{"id":"https://openalex.org/W2154990886","doi":null,"title":"Genetic studies of osteoporosis in Malta : a review","display_name":"Genetic studies of osteoporosis in Malta : a review","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2154990886","mag":"2154990886"},"language":"en","primary_location":{"id":"pmh:oai:www.um.edu.mt:123456789/949","doi":null,"is_oa":true,"landing_page_url":"https://www.um.edu.mt/library/oar//handle/123456789/949","pdf_url":"https://www.um.edu.mt/library/oar//handle/123456789/949","source":{"id":"https://openalex.org/S4306400782","display_name":"OAR@UM (University of Malta)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I197854408","host_organization_name":"University of Malta","host_organization_lineage":["https://openalex.org/I197854408"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.um.edu.mt/library/oar//handle/123456789/949","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007123752","display_name":"Christopher Vidal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Vidal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008386607","display_name":"Angela Xuereb\u2010Anastasi","orcid":"https://orcid.org/0000-0001-6361-6345","observed_orcids":["https://orcid.org/0000-0001-6361-6345"]},"institutions":[{"id":"https://openalex.org/I197854408","display_name":"University of Malta","ror":"https://ror.org/03a62bv60","country_code":"MT","type":"education","lineage":["https://openalex.org/I197854408"]}],"countries":["MT"],"is_corresponding":false,"raw_author_name":"Angela Xuereb\u2010Anastasi","raw_affiliation_strings":["Univ. of Malta#TAB#"],"raw_orcid":"https://orcid.org/0000-0001-6361-6345","affiliations":[{"raw_affiliation_string":"Univ. of Malta#TAB#","institution_ids":["https://openalex.org/I197854408"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"4","first_page":"6","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9190000295639038},{"id":"https://openalex.org/keywords/maltese-population","display_name":"Maltese population","score":0.8840000033378601},{"id":"https://openalex.org/keywords/traf6","display_name":"TRAF6","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.996999979019165},{"id":"https://openalex.org/keywords/pre-mrna-splicing","display_name":"pre-mRNA splicing","score":0.9520000219345093},{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.9490000009536743},{"id":"https://openalex.org/keywords/promoter-polymorphism","display_name":"promoter polymorphism","score":0.7639999985694885},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.9700000286102295},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.7630000114440918},{"id":"https://openalex.org/keywords/oestrogen-receptor","display_name":"oestrogen receptor","score":0.7829999923706055},{"id":"https://openalex.org/keywords/col1a1","display_name":"COL1A1","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mthfr","display_name":"MTHFR","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lrp5","display_name":"LRP5","score":0.9449999928474426},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.42899999022483826},{"id":"https://openalex.org/keywords/linkage-analysis","display_name":"linkage analysis","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7487457394599915},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.5821205973625183},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5786897540092468},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.5511873364448547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49111315608024597},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.4872983694076538},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.48632511496543884},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4682014584541321},{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.466044545173645},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43327462673187256},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4325534999370575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3453354835510254},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.2226717472076416},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14146825671195984},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.um.edu.mt:123456789/949","doi":null,"is_oa":true,"landing_page_url":"https://www.um.edu.mt/library/oar//handle/123456789/949","pdf_url":"https://www.um.edu.mt/library/oar//handle/123456789/949","source":{"id":"https://openalex.org/S4306400782","display_name":"OAR@UM (University of Malta)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I197854408","host_organization_name":"University of Malta","host_organization_lineage":["https://openalex.org/I197854408"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2154990886","doi":null,"is_oa":false,"landing_page_url":"http://biotech.christopher-vidal.com/Vidal%20and%20Xuereb-Anastasi%20-%20Osteoporosis.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306519138","display_name":"Malta medical journal","issn_l":"1813-3339","issn":["1813-3339","2308-4103"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Malta medical journal","raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.um.edu.mt:123456789/949","doi":null,"is_oa":true,"landing_page_url":"https://www.um.edu.mt/library/oar//handle/123456789/949","pdf_url":"https://www.um.edu.mt/library/oar//handle/123456789/949","source":{"id":"https://openalex.org/S4306400782","display_name":"OAR@UM (University of Malta)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I197854408","host_organization_name":"University of Malta","host_organization_lineage":["https://openalex.org/I197854408"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2154990886.pdf","grobid_xml":"https://content.openalex.org/works/W2154990886.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1579564476","https://openalex.org/W1972354950","https://openalex.org/W1973565550","https://openalex.org/W1993484468","https://openalex.org/W1994348798","https://openalex.org/W2001158499","https://openalex.org/W2001169216","https://openalex.org/W2007601419","https://openalex.org/W2012549421","https://openalex.org/W2013189012","https://openalex.org/W2014469644","https://openalex.org/W2017393694","https://openalex.org/W2021131499","https://openalex.org/W2035559267","https://openalex.org/W2035564043","https://openalex.org/W2036610291","https://openalex.org/W2038089459","https://openalex.org/W2048758730","https://openalex.org/W2053157117","https://openalex.org/W2058864686","https://openalex.org/W2062322802","https://openalex.org/W2066725107","https://openalex.org/W2073233638","https://openalex.org/W2073618830","https://openalex.org/W2077197120","https://openalex.org/W2085611861","https://openalex.org/W2092592423","https://openalex.org/W2097976832","https://openalex.org/W2105118448","https://openalex.org/W2107795895","https://openalex.org/W2124273389","https://openalex.org/W2132046245","https://openalex.org/W2132892038","https://openalex.org/W2146114310","https://openalex.org/W2147162951","https://openalex.org/W2154036033","https://openalex.org/W2155288204","https://openalex.org/W2155352301","https://openalex.org/W2165936586","https://openalex.org/W2937933923"],"related_works":["https://openalex.org/W2107795895","https://openalex.org/W2165936586","https://openalex.org/W7071447908","https://openalex.org/W2144168289","https://openalex.org/W2146693532","https://openalex.org/W2077196315","https://openalex.org/W1996503039","https://openalex.org/W2043852283","https://openalex.org/W2073283175","https://openalex.org/W4206969953"],"abstract_inverted_index":{"Osteoporosis":[0],"is":[1,116],"a":[2,7,14,38,51,78,196,209],"complex":[3],"metabolic":[4],"disease":[5],"with":[6],"strong":[8,121],"genetic":[9,41,53],"component":[10,54],"which":[11,55,84,136,204],"results":[12],"in":[13,16,22,95,110,140,154,198,239],"decrease":[15],"bone":[17,213],"mineral":[18,214],"density":[19],"and":[20,64,100,143,165,180,235,248],"deterioration":[21],"the":[23,35,44,57,111,117,129,162,187,190,199,218,244],"microarchitecture":[24],"of":[25,32,40,43,113,120,124,156,202,246],"bone,":[26],"leading":[27],"to":[28,49,60,126,146,149,151,220],"an":[29],"increased":[30],"risk":[31,245],"fractures.":[33],"During":[34],"last":[36],"decade,":[37],"number":[39],"studies":[42,86,223],"Maltese":[45,188],"population":[46,65],"were":[47,68],"performed":[48],"determine":[50],"potential":[52],"increases":[56],"individual\u2019s":[58],"susceptibility":[59,148,219],"osteoporosis.":[61,127,221],"Both":[62],"family":[63],"case-control":[66],"approaches":[67],"used.":[69],"Linkage":[70],"analysis":[71],"using":[72],"large":[73],"affected":[74],"families":[75],"has":[76],"identified":[77],"region":[79,97,201],"on":[80,212],"chromosome":[81],"11p12,":[82],"following":[83],"functional":[85],"have":[87,224],"shown":[88,225],"that":[89,96,195,226],"variations":[90,227],"within":[91,228],"two":[92],"genes":[93],"found":[94,145],"namely,":[98],"TRAF6":[99],"CD44,":[101],"affect":[102],"gene":[103,131],"expression,":[104],"and,":[105],"more":[106],"specifically,":[107],"pre-mRNA":[108],"splicing":[109],"case":[112],"CD44.":[114],"This":[115],"first":[118],"report":[119],"suggestive":[122],"linkage":[123],"11p12":[125],"Using":[128],"candidate":[130,134],"approach,":[132],"selected":[133],"genes,":[135,231],"had":[137,208],"been":[138,144],"studied":[139],"other":[141],"populations":[142],"increase":[147,243],"osteoporosis":[150,247],"varying":[152],"degrees":[153],"some":[155],"them,":[157],"included":[158],"those":[159],"coding":[160],"for":[161,206,254],"vitamin":[163],"D":[164],"oestrogen":[166],"receptors":[167],"(VDR":[168],"&":[169],"ER1),":[170],"osteoprotegerin":[171],"(TNFRSF11B),":[172],"collagen":[173],"type":[174],"1":[175],"(COL1A1),":[176],"methylenetetrahydrofolate":[177],"reductase":[178],"(MTHFR)":[179],"lipoprotein":[181],"receptor":[182],"related":[183],"protein":[184],"(LRP)-5.":[185],"In":[186],"population,":[189],"most":[191],"significant":[192,210],"result":[193],"showed":[194],"polymorphism":[197],"promoter":[200],"TNFRSF11B,":[203,236],"codes":[205],"osteoprotegerin,":[207],"effect":[211],"density,":[215],"thus":[216],"increasing":[217],"These":[222],"three":[229],"different":[230],"namely":[232],"TRAF6,":[233],"CD44":[234],"all":[237],"involved":[238],"osteoclast":[240],"biology,":[241],"might":[242],"could":[249],"therefore":[250],"serve":[251],"as":[252],"targets":[253],"novel":[255],"therapeutic":[256],"agents.":[257]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2016-06-24T00:00:00"}