{"id":"https://openalex.org/W2155073725","doi":"https://doi.org/10.2174/187221511794839219","title":"Significance of P2X7 Receptor Variants to Human Health and Disease","display_name":"Significance of P2X7 Receptor Variants to Human Health and Disease","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2155073725","doi":"https://doi.org/10.2174/187221511794839219","mag":"2155073725","pmid":"https://pubmed.ncbi.nlm.nih.gov/21303345"},"language":"en","primary_location":{"id":"doi:10.2174/187221511794839219","doi":"https://doi.org/10.2174/187221511794839219","is_oa":false,"landing_page_url":"https://doi.org/10.2174/187221511794839219","pdf_url":null,"source":{"id":"https://openalex.org/S149703013","display_name":"Recent Patents on DNA & Gene Sequences","issn_l":"1872-2156","issn":["1872-2156","2212-3431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent Patents on DNA &amp; Gene Sequences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/journal_contribution/Significance_of_P2X7_receptor_variants_to_human_health_and_disease/27458877","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041363133","display_name":"Ronald Sluyter","orcid":"https://orcid.org/0000-0003-4909-686X","observed_orcids":["https://orcid.org/0000-0003-4909-686X"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ronald Sluyter","raw_affiliation_strings":["School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia. rsluyter@uow.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia. rsluyter@uow.edu.au","institution_ids":["https://openalex.org/I204824540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021311826","display_name":"Leanne Stokes","orcid":"https://orcid.org/0000-0003-4013-6781","observed_orcids":["https://orcid.org/0000-0003-4013-6781"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Leanne Stokes","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.,Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021311826"],"corresponding_institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"],"apc_list":null,"apc_paid":null,"fwci":7.8112,"has_fulltext":false,"cited_by_count":147,"citation_normalized_percentile":{"value":0.98602918,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"5","issue":"1","first_page":"41","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p2x7-receptor","display_name":"P2X7 receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/purinergic-receptors","display_name":"purinergic receptors","score":0.796999990940094},{"id":"https://openalex.org/keywords/splice-variants","display_name":"splice variants","score":0.8059999942779541},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":1.0},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.9459999799728394},{"id":"https://openalex.org/keywords/loss-of-function-variants","display_name":"loss-of-function mutations","score":0.7480000257492065},{"id":"https://openalex.org/keywords/gain-of-function-mutations","display_name":"gain-of-function mutations","score":0.9729999899864197},{"id":"https://openalex.org/keywords/extracellular-atp","display_name":"extracellular ATP","score":0.7630000114440918},{"id":"https://openalex.org/keywords/purinergic-signaling","display_name":"purinergic signaling","score":0.7789999842643738},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/immunity","display_name":"immunity","score":0.7250000238418579},{"id":"https://openalex.org/keywords/bone-homeostasis","display_name":"bone homeostasis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/neurological-function","display_name":"neurological function","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.953000009059906},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7120000123977661},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.7760000228881836},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7789999842643738},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/langerhans-cells","display_name":"Langerhans cells","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6503616571426392},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5845787525177002},{"id":"https://openalex.org/C16587737","wikidata":"https://www.wikidata.org/wiki/Q4682273","display_name":"Adenosine A2B receptor","level":5,"score":0.5815103650093079},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5329785346984863},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5098065733909607},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.4726475775241852},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.46520763635635376},{"id":"https://openalex.org/C57306754","wikidata":"https://www.wikidata.org/wiki/Q1010629","display_name":"Purinergic receptor","level":3,"score":0.45856866240501404},{"id":"https://openalex.org/C17971392","wikidata":"https://www.wikidata.org/wiki/Q18027445","display_name":"5-HT5A receptor","level":3,"score":0.4249057173728943},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.4242258667945862},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41993436217308044},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4187563359737396},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.41265127062797546},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.2642541527748108},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1314353346824646},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010330","descriptor_name":"Patents as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.2174/187221511794839219","doi":"https://doi.org/10.2174/187221511794839219","is_oa":false,"landing_page_url":"https://doi.org/10.2174/187221511794839219","pdf_url":null,"source":{"id":"https://openalex.org/S149703013","display_name":"Recent Patents on DNA & Gene Sequences","issn_l":"1872-2156","issn":["1872-2156","2212-3431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent Patents on DNA &amp; Gene Sequences","raw_type":"journal-article"},{"id":"pmid:21303345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21303345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent patents on DNA & gene sequences","raw_type":"Journal Article"},{"id":"pmh:oai:ro.uow.edu.au:scipapers-2181","doi":null,"is_oa":false,"landing_page_url":"https://ro.uow.edu.au/scipapers/1114","pdf_url":null,"source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty of Science - Papers (Archive)","raw_type":"article"},{"id":"pmh:oai:alma.61RMIT_INST:11246820980001341","doi":null,"is_oa":false,"landing_page_url":"http://www.eurekaselect.com/93765/article","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:alma61RMIT.INST:11246820980001341","doi":null,"is_oa":false,"landing_page_url":"http://www.eurekaselect.com/93765/article","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:figshare.com:article/27458877","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Significance_of_P2X7_receptor_variants_to_human_health_and_disease/27458877","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/27714546","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/Significance_of_P2X7_Receptor_Variants_to_Human_Health_and_Disease/27714546","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/27458877","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Significance_of_P2X7_receptor_variants_to_human_health_and_disease/27458877","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309813","display_name":"Canine Research Foundation","ror":"https://ror.org/00xny7d86"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":163,"referenced_works":["https://openalex.org/W169752128","https://openalex.org/W945340878","https://openalex.org/W1031954890","https://openalex.org/W1481135965","https://openalex.org/W1485797978","https://openalex.org/W1495057561","https://openalex.org/W1503696655","https://openalex.org/W1518128836","https://openalex.org/W1531005999","https://openalex.org/W1531401428","https://openalex.org/W1551990832","https://openalex.org/W1553498014","https://openalex.org/W1554969768","https://openalex.org/W1579846548","https://openalex.org/W1581373047","https://openalex.org/W1586346422","https://openalex.org/W1604241772","https://openalex.org/W1759386396","https://openalex.org/W1771486037","https://openalex.org/W1837642243","https://openalex.org/W1840018339","https://openalex.org/W1885311483","https://openalex.org/W1906615145","https://openalex.org/W1933120550","https://openalex.org/W1935099637","https://openalex.org/W1958327995","https://openalex.org/W1964755615","https://openalex.org/W1966825127","https://openalex.org/W1968122621","https://openalex.org/W1968681393","https://openalex.org/W1970033359","https://openalex.org/W1970613983","https://openalex.org/W1971817436","https://openalex.org/W1972204801","https://openalex.org/W1972428372","https://openalex.org/W1974924721","https://openalex.org/W1976749946","https://openalex.org/W1977772978","https://openalex.org/W1981157963","https://openalex.org/W1981608729","https://openalex.org/W1983504852","https://openalex.org/W1985080645","https://openalex.org/W1986062689","https://openalex.org/W1987945720","https://openalex.org/W1988033098","https://openalex.org/W1991376713","https://openalex.org/W1993059138","https://openalex.org/W1993211242","https://openalex.org/W1994074692","https://openalex.org/W1995810932","https://openalex.org/W1998545579","https://openalex.org/W2004723852","https://openalex.org/W2005717890","https://openalex.org/W2006646148","https://openalex.org/W2007231952","https://openalex.org/W2008987492","https://openalex.org/W2010596549","https://openalex.org/W2015495495","https://openalex.org/W2017077979","https://openalex.org/W2017990694","https://openalex.org/W2019444845","https://openalex.org/W2020721601","https://openalex.org/W2022291383","https://openalex.org/W2026503661","https://openalex.org/W2026928679","https://openalex.org/W2028676368","https://openalex.org/W2029069980","https://openalex.org/W2029728509","https://openalex.org/W2030236680","https://openalex.org/W2034182613","https://openalex.org/W2034442219","https://openalex.org/W2035279478","https://openalex.org/W2038595980","https://openalex.org/W2038735315","https://openalex.org/W2041069934","https://openalex.org/W2043464754","https://openalex.org/W2044259424","https://openalex.org/W2047324800","https://openalex.org/W2049110510","https://openalex.org/W2050728893","https://openalex.org/W2051238731","https://openalex.org/W2051271802","https://openalex.org/W2056148352","https://openalex.org/W2058064767","https://openalex.org/W2061688009","https://openalex.org/W2062439601","https://openalex.org/W2064186269","https://openalex.org/W2065319956","https://openalex.org/W2065336052","https://openalex.org/W2066784771","https://openalex.org/W2068569140","https://openalex.org/W2069799943","https://openalex.org/W2070307854","https://openalex.org/W2078551078","https://openalex.org/W2080468709","https://openalex.org/W2081180556","https://openalex.org/W2084379750","https://openalex.org/W2084403509","https://openalex.org/W2084501633","https://openalex.org/W2085717243","https://openalex.org/W2085731175","https://openalex.org/W2086369986","https://openalex.org/W2086828943","https://openalex.org/W2091664603","https://openalex.org/W2092850548","https://openalex.org/W2093806289","https://openalex.org/W2097991762","https://openalex.org/W2099163813","https://openalex.org/W2102096852","https://openalex.org/W2102130333","https://openalex.org/W2103370406","https://openalex.org/W2105149937","https://openalex.org/W2107137580","https://openalex.org/W2109514123","https://openalex.org/W2111178472","https://openalex.org/W2116636936","https://openalex.org/W2116796589","https://openalex.org/W2118020958","https://openalex.org/W2118652772","https://openalex.org/W2119517477","https://openalex.org/W2122246903","https://openalex.org/W2126106112","https://openalex.org/W2126695278","https://openalex.org/W2128308693","https://openalex.org/W2130153302","https://openalex.org/W2131206655","https://openalex.org/W2131273636","https://openalex.org/W2132958789","https://openalex.org/W2133727943","https://openalex.org/W2134184719","https://openalex.org/W2136886131","https://openalex.org/W2137151361","https://openalex.org/W2137219574","https://openalex.org/W2137756761","https://openalex.org/W2139928257","https://openalex.org/W2142120822","https://openalex.org/W2142726154","https://openalex.org/W2144183176","https://openalex.org/W2145525392","https://openalex.org/W2147386725","https://openalex.org/W2148053686","https://openalex.org/W2151516998","https://openalex.org/W2157724221","https://openalex.org/W2159938460","https://openalex.org/W2161024433","https://openalex.org/W2161619210","https://openalex.org/W2165271332","https://openalex.org/W2165709201","https://openalex.org/W2169420589","https://openalex.org/W2169717283","https://openalex.org/W2170277420","https://openalex.org/W2172099127","https://openalex.org/W2205437097","https://openalex.org/W2216537716","https://openalex.org/W2248033023","https://openalex.org/W2253886740","https://openalex.org/W2333209163","https://openalex.org/W2346500472","https://openalex.org/W2358232982","https://openalex.org/W2467902449","https://openalex.org/W2603738266","https://openalex.org/W4252737699","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2729475301","https://openalex.org/W2891867248","https://openalex.org/W6982005878","https://openalex.org/W2124264362","https://openalex.org/W4399760499","https://openalex.org/W1968681393","https://openalex.org/W4287838975","https://openalex.org/W2055204341","https://openalex.org/W7095919190","https://openalex.org/W3004043043"],"abstract_inverted_index":{"The":[0,77],"human":[1,119,163],"P2X7":[2,20,64,82,115,146],"receptor":[3,36,95,106,200],"is":[4,21],"a":[5,24,62,81,173],"trimeric":[6],"ligand-gated":[7],"cation":[8],"channel":[9],"coded":[10],"by":[11,37],"the":[12,47,101,111,168],"P2XR7":[13,78],"gene":[14,79],"located":[15],"at":[16],"chromosome":[17],"position":[18],"12q24.":[19],"expressed":[22],"in":[23,42,68,87,128,160],"wide":[25],"variety":[26],"of":[27,34,49,58,105,114,134,172,175],"normal":[28],"and":[29,56,75,97,99,150,153,165,170],"disease-associated":[30],"cell":[31,52],"types.":[32],"Activation":[33],"this":[35],"extracellular":[38,186],"adenosine":[39],"5'-triphosphate":[40],"results":[41],"numerous":[43,123],"downstream":[44,104],"events":[45],"including":[46,167],"release":[48],"pro-inflammatory":[50,190],"mediators,":[51,191],"proliferation":[53],"or":[54,131],"death,":[55],"killing":[57],"intracellular":[59],"pathogens.":[60],"As":[61],"result,":[63],"plays":[65],"important":[66],"roles":[67],"inflammation,":[69],"immunity,":[70],"bone":[71],"homeostasis,":[72],"neurological":[73],"function":[74,116],"neoplasia.":[76],"encodes":[80],"subunit":[83],"595":[84],"amino":[85],"acids":[86],"length,":[88],"however":[89],"splice":[90,152,181],"isoforms":[91],"that":[92,142],"can":[93,143],"alter":[94],"expression":[96],"function,":[98],"modify":[100,145],"signaling":[102],"properties":[103],"activation":[107],"also":[108,144],"exist.":[109],"Moreover,":[110],"relative":[112],"amount":[113],"varies":[117],"between":[118],"individuals":[120],"due":[121],"to":[122,139,162],"single":[124,183],"nucleotide":[125,184],"polymorphisms":[126,136],"resulting":[127],"either":[129],"loss-":[130],"gain-of-function.":[132],"Combinations":[133],"these":[135],"give":[137],"rise":[138],"various":[140],"haplotypes":[141],"function.":[147],"Collectively,":[148],"P2X7,":[149],"its":[151],"polymorphic":[154],"variants":[155],"are":[156],"attracting":[157],"considerable":[158],"interest":[159],"relation":[161],"health":[164],"disease,":[166],"development":[169],"publication":[171],"number":[174],"patents.":[176],"Keywords:":[177],"P2RX7,":[178],"purinergic":[179],"receptor,":[180],"isoform,":[182],"polymorphism,":[185],"ATP,":[187],"patent,":[188],"ectoenzymes,":[189],"oligodendrocytes,":[192],"NALP3":[193],"inflammasome,":[194],"transmembrane":[195],"domain,":[196],"macrophages,":[197],"tuberculosis,":[198],"mutant":[199],"displays,":[201],"T-lymphocytes,":[202],"dendritic":[203],"cells,":[204],"Langerhans":[205],"cells":[206]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
