{"id":"https://openalex.org/W2154759788","doi":"https://doi.org/10.1093/nar/gkl725","title":"Diversity of tRNA genes in eukaryotes","display_name":"Diversity of tRNA genes in eukaryotes","publication_year":2006,"publication_date":"2006-11-06","ids":{"openalex":"https://openalex.org/W2154759788","doi":"https://doi.org/10.1093/nar/gkl725","mag":"2154759788","pmid":"https://pubmed.ncbi.nlm.nih.gov/17088292","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1693877"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkl725","doi":"https://doi.org/10.1093/nar/gkl725","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkl725","pdf_url":"https://academic.oup.com/nar/article-pdf/34/21/6137/11171043/gkl725.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/34/21/6137/11171043/gkl725.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081972050","display_name":"Jeffrey M. Goodenbour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey M. Goodenbour","raw_affiliation_strings":["Department of Human Genetics, 929 East 57th street, Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, 929 East 57th street, Chicago, IL 60637, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003648553","display_name":"Tao Pan","orcid":"https://orcid.org/0000-0003-1096-8405","observed_orcids":["https://orcid.org/0000-0003-1096-8405"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tao Pan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology 929 East 57th street, Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology 929 East 57th street, Chicago, IL 60637, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003648553"],"corresponding_institution_ids":[],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":2.3638,"has_fulltext":true,"cited_by_count":233,"citation_normalized_percentile":{"value":0.88624864,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"34","issue":"21","first_page":"6137","last_page":"6146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trna-genes","display_name":"tRNA genes","score":0.875},{"id":"https://openalex.org/keywords/trna-isoacceptors","display_name":"tRNA isoacceptors","score":0.9419999718666077},{"id":"https://openalex.org/keywords/anticodon","display_name":"anticodon","score":0.6840000152587891},{"id":"https://openalex.org/keywords/rna-polymerase-iii-promoter","display_name":"RNA polymerase III promoter","score":0.7730000019073486},{"id":"https://openalex.org/keywords/trna-gene-copy-number","display_name":"tRNA gene copy number","score":0.4569999873638153},{"id":"https://openalex.org/keywords/trna-function","display_name":"tRNA function","score":0.4959999918937683},{"id":"https://openalex.org/keywords/eukaryotic-genomes","display_name":"eukaryotic genomes","score":0.6050000190734863},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.9108113050460815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.897295355796814},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7587959170341492},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7169886827468872},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.44056445360183716},{"id":"https://openalex.org/C70916841","wikidata":"https://www.wikidata.org/wiki/Q3501658","display_name":"RNA polymerase III","level":5,"score":0.4285040497779846},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.1804729700088501}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000926","descriptor_name":"Anticodon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/nar/gkl725","doi":"https://doi.org/10.1093/nar/gkl725","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkl725","pdf_url":"https://academic.oup.com/nar/article-pdf/34/21/6137/11171043/gkl725.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1693877","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1693877","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:17088292","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17088292","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.280.9694","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.9694","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/0d/86/Nucleic_Acids_Res_2006_Dec_6_34(21)_6137-6146.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.576.733","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.576.733","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/34/21/6137.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.626.6817","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.626.6817","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/early/2006/11/06/nar.gkl725.full-text-lowres.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.632.3059","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.632.3059","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/34/21/6137.full-text-lowres.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkl725","doi":"https://doi.org/10.1093/nar/gkl725","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkl725","pdf_url":"https://academic.oup.com/nar/article-pdf/34/21/6137/11171043/gkl725.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7100900607","display_name":"Genetics and Regulation","funder_award_id":"T32GM007197","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320309626","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2154759788.pdf","grobid_xml":"https://content.openalex.org/works/W2154759788.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W651022058","https://openalex.org/W658194340","https://openalex.org/W1605888594","https://openalex.org/W1981078760","https://openalex.org/W2000908381","https://openalex.org/W2001393706","https://openalex.org/W2004733488","https://openalex.org/W2009512566","https://openalex.org/W2011357268","https://openalex.org/W2018590530","https://openalex.org/W2029422324","https://openalex.org/W2033713984","https://openalex.org/W2042700625","https://openalex.org/W2050110866","https://openalex.org/W2053640718","https://openalex.org/W2056474690","https://openalex.org/W2057081312","https://openalex.org/W2057733356","https://openalex.org/W2057892106","https://openalex.org/W2074466923","https://openalex.org/W2077686875","https://openalex.org/W2082395806","https://openalex.org/W2083812890","https://openalex.org/W2090706358","https://openalex.org/W2096525273","https://openalex.org/W2096627686","https://openalex.org/W2097382368","https://openalex.org/W2097706568","https://openalex.org/W2108508097","https://openalex.org/W2123625529","https://openalex.org/W2127893541","https://openalex.org/W2134153749","https://openalex.org/W2140486583","https://openalex.org/W2149429041","https://openalex.org/W2151632575","https://openalex.org/W2162204750","https://openalex.org/W2164618276","https://openalex.org/W2167673850","https://openalex.org/W2324849642","https://openalex.org/W4230903726","https://openalex.org/W4234879553","https://openalex.org/W4244116275","https://openalex.org/W4247964656","https://openalex.org/W6607685104","https://openalex.org/W7098204124"],"related_works":["https://openalex.org/W7097438256","https://openalex.org/W2014456355","https://openalex.org/W3048999744","https://openalex.org/W2939643004","https://openalex.org/W4402285418","https://openalex.org/W7140026519","https://openalex.org/W4285282800","https://openalex.org/W2967458504","https://openalex.org/W2001394720","https://openalex.org/W2592757011"],"abstract_inverted_index":{"We":[0,153],"compare":[1],"the":[2,23,50,61,67,75,114,129,145],"diversity":[3],"of":[4,17,41,52,63,119,135,174,185],"chromosomal-encoded":[5],"transfer":[6],"RNA":[7,150],"(tRNA)":[8],"genes":[9,43,65,89,102,112,122,126,142,188],"from":[10,56,100,110],"11":[11],"eukaryotes":[12,190],"as":[13,80],"identified":[14],"by":[15],"tRNAScan-SE":[16],"their":[18],"respective":[19],"genomes.":[20],"They":[21],"include":[22],"budding":[24,115],"and":[25,37,47,49,162,170],"fission":[26],"yeast,":[27],"worm,":[28],"fruit":[29],"fly,":[30],"fugu,":[31],"chicken,":[32],"dog,":[33],"rat,":[34],"mouse,":[35],"chimp":[36],"human.":[38],"The":[39,117,182],"number":[40,51,62,134,184],"tRNA":[42,53,64,76,81,87,95,120,125,140,164,176,186,193],"are":[44],"between":[45],"170":[46],"570":[48],"isoacceptors":[54],"range":[55],"41":[57],"to":[58,92,97,108,160],"55.":[59],"Unexpectedly,":[60],"having":[66],"same":[68],"anticodon":[69],"but":[70,105],"different":[71,94],"sequences":[72],"elsewhere":[73],"in":[74,103,113,138,144,167,178,189],"body":[77],"(defined":[78],"here":[79],"isodecoder":[82,88,121,141,165,187],"genes)":[83],"varies":[84],"significantly":[85],"(10-246).":[86],"allow":[90],"up":[91,107],"274":[93],"species":[96],"be":[98,196],"produced":[99],"446":[101],"humans,":[104],"only":[106],"51":[109],"275":[111],"yeast.":[116],"fraction":[118],"among":[123],"all":[124],"increases":[127],"across":[128],"phylogenetic":[130],"spectrum.":[131],"A":[132],"large":[133,183],"sequence":[136],"differences":[137],"human":[139,168,180],"occurs":[143],"internal":[146],"promoter":[147],"regions":[148],"for":[149],"polymerase":[151],"III.":[152],"also":[154],"describe":[155],"a":[156],"systematic,":[157],"ligation-based":[158],"method":[159],"detect":[161],"quantify":[163],"molecules":[166],"samples,":[169],"show":[171],"differential":[172],"expression":[173],"three":[175],"isodecoders":[177],"six":[179],"tissues.":[181],"suggests":[191],"that":[192],"function":[194],"may":[195],"more":[197],"diverse":[198],"than":[199],"previously":[200],"appreciated.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
