{"id":"https://openalex.org/W2155016470","doi":"https://doi.org/10.1111/j.1582-4934.2010.01246.x","title":"Caveolin-1 is required for contractile phenotype expression by airway smooth muscle cells","display_name":"Caveolin-1 is required for contractile phenotype expression by airway smooth muscle cells","publication_year":2010,"publication_date":"2010-12-30","ids":{"openalex":"https://openalex.org/W2155016470","doi":"https://doi.org/10.1111/j.1582-4934.2010.01246.x","mag":"2155016470","pmid":"https://pubmed.ncbi.nlm.nih.gov/21199324","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3822954"},"language":"en","primary_location":{"id":"doi:10.1111/j.1582-4934.2010.01246.x","doi":"https://doi.org/10.1111/j.1582-4934.2010.01246.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1582-4934.2010.01246.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2010.01246.x","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2010.01246.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060340541","display_name":"Reinoud Gosens","orcid":"https://orcid.org/0000-0002-5595-152X","observed_orcids":["https://orcid.org/0000-0002-5595-152X"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I4210091102","display_name":"Children's Hospital Research Institute of Manitoba","ror":"https://ror.org/00ag0rb94","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210091102","https://openalex.org/I4391767879"]},{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA","NL"],"is_corresponding":false,"raw_author_name":"Reinoud Gosens","raw_affiliation_strings":["Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada","Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada","Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands","Departments of Physiology & Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I4210091102"]},{"raw_affiliation_string":"Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]},{"raw_affiliation_string":"Departments of Physiology & Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111479211","display_name":"Gerald L. Stelmack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091102","display_name":"Children's Hospital Research Institute of Manitoba","ror":"https://ror.org/00ag0rb94","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210091102","https://openalex.org/I4391767879"]},{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gerald L. Stelmack","raw_affiliation_strings":["Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada","Departments of Physiology & Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I4210091102"]},{"raw_affiliation_string":"Departments of Physiology & Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103933143","display_name":"Sophie T. Bos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sophie T. Bos","raw_affiliation_strings":["Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015528726","display_name":"Gordon Dueck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091102","display_name":"Children's Hospital Research Institute of Manitoba","ror":"https://ror.org/00ag0rb94","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210091102","https://openalex.org/I4391767879"]},{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gordon Dueck","raw_affiliation_strings":["Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada","Departments of Physiology & Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I4210091102"]},{"raw_affiliation_string":"Departments of Physiology & Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110189777","display_name":"Mark M. Mutawe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091102","display_name":"Children's Hospital Research Institute of Manitoba","ror":"https://ror.org/00ag0rb94","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210091102","https://openalex.org/I4391767879"]},{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mark M. Mutawe","raw_affiliation_strings":["Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada","Departments of Physiology & Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I4210091102"]},{"raw_affiliation_string":"Departments of Physiology & Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064654998","display_name":"Dedmer Schaafsma","orcid":"https://orcid.org/0000-0003-0898-7973","observed_orcids":["https://orcid.org/0000-0003-0898-7973"]},"institutions":[{"id":"https://openalex.org/I4210091102","display_name":"Children's Hospital Research Institute of Manitoba","ror":"https://ror.org/00ag0rb94","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210091102","https://openalex.org/I4391767879"]},{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dedmer Schaafsma","raw_affiliation_strings":["Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada","Departments of Physiology & Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I4210091102"]},{"raw_affiliation_string":"Departments of Physiology & Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077720010","display_name":"Helmut W. Unruh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Helmut Unruh","raw_affiliation_strings":["Section of Thoracic Surgery, University of Manitoba, Winnipeg, Manitoba, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Thoracic Surgery, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027326839","display_name":"William T. Gerthoffer","orcid":"https://orcid.org/0000-0001-5154-4962","observed_orcids":["https://orcid.org/0000-0001-5154-4962"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William T. Gerthoffer","raw_affiliation_strings":["Department of Pharmacology, University of Nevada School of Medicine, Reno, NV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Nevada School of Medicine, Reno, NV, USA","institution_ids":["https://openalex.org/I134113660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002840362","display_name":"Johan Zaagsma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Johan Zaagsma","raw_affiliation_strings":["Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111518870","display_name":"Herman Meurs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Herman Meurs","raw_affiliation_strings":["Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004657168","display_name":"Andrew J. Halayko","orcid":"https://orcid.org/0000-0002-7865-4552","observed_orcids":["https://orcid.org/0000-0002-7865-4552"]},"institutions":[{"id":"https://openalex.org/I4210091102","display_name":"Children's Hospital Research Institute of Manitoba","ror":"https://ror.org/00ag0rb94","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210091102","https://openalex.org/I4391767879"]},{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Andrew J. Halayko","raw_affiliation_strings":["Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada","Departments of Physiology & Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology of Breathing Group, Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I4210091102"]},{"raw_affiliation_string":"Departments of Physiology & Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004657168"],"corresponding_institution_ids":["https://openalex.org/I4210091102","https://openalex.org/I46247651"],"apc_list":{"value":5210,"currency":"USD","value_usd":5210},"apc_paid":null,"fwci":1.8669,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.83994394,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"11","first_page":"2430","last_page":"2442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":1.0},{"id":"https://openalex.org/keywords/airway-smooth-muscle-cells","display_name":"airway smooth muscle cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tgf-beta1-signaling","display_name":"TGF-\u03b21 signaling","score":0.8370000123977661},{"id":"https://openalex.org/keywords/caveolae","display_name":"caveolae","score":0.8889999985694885},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.7429999709129333},{"id":"https://openalex.org/keywords/4e-bp1-phosphorylation","display_name":"4E-BP1 phosphorylation","score":0.902999997138977},{"id":"https://openalex.org/keywords/smooth-muscle-hypertrophy","display_name":"smooth muscle hypertrophy","score":0.8130000233650208},{"id":"https://openalex.org/keywords/calponin","display_name":"calponin","score":1.0},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.8619999885559082},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.9409999847412109},{"id":"https://openalex.org/keywords/allergen-challenge","display_name":"allergen challenge","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C49866891","wikidata":"https://www.wikidata.org/wiki/Q1051872","display_name":"Caveolae","level":3,"score":0.6719143390655518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6314440369606018},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.604812502861023},{"id":"https://openalex.org/C2779403975","wikidata":"https://www.wikidata.org/wiki/Q24724230","display_name":"Caveolin","level":4,"score":0.588308572769165},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.51931232213974},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5088565349578857},{"id":"https://openalex.org/C2781122658","wikidata":"https://www.wikidata.org/wiki/Q24744812","display_name":"Calponin","level":3,"score":0.5061137080192566},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.49193525314331055},{"id":"https://openalex.org/C2780870201","wikidata":"https://www.wikidata.org/wiki/Q17855958","display_name":"Caveolin 1","level":2,"score":0.47020962834358215},{"id":"https://openalex.org/C2776410257","wikidata":"https://www.wikidata.org/wiki/Q14901714","display_name":"Caveolin 3","level":4,"score":0.448900431394577},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.43225157260894775},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4162790775299072},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33538806438446045},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1246294379234314},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000096985","descriptor_name":"Calponins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012137","descriptor_name":"Respiratory System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021941","descriptor_name":"Caveolae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021941","descriptor_name":"Caveolae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039561","descriptor_name":"Eukaryotic Initiation Factor-4E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056151","descriptor_name":"Airway Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1111/j.1582-4934.2010.01246.x","doi":"https://doi.org/10.1111/j.1582-4934.2010.01246.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1582-4934.2010.01246.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2010.01246.x","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3270915","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3822954","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:21199324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21199324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular and molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire/da7e5804-bf45-469a-a2b1-8b5cba405fd4","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/da7e5804-bf45-469a-a2b1-8b5cba405fd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gosens, R, Stelmack, G L, Bos, S T, Dueck, G, Mutawe, M M, Schaafsma, D, Unruh, H, Gerthoffer, W T, Zaagsma, J, Meurs, H & Halayko, A J 2011, 'Caveolin-1 is required for contractile phenotype expression by airway smooth muscle cells', Journal of cellular and molecular medicine, vol. 15, no. 11, pp. 2430-2442. https://doi.org/10.1111/j.1582-4934.2010.01246.x","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3822954","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3822954/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Cell Mol Med","raw_type":"Text"},{"id":"pmh:rug:oai:pure.rug.nl:publications/da7e5804-bf45-469a-a2b1-8b5cba405fd4","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/da7e5804-bf45-469a-a2b1-8b5cba405fd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of cellular and molecular medicine, 15(11), 2430 - 2442. Wiley","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/j.1582-4934.2010.01246.x","doi":"https://doi.org/10.1111/j.1582-4934.2010.01246.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1582-4934.2010.01246.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2010.01246.x","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8208000063896179,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1100136571","display_name":"Small heat shock proteins in smooth muscle plasticity","funder_award_id":"R01HL077726","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2155016470.pdf","grobid_xml":"https://content.openalex.org/works/W2155016470.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1567197431","https://openalex.org/W1797076797","https://openalex.org/W1971722372","https://openalex.org/W1978279440","https://openalex.org/W1989868904","https://openalex.org/W1993233373","https://openalex.org/W1993479746","https://openalex.org/W1994508335","https://openalex.org/W2000575578","https://openalex.org/W2002340060","https://openalex.org/W2006842584","https://openalex.org/W2017944609","https://openalex.org/W2023468848","https://openalex.org/W2029294708","https://openalex.org/W2029634948","https://openalex.org/W2032633219","https://openalex.org/W2034965329","https://openalex.org/W2035684590","https://openalex.org/W2040712401","https://openalex.org/W2048405500","https://openalex.org/W2048917611","https://openalex.org/W2051438989","https://openalex.org/W2054405162","https://openalex.org/W2055865356","https://openalex.org/W2057659446","https://openalex.org/W2060777875","https://openalex.org/W2066371679","https://openalex.org/W2069444054","https://openalex.org/W2084762928","https://openalex.org/W2093263274","https://openalex.org/W2093749420","https://openalex.org/W2096480261","https://openalex.org/W2099761715","https://openalex.org/W2102325736","https://openalex.org/W2102824996","https://openalex.org/W2103839359","https://openalex.org/W2107125775","https://openalex.org/W2107481387","https://openalex.org/W2110169410","https://openalex.org/W2110558195","https://openalex.org/W2111833940","https://openalex.org/W2112871329","https://openalex.org/W2114339207","https://openalex.org/W2119878648","https://openalex.org/W2123994460","https://openalex.org/W2124317881","https://openalex.org/W2124573847","https://openalex.org/W2131758520","https://openalex.org/W2132376669","https://openalex.org/W2133940565","https://openalex.org/W2134664548","https://openalex.org/W2136521320","https://openalex.org/W2138075820","https://openalex.org/W2142158607","https://openalex.org/W2145466675","https://openalex.org/W2151129997","https://openalex.org/W2152879293","https://openalex.org/W2162973968","https://openalex.org/W2164602156","https://openalex.org/W2169050830","https://openalex.org/W2170257106","https://openalex.org/W2177245348","https://openalex.org/W2183101076","https://openalex.org/W2183221588","https://openalex.org/W2230962348","https://openalex.org/W2400236325","https://openalex.org/W2417576966","https://openalex.org/W4210799980","https://openalex.org/W4233491463","https://openalex.org/W6689295857"],"related_works":["https://openalex.org/W1797076797","https://openalex.org/W2074540763","https://openalex.org/W2096480261","https://openalex.org/W2790524917","https://openalex.org/W7161651480","https://openalex.org/W2329476317","https://openalex.org/W2270456335","https://openalex.org/W1588481932","https://openalex.org/W1757280304","https://openalex.org/W2106701627"],"abstract_inverted_index":{"Airway":[0],"smooth":[1,32,63,84,164,208,250],"muscle":[2,33,64,85,165,209,251],"cells":[3,34,127],"exhibit":[4],"phenotype":[5,65,79,109,121,148,238],"plasticity":[6,66],"that":[7,44,128,186],"underpins":[8],"their":[9],"ability":[10],"to":[11,14,18,157,257],"contribute":[12,256],"both":[13],"acute":[15],"bronchospasm":[16],"and":[17,60,97,124,196],"the":[19,36,47,55,119,143,160,206],"features":[20],"of":[21,29,38,49,58,81,138,145,162,175,203,211,236],"airway":[22,83,110,207],"remodelling":[23],"in":[24,62,77,107,118,126,228,248],"chronic":[25],"asthma.":[26,259],"A":[27],"feature":[28],"mature,":[30],"contractile":[31,108,120,147,223,237],"is":[35,67],"presence":[37],"abundant":[39,131],"caveolae,":[40],"plasma":[41],"membrane":[42],"invaginations":[43],"develop":[45],"from":[46],"association":[48],"lipid":[50],"rafts":[51],"with":[52,113,182,193,216,221,234],"caveolin-1,":[53],"but":[54],"functional":[56],"role":[57,74],"caveolae":[59],"caveolin-1":[61,76,101,139,183,187,204,232,247],"unknown.":[68],"Here,":[69],"we":[70,199,241],"report":[71],"a":[72,171,243],"key":[73],"for":[75,246],"promoting":[78],"maturation":[80,195],"differentiated":[82],"induced":[86,115],"by":[87,94,151,155,170],"transforming":[88],"growth":[89],"factor":[90],"(TGF)-\u03b2(1).":[91],"As":[92],"assessed":[93],"Western":[95],"analysis":[96],"laser":[98],"scanning":[99],"cytometry,":[100],"protein":[102,224],"expression":[103,140,161,188,202,233],"was":[104,168,219],"selectively":[105],"enriched":[106],"myocytes.":[111,239],"Treatment":[112],"TGF-\u03b2(1)":[114,156,190],"profound":[116],"increases":[117],"markers":[122],"sm-\u03b1-actin":[123],"calponin":[125],"also":[129],"accumulated":[130],"caveolin-1;":[132],"however,":[133],"siRNA":[134],"or":[135],"shRNAi":[136],"inhibition":[137],"largely":[141],"prevented":[142],"induction":[144,174],"these":[146,163],"marker":[149],"proteins":[150,167],"TGF-\u03b2(1).":[152],"The":[153],"failure":[154],"adequately":[158],"induce":[159],"specific":[166],"accompanied":[169],"strongly":[172],"impaired":[173],"eukaryotic":[176],"initiation":[177],"factor-4E":[178],"binding":[179],"protein(4E-BP)1":[180],"phosphorylation":[181],"knockdown,":[184],"indicating":[185],"promotes":[189],"signalling":[191],"associated":[192,220],"myocyte":[194],"hypertrophy.":[197],"Furthermore,":[198],"observed":[200],"increased":[201,222],"within":[205],"bundle":[210],"guinea":[212],"pigs":[213],"repeatedly":[214],"challenged":[215],"allergen,":[217],"which":[218],"expression,":[225],"thus":[226],"providing":[227],"vivo":[229],"evidence":[230],"linking":[231],"accumulation":[235],"Collectively,":[240],"identify":[242],"new":[244],"function":[245],"controlling":[249],"phenotype;":[252],"this":[253],"mechanism":[254],"could":[255],"allergic":[258]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}