{"id":"https://openalex.org/W2155010287","doi":"https://doi.org/10.1016/0014-5793(90)80715-u","title":"Erbstatin blocks platelet activating factor\u2010induced protein\u2010tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets","display_name":"Erbstatin blocks platelet activating factor\u2010induced protein\u2010tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets","publication_year":1990,"publication_date":"1990-04-09","ids":{"openalex":"https://openalex.org/W2155010287","doi":"https://doi.org/10.1016/0014-5793(90)80715-u","mag":"2155010287","pmid":"https://pubmed.ncbi.nlm.nih.gov/1691984"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(90)80715-u","doi":"https://doi.org/10.1016/0014-5793(90)80715-u","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(90)80715-u","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110062160","display_name":"Hassan Salari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hassan Salari","raw_affiliation_strings":["Department of Medicine, University of British Columbia, Vancouver, Canada, UK","Department of Medicine, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of British Columbia, Vancouver, Canada, UK","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Department of Medicine, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050668557","display_name":"Vincent Duronio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Vincent Duronio","raw_affiliation_strings":["The Biomedical Research Centre, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Biomedical Research Centre, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108358625","display_name":"Sandra L. Howard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sandra L. Howard","raw_affiliation_strings":["Department of Medicine, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051632364","display_name":"Michelle K. Demos","orcid":"https://orcid.org/0000-0002-3380-0843","observed_orcids":["https://orcid.org/0000-0002-3380-0843"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michelle Demos","raw_affiliation_strings":["Department of Medicine, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048163527","display_name":"Kelvin Edward Jones","orcid":"https://orcid.org/0000-0003-4764-7031","observed_orcids":["https://orcid.org/0000-0003-4764-7031"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kelvin Jones","raw_affiliation_strings":["Department of Medicine, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049440495","display_name":"Anne Reany","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Anne Reany","raw_affiliation_strings":["Department of Medicine, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063702044","display_name":"Alan T. Hudson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan T. Hudson","raw_affiliation_strings":["The Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, UK","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084875396","display_name":"Steven Pelech","orcid":"https://orcid.org/0000-0003-1112-903X","observed_orcids":["https://orcid.org/0000-0003-1112-903X"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Steven L. Pelech","raw_affiliation_strings":["Department of Medicine, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada","The Biomedical Research Centre, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"The Biomedical Research Centre, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":3.4685,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.93814839,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"263","issue":"1","first_page":"104","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.3402999937534332,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erbstatin","display_name":"erbstatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/platelet-activating-factor","display_name":"platelet-activating factor","score":0.984000027179718},{"id":"https://openalex.org/keywords/protein-tyrosine-kinase-inhibitors","display_name":"protein tyrosine kinase inhibitors","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/polyphosphoinositide-hydrolysis","display_name":"polyphosphoinositide hydrolysis","score":0.949999988079071},{"id":"https://openalex.org/keywords/protein-kinase-c-activation","display_name":"protein kinase C activation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/serotonin-release","display_name":"serotonin release","score":0.8679999709129333},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":1.0},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.8510000109672546},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8209999799728394},{"id":"https://openalex.org/keywords/rabbit-platelets","display_name":"rabbit platelets","score":0.9139999747276306}],"concepts":[{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.6470469236373901},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.6332952976226807},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6242608428001404},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5662497282028198},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.5518400073051453},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5309547781944275},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.4969182312488556},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4779912829399109},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.47233596444129944},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43913397192955017},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3891434073448181},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3207198977470398},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07887014746665955}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006873","descriptor_name":"Hydroquinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018129","descriptor_name":"Phosphatidylinositol Phosphates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019000","descriptor_name":"Phosphotyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(90)80715-u","doi":"https://doi.org/10.1016/0014-5793(90)80715-u","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(90)80715-u","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:1691984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1691984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1505417279","https://openalex.org/W1514833272","https://openalex.org/W1540941492","https://openalex.org/W1555606052","https://openalex.org/W1568982528","https://openalex.org/W1604213714","https://openalex.org/W1656644300","https://openalex.org/W1966520635","https://openalex.org/W1968966545","https://openalex.org/W1980633655","https://openalex.org/W1981810445","https://openalex.org/W1985825181","https://openalex.org/W1993282564","https://openalex.org/W1998273541","https://openalex.org/W2020707154","https://openalex.org/W2024208090","https://openalex.org/W2037434894","https://openalex.org/W2047613580","https://openalex.org/W2049455947","https://openalex.org/W2082929638","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2167963365","https://openalex.org/W2236226837","https://openalex.org/W2314347700","https://openalex.org/W2401074096"],"related_works":["https://openalex.org/W2372177478","https://openalex.org/W1907514224","https://openalex.org/W1563196726","https://openalex.org/W7096539854","https://openalex.org/W1977173640","https://openalex.org/W1980633655","https://openalex.org/W2284167061","https://openalex.org/W2007252809","https://openalex.org/W2953806854","https://openalex.org/W7096577267"],"abstract_inverted_index":{"The":[0],"role":[1],"of":[2,9,22,40,48,54,68,71,78,95],"protein-tyrosine":[3,27],"phosphorylation":[4,47],"in":[5,16],"the":[6,69,93],"signal":[7],"transduction":[8],"platelet":[10,41,59,99],"activating":[11],"factor":[12],"(PAF)":[13],"was":[14,104],"investigated":[15],"rabbit":[17],"platelets":[18],"with":[19],"a":[20,37,66],"range":[21,39],"synthetic":[23],"compounds":[24],"that":[25],"inhibit":[26],"kinases.":[28],"In":[29],"particular,":[30],"erbstatin":[31],"(IC50":[32],"approximately":[33],"20":[34],"micrograms/ml)":[35],"abrogated":[36],"wide":[38],"responses":[42],"to":[43,97],"PAF,":[44],"including":[45],"tyrosine":[46],"cellular":[49],"proteins,":[50],"polyphosphoinositide":[51],"turnover,":[52],"activation":[53],"membranous":[55],"protein":[56],"kinase":[57],"C,":[58],"aggregation,":[60],"and":[61,87,101],"serotonin":[62,102],"secretion.":[63],"With":[64],"about":[65],"third":[67],"potency":[70],"erbstatin,":[72],"compound":[73],"RG50864":[74],"also":[75,105],"inhibited":[76],"many":[77],"these":[79],"responses,":[80],"whereas":[81],"at":[82],"100":[83],"micrograms/ml,":[84],"genistein,":[85],"670C88":[86],"ST271":[88],"were":[89],"without":[90],"effect.":[91],"Finally,":[92],"ability":[94],"thrombin":[96],"cause":[98],"aggregation":[100],"secretion":[103],"compromised":[106],"by":[107],"erbstatin.":[108]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
