{"id":"https://openalex.org/W2155127403","doi":"https://doi.org/10.1016/s0092-8674(02)00627-x","title":"A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing","display_name":"A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W2155127403","doi":"https://doi.org/10.1016/s0092-8674(02)00627-x","mag":"2155127403","pmid":"https://pubmed.ncbi.nlm.nih.gov/11909523"},"language":"en","primary_location":{"id":"doi:10.1016/s0092-8674(02)00627-x","doi":"https://doi.org/10.1016/s0092-8674(02)00627-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0092-8674(02)00627-x","pdf_url":"http://www.cell.com/article/S009286740200627X/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S009286740200627X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038314229","display_name":"Robin Reed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robin Reed","raw_affiliation_strings":["Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. robin_reed@hms.harvard.edu","Department of Cell Biology, Harvard Medical School, Boston, MA 02115 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. robin_reed@hms.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115 USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057468179","display_name":"Ed Hurt","orcid":"https://orcid.org/0000-0002-4535-8255","observed_orcids":["https://orcid.org/0000-0002-4535-8255"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ed Hurt","raw_affiliation_strings":["University of Heidelberg, Biochemie-Zentrum Heidelberg, D-69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Heidelberg, Biochemie-Zentrum Heidelberg, D-69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038314229"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":11400,"currency":"USD","value_usd":11400},"apc_paid":null,"fwci":3.541,"has_fulltext":false,"cited_by_count":401,"citation_normalized_percentile":{"value":0.95993884,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"108","issue":"4","first_page":"523","last_page":"531"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrna-export","display_name":"mRNA export","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pre-mrna-splicing","display_name":"pre-mRNA splicing","score":0.902999997138977},{"id":"https://openalex.org/keywords/nuclear-export","display_name":"nuclear export","score":0.5899999737739563},{"id":"https://openalex.org/keywords/nonsense-mediated-mrna-decay","display_name":"nonsense-mediated mRNA decay","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8850901126861572},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.8053977489471436},{"id":"https://openalex.org/C70219777","wikidata":"https://www.wikidata.org/wiki/Q14911527","display_name":"Nonsense-mediated decay","level":5,"score":0.747200071811676},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6546504497528076},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5701366662979126},{"id":"https://openalex.org/C162419368","wikidata":"https://www.wikidata.org/wiki/Q14864908","display_name":"P-bodies","level":5,"score":0.5031937956809998},{"id":"https://openalex.org/C102063271","wikidata":"https://www.wikidata.org/wiki/Q7243183","display_name":"Precursor mRNA","level":5,"score":0.477680504322052},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.47369906306266785},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.44544070959091187},{"id":"https://openalex.org/C54757728","wikidata":"https://www.wikidata.org/wiki/Q3511067","display_name":"Nuclear export signal","level":4,"score":0.4271131753921509},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4097108244895935},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3567039966583252},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.3366623818874359},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.27483177185058594},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.20989635586738586}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017381","descriptor_name":"Spliceosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D034441","descriptor_name":"Heterogeneous-Nuclear Ribonucleoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0092-8674(02)00627-x","doi":"https://doi.org/10.1016/s0092-8674(02)00627-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0092-8674(02)00627-x","pdf_url":"http://www.cell.com/article/S009286740200627X/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},{"id":"pmid:11909523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11909523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0092-8674(02)00627-x","doi":"https://doi.org/10.1016/s0092-8674(02)00627-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0092-8674(02)00627-x","pdf_url":"http://www.cell.com/article/S009286740200627X/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2155127403.pdf"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1508541438","https://openalex.org/W1558558866","https://openalex.org/W1923529605","https://openalex.org/W1966677529","https://openalex.org/W1967536667","https://openalex.org/W1967971115","https://openalex.org/W1972877825","https://openalex.org/W1973052124","https://openalex.org/W1974199167","https://openalex.org/W1975353293","https://openalex.org/W1983315505","https://openalex.org/W1984013070","https://openalex.org/W1986011347","https://openalex.org/W1988904557","https://openalex.org/W1989804578","https://openalex.org/W1991301196","https://openalex.org/W1994852911","https://openalex.org/W1996381709","https://openalex.org/W2005100774","https://openalex.org/W2005855998","https://openalex.org/W2006242576","https://openalex.org/W2009207482","https://openalex.org/W2015506926","https://openalex.org/W2015775176","https://openalex.org/W2015851068","https://openalex.org/W2018914487","https://openalex.org/W2019860831","https://openalex.org/W2027999077","https://openalex.org/W2033680770","https://openalex.org/W2033983825","https://openalex.org/W2037534409","https://openalex.org/W2045845081","https://openalex.org/W2049314528","https://openalex.org/W2050501365","https://openalex.org/W2050908337","https://openalex.org/W2058949200","https://openalex.org/W2059569036","https://openalex.org/W2062400674","https://openalex.org/W2066043643","https://openalex.org/W2066835429","https://openalex.org/W2082949426","https://openalex.org/W2084648912","https://openalex.org/W2087202439","https://openalex.org/W2093316822","https://openalex.org/W2094095762","https://openalex.org/W2095915699","https://openalex.org/W2098441269","https://openalex.org/W2102005607","https://openalex.org/W2102018304","https://openalex.org/W2109354723","https://openalex.org/W2110211434","https://openalex.org/W2111674631","https://openalex.org/W2113427328","https://openalex.org/W2113459103","https://openalex.org/W2114351702","https://openalex.org/W2118929024","https://openalex.org/W2121877938","https://openalex.org/W2123898323","https://openalex.org/W2124007474","https://openalex.org/W2126409874","https://openalex.org/W2127534226","https://openalex.org/W2127701573","https://openalex.org/W2127901995","https://openalex.org/W2132300055","https://openalex.org/W2132319942","https://openalex.org/W2133201628","https://openalex.org/W2137990405","https://openalex.org/W2138459463","https://openalex.org/W2138647063","https://openalex.org/W2139934144","https://openalex.org/W2140044545","https://openalex.org/W2143718571","https://openalex.org/W2143814486","https://openalex.org/W2144376209","https://openalex.org/W2145322004","https://openalex.org/W2147543837","https://openalex.org/W2151298994","https://openalex.org/W2153823864","https://openalex.org/W2154925328","https://openalex.org/W2155915917","https://openalex.org/W2159391740","https://openalex.org/W2159864549","https://openalex.org/W2160516095","https://openalex.org/W2160579210","https://openalex.org/W2163110519","https://openalex.org/W2163765191","https://openalex.org/W2164735945","https://openalex.org/W2165306451","https://openalex.org/W2165589515","https://openalex.org/W2166206156","https://openalex.org/W2167153618","https://openalex.org/W2171171901","https://openalex.org/W4239681659","https://openalex.org/W6640108803"],"related_works":["https://openalex.org/W3211637351","https://openalex.org/W2137302306","https://openalex.org/W2062400674","https://openalex.org/W2351468342","https://openalex.org/W2045624581","https://openalex.org/W2133205331","https://openalex.org/W2130312623","https://openalex.org/W2015775176","https://openalex.org/W2129952868","https://openalex.org/W2020628152"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}