{"id":"https://openalex.org/W2155035604","doi":null,"title":"A t(4;22) in a meningioma points to the localization of a putative tumor-suppressor gene.","display_name":"A t(4;22) in a meningioma points to the localization of a putative tumor-suppressor gene.","publication_year":1991,"publication_date":"1991-04-01","ids":{"openalex":"https://openalex.org/W2155035604","mag":"2155035604","pmid":"https://pubmed.ncbi.nlm.nih.gov/2014801","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1682947"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:386508","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1682947","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1682947","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059476156","display_name":"Ronald H. Lekanne Deprez","orcid":"https://orcid.org/0000-0003-4687-0186","observed_orcids":["https://orcid.org/0000-0003-4687-0186"]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R H Lekanne Deprez","raw_affiliation_strings":["Departments of Pathology, Erasmus University, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Erasmus University, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041964946","display_name":"Nicole A. Groen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N A Groen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006578076","display_name":"Nick A. van Biezen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N A van Biezen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113528154","display_name":"A. Hagemeijer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Hagemeijer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108519200","display_name":"Ellen van Drunen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E van Drunen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106127913","display_name":"Jan Willem Koper","orcid":"https://orcid.org/0009-0004-4269-532X","observed_orcids":["https://orcid.org/0009-0004-4269-532X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J W Koper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020213345","display_name":"C. J. J. Avezaat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C J Avezaat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029869412","display_name":"D. Bootsma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Bootsma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038176751","display_name":"Ellen C. Zwarthoff","orcid":"https://orcid.org/0000-0002-9853-4953","observed_orcids":["https://orcid.org/0000-0002-9853-4953"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E C Zwarthoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.4183,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.98161903,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"48","issue":"4","first_page":"783","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.06599999964237213,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meningioma","display_name":"meningioma","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7419999837875366},{"id":"https://openalex.org/keywords/chromosome-22q-deletion","display_name":"chromosome 22q deletion","score":0.8999999761581421},{"id":"https://openalex.org/keywords/reciprocal-translocation","display_name":"reciprocal translocation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/dicentric-chromosomes","display_name":"dicentric chromosomes","score":0.6990000009536743},{"id":"https://openalex.org/keywords/somatic-hybrids","display_name":"somatic cell hybrids","score":0.6919999718666077},{"id":"https://openalex.org/keywords/neurofibromatosis-type-2","display_name":"neurofibromatosis type 2","score":0.8500000238418579},{"id":"https://openalex.org/keywords/genetic-mapping","display_name":"gene mapping","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.7941162586212158},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7318329811096191},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5690728425979614},{"id":"https://openalex.org/C54815482","wikidata":"https://www.wikidata.org/wiki/Q753805","display_name":"Chromosome 22","level":4,"score":0.537123441696167},{"id":"https://openalex.org/C63491729","wikidata":"https://www.wikidata.org/wiki/Q14762596","display_name":"Centromere","level":4,"score":0.5369552969932556},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4339596629142761},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4163282513618469},{"id":"https://openalex.org/C103037022","wikidata":"https://www.wikidata.org/wiki/Q5272374","display_name":"Dicentric chromosome","level":5,"score":0.4146481454372406},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.3936595022678375},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.3337460160255432}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002871","descriptor_name":"Chromosome Banding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002892","descriptor_name":"Chromosomes, Human, Pair 22","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D002894","descriptor_name":"Chromosomes, Human, Pair 4","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006822","descriptor_name":"Hybrid Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008579","descriptor_name":"Meningioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:386508","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1682947","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:2014801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2014801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1682947","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1682947/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},{"id":"mag:2155035604","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2014801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:386508","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1682947","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W10107572","https://openalex.org/W179568943","https://openalex.org/W1513141222","https://openalex.org/W1564653367","https://openalex.org/W1867918175","https://openalex.org/W1893545268","https://openalex.org/W1972651910","https://openalex.org/W1982791705","https://openalex.org/W1986036115","https://openalex.org/W1991917274","https://openalex.org/W1993951035","https://openalex.org/W1995640672","https://openalex.org/W1996449685","https://openalex.org/W1998030944","https://openalex.org/W2010965145","https://openalex.org/W2011446264","https://openalex.org/W2014669590","https://openalex.org/W2016055379","https://openalex.org/W2017056425","https://openalex.org/W2020778089","https://openalex.org/W2052820687","https://openalex.org/W2053310263","https://openalex.org/W2061779359","https://openalex.org/W2067041880","https://openalex.org/W2068402552","https://openalex.org/W2071893342","https://openalex.org/W2072971752","https://openalex.org/W2076357883","https://openalex.org/W2089023484","https://openalex.org/W2090040363","https://openalex.org/W2091829740","https://openalex.org/W2092765135","https://openalex.org/W2094386686","https://openalex.org/W2126744713","https://openalex.org/W2128627950","https://openalex.org/W2138616826","https://openalex.org/W2148069086","https://openalex.org/W2151067616","https://openalex.org/W2151565238","https://openalex.org/W2153451119","https://openalex.org/W2158510547","https://openalex.org/W2163565167","https://openalex.org/W2163743218","https://openalex.org/W2397505142","https://openalex.org/W2413978147","https://openalex.org/W4299867004"],"related_works":["https://openalex.org/W2003455333","https://openalex.org/W49662148","https://openalex.org/W2158510547","https://openalex.org/W1988683372","https://openalex.org/W2082461806","https://openalex.org/W1998443229","https://openalex.org/W1757036739","https://openalex.org/W2338112712","https://openalex.org/W4252789598","https://openalex.org/W2001798731"],"abstract_inverted_index":{"Cytogenetic":[0],"analysis":[1,109],"of":[2,24,40,75,142,159,171,185,192],"meningioma":[3],"cells":[4],"from":[5,112,118,129],"one":[6],"particular":[7],"patient":[8],"(MN32)":[9],"displayed":[10],"the":[11,73,86,102,140,157,160,165,168,189,202,206,209],"stem-line":[12],"karyo-type":[13],"45,":[14],"XY,":[15],"-1,":[16],"4p+,":[17],"22q-,":[18,134],"22q+,":[19],"which":[20,198],"thus":[21],"had":[22],"rearrangements":[23],"both":[25],"chromosomes":[26,80,90],"22.":[27,83],"The":[28,37,52,174,195],"22q+":[29,161],"marker":[30,69,162],"appeared":[31,56],"as":[32],"a":[33,50,76,136,151,183],"dicentric:":[34],"22":[35],"pter----q11::1p11----qter.":[36],"reciprocal":[38,77],"product":[39],"this":[41,68,149,172,193],"translocation":[42,78,176,203],"has":[43,215],"presumably":[44],"been":[45,72,216],"lost":[46,59],"because":[47],"it":[48],"lacked":[49],"centromere.":[51],"22q-":[53,89,103],"chromosome":[54],"also":[55],"to":[57,62,123,133,212],"have":[58,71,200],"sequences":[60,117,128],"distal":[61],"band":[63],"q11.":[64],"We":[65],"assumed":[66],"that":[67,100,116,126,147,164],"could":[70],"result":[74],"between":[79,179],"4":[81],"and":[82,88,104,125,163,181],"To":[84],"investigate":[85],"4p+":[87,105,124],"in":[91,148,156,197],"more":[92],"detail,":[93],"human-hamster":[94],"somatic":[95],"cell":[96],"hybrids":[97,114],"were":[98,120,131],"constructed":[99],"segregated":[101],"chromosomes.":[106],"Southern":[107],"blot":[108],"with":[110],"DNA":[111],"these":[113,143],"showed":[115],"22q":[119],"indeed":[121],"translocated":[122,132],"reciprocally":[127],"4p":[130],"demonstrating":[135],"balanced":[137],"t(4;22)(p16;q11).":[138],"On":[139],"basis":[141],"results":[144],"we":[145,199],"presume":[146],"tumor":[150],"tumor-suppressor":[152],"gene":[153,210],"is":[154,204],"deleted":[155],"case":[158],"t(4;22)":[166],"disrupts":[167],"second":[169],"allele":[170],"gene.":[173],"latter":[175],"was":[177],"mapped":[178],"D22S1":[180],"D22S15,":[182],"distance":[184],"1":[186],"cM":[187],"on":[188],"linkage":[190],"map":[191],"chromosome.":[194],"area":[196],"located":[201],"within":[205],"region":[207],"where":[208],"predisposing":[211],"neurofibromatosis":[213],"2":[214],"mapped.":[217]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
