{"id":"https://openalex.org/W2154996005","doi":"https://doi.org/10.1016/j.eurpsy.2010.12.004","title":"Pregabalin for the discontinuation of long-term benzodiazepines use: An assessment of its effectiveness in daily clinical practice","display_name":"Pregabalin for the discontinuation of long-term benzodiazepines use: An assessment of its effectiveness in daily clinical practice","publication_year":2011,"publication_date":"2011-02-22","ids":{"openalex":"https://openalex.org/W2154996005","doi":"https://doi.org/10.1016/j.eurpsy.2010.12.004","mag":"2154996005","pmid":"https://pubmed.ncbi.nlm.nih.gov/21334859"},"language":"en","primary_location":{"id":"doi:10.1016/j.eurpsy.2010.12.004","doi":"https://doi.org/10.1016/j.eurpsy.2010.12.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.eurpsy.2010.12.004","pdf_url":null,"source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10651/11409","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083202579","display_name":"Julio Bobes","orcid":"https://orcid.org/0000-0003-2187-4033","observed_orcids":["https://orcid.org/0000-0003-2187-4033"]},"institutions":[{"id":"https://openalex.org/I165339363","display_name":"Universidad de Oviedo","ror":"https://ror.org/006gksa02","country_code":"ES","type":"education","lineage":["https://openalex.org/I165339363"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"J. Bobes","raw_affiliation_strings":["School of Medicine, Psychiatry Department, University of Oviedo, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM. Juli\u00e1n Claver\u00eda, 6 33006 Oviedo, Spain. bobes@uniovi.es","School of Medicine, Psychiatry Department, University of Oviedo, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM. Juli\u00e1n Claver\u00eda, 6 33006Oviedo, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Psychiatry Department, University of Oviedo, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM. Juli\u00e1n Claver\u00eda, 6 33006 Oviedo, Spain. bobes@uniovi.es","institution_ids":["https://openalex.org/I165339363","https://openalex.org/I4210090703"]},{"raw_affiliation_string":"School of Medicine, Psychiatry Department, University of Oviedo, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM. Juli\u00e1n Claver\u00eda, 6 33006Oviedo, Spain","institution_ids":["https://openalex.org/I165339363","https://openalex.org/I4210090703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063970223","display_name":"Gabriel Rubio","orcid":"https://orcid.org/0000-0001-5485-6646","observed_orcids":["https://orcid.org/0000-0001-5485-6646"]},"institutions":[{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"G. Rubio","raw_affiliation_strings":["Department of Psychiatry, Hospital 12 de Octubre. Avda de C\u00f3rdoba s/n28041Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Hospital 12 de Octubre. Avda de C\u00f3rdoba s/n28041Madrid, Spain","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010103562","display_name":"A. Ter\u00e1n","orcid":"https://orcid.org/0000-0002-5046-7915","observed_orcids":["https://orcid.org/0000-0002-5046-7915"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Ter\u00e1n","raw_affiliation_strings":["Center for Drug Dependence Treatment San Juan de Dios. Paseo Padre Faustino Calvo s/n, apartado 66, 34005Palencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Dependence Treatment San Juan de Dios. Paseo Padre Faustino Calvo s/n, apartado 66, 34005Palencia, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043149484","display_name":"Gaspar Cervera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"G. Cervera","raw_affiliation_strings":["Department of Psychiatry, Hospital Cl\u00ednico Universitario, Avda. Blasco Iba\u00f1ez, 17 46010Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Hospital Cl\u00ednico Universitario, Avda. Blasco Iba\u00f1ez, 17 46010Valencia, Spain","institution_ids":["https://openalex.org/I4210094406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072890394","display_name":"V. L\u00f3pez-G\u00f3mez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138890","display_name":"Pfizer (Spain)","ror":"https://ror.org/03x2xt559","country_code":"ES","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210138890"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"V. L\u00f3pez-G\u00f3mez","raw_affiliation_strings":["Medical Unit, Pfizer Espa\u00f1a. Avda. Europa, 20B, Parque Empresarial La Moraleja 28108 Alcobendas, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Unit, Pfizer Espa\u00f1a. Avda. Europa, 20B, Parque Empresarial La Moraleja 28108 Alcobendas, Madrid, Spain","institution_ids":["https://openalex.org/I4210138890"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090620709","display_name":"Inma Vilardaga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Vilardaga","raw_affiliation_strings":["European Biometrics Institute. C/ Diputaci\u00f3n, 284 4\u00aa 08009 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Biometrics Institute. C/ Diputaci\u00f3n, 284 4\u00aa 08009 Barcelona, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"M. P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138890","display_name":"Pfizer (Spain)","ror":"https://ror.org/03x2xt559","country_code":"ES","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210138890"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. P\u00e9rez","raw_affiliation_strings":["Medical Unit, Pfizer Espa\u00f1a. Avda. Europa, 20B, Parque Empresarial La Moraleja 28108 Alcobendas Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Unit, Pfizer Espa\u00f1a. Avda. Europa, 20B, Parque Empresarial La Moraleja 28108 Alcobendas Madrid, Spain","institution_ids":["https://openalex.org/I4210138890"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5083202579"],"corresponding_institution_ids":["https://openalex.org/I165339363","https://openalex.org/I4210090703"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":4.7819,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.95248876,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"27","issue":"4","first_page":"301","last_page":"307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.08619999885559082,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.04619999974966049,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pregabalin","display_name":"pregabalin","score":1.0},{"id":"https://openalex.org/keywords/benzodiazepine-withdrawal","display_name":"benzodiazepine withdrawal","score":0.9480000138282776},{"id":"https://openalex.org/keywords/benzodiazepine-dependence","display_name":"benzodiazepine dependence","score":0.9449999928474426},{"id":"https://openalex.org/keywords/withdrawal-symptoms","display_name":"withdrawal symptoms","score":0.7390000224113464},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.7250000238418579},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.7450000047683716},{"id":"https://openalex.org/keywords/long-term-benzodiazepine-use","display_name":"long-term benzodiazepine use","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8329302072525024},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8215660452842712},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.7451832890510559},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6534016728401184},{"id":"https://openalex.org/C2776000289","wikidata":"https://www.wikidata.org/wiki/Q5133761","display_name":"Clinical Global Impression","level":4,"score":0.6399799585342407},{"id":"https://openalex.org/C2776468701","wikidata":"https://www.wikidata.org/wiki/Q412174","display_name":"Pregabalin","level":2,"score":0.5920049548149109},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5796595215797424},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4650042951107025},{"id":"https://openalex.org/C2777696351","wikidata":"https://www.wikidata.org/wiki/Q5644839","display_name":"Hamilton Anxiety Rating Scale","level":3,"score":0.4105707108974457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3957921862602234},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3874983787536621},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3799799084663391},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2331492006778717},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069583","descriptor_name":"Pregabalin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.eurpsy.2010.12.004","doi":"https://doi.org/10.1016/j.eurpsy.2010.12.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.eurpsy.2010.12.004","pdf_url":null,"source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},{"id":"pmid:21334859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21334859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European psychiatry : the journal of the Association of European Psychiatrists","raw_type":"Journal Article"},{"id":"pmh:oai:digibuo.uniovi.es:10651/11409","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10651/11409","pdf_url":null,"source":{"id":"https://openalex.org/S4306402334","display_name":"Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educaci\u00f3n, Cultura y Deporte)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801976130","host_organization_name":"Ministerio de Educaci\u00f3n Cultura y Deporte","host_organization_lineage":["https://openalex.org/I2801976130"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SCOPUS","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:digibuo.uniovi.es:10651/11409","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10651/11409","pdf_url":null,"source":{"id":"https://openalex.org/S4306402334","display_name":"Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educaci\u00f3n, Cultura y Deporte)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801976130","host_organization_name":"Ministerio de Educaci\u00f3n Cultura y Deporte","host_organization_lineage":["https://openalex.org/I2801976130"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SCOPUS","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W99098873","https://openalex.org/W635630645","https://openalex.org/W1689773422","https://openalex.org/W1834607013","https://openalex.org/W1967384063","https://openalex.org/W1968403379","https://openalex.org/W1969466789","https://openalex.org/W1980843180","https://openalex.org/W1993810702","https://openalex.org/W2003320371","https://openalex.org/W2016589772","https://openalex.org/W2035246885","https://openalex.org/W2041853216","https://openalex.org/W2046670706","https://openalex.org/W2053087078","https://openalex.org/W2058713081","https://openalex.org/W2060713002","https://openalex.org/W2069850786","https://openalex.org/W2073827625","https://openalex.org/W2081621636","https://openalex.org/W2083529108","https://openalex.org/W2089800404","https://openalex.org/W2091943926","https://openalex.org/W2097536190","https://openalex.org/W2108608442","https://openalex.org/W2115131161","https://openalex.org/W2122176511","https://openalex.org/W2129632383","https://openalex.org/W2133039415","https://openalex.org/W2137401427","https://openalex.org/W2139794866","https://openalex.org/W2151756295","https://openalex.org/W2160070901","https://openalex.org/W2170536966","https://openalex.org/W2576653843","https://openalex.org/W3090293687"],"related_works":["https://openalex.org/W2784016584","https://openalex.org/W2035246885","https://openalex.org/W1967384063","https://openalex.org/W1983919275","https://openalex.org/W2007168079","https://openalex.org/W2058983699","https://openalex.org/W2105781860","https://openalex.org/W2160797858","https://openalex.org/W4220809068","https://openalex.org/W2151253343"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"evaluate":[2],"the":[3,10,13,55,60,65,71,108,129,133,171,176,216],"effectiveness":[4,92],"and":[5,30,70,85,149,156,184,192,213,218,230],"tolerability":[6,204],"of":[7,12,15,100,128,173,178,215],"pregabalin":[8,226],"in":[9,17,33,132,190,198],"management":[11],"discontinuation":[14],"benzodiazepines":[16,80],"long-term":[18],"users.":[19],"SUBJECTS":[20],"AND":[21,113],"METHODS:":[22],"We":[23],"performed":[24,82],"a":[25],"12-week,":[26],"prospective,":[27],"uncontrolled,":[28],"non-interventional,":[29],"observational":[31],"study":[32],"patients":[34],"aged":[35],"18":[36],"years":[37],"old":[38],"or":[39,175,209],"above,":[40],"who":[41],"met":[42],"DSM-IV-TR":[43],"criteria":[44],"for":[45,79,147,234],"benzodiazepine":[46,130,172,235],"dependence":[47],"without":[48],"other":[49,179],"major":[50],"psychiatry":[51],"disorder.":[52],"Evaluations":[53],"included":[54],"Benzodiazepine":[56],"Withdrawal":[57],"Symptom":[58],"Questionnaire,":[59],"Hamilton":[61],"Anxiety":[62],"Rating":[63],"Scale,":[64,69],"Clinical":[66],"Global":[67],"Impression":[68],"Sheehan":[72],"Disability":[73],"Scale.":[74],"A":[75],"urine":[76,109],"drug":[77,110],"screen":[78],"was":[81,94,121,138,205],"at":[83,103,118],"baseline":[84],"every":[86],"4":[87],"weeks":[88],"thereafter.":[89],"The":[90,115,125,162],"primary":[91,134],"variable":[93],"success":[95,126,163],"rate,":[96],"defined":[97],"as":[98,195,197,207],"achievement":[99],"benzodiazepine-free":[101],"status":[102],"week":[104,119,202],"12":[105,120],"according":[106,168],"to":[107,169],"screen.":[111],"RESULTS":[112],"DISCUSSION:":[114],"mean":[116],"dose":[117],"315":[122],"(\u00b1166)":[123],"mg/day.":[124],"rate":[127],"taper":[131],"efficacy":[135],"population":[136],"(n=282)":[137],"52%":[139],"(95%":[140,153,158],"confidence":[141],"interval":[142],"[CI],":[143],"46-58).":[144],"Success":[145],"rates":[146,164],"women":[148],"men":[150],"were":[151,188],"58%":[152],"CI,":[154,159],"49-67)":[155],"46%":[157],"38-55),":[160],"respectively.":[161,220],"did":[165],"not":[166],"differ":[167],"either":[170],"abuse":[174],"presence":[177],"substance":[180],"use":[181],"disorders.":[182],"Significant":[183],"clinically":[185],"relevant":[186],"improvements":[187],"observed":[189],"withdrawal":[191],"anxiety":[193],"symptoms,":[194],"well":[196],"patients'":[199],"functioning.":[200],"At":[201],"12,":[203],"rated":[206],"good":[208],"excellent":[210],"by":[211],"90%":[212],"83%":[214],"clinicians":[217],"patients,":[219],"CONCLUSION:":[221],"Our":[222],"results":[223],"suggest":[224],"that":[225],"is":[227],"an":[228],"efficacious":[229],"well-tolerated":[231],"adjunctive":[232],"treatment":[233],"withdrawal.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}