{"id":"https://openalex.org/W2155160447","doi":"https://doi.org/10.1126/science.149.3681.310","title":"Interferon-Like Virus-Inhibitor Induced in Human Leukocytes by Phytohemagglutinin","display_name":"Interferon-Like Virus-Inhibitor Induced in Human Leukocytes by Phytohemagglutinin","publication_year":1965,"publication_date":"1965-07-16","ids":{"openalex":"https://openalex.org/W2155160447","doi":"https://doi.org/10.1126/science.149.3681.310","mag":"2155160447","pmid":"https://pubmed.ncbi.nlm.nih.gov/17838106"},"language":"en","primary_location":{"id":"doi:10.1126/science.149.3681.310","doi":"https://doi.org/10.1126/science.149.3681.310","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.149.3681.310","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2155160447"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111881268","display_name":"\u0395. Frederick Wheelock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"E. Frederick Wheelock","raw_affiliation_strings":["Departments of Preventive Medicinev and Medicine, School of Medicine, Western Reserve University, and University Hospitals, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Preventive Medicinev and Medicine, School of Medicine, Western Reserve University, and University Hospitals, Cleveland, Ohio","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111881268"],"corresponding_institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":11.3265,"has_fulltext":false,"cited_by_count":736,"citation_normalized_percentile":{"value":0.9937727,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"149","issue":"3681","first_page":"310","last_page":"311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phytohemagglutinin","display_name":"phytohemagglutinin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sindbis-virus","display_name":"Sindbis virus","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cytopathic-effect-inhibition","display_name":"cytopathic effect inhibition","score":0.8450000286102295},{"id":"https://openalex.org/keywords/human-leukocytes","display_name":"human leukocytes","score":0.9599999785423279},{"id":"https://openalex.org/keywords/common-bean","display_name":"Phaseolus vulgaris","score":0.8500000238418579},{"id":"https://openalex.org/keywords/newcastle-disease-virus","display_name":"Newcastle disease virus","score":0.7580000162124634},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.6069999933242798},{"id":"https://openalex.org/keywords/leukocyte-culture","display_name":"leukocyte culture","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C2777343345","wikidata":"https://www.wikidata.org/wiki/Q2302993","display_name":"Sindbis virus","level":4,"score":0.8331226110458374},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.772527813911438},{"id":"https://openalex.org/C2778116459","wikidata":"https://www.wikidata.org/wiki/Q327082","display_name":"Newcastle disease","level":3,"score":0.7065691947937012},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6919046640396118},{"id":"https://openalex.org/C2775996393","wikidata":"https://www.wikidata.org/wiki/Q1149147","display_name":"Cytopathic effect","level":3,"score":0.662903904914856},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6357645392417908},{"id":"https://openalex.org/C2776286235","wikidata":"https://www.wikidata.org/wiki/Q310438","display_name":"Phaseolus","level":2,"score":0.624902606010437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.60389643907547},{"id":"https://openalex.org/C2909702823","wikidata":"https://www.wikidata.org/wiki/Q2702796","display_name":"Phytohemagglutinins","level":5,"score":0.48893943428993225},{"id":"https://openalex.org/C3020395395","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Human kidney","level":3,"score":0.48836347460746765},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.430797815322876},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.2871097922325134},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2557923495769501},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.11448261141777039},{"id":"https://openalex.org/C3017602531","wikidata":"https://www.wikidata.org/wiki/Q632518","display_name":"Lymphocyte activation","level":4,"score":0.08405166864395142},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05687892436981201},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1126/science.149.3681.310","doi":"https://doi.org/10.1126/science.149.3681.310","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.149.3681.310","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:17533668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17533668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmid:17838106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17838106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W61522056","https://openalex.org/W1964445038","https://openalex.org/W1968366884","https://openalex.org/W1970537831","https://openalex.org/W1999816900","https://openalex.org/W2007401819","https://openalex.org/W2053650256","https://openalex.org/W2061905027","https://openalex.org/W2091183021","https://openalex.org/W2121824751","https://openalex.org/W2165876470","https://openalex.org/W2235171644"],"related_works":["https://openalex.org/W2092099028","https://openalex.org/W1768409951","https://openalex.org/W2070501218","https://openalex.org/W2317350493","https://openalex.org/W2045850065","https://openalex.org/W2408971203","https://openalex.org/W2318016410","https://openalex.org/W2334901019","https://openalex.org/W2415444104","https://openalex.org/W756653484"],"abstract_inverted_index":{"Phytohemagglutinin,":[0],"an":[1,14,44],"extract":[2],"of":[3,16,20,28,35],"the":[4,17],"kidney":[5],"bean,":[6],"Phaseolus":[7],"vulgaris,":[8],"induces":[9],"in":[10],"human":[11],"leukocyte":[12],"cultures":[13],"inhibitor":[15],"cytopathic":[18],"effects":[19],"Sindbis":[21],"virus.":[22],"The":[23],"physicochemical":[24],"and":[25,49,51],"biological":[26],"properties":[27],"this":[29],"virus-inhibitor":[30],"are":[31],"similar":[32],"to":[33],"those":[34],"interferon":[36],"induced":[37],"by":[38],"Newcastle":[39],"disease":[40],"virus,":[41],"except":[42],"for":[43],"instability":[45],"at":[46,52],"pH":[47],"2":[48],"10":[50],"56":[53],"degrees":[54],"C.":[55]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
