{"id":"https://openalex.org/W2155045985","doi":"https://doi.org/10.1016/j.jalz.2012.05.1726","title":"P4\u2010025: SMases increase BACE1 levels in primary neurons through palmitate astrocyte\u2010conditioned media","display_name":"P4\u2010025: SMases increase BACE1 levels in primary neurons through palmitate astrocyte\u2010conditioned media","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2155045985","doi":"https://doi.org/10.1016/j.jalz.2012.05.1726","mag":"2155045985"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2012.05.1726","doi":"https://doi.org/10.1016/j.jalz.2012.05.1726","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2012.05.1726","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2012.05.1726","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2012.05.1726","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Li Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Liu","raw_affiliation_strings":["Michigan State University, East Lansing, Michigan, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michigan State University, East Lansing, Michigan, United States","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rebecca Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Martin","raw_affiliation_strings":["Michigan State University, East Lansing, Michigan, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michigan State University, East Lansing, Michigan, United States","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102757744","display_name":"Christina Chan","orcid":"https://orcid.org/0000-0003-3054-2727","observed_orcids":["https://orcid.org/0000-0003-3054-2727","https://orcid.org/0009-0003-7693-8206"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Chan","raw_affiliation_strings":["Michigan State University, East Lansing, Michigan, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michigan State University, East Lansing, Michigan, United States","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20590043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"4S_Part_17","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bace1","display_name":"BACE1","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.8668805956840515},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7778191566467285},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5634370446205139},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5306994318962097},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.48970821499824524},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48707154393196106},{"id":"https://openalex.org/C2781457462","wikidata":"https://www.wikidata.org/wiki/Q16245045","display_name":"Acid sphingomyelinase","level":4,"score":0.4851253926753998},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.44476965069770813},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.433859646320343},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.2957327961921692},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28979527950286865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26308396458625793},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2361045479774475},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23362252116203308},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.19820734858512878},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0981866717338562},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.09750109910964966},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2012.05.1726","doi":"https://doi.org/10.1016/j.jalz.2012.05.1726","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2012.05.1726","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2012.05.1726","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2012.05.1726","doi":"https://doi.org/10.1016/j.jalz.2012.05.1726","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2012.05.1726","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2012.05.1726","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2155045985.pdf","grobid_xml":"https://content.openalex.org/works/W2155045985.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1999938863","https://openalex.org/W2302335613","https://openalex.org/W2043207201","https://openalex.org/W2020743905","https://openalex.org/W2017560509","https://openalex.org/W2022964248","https://openalex.org/W2034807178","https://openalex.org/W2005032657","https://openalex.org/W1863276550","https://openalex.org/W2769471934"],"abstract_inverted_index":{"Astrocytes":[0],"play":[1],"a":[2],"critical":[3],"role":[4],"in":[5,20,41,76,84,89,96,101,113,116,130,138,152,167,174,185,204,212],"Alzheimer's":[6],"disease.":[7],"Previously,":[8],"we":[9],"showed":[10],"that":[11,66,107],"saturated":[12],"free-fatty":[13],"acid,":[14],"palmitate":[15],"(PA),":[16],"upregulates":[17,38],"BACE1":[18,39,87,102,147,159,183,210],"level":[19,40,88,112,184,211],"primary":[21,91],"rat":[22],"neurons":[23,42,77,97,140,213],"mediated":[24,200,214],"by":[25,31,171,197,201,215],"astrocytes.":[26],"However,":[27],"the":[28,90,94,99,126,131,139,143,150,153,168,175,179,186,193,206],"molecular":[29],"mechanisms":[30],"which":[32,83],"conditioned":[33,81,132,156,169],"media":[34,133,157,170],"from":[35],"PA-treated":[36,114,154],"astrocytes":[37,115,176,196,208],"are":[43,74],"unknown.":[44],"Western":[45],"blot,":[46],"Quantitative":[47],"real":[48],"time":[49],"polymerase":[50],"chain":[51],"reaction,":[52],"Enzyme-linked":[53],"immunosorbent":[54],"assay":[55],"(ELISA)":[56],"and":[57,68,72,122,136,164,182,203],"quantitative":[58],"mass":[59],"spectrometry":[60],"were":[61],"performed.":[62],"This":[63],"study":[64],"demonstrates":[65],"neural":[67],"acidic":[69],"sphingomyelinase":[70],"(N-SMase":[71],"A-SMase)":[73],"activated":[75,207],"cultured":[78],"with":[79],"palmitate-astrocyte":[80],"media,":[82],"turn":[85,117],"increase":[86],"neurons.":[92,187],"Silencing":[93],"SMases":[95],"decreased":[98],"upregulation":[100],"level.":[103],"Further":[104],"studies":[105],"indicate":[106],"increased":[108,209],"serine":[109],"palmitoyltransferase":[110],"(SPT)":[111],"enhanced":[118],"cytokine,":[119],"namely":[120],"TNFa":[121,163],"IL-1b,":[123],"secretions":[124],"into":[125],"media.":[127],"The":[128],"cytokines":[129,151],"activate":[134],"N-SMase":[135],"A-SMase":[137],"to":[141],"propagate":[142],"deleterious":[144],"effects":[145],"of":[146,195],"upregulation.":[148,160],"Neutralizing":[149],"astrocyte":[155],"reduced":[158,178],"Notably,":[161],"decreasing":[162],"IL-1b":[165],"levels":[166],"inhibiting":[172],"SPT":[173],"also":[177],"SMase":[180],"activities":[181],"In":[188],"summary,":[189],"our":[190],"data":[191],"suggest":[192],"activation":[194],"PA":[198],"is":[199],"SPT,":[202],"turn,":[205],"SMases.":[216]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}