{"id":"https://openalex.org/W2154883983","doi":"https://doi.org/10.1161/01.cir.0000022844.50161.3b","title":"Catechol-O-Methyltransferase and Blood Pressure in Humans","display_name":"Catechol-O-Methyltransferase and Blood Pressure in Humans","publication_year":2002,"publication_date":"2002-07-23","ids":{"openalex":"https://openalex.org/W2154883983","doi":"https://doi.org/10.1161/01.cir.0000022844.50161.3b","mag":"2154883983","pmid":"https://pubmed.ncbi.nlm.nih.gov/12135946"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.0000022844.50161.3b","doi":"https://doi.org/10.1161/01.cir.0000022844.50161.3b","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.0000022844.50161.3b","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017690840","display_name":"Jens Jordan","orcid":"https://orcid.org/0000-0003-4518-0706","observed_orcids":["https://orcid.org/0000-0003-4518-0706"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Jens Jordan","raw_affiliation_strings":["From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I39343248","https://openalex.org/I4210110767","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061617255","display_name":"Axel Lipp","orcid":"https://orcid.org/0000-0002-4422-3308","observed_orcids":["https://orcid.org/0000-0002-4422-3308"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Axel Lipp","raw_affiliation_strings":["From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I39343248","https://openalex.org/I4210110767","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089388570","display_name":"Jens Tank","orcid":"https://orcid.org/0000-0002-5672-1187","observed_orcids":["https://orcid.org/0000-0002-5672-1187"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Jens Tank","raw_affiliation_strings":["From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I39343248","https://openalex.org/I4210110767","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054093024","display_name":"Christoph Schr\u00f6der","orcid":"https://orcid.org/0000-0001-6177-1042","observed_orcids":["https://orcid.org/0000-0001-6177-1042"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Christoph Schro\u0308der","raw_affiliation_strings":["From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I39343248","https://openalex.org/I4210110767","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047714922","display_name":"Mandy Stoffels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Mandy Stoffels","raw_affiliation_strings":["From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I39343248","https://openalex.org/I4210110767","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gabriele Franke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Gabriele Franke","raw_affiliation_strings":["From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I39343248","https://openalex.org/I4210110767","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023424927","display_name":"Andr\u00e9 Diedrich","orcid":"https://orcid.org/0000-0001-5643-0294","observed_orcids":["https://orcid.org/0000-0001-5643-0294"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Andre Diedrich","raw_affiliation_strings":["From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I39343248","https://openalex.org/I4210110767","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079018622","display_name":"Guy Arnold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Guy Arnold","raw_affiliation_strings":["From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I39343248","https://openalex.org/I4210110767","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050003203","display_name":"David S. Goldstein","orcid":"https://orcid.org/0000-0002-5709-9940","observed_orcids":["https://orcid.org/0000-0002-5709-9940"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"David S. Goldstein","raw_affiliation_strings":["From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I39343248","https://openalex.org/I4210110767","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003445142","display_name":"Arya Mitra Sharma","orcid":"https://orcid.org/0000-0001-9360-6519","observed_orcids":["https://orcid.org/0000-0001-9360-6519"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Arya M. Sharma","raw_affiliation_strings":["From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I39343248","https://openalex.org/I4210110767","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056794023","display_name":"Friedrich Cameron Luft","orcid":"https://orcid.org/0000-0002-8635-1199","observed_orcids":["https://orcid.org/0000-0002-8635-1199"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Friedrich C. Luft","raw_affiliation_strings":["From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Franz-Volhard Clinical Research Center and HELIOS Klinikum Berlin (J.J., J.T., C.S., M.S., G.F., A.M.S., F.C.L.) and the Department of Neurology (A.L., G.A.), Medical Faculty of the Charite\u0301, Humboldt-University, Berlin, Germany; Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.); and the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (D.S.G.)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I200719446","https://openalex.org/I39343248","https://openalex.org/I4210110767","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tenn (A.D.)","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.842,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.78230436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"106","issue":"4","first_page":"460","last_page":"465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.26249998807907104,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.06289999932050705,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/catechol-o-methyltransferase","display_name":"catechol-O-methyltransferase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/blood-pressure-regulation","display_name":"blood pressure regulation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/entacapone","display_name":"entacapone","score":0.953000009059906},{"id":"https://openalex.org/keywords/yohimbine","display_name":"yohimbine","score":0.890999972820282},{"id":"https://openalex.org/keywords/multiple-system-atrophy","display_name":"multiple system atrophy","score":0.8820000290870667},{"id":"https://openalex.org/keywords/shy-drager-syndrome","display_name":"Shy-Drager syndrome","score":0.9649999737739563},{"id":"https://openalex.org/keywords/norepinephrine-turnover","display_name":"norepinephrine turnover","score":0.9440000057220459},{"id":"https://openalex.org/keywords/baroreflex-sensitivity","display_name":"baroreflex sensitivity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/autonomic-dysfunction","display_name":"autonomic dysfunction","score":0.7400000095367432},{"id":"https://openalex.org/keywords/phenylephrine-pressor-response","display_name":"phenylephrine pressor response","score":0.8500000238418579},{"id":"https://openalex.org/keywords/ganglionic-blockade","display_name":"ganglionic blockade","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2776976799","wikidata":"https://www.wikidata.org/wiki/Q416444","display_name":"Entacapone","level":5,"score":0.9267763495445251},{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.8811007738113403},{"id":"https://openalex.org/C191237925","wikidata":"https://www.wikidata.org/wiki/Q808725","display_name":"Baroreflex","level":4,"score":0.82675701379776},{"id":"https://openalex.org/C185361966","wikidata":"https://www.wikidata.org/wiki/Q94291140","display_name":"Catechol-O-methyl transferase","level":4,"score":0.8205658197402954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7835755348205566},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.724756121635437},{"id":"https://openalex.org/C2777676773","wikidata":"https://www.wikidata.org/wiki/Q412226","display_name":"Yohimbine","level":4,"score":0.7102304100990295},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.6354678869247437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5027210712432861},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.461327463388443},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.37616559863090515},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3241227865219116},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.2433062195777893},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.16900017857551575},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.14957648515701294},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.12032395601272583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05721116065979004},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.05412006378173828},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002394","descriptor_name":"Catechol O-Methyltransferase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005730","descriptor_name":"Ganglionic Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012791","descriptor_name":"Shy-Drager Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012791","descriptor_name":"Shy-Drager Syndrome","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012791","descriptor_name":"Shy-Drager Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013566","descriptor_name":"Sympathomimetics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014294","descriptor_name":"Trimethaphan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015016","descriptor_name":"Yohimbine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017704","descriptor_name":"Baroreflex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065098","descriptor_name":"Catechol O-Methyltransferase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.cir.0000022844.50161.3b","doi":"https://doi.org/10.1161/01.cir.0000022844.50161.3b","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.0000022844.50161.3b","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:12135946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12135946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W45841934","https://openalex.org/W624801343","https://openalex.org/W1462453977","https://openalex.org/W1481516030","https://openalex.org/W1964266581","https://openalex.org/W1967910846","https://openalex.org/W1970900418","https://openalex.org/W1971256189","https://openalex.org/W1984277280","https://openalex.org/W1988534299","https://openalex.org/W1991844041","https://openalex.org/W1996187369","https://openalex.org/W1998955929","https://openalex.org/W2002442019","https://openalex.org/W2006784076","https://openalex.org/W2012638983","https://openalex.org/W2025369462","https://openalex.org/W2064579956","https://openalex.org/W2086550795","https://openalex.org/W2090153990","https://openalex.org/W2095068860","https://openalex.org/W2095331729","https://openalex.org/W2100040984","https://openalex.org/W2112214600","https://openalex.org/W2116757809","https://openalex.org/W2123924169","https://openalex.org/W2137335941","https://openalex.org/W2142122899","https://openalex.org/W2153884671","https://openalex.org/W2160222961","https://openalex.org/W2166630765","https://openalex.org/W2322081653","https://openalex.org/W2404194266","https://openalex.org/W2569094787","https://openalex.org/W4241523364"],"related_works":["https://openalex.org/W2949775092","https://openalex.org/W1994632036","https://openalex.org/W2095900137","https://openalex.org/W1977005315","https://openalex.org/W1980652256","https://openalex.org/W1966820418","https://openalex.org/W7095625031","https://openalex.org/W2034564944","https://openalex.org/W45841934","https://openalex.org/W1590034564"],"abstract_inverted_index":{"BACKGROUND:":[0],"Whether":[1],"catechol-O-methyltransferase":[2],"(COMT),":[3],"the":[4,27,31,103,114,129,143],"enzyme":[5],"that":[6],"metabolizes":[7],"extraneuronal":[8],"norepinephrine,":[9],"contributes":[10],"to":[11,78,106,117],"blood":[12,59,99,152],"pressure":[13,60,100,153],"regulation":[14,65,154],"in":[15,37,58,61,128,155],"humans":[16],"is":[17],"unknown.":[18],"METHODS":[19],"AND":[20],"RESULTS:":[21],"We":[22,47],"studied":[23],"incremental":[24],"doses":[25],"of":[26,131,145,148,158],"COMT":[28,120],"inhibitor":[29],"entacapone,":[30],"sympathetic":[32],"stimulant":[33],"yohimbine,":[34],"and":[35,72,80,151],"placebo":[36],"7":[38],"patients":[39],"with":[40,68,137],"multiple":[41,138],"system":[42,139],"atrophy":[43,140],"(Shy":[44],"Drager":[45],"syndrome).":[46],"selected":[48],"these":[49,62],"unique":[50],"subjects":[51],"because":[52],"norepinephrine":[53,149],"exerts":[54],"an":[55],"exaggerated":[56],"increase":[57],"patients.":[63],"Autonomic":[64],"was":[66,108],"characterized":[67],"intravenous":[69],"phenylephrine,":[70],"nitroprusside,":[71],"trimethaphan.":[73],"Patients":[74,136],"were":[75],"extremely":[76],"hypersensitive":[77],"phenylephrine":[79],"nitroprusside.":[81],"Trimethaphan":[82],"elicited":[83],"a":[84,123],"profound":[85],"depressor":[86],"response.":[87],"Phenylephrine":[88],"sensitivity":[89],"increased":[90,97],"only":[91],"slightly":[92],"during":[93],"ganglionic":[94],"blockade.":[95],"Entacapone":[96],"systolic":[98],"dose-dependently;":[101],"however,":[102],"pressor":[104,126],"response":[105,116,127],"yohimbine":[107],"approximately":[109],"3.5":[110],"times":[111],"greater":[112],"than":[113],"maximal":[115],"entacapone.":[118],"CONCLUSIONS:":[119],"inhibition":[121],"elicits":[122],"moderate,":[124],"dose-dependent":[125],"setting":[130],"severely":[132],"impaired":[133],"baroreflex":[134],"buffering.":[135],"allow":[141],"for":[142],"characterization":[144],"subtle":[146],"manipulations":[147],"turnover":[150],"small":[156],"numbers":[157],"subjects.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
