{"id":"https://openalex.org/W2155108482","doi":"https://doi.org/10.2174/138920011798357042","title":"The Coordinated Role of CYP450 Enzymes and P-gp in Determining Cancer Resistance to Chemotherapy","display_name":"The Coordinated Role of CYP450 Enzymes and P-gp in Determining Cancer Resistance to Chemotherapy","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W2155108482","doi":"https://doi.org/10.2174/138920011798357042","mag":"2155108482","pmid":"https://pubmed.ncbi.nlm.nih.gov/21434858"},"language":"en","primary_location":{"id":"doi:10.2174/138920011798357042","doi":"https://doi.org/10.2174/138920011798357042","is_oa":false,"landing_page_url":"https://doi.org/10.2174/138920011798357042","pdf_url":null,"source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050514750","display_name":"Amalia Azzariti","orcid":"https://orcid.org/0000-0002-6149-5049","observed_orcids":["https://orcid.org/0000-0002-6149-5049"]},"institutions":[{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Amalia Azzariti","raw_affiliation_strings":["Clinical Experimental Oncology Laboratory, National Cancer Institute \u201cGiovanni Paolo II\u201d, Viale Orazio Flacco, 65 - 70124 Bari, Italy. a.azzariti@oncologico.bari.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Experimental Oncology Laboratory, National Cancer Institute \u201cGiovanni Paolo II\u201d, Viale Orazio Flacco, 65 - 70124 Bari, Italy. a.azzariti@oncologico.bari.it","institution_ids":["https://openalex.org/I4210131058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029535504","display_name":"Letizia Porcelli","orcid":"https://orcid.org/0000-0003-0175-9716","observed_orcids":["https://orcid.org/0000-0003-0175-9716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Letizia Porcelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113619540","display_name":"Anna Elisa Quatrale","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Elisa Quatrale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086984759","display_name":"Nicola Silvestris","orcid":"https://orcid.org/0000-0001-7814-7318","observed_orcids":["https://orcid.org/0000-0001-7814-7318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicola Silvestris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085211609","display_name":"Angelo Paradiso","orcid":"https://orcid.org/0000-0001-6495-2295","observed_orcids":["https://orcid.org/0000-0001-6495-2295"]},"institutions":[{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Angelo Paradiso","raw_affiliation_strings":["Clinical Experimental Oncology Laboratory National Cancer Institute Giovanni Paolo II Viale Orazio Flacco, 65 70124 Bari, Italy.,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Experimental Oncology Laboratory National Cancer Institute Giovanni Paolo II Viale Orazio Flacco, 65 70124 Bari, Italy.,Italy","institution_ids":["https://openalex.org/I4210131058"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085211609"],"corresponding_institution_ids":["https://openalex.org/I4210131058"],"apc_list":null,"apc_paid":null,"fwci":0.3243,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.65184274,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"8","first_page":"713","last_page":"721"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.09319999814033508,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9120000004768372},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9710000157356262},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.8320000171661377},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cancer-chemoresistance","display_name":"cancer chemotherapy resistance","score":0.8009999990463257},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6119999885559082},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8949999809265137},{"id":"https://openalex.org/keywords/drug-response-variability","display_name":"drug response variability","score":0.8799999952316284},{"id":"https://openalex.org/keywords/platinum-complexes","display_name":"platinum complexes","score":0.8930000066757202},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dubin-johnson-syndrome","display_name":"Dubin-Johnson syndrome","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6111374497413635},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5913642048835754},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5539553761482239},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.5389886498451233},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5249935388565063},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5005981922149658},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5005526542663574},{"id":"https://openalex.org/C2983288658","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer chemotherapy","level":3,"score":0.484973669052124},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.449789822101593},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4395417869091034},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4272347688674927},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.42406585812568665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41963425278663635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4116480350494385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39743950963020325},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39648523926734924},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3413131833076477},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.2828863561153412},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.185664564371109},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15606972575187683}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.2174/138920011798357042","doi":"https://doi.org/10.2174/138920011798357042","is_oa":false,"landing_page_url":"https://doi.org/10.2174/138920011798357042","pdf_url":null,"source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},{"id":"pmid:21434858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21434858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:ricerca.uniba.it:11586/250873","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11586/250873","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2077522929","https://openalex.org/W1972352373","https://openalex.org/W1965059036","https://openalex.org/W2026900314","https://openalex.org/W2112390445","https://openalex.org/W3216841444","https://openalex.org/W2438706428","https://openalex.org/W1979398278","https://openalex.org/W3134882842","https://openalex.org/W2003494055"],"abstract_inverted_index":{"The":[0,39],"relationship":[1,60],"between":[2,61],"CYP450":[3,23,66,95],"and":[4,37,67,69,96,111,128],"P-gp":[5,17,36,68,110],"occurs":[6],"at":[7],"different":[8],"levels.":[9],"It":[10],"is":[11,53,58,116],"known":[12],"that":[13],"certain":[14],"substrates":[15],"of":[16,28,34,41,50,65,72,84,94,104,122,132],"undergo":[18],"metabolic":[19],"transformations":[20],"by":[21],"various":[22,91],"isoforms;":[24],"in":[25,75,87,107,125,135,140,143],"addition":[26],"some":[27,105],"them":[29],"demonstrated":[30],"to":[31,54,89,154],"be":[32],"activators":[33],"both":[35,109],"CYP450.":[38],"majority":[40],"such":[42],"compounds":[43],"are":[44],"well-known":[45],"chemotherapeutics,":[46,159],"therefore":[47],"the":[48,62,70,81,85,90,98,102,120,129,137],"purpose":[49],"this":[51,114],"review":[52],"clarify":[55],"whether":[56,113],"there":[57],"a":[59],"simultaneous":[63],"modulation":[64,115],"onset":[71,121],"drug":[73,123,141],"resistance":[74,124,153],"tumors":[76],"treatment.":[77],"Here,":[78],"we":[79],"discuss":[80],"biological":[82],"aspects":[83],"topic":[86],"relation":[88],"tissues":[92],"distribution":[93],"P-gp,":[97],"recent":[99],"findings":[100],"regarding":[101],"ability":[103],"chemotherapeutics":[106],"modulating":[108],"CYP450,":[112,148],"ultimately":[117],"responsible":[118],"for":[119],"cancer":[126],"treatment":[127],"promising":[130],"role":[131],"gene":[133],"polymorphisms":[134],"determining":[136],"interindividual":[138],"variability":[139],"responses":[142],"clinical":[144],"practice.":[145],"Keywords:":[146],"Cancer,":[147],"Glycoprotein":[149],"P,":[150],"platinum":[151],"compounds,":[152],"chemotherapy,":[155],"tyrosine":[156],"kinase":[157],"inhibitors,":[158],"Dubin-Johnson":[160],"syndrome,":[161],"ATP-Binding":[162],"Cassette":[163],"(ABC)":[164],"proteins,":[165],"Byler's":[166],"disease":[167]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}