{"id":"https://openalex.org/W2154776022","doi":"https://doi.org/10.1093/humrep/des104","title":"Cytogenetic analysis of 531 Chinese women with premature ovarian failure","display_name":"Cytogenetic analysis of 531 Chinese women with premature ovarian failure","publication_year":2012,"publication_date":"2012-04-18","ids":{"openalex":"https://openalex.org/W2154776022","doi":"https://doi.org/10.1093/humrep/des104","mag":"2154776022","pmid":"https://pubmed.ncbi.nlm.nih.gov/22513983"},"language":"en","primary_location":{"id":"doi:10.1093/humrep/des104","doi":"https://doi.org/10.1093/humrep/des104","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/des104","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033629741","display_name":"Xue Jiao","orcid":"https://orcid.org/0000-0002-2936-2166","observed_orcids":["https://orcid.org/0000-0002-2936-2166"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4405277027","display_name":"Hospital for Reproductive Medicine Affiliated to Shandong University","ror":"https://ror.org/0168ksk34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X. Jiao","raw_affiliation_strings":["Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, 324 Jingwu Road, Jinan 250021, China","Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan 250021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, 324 Jingwu Road, Jinan 250021, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4405277027"]},{"raw_affiliation_string":"Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan 250021, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4405277027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083381099","display_name":"Chunrong Qin","orcid":"https://orcid.org/0000-0001-7230-3455","observed_orcids":["https://orcid.org/0000-0001-7230-3455"]},"institutions":[{"id":"https://openalex.org/I4210104539","display_name":"Shenzhen Maternity and Child Healthcare Hospital","ror":"https://ror.org/01me2d674","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"C. Qin","raw_affiliation_strings":["Maternal and Child Health Hospital in Shenzhen, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maternal and Child Health Hospital in Shenzhen, Shenzhen, China","institution_ids":["https://openalex.org/I4210104539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103011768","display_name":"Jiaqing Li","orcid":"https://orcid.org/0009-0003-7568-9551","observed_orcids":["https://orcid.org/0009-0003-7568-9551","https://orcid.org/0000-0002-4715-3333"]},"institutions":[{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Li","raw_affiliation_strings":["Reproductive Medical Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medical Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100608601","display_name":"Yingying Qin","orcid":"https://orcid.org/0000-0002-0319-7799","observed_orcids":["https://orcid.org/0000-0002-0319-7799"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4405277027","display_name":"Hospital for Reproductive Medicine Affiliated to Shandong University","ror":"https://ror.org/0168ksk34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Qin","raw_affiliation_strings":["Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan 250021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan 250021, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4405277027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044683577","display_name":"Xuan Gao","orcid":"https://orcid.org/0000-0002-9437-389X","observed_orcids":["https://orcid.org/0000-0002-9437-389X"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4405277027","display_name":"Hospital for Reproductive Medicine Affiliated to Shandong University","ror":"https://ror.org/0168ksk34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X. Gao","raw_affiliation_strings":["Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan 250021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan 250021, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4405277027"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B. Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127779","display_name":"Guangxi Maternal and Child Health Hospital","ror":"https://ror.org/0389fv189","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127779"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"B. Zhang","raw_affiliation_strings":["Center for Reproductive Medicine, Maternal and Child Health Hospital in Guangxi, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Maternal and Child Health Hospital in Guangxi, Guangxi, China","institution_ids":["https://openalex.org/I4210127779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108581106","display_name":"X. Zhen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X. Zhen","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100697013","display_name":"Yun Feng","orcid":"https://orcid.org/0000-0001-7524-3718","observed_orcids":["https://orcid.org/0000-0001-7524-3718"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Feng","raw_affiliation_strings":["Reproductive Medical Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medical Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080697469","display_name":"Joe Leigh Simpson","orcid":"https://orcid.org/0000-0002-5309-6881","observed_orcids":["https://orcid.org/0000-0002-5309-6881"]},"institutions":[{"id":"https://openalex.org/I19700959","display_name":"Florida International University","ror":"https://ror.org/02gz6gg07","country_code":"US","type":"education","lineage":["https://openalex.org/I19700959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. L. Simpson","raw_affiliation_strings":["Florida International University, College of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florida International University, College of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I19700959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108064842","display_name":"Zi\u2010Jiang Chen","orcid":"https://orcid.org/0000-0001-6637-6631","observed_orcids":["https://orcid.org/0000-0001-6637-6631"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4405277027","display_name":"Hospital for Reproductive Medicine Affiliated to Shandong University","ror":"https://ror.org/0168ksk34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405277027"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Z.-J. Chen","raw_affiliation_strings":["Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan 250021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan 250021, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4405277027"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5108064842"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4405277027"],"apc_list":{"value":4097,"currency":"EUR","value_usd":4630},"apc_paid":null,"fwci":4.7937,"has_fulltext":true,"cited_by_count":123,"citation_normalized_percentile":{"value":0.95965517,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"27","issue":"7","first_page":"2201","last_page":"2207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/premature-ovarian-failure","display_name":"premature ovarian failure","score":1.0},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9879999756813049},{"id":"https://openalex.org/keywords/x-autosome-translocation","display_name":"X-autosome translocation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/45-x-46-xx-mosaicism","display_name":"45,X/46,XX mosaicism","score":0.9449999928474426},{"id":"https://openalex.org/keywords/primary-amenorrhea","display_name":"primary amenorrhea","score":0.8880000114440918},{"id":"https://openalex.org/keywords/secondary-amenorrhea","display_name":"secondary amenorrhea","score":0.9850000143051147},{"id":"https://openalex.org/keywords/han-chinese-women","display_name":"Han Chinese women","score":0.7860000133514404},{"id":"https://openalex.org/keywords/robertsonian-translocation","display_name":"Robertsonian translocation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/karyology","display_name":"karyology","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2777395788","wikidata":"https://www.wikidata.org/wiki/Q647630","display_name":"Premature ovarian failure","level":2,"score":0.9216316938400269},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.501056432723999},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4747605621814728},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.33502528071403503},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3317086696624756}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002871","descriptor_name":"Chromosome Banding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008677","descriptor_name":"Metaphase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016649","descriptor_name":"Primary Ovarian Insufficiency","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D016649","descriptor_name":"Primary Ovarian Insufficiency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020732","descriptor_name":"Cytogenetic Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D041321","descriptor_name":"Chromosomes, Human, X","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/humrep/des104","doi":"https://doi.org/10.1093/humrep/des104","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/des104","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},{"id":"pmid:22513983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22513983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human reproduction (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W155506316","https://openalex.org/W181681831","https://openalex.org/W407573252","https://openalex.org/W1541230922","https://openalex.org/W1568492360","https://openalex.org/W1591318751","https://openalex.org/W1973857941","https://openalex.org/W1983616787","https://openalex.org/W2003538061","https://openalex.org/W2005010939","https://openalex.org/W2005271852","https://openalex.org/W2011488389","https://openalex.org/W2013730902","https://openalex.org/W2015481560","https://openalex.org/W2015603708","https://openalex.org/W2021886600","https://openalex.org/W2024801099","https://openalex.org/W2034478166","https://openalex.org/W2034832301","https://openalex.org/W2035117655","https://openalex.org/W2035384776","https://openalex.org/W2039242083","https://openalex.org/W2056703831","https://openalex.org/W2059970788","https://openalex.org/W2068010208","https://openalex.org/W2069124192","https://openalex.org/W2080898126","https://openalex.org/W2089064691","https://openalex.org/W2091317841","https://openalex.org/W2092758454","https://openalex.org/W2103040888","https://openalex.org/W2109192557","https://openalex.org/W2113547468","https://openalex.org/W2115932490","https://openalex.org/W2129994886","https://openalex.org/W2143843084","https://openalex.org/W2146017609","https://openalex.org/W2152589678","https://openalex.org/W2159707008","https://openalex.org/W2162900761","https://openalex.org/W2165923586","https://openalex.org/W2170353167","https://openalex.org/W2320333627","https://openalex.org/W2384224882","https://openalex.org/W2398382881","https://openalex.org/W2409373478","https://openalex.org/W2414393695","https://openalex.org/W2414469382","https://openalex.org/W2415688090","https://openalex.org/W2417538570","https://openalex.org/W2424463264","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7098746677","https://openalex.org/W155506316","https://openalex.org/W2039242083","https://openalex.org/W2027411762","https://openalex.org/W1978490874","https://openalex.org/W4221086314","https://openalex.org/W2890510897","https://openalex.org/W2267199903","https://openalex.org/W2091180227","https://openalex.org/W3126182832"],"abstract_inverted_index":{"BACKGROUND:":[0],"This":[1],"retrospective":[2],"cohort":[3],"study":[4],"was":[5,130,204,214],"to":[6,30,64],"determine":[7],"the":[8,176,187,233,244,255],"frequency":[9],"and":[10,28,56,109,141,172,251],"types":[11],"of":[12,76,81,186,211,222,232,236,246],"chromosomal":[13,212,223,259],"abnormalities":[14,71,150,213,260],"in":[15,49,74,132,154,216,225,262],"Han":[16],"Chinese":[17,36,226],"women":[18,227,237],"with":[19,38,58,146,156,163,181,190,196,228,238],"well-documented":[20],"premature":[21],"ovarian":[22],"failure":[23],"(POF).":[24],"METHODS:":[25],"Karyotype":[26],"analysis":[27],"correlation":[29],"phenotypes":[31],"were":[32,54,72,84,117,151,175],"performed":[33],"on":[34],"531":[35,77],"patients":[37,155],"proven":[39],"POF":[40,79,239],"(FSH":[41],">":[42],"40":[43],"mIU/ml)":[44],"attending":[45],"four":[46],"reproductive":[47],"centers":[48],"China.":[50],"G-banded":[51],"metaphase":[52],"chromosomes":[53],"prepared":[55],"analyzed,":[57],"mosaicism":[59,174],"excluded":[60],"by":[61],"counting":[62],"up":[63],"100":[65],"cells":[66],"from":[67,241],"lymphocytes.":[68],"RESULTS:":[69],"Chromosomal":[70],"present":[73],"64":[75],"(12.1%)":[78],"cases,":[80],"which":[82],"32":[83],"X-structural":[85,247],"aberrations":[86,224],"(7":[87],"mosaic):":[88],"15":[89],"del(Xq),":[90],"2":[91],"del(Xp),":[92],"11":[93],"isochromosomes":[94],"[6":[95],"i(Xp);":[96],"5":[97],"i(Xq)],":[98],"1":[99,103,106,110,121],"ring":[100],"chromosome":[101,108],"(mosaic),":[102,105],"inversion":[104],"isodicentric":[107],"complex":[111],"arrangement.":[112],"Nine":[113],"non-mosaic":[114,136],"X-autosome":[115,249],"translocations":[116,250],"detected,":[118],"all":[119],"but":[120],"involving":[122],"Xq.":[123],"Aneuploidy":[124],"without":[125],"a":[126],"structurally":[127],"abnormal":[128],"X":[129,252,258],"found":[131],"19":[133],"cases:":[134],"7":[135],"45,X,":[137],"9":[138],"45,X":[139,171],"mosaicisms":[140],"3":[142],"47,XXX":[143],"(1":[144],"mosaic":[145],"46,XX":[147],"line).":[148],"Karyotypic":[149],"more":[152],"frequent":[153],"primary":[157,182],"amenorrhea":[158,165,183],"(15/70,":[159],"21.4%)":[160],"than":[161],"those":[162],"secondary":[164],"(49/461,":[166],"10.6%;":[167],"P":[168],"=":[169],"0.01).":[170],"45,X/46,XX":[173],"complements":[177],"most":[178],"frequently":[179],"associated":[180],"(46.7%).":[184],"Two":[185],"three":[188],"cases":[189],"46,XY":[191],"or":[192],"45,X/46,XY":[193],"karyotype":[194],"presented":[195],"'secondary":[197],"amenorrhea'.":[198],"One":[199],"balanced":[200],"autosomal":[201],"Robertsonian":[202],"translocation":[203],"also":[205],"detected.":[206],"CONCLUSIONS:":[207],"The":[208],"overall":[209],"prevalence":[210,245],"12.1%":[215],"this":[217],"first":[218],"large":[219],"scale":[220],"report":[221],"POF.":[229,263],"In":[230],"one":[231],"largest":[234],"samples":[235],"reported":[240],"any":[242],"population,":[243],"abnormalities,":[248],"aneuploidy":[253],"confirms":[254],"essential":[256],"role":[257],"play":[261]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}