex.org/W2021379115","https://openalex.org/W2025126145","https://openalex.org/W2025951355","https://openalex.org/W2042971327","https://openalex.org/W2049675690","https://openalex.org/W2052481735","https://openalex.org/W2079757735","https://openalex.org/W2080354196","https://openalex.org/W2080583113","https://openalex.org/W2082573007","https://openalex.org/W2082836545","https://openalex.org/W2083701335","https://openalex.org/W2093423705","https://openalex.org/W2094222845","https://openalex.org/W2096606273","https://openalex.org/W2097421503","https://openalex.org/W2098644908","https://openalex.org/W2106528225","https://openalex.org/W2106549015","https://openalex.org/W2114004413","https://openalex.org/W2115438934","https://openalex.org/W2116738290","https://openalex.org/W2118508196","https://openalex.org/W2120234524","https://openalex.org/W2120842435","https://openalex.org/W2123084649","https://openalex.org/W2124001620","https://openalex.org/W2124569362","https://openalex.org/W2125112523","https://openalex.org/W2126227426","https://openalex.org/W2128128786","https://openalex.org/W2131731929","https://openalex.org/W2132298801","https://openalex.org/W2134631580","https://openalex.org/W2146815688","https://openalex.org/W2156343505","https://openalex.org/W2158023121","https://openalex.org/W2165885466","https://openalex.org/W2170209192","https://openalex.org/W3129772858"],"related_works":["https://openalex.org/W2883057068","https://openalex.org/W7025183254","https://openalex.org/W2019835759","https://openalex.org/W3002402303","https://openalex.org/W1536867637","https://openalex.org/W2166978557","https://openalex.org/W4233652381","https://openalex.org/W1543888238","https://openalex.org/W2079757735","https://openalex.org/W7036142920"],"abstract_inverted_index":{"Mycobacterium":[0],"tuberculosis,":[1,7],"el":[2,18,106,130,133,166],"agente":[3],"causal":[4],"de":[5,11,14,25,29,37,61,71,77,89,92,95,104,113,121,125,135,137,143,169,173,180],"la":[6,50,72,75,110,153,162],"infecta":[8],"aproximadamente":[9],"alrededor":[10],"54":[12],"millones":[13],"personas":[15],"en":[16,49,171,177],"todo":[17],"mundo":[19],"cada":[20],"a\u00f1o":[21],"y":[22,132,182],"constituye":[23],"una":[24,45,149],"las":[26,32,178],"principales":[27,146],"causas":[28],"muerte":[30],"entre":[31],"enfermedades":[33],"infecciosas.":[34],"La":[35,68],"mayor\u00eda":[36],"los":[38,59,119,126,144],"individuos":[39],"infectados":[40],"con":[41,97],"M.":[42,85,138],"tuberculosis":[43,73,86,139],"desarrollan":[44],"infecci\u00f3n":[46],"latente,":[47],"etapa":[48],"que":[51,105,164],"este":[52],"microorganismo":[53],"sobrevive":[54],"dentro":[55],"del":[56,63,66],"hospedero,":[57],"evadiendo":[58],"mecanismos":[60],"defensa":[62],"sistema":[64],"inmune":[65],"portador.":[67],"terapia":[69],"actual":[70],"comprende":[74],"administraci\u00f3n":[76],"cuatro":[78],"antimicrobianos":[79],"durante":[80,109,175],"seis":[81],"meses.":[82],"No":[83],"obstante,":[84],"es":[87],"capaz":[88],"sobrevivir":[90,170],"despu\u00e9s":[91],"varios":[93],"meses":[94],"tratamiento":[96,131],"esa":[98],"terap\u00e9utica":[99],"antimicrobiana":[100],"combinada.":[101],"Existen":[102],"evidencias":[103],"bacilo":[107,167],"tuberculoso,":[108],"fase":[111],"estacionaria":[112],"crecimiento,":[114],"incrementa":[115],"su":[116,157],"tolerancia":[117],"a":[118],"ambientes":[120],"estr\u00e9s.":[122],"El":[123],"costo":[124],"f\u00e1rmacos":[127],"empleados":[128],"para":[129,147],"incremento":[134],"cepas":[136],"multidrogorresistentes":[140],"constituyen":[141],"uno":[142],"motivos":[145],"desarrollar":[148],"nueva":[150],"vacuna":[151],"contra":[152],"tuberculosis.":[154],"Sin":[155],"embargo,":[156],"erradicaci\u00f3n":[158],"est\u00e1":[159],"afectada":[160],"por":[161],"capacidad":[163],"posee":[165],"tuberculoso":[168],"estado":[172],"latencia":[174],"d\u00e9cadas,":[176],"condiciones":[179],"hipoxia":[181],"causar":[183],"infecciones":[184],"recurrentes":[185]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
