{"id":"https://openalex.org/W2154753141","doi":"https://doi.org/10.1177/0192623308315829","title":"Spontaneous Occurrence of a Distinctive Renal Tubule Tumor Phenotype in Rat Carcinogenicity Studies Conducted by the National Toxicology Program","display_name":"Spontaneous Occurrence of a Distinctive Renal Tubule Tumor Phenotype in Rat Carcinogenicity Studies Conducted by the National Toxicology Program","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W2154753141","doi":"https://doi.org/10.1177/0192623308315829","mag":"2154753141","pmid":"https://pubmed.ncbi.nlm.nih.gov/18441261","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2905801"},"language":"en","primary_location":{"id":"doi:10.1177/0192623308315829","doi":"https://doi.org/10.1177/0192623308315829","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0192623308315829","pdf_url":null,"source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2905801","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085815037","display_name":"Gordon C. Hard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gordon C. Hard","raw_affiliation_strings":["Private Consultant, Tairua, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Private Consultant, Tairua, New Zealand","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015910036","display_name":"John Curtis Seely","orcid":"https://orcid.org/0000-0003-1050-4096","observed_orcids":["https://orcid.org/0000-0003-1050-4096"]},"institutions":[{"id":"https://openalex.org/I4210090135","display_name":"Experimental Pathology Laboratories","ror":"https://ror.org/00dv9aw81","country_code":"US","type":"company","lineage":["https://openalex.org/I4210090135"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Curtis Seely","raw_affiliation_strings":["Experimental Pathology Laboratories Inc, Research Triangle Park, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pathology Laboratories Inc, Research Triangle Park, North Carolina, USA","institution_ids":["https://openalex.org/I4210090135"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110254923","display_name":"Grace E. Kissling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace E. Kissling","raw_affiliation_strings":["National Institutes of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109993789","display_name":"Laura J. Betz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura J. Betz","raw_affiliation_strings":["Constella Health Sciences, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Constella Health Sciences, Durham, North Carolina, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085815037"],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.1138,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.56994373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"36","issue":"3","first_page":"388","last_page":"396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8314999938011169,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8314999938011169,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.11890000104904175,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spontaneous-tumors","display_name":"spontaneous tumors","score":0.6729999780654907},{"id":"https://openalex.org/keywords/renal-adenoma","display_name":"renal adenoma","score":0.8209999799728394},{"id":"https://openalex.org/keywords/renal-carcinoma","display_name":"renal carcinoma","score":0.8700000047683716},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9490000009536743},{"id":"https://openalex.org/keywords/carcinogenicity-testing","display_name":"carcinogenicity testing","score":0.6079999804496765},{"id":"https://openalex.org/keywords/fischer-344-rats","display_name":"F344 rats","score":0.8069999814033508},{"id":"https://openalex.org/keywords/sprague-dawley-rats","display_name":"Sprague-Dawley rats","score":0.9020000100135803},{"id":"https://openalex.org/keywords/wistar-rats","display_name":"Wistar rats","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tumor-morphology","display_name":"tumor morphology","score":0.42800000309944153},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.695013701915741},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6142566204071045},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6007635593414307},{"id":"https://openalex.org/C2779758542","wikidata":"https://www.wikidata.org/wiki/Q2106364","display_name":"Eosinophilic","level":2,"score":0.5407031178474426},{"id":"https://openalex.org/C2779010597","wikidata":"https://www.wikidata.org/wiki/Q5166601","display_name":"Convoluted tubule","level":3,"score":0.5187828540802002},{"id":"https://openalex.org/C2780222010","wikidata":"https://www.wikidata.org/wiki/Q2916078","display_name":"Proximal tubule","level":3,"score":0.5129263401031494},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.46701934933662415},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.4498509466648102},{"id":"https://openalex.org/C3018884230","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Renal tubule","level":3,"score":0.43626856803894043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40322786569595337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34832924604415894},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34426945447921753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24194088578224182},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009378","descriptor_name":"Neoplasms, Multiple Primary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014617","descriptor_name":"Vacuoles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015197","descriptor_name":"Carcinogenicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054585","descriptor_name":"National Institute of Environmental Health Sciences (U.S.)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/0192623308315829","doi":"https://doi.org/10.1177/0192623308315829","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0192623308315829","pdf_url":null,"source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},{"id":"pmid:18441261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18441261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2905801","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2905801","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicol Pathol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2905801","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2905801","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicol Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1631400564","display_name":null,"funder_award_id":"N01 ES 95435","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G1813908254","display_name":"Identifying And Evaluating Sources Of Variability In Rodent Studies","funder_award_id":"ZIAES045003","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G880199829","display_name":"NIEHS ARCHIVES AND SPECIMEN REPOSITORY","funder_award_id":"n01es095435-000","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8835369723","display_name":null,"funder_award_id":"N01 ES095435","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W82303462","https://openalex.org/W1510217330","https://openalex.org/W1967807729","https://openalex.org/W1974039242","https://openalex.org/W1977947318","https://openalex.org/W1980207101","https://openalex.org/W1980754624","https://openalex.org/W2000832859","https://openalex.org/W2006682466","https://openalex.org/W2026342193","https://openalex.org/W2028224680","https://openalex.org/W2032546548","https://openalex.org/W2037391960","https://openalex.org/W2060124519","https://openalex.org/W2065796355","https://openalex.org/W2096850473","https://openalex.org/W2099137078","https://openalex.org/W2104890054","https://openalex.org/W2125825251","https://openalex.org/W2132997466","https://openalex.org/W2151109331","https://openalex.org/W2163159470","https://openalex.org/W2163176981","https://openalex.org/W2319829135"],"related_works":["https://openalex.org/W4408159188","https://openalex.org/W2162589676","https://openalex.org/W1967919275","https://openalex.org/W7097031416","https://openalex.org/W1977947318","https://openalex.org/W2279359669","https://openalex.org/W1984017160","https://openalex.org/W2034186705","https://openalex.org/W2119207335","https://openalex.org/W7096989992"],"abstract_inverted_index":{"The":[0,36,124,175],"Toxicology":[1,9],"Data":[2],"Management":[3],"System":[4],"(TDMS)":[5],"of":[6,13,19,27,39,64,84,101,177,195,226],"the":[7,60,80,87,105,114,119,139,157,165,190,223],"National":[8,11,17],"Program,":[10],"Institutes":[12,18],"Environmental":[14],"Health":[15],"Sciences,":[16],"Health,":[20],"was":[21,182,194],"surveyed":[22],"for":[23],"occurrence":[24],"and":[25,49,100,121,146,167,186,198],"distribution":[26,176],"a":[28,149,215,227],"distinctive":[29,106,208],"renal":[30,65,73,95,179,209],"tubule":[31,66,74],"tumor":[32,41,180,210],"type":[33,181],"in":[34,71,79,86,138,148],"rats.":[35],"hallmark":[37],"features":[38],"this":[40,178,207],"included":[42],"eosinophilic/amphophilic":[43],"staining,":[44],"large":[45],"finely":[46],"granular":[47],"cells,":[48],"numerous":[50],"vacuoles":[51],"and/or":[52],"minilumens.":[53],"It":[54],"is":[55,204],"referred":[56],"to":[57,164],"here":[58],"as":[59,135,214],"amphophilic-vacuolar":[61],"(AV)":[62],"variant":[63],"tumor.":[67],"Of":[68],"154":[69],"studies":[70,111,185],"which":[72],"tumors":[75,126],"had":[76],"been":[77],"recorded":[78,213],"standard":[81],"single":[82],"sections":[83],"kidney":[85],"TDMS,":[88],"there":[89],"were":[90,144,153,168],"collectively":[91],"1012":[92],"rats":[93],"with":[94,171],"adenomas,":[96],"carcinomas,":[97],"or":[98],"adenocarcinomas,":[99],"these,":[102],"100":[103],"displayed":[104],"AV":[107,125],"morphology,":[108],"representing":[109],"74":[110],"involving":[112],"mostly":[113],"F344":[115],"rat,":[116],"but":[117,129],"also":[118,130],"Sprague-Dawley":[120],"Wistar":[122],"strains.":[123],"(mainly":[127],"adenomas":[128],"some":[131],"carcinomas)":[132],"occurred":[133],"usually":[134],"solitary":[136],"lesions":[137],"affected":[140],"animals.":[141],"However,":[142],"they":[143],"multiple":[145],"bilateral":[147],"few":[150],"cases.":[151],"They":[152],"equally":[154],"distributed":[155],"between":[156],"sexes,":[158],"did":[159],"not":[160,169,199],"metastasize":[161],"(at":[162],"least":[163],"lung),":[166],"associated":[170],"chronic":[172],"progressive":[173],"nephropathy.":[174],"random":[183],"across":[184],"dose":[187],"groups,":[188],"underscoring":[189],"likelihood":[191],"that":[192,206],"it":[193,203],"spontaneous":[196],"origin":[197],"chemically":[200],"induced.":[201],"Accordingly,":[202],"suggested":[205],"phenotype":[211],"be":[212],"separate":[216],"category":[217],"from":[218],"conventional":[219],"RTT":[220],"when":[221],"assessing":[222],"carcinogenic":[224],"potential":[225],"test":[228],"compound.":[229]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}