{"id":"https://openalex.org/W2155124013","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a122983","title":"Isolation and Fundamental Properties of a Phospholipase A2 Inhibitor from the Blood Plasma of Trimeresurus flavoviridis1","display_name":"Isolation and Fundamental Properties of a Phospholipase A2 Inhibitor from the Blood Plasma of Trimeresurus flavoviridis1","publication_year":1989,"publication_date":"1989-12-01","ids":{"openalex":"https://openalex.org/W2155124013","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a122983","mag":"2155124013","pmid":"https://pubmed.ncbi.nlm.nih.gov/2628432"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.jbchem.a122983","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a122983","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a122983","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077212050","display_name":"Hiroyuki Kogaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Kogaki","raw_affiliation_strings":["Department of Biology, Faculty of Science, Osaka University","Department of Biology, Faculty of Science, Osaka UniversityToyonaka, Osaka 560"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science, Osaka University","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Biology, Faculty of Science, Osaka UniversityToyonaka, Osaka 560","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014577195","display_name":"Seiji Inoue","orcid":"https://orcid.org/0009-0000-5872-0383","observed_orcids":["https://orcid.org/0009-0000-5872-0383"]},"institutions":[{"id":"https://openalex.org/I90237989","display_name":"Osaka University of Pharmaceutical Sciences","ror":"https://ror.org/029yaft79","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321","https://openalex.org/I90237989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiji Inoue","raw_affiliation_strings":["Department of Biochemistry, Osaka University of Pharmaceutical SciencesKawai, Matsubara, Osaka 580"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Osaka University of Pharmaceutical SciencesKawai, Matsubara, Osaka 580","institution_ids":["https://openalex.org/I90237989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032264858","display_name":"Kiyoshi Ikeda","orcid":"https://orcid.org/0000-0003-4857-6976","observed_orcids":["https://orcid.org/0000-0003-4857-6976"]},"institutions":[{"id":"https://openalex.org/I90237989","display_name":"Osaka University of Pharmaceutical Sciences","ror":"https://ror.org/029yaft79","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321","https://openalex.org/I90237989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Ikeda","raw_affiliation_strings":["Department of Biochemistry, Osaka University of Pharmaceutical SciencesKawai, Matsubara, Osaka 580"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Osaka University of Pharmaceutical SciencesKawai, Matsubara, Osaka 580","institution_ids":["https://openalex.org/I90237989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072874643","display_name":"Yuji Samejima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Samejima","raw_affiliation_strings":["Department of Hygienic Chemistry, Faculty of Pharmacy, Hoshi UniversityShinagawa-ku, Tokyo 142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygienic Chemistry, Faculty of Pharmacy, Hoshi UniversityShinagawa-ku, Tokyo 142","institution_ids":["https://openalex.org/I36296616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110101667","display_name":"Tamotsu Omori\u2010Satoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tamotsu Omori-Satoh","raw_affiliation_strings":["Department of Applied Immunology, National Institute of HealthShinagawa-ku, Tokyo 141"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Immunology, National Institute of HealthShinagawa-ku, Tokyo 141","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108500679","display_name":"Kozo HAMAGUCHI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kozo Hamaguchi","raw_affiliation_strings":["Department of Biology, Faculty of Science, Osaka UniversityToyonaka, Osaka 560"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science, Osaka UniversityToyonaka, Osaka 560","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":0.6285,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.71876473,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"106","issue":"6","first_page":"966","last_page":"971"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phospholipase-a2-inhibitors","display_name":"phospholipase A2 inhibitors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/trimeresurus-flavoviridis","display_name":"Trimeresurus flavoviridis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/habu-snake-venom","display_name":"habu snake venom","score":0.6980000138282776},{"id":"https://openalex.org/keywords/glycoproteins","display_name":"glycoproteins","score":0.6890000104904175},{"id":"https://openalex.org/keywords/enzyme-inhibitor-interaction","display_name":"enzyme-inhibitor binding","score":0.6119999885559082},{"id":"https://openalex.org/keywords/dissociation-constant","display_name":"dissociation constant","score":0.7839999794960022},{"id":"https://openalex.org/keywords/crotalidae","display_name":"Crotalidae","score":0.6240000128746033},{"id":"https://openalex.org/keywords/enzyme-purification","display_name":"enzyme purification","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C163994747","wikidata":"https://www.wikidata.org/wiki/Q2916358","display_name":"Sephadex","level":3,"score":0.8437803983688354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7339096665382385},{"id":"https://openalex.org/C193363816","wikidata":"https://www.wikidata.org/wiki/Q1617865","display_name":"Size-exclusion chromatography","level":3,"score":0.6638613343238831},{"id":"https://openalex.org/C2776551241","wikidata":"https://www.wikidata.org/wiki/Q24768001","display_name":"Phospholipase A2","level":3,"score":0.6597385406494141},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5260650515556335},{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.5088727474212646},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5008587837219238},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.46339279413223267},{"id":"https://openalex.org/C2776725428","wikidata":"https://www.wikidata.org/wiki/Q424200","display_name":"Snake venom","level":3,"score":0.4625474810600281},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4582985043525696},{"id":"https://openalex.org/C2776888444","wikidata":"https://www.wikidata.org/wiki/Q7187515","display_name":"Phospholipase A","level":4,"score":0.441707581281662}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010740","descriptor_name":"Phospholipases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012685","descriptor_name":"Sepharose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D012911","descriptor_name":"Snakes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D054467","descriptor_name":"Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/oxfordjournals.jbchem.a122983","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a122983","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a122983","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:2628432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2628432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2109777860","https://openalex.org/W7095259605","https://openalex.org/W7145203034","https://openalex.org/W1939357795","https://openalex.org/W194454686","https://openalex.org/W4249259393","https://openalex.org/W2425498117","https://openalex.org/W1874316998","https://openalex.org/W1561537921","https://openalex.org/W2093272291"],"abstract_inverted_index":{"Phospholipase":[0],"A2":[1,73,96,111],"inhibitor":[2,27,69,86,107],"was":[3,28,42,78,88],"purified":[4,26],"from":[5,74,112,152],"the":[6,59,63,65,68,100,109,129,134,141,149],"blood":[7],"plasma":[8],"of":[9,38,46,62,67,104,122],"Habu,":[10],"Trimeresurus":[11],"flavoviridis,":[12,147],"by":[13,80],"Sephadex":[14,81],"G-200":[15],"gel":[16,83],"filtration,":[17],"DEAE-cellulose":[18],"chromatography,":[19],"and":[20,102],"Blue-Sepharose":[21],"CL-6B":[22],"column":[23],"chromatography.":[24],"The":[25,106],"shown":[29],"to":[30,44,57,90,93,140],"be":[31],"a":[32,35,71],"glycoprotein":[33],"with":[34,70,116],"molecular":[36,50],"weight":[37],"about":[39],"100K.":[40],"It":[41],"found":[43,89],"consist":[45],"four":[47],"subunits":[48],"whose":[49],"weights":[51],"were":[52],"around":[53],"20-24K.":[54],"In":[55],"order":[56],"examine":[58],"inhibition":[60],"mechanism":[61],"inhibitor,":[64],"interaction":[66],"phospholipase":[72,95,110,150],"T.":[75,113,146],"flavoviridis":[76,114],"venom":[77,115],"examined":[79],"G-100":[82],"filtration.":[84],"One":[85],"molecule":[87,97],"bind":[91],"directly":[92],"one":[94],"in":[98],"both":[99],"presence":[101],"absence":[103],"Ca2+.":[105],"inhibited":[108],"an":[117],"apparent":[118],"dissociation":[119],"constant,":[120],"Ki,":[121],"1.7":[123],"X":[124],"10(-10)":[125],"M,":[126],"but":[127],"not":[128],"porcine":[130],"pancreas":[131],"enzyme":[132,138],"or":[133,148],"Agkistrodon":[135],"halys":[136],"blomhoffii":[137],"belonging":[139],"same":[142],"family,":[143],"Crotalidae,":[144],"as":[145],"C":[151],"Bacillus":[153],"cereus.":[154]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
