{"id":"https://openalex.org/W2154945604","doi":"https://doi.org/10.1074/jbc.m111.264978","title":"Dynamic Na+-H+ Exchanger Regulatory Factor-1 Association and Dissociation Regulate Parathyroid Hormone Receptor Trafficking at Membrane Microdomains","display_name":"Dynamic Na+-H+ Exchanger Regulatory Factor-1 Association and Dissociation Regulate Parathyroid Hormone Receptor Trafficking at Membrane Microdomains","publication_year":2011,"publication_date":"2011-08-09","ids":{"openalex":"https://openalex.org/W2154945604","doi":"https://doi.org/10.1074/jbc.m111.264978","mag":"2154945604","pmid":"https://pubmed.ncbi.nlm.nih.gov/21832055","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3186428"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.264978","doi":"https://doi.org/10.1074/jbc.m111.264978","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.264978","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m111.264978","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032332296","display_name":"Juan Antonio Ardura","orcid":"https://orcid.org/0000-0002-2827-3364","observed_orcids":["https://orcid.org/0000-0002-2827-3364"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan A. Ardura","raw_affiliation_strings":["Laboratory for G Protein-Coupled Receptor Biology, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA","Laboratory for G Protein-Coupled Receptor Biology, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for G Protein-Coupled Receptor Biology, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Laboratory for G Protein-Coupled Receptor Biology, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050523718","display_name":"Bin Wang","orcid":"https://orcid.org/0000-0002-5396-6111","observed_orcids":["https://orcid.org/0000-0002-5396-6111"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Wang","raw_affiliation_strings":["Laboratory for G Protein-Coupled Receptor Biology, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for G Protein-Coupled Receptor Biology, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088924932","display_name":"Simon C. Watkins","orcid":"https://orcid.org/0000-0003-4092-1552","observed_orcids":["https://orcid.org/0000-0003-4092-1552","https://orcid.org/0000-0003-0825-0795"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon C. Watkins","raw_affiliation_strings":["Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081576808","display_name":"Jean\u2010Pierre Vilardaga","orcid":"https://orcid.org/0000-0002-1217-1435","observed_orcids":["https://orcid.org/0000-0002-1217-1435"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Vilardaga","raw_affiliation_strings":["Laboratory for G Protein-Coupled Receptor Biology, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for G Protein-Coupled Receptor Biology, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072441929","display_name":"Peter A. Friedman","orcid":"https://orcid.org/0000-0003-1905-1468","observed_orcids":["https://orcid.org/0000-0003-1905-1468"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter A. Friedman","raw_affiliation_strings":["Laboratory for G Protein-Coupled Receptor Biology, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for G Protein-Coupled Receptor Biology, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072441929"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.816,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.85162254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"286","issue":"40","first_page":"35020","last_page":"35029"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nherf1","display_name":"NHERF1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/parathyroid-hormone-receptor","display_name":"parathyroid hormone receptor","score":0.972000002861023},{"id":"https://openalex.org/keywords/pdz-domain","display_name":"PDZ domain","score":0.5410000085830688},{"id":"https://openalex.org/keywords/receptor-trafficking","display_name":"receptor trafficking","score":0.7730000019073486},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.7009999752044678},{"id":"https://openalex.org/keywords/ezrin","display_name":"ezrin","score":0.8560000061988831},{"id":"https://openalex.org/keywords/clathrin","display_name":"clathrin","score":0.8690000176429749},{"id":"https://openalex.org/keywords/beta-arrestin","display_name":"beta-arrestin","score":0.8629999756813049},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9089999794960022},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.8009999990463257},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.8610000014305115},{"id":"https://openalex.org/keywords/receptor-aggregation","display_name":"receptor aggregation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/protein-complex-dissociation","display_name":"protein complex dissociation","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C154428179","wikidata":"https://www.wikidata.org/wiki/Q24721050","display_name":"PDZ domain","level":2,"score":0.7695925235748291},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7238189578056335},{"id":"https://openalex.org/C2780246058","wikidata":"https://www.wikidata.org/wiki/Q18032329","display_name":"Ezrin","level":4,"score":0.6624270081520081},{"id":"https://openalex.org/C168557967","wikidata":"https://www.wikidata.org/wiki/Q24772254","display_name":"Parathyroid hormone receptor","level":5,"score":0.6582801938056946},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.5328420400619507},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49306485056877136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4794161021709442},{"id":"https://openalex.org/C63162447","wikidata":"https://www.wikidata.org/wiki/Q21100804","display_name":"Clathrin","level":4,"score":0.4624704420566559},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.4595694839954376},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.43024998903274536},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.4241657853126526},{"id":"https://openalex.org/C53645450","wikidata":"https://www.wikidata.org/wiki/Q907093","display_name":"Scaffold protein","level":3,"score":0.41892462968826294},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36691489815711975},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.36481356620788574},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.3350242078304291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30165889859199524},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.2095249593257904},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.17721229791641235},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16174688935279846},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099149","descriptor_name":"Ezrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019393","descriptor_name":"Arrestin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044168","descriptor_name":"Receptor, Parathyroid Hormone, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m111.264978","doi":"https://doi.org/10.1074/jbc.m111.264978","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.264978","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2461850","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3186428","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3186428","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3186428","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:21832055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21832055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.264978","doi":"https://doi.org/10.1074/jbc.m111.264978","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.264978","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1052446545","display_name":null,"funder_award_id":"R01DK06998","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5585903592","display_name":"EBP50 Regulation of PTH Receptor in Bone","funder_award_id":"R01DK069998","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6597471514","display_name":"Fluorescent Biosensors for Networks and Pathways","funder_award_id":"U54RR022241","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7520302873","display_name":"Sustained cAMP Signals Triggered by Internalized PTH Receptor: New Consequences f","funder_award_id":"R01DK087688","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8793768649","display_name":"PTH Receptor: Posttranslational Modification and Recycling in Bone","funder_award_id":"R01DK054171","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1483932465","https://openalex.org/W1521693111","https://openalex.org/W1934802014","https://openalex.org/W1971748110","https://openalex.org/W1972149776","https://openalex.org/W1974160984","https://openalex.org/W1974662997","https://openalex.org/W1975386197","https://openalex.org/W1975670650","https://openalex.org/W1981260145","https://openalex.org/W1982412212","https://openalex.org/W1983989958","https://openalex.org/W1985446591","https://openalex.org/W1987704449","https://openalex.org/W1988594478","https://openalex.org/W1996836065","https://openalex.org/W1998704876","https://openalex.org/W2005252392","https://openalex.org/W2006511764","https://openalex.org/W2008186223","https://openalex.org/W2011113065","https://openalex.org/W2014390733","https://openalex.org/W2020258553","https://openalex.org/W2022050193","https://openalex.org/W2027639590","https://openalex.org/W2027764322","https://openalex.org/W2031000099","https://openalex.org/W2032795118","https://openalex.org/W2034919163","https://openalex.org/W2035726898","https://openalex.org/W2042015318","https://openalex.org/W2052473372","https://openalex.org/W2062528182","https://openalex.org/W2062655974","https://openalex.org/W2063447621","https://openalex.org/W2080100552","https://openalex.org/W2082289623","https://openalex.org/W2090071443","https://openalex.org/W2099405335","https://openalex.org/W2113737776","https://openalex.org/W2122924759","https://openalex.org/W2124733101","https://openalex.org/W2127106513","https://openalex.org/W2127325055","https://openalex.org/W2132762811","https://openalex.org/W2139286816","https://openalex.org/W2156999424","https://openalex.org/W2166569849","https://openalex.org/W2169664022","https://openalex.org/W2171060697","https://openalex.org/W2183657089","https://openalex.org/W4253540274"],"related_works":["https://openalex.org/W2053287154","https://openalex.org/W2082289623","https://openalex.org/W1996836065","https://openalex.org/W2095277255","https://openalex.org/W2151872883","https://openalex.org/W1974337025","https://openalex.org/W7096945365","https://openalex.org/W2008186223","https://openalex.org/W7099764133","https://openalex.org/W2039397274"],"abstract_inverted_index":{"Na/H":[0],"exchanger":[1],"regulatory":[2],"factor-1":[3],"(NHERF1)":[4],"is":[5,48,161,170],"a":[6,49,54,197],"cytoplasmic":[7],"PDZ":[8],"(postsynaptic":[9],"density":[10],"95/disc":[11],"large/zona":[12],"occludens)":[13],"protein":[14,129],"that":[15,57,123],"assembles":[16],"macromolecular":[17],"complexes":[18],"and":[19,24,31,45,62,76,115,131,187,194,199],"determines":[20],"the":[21,65,71,85,90,98,113,127,138,145,149,152,159,167,185],"localization,":[22],"trafficking,":[23],"signaling":[25,195],"of":[26,92,100,156,179],"select":[27],"G":[28,50],"protein-coupled":[29,51],"receptors":[30],"other":[32],"membrane-delimited":[33],"proteins.":[34],"The":[35,177],"parathyroid":[36],"hormone":[37],"receptor":[38,52,104,114,117,192],"(PTHR),":[39],"which":[40,169],"regulates":[41,191],"mineral":[42],"ion":[43],"homeostasis":[44],"bone":[46],"turnover,":[47],"harboring":[53],"PDZ-binding":[55],"motif":[56],"enables":[58],"association":[59],"with":[60,70,126,132,144,184],"NHERF1":[61,68,88,101,109,135,164],"tethering":[63],"to":[64,147,158,173,181],"actin":[66],"cytoskeleton.":[67],"interactions":[69,91],"PTHR":[72,107,146,150,160,186],"modify":[73],"its":[74],"trafficking":[75,193],"signaling.":[77],"Here,":[78],"we":[79],"characterized":[80],"by":[81],"live":[82],"cell":[83,153],"imaging":[84],"mechanism":[86],"whereby":[87],"coordinates":[89],"multiple":[93],"proteins,":[94],"as":[95,97],"well":[96],"fate":[99],"itself":[102],"upon":[103],"activation.":[105],"Upon":[106],"stimulation,":[108],"rapidly":[110],"dissociates":[111,136,165],"from":[112,137,166],"induces":[116],"aggregation":[118],"in":[119,196],"long":[120],"lasting":[121],"clusters":[122],"are":[124],"enriched":[125],"actin-binding":[128],"ezrin":[130,140],"clathrin.":[133],"After":[134],"PTHR,":[139],"then":[141,171],"directly":[142],"interacts":[143],"stabilize":[148],"at":[151],"membrane.":[154],"Recruitment":[155],"\u03b2-arrestins":[157],"delayed":[162],"until":[163],"receptor,":[168],"trafficked":[172],"clathrin":[174],"for":[175],"internalization.":[176],"ability":[178],"NHERF":[180],"interact":[182],"dynamically":[183],"cognate":[188],"adapter":[189],"proteins":[190],"spatially":[198],"temporally":[200],"coordinated":[201],"manner.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}