{"id":"https://openalex.org/W2154747925","doi":"https://doi.org/10.1091/mbc.e14-04-0916","title":"How Taxol/paclitaxel kills cancer cells","display_name":"How Taxol/paclitaxel kills cancer cells","publication_year":2014,"publication_date":"2014-09-11","ids":{"openalex":"https://openalex.org/W2154747925","doi":"https://doi.org/10.1091/mbc.e14-04-0916","mag":"2154747925","pmid":"https://pubmed.ncbi.nlm.nih.gov/25213191","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161504"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.e14-04-0916","doi":"https://doi.org/10.1091/mbc.e14-04-0916","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e14-04-0916","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161504","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008049256","display_name":"Beth A. A. Weaver","orcid":"https://orcid.org/0000-0002-7830-3816","observed_orcids":["https://orcid.org/0000-0002-7830-3816"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Beth A. Weaver","raw_affiliation_strings":["Department of Cell and Regenerative Biology and Carbone Cancer Center, University of Wisconsin, Madison, WI 53705"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Regenerative Biology and Carbone Cancer Center, University of Wisconsin, Madison, WI 53705","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008049256"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"],"apc_list":null,"apc_paid":null,"fwci":16.915,"has_fulltext":false,"cited_by_count":1569,"citation_normalized_percentile":{"value":0.99701214,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"25","issue":"18","first_page":"2677","last_page":"2681"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.08820000290870667,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":1.0},{"id":"https://openalex.org/keywords/microtubule-stabilization","display_name":"microtubule stabilization","score":0.8830000162124634},{"id":"https://openalex.org/keywords/mitotic-arrest","display_name":"mitotic arrest","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.7289999723434448},{"id":"https://openalex.org/keywords/multipolar-mitosis","display_name":"multipolar mitosis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/intratumoral-drug-concentration","display_name":"intratumoral drug concentration","score":0.7450000047683716},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.933944582939148},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6829502582550049},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.5141287446022034},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5098454356193542},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48156359791755676},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.460498571395874},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.44835859537124634},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42302224040031433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3830621540546417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23143270611763},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22396859526634216},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1091/mbc.e14-04-0916","doi":"https://doi.org/10.1091/mbc.e14-04-0916","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e14-04-0916","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3213359","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161504","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4161504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161504","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},{"id":"pmid:25213191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25213191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology of the cell","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.805.1595","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.805.1595","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/43/c0/2677.PMC4161504.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3213359","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161504","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G545082734","display_name":"Mitosis, Aneuploidy and Cancer","funder_award_id":"R01CA140458","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000870050","display_name":"UW Comprehensive Cancer Center Support","funder_award_id":"P30CA014520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1568060924","https://openalex.org/W1616592835","https://openalex.org/W1965332656","https://openalex.org/W1965614813","https://openalex.org/W1968204833","https://openalex.org/W1971579914","https://openalex.org/W1975533327","https://openalex.org/W1976033985","https://openalex.org/W1977345614","https://openalex.org/W1981433220","https://openalex.org/W1981534406","https://openalex.org/W1982746572","https://openalex.org/W1989367285","https://openalex.org/W1990983360","https://openalex.org/W1994406643","https://openalex.org/W1994550568","https://openalex.org/W1998766450","https://openalex.org/W2007877171","https://openalex.org/W2029988478","https://openalex.org/W2030453862","https://openalex.org/W2036292773","https://openalex.org/W2037490361","https://openalex.org/W2037834300","https://openalex.org/W2042531775","https://openalex.org/W2045897698","https://openalex.org/W2047521557","https://openalex.org/W2048363916","https://openalex.org/W2051000382","https://openalex.org/W2052853635","https://openalex.org/W2055171674","https://openalex.org/W2067299834","https://openalex.org/W2070611680","https://openalex.org/W2071359790","https://openalex.org/W2074449987","https://openalex.org/W2081406767","https://openalex.org/W2083226227","https://openalex.org/W2083705089","https://openalex.org/W2083980483","https://openalex.org/W2089217892","https://openalex.org/W2090018126","https://openalex.org/W2096059000","https://openalex.org/W2101256833","https://openalex.org/W2101447738","https://openalex.org/W2102531181","https://openalex.org/W2108489838","https://openalex.org/W2123244616","https://openalex.org/W2125610733","https://openalex.org/W2128796750","https://openalex.org/W2131817855","https://openalex.org/W2134435289","https://openalex.org/W2138659386","https://openalex.org/W2140029079","https://openalex.org/W2145032863","https://openalex.org/W2151395731","https://openalex.org/W2154241215","https://openalex.org/W2154603906","https://openalex.org/W2162546286","https://openalex.org/W2162643935","https://openalex.org/W2169517204","https://openalex.org/W2170507464","https://openalex.org/W2326740736","https://openalex.org/W2333753059","https://openalex.org/W2430094578","https://openalex.org/W2464465175"],"related_works":["https://openalex.org/W3206612685","https://openalex.org/W2996631140","https://openalex.org/W2319806886","https://openalex.org/W4200052869","https://openalex.org/W1999250859","https://openalex.org/W7078745271","https://openalex.org/W2071359790","https://openalex.org/W2886296919","https://openalex.org/W1589149217","https://openalex.org/W1616592835"],"abstract_inverted_index":{"Taxol":[0],"(generic":[1],"name":[2],"paclitaxel)":[3],"is":[4,9,32,97],"a":[5,68,108],"microtubule-stabilizing":[6],"drug":[7],"that":[8,78,99,116],"approved":[10],"by":[11],"the":[12,18,71,112,125],"Food":[13],"and":[14,23,41,43,51,90,129],"Drug":[15],"Administration":[16],"for":[17],"treatment":[19],"of":[20,70,81,114,127,134,137],"ovarian,":[21],"breast,":[22],"lung":[24],"cancer,":[25],"as":[26,28],"well":[27],"Kaposi's":[29],"sarcoma.":[30],"It":[31,96],"used":[33,105],"off-label":[34],"to":[35,48,58,64,86,106,110],"treat":[36],"gastroesophageal,":[37],"endometrial,":[38],"cervical,":[39],"prostate,":[40],"head":[42],"neck":[44],"cancers,":[45],"in":[46,67,92],"addition":[47],"sarcoma,":[49],"lymphoma,":[50],"leukemia.":[52],"Paclitaxel":[53],"has":[54],"long":[55],"been":[56],"recognized":[57],"induce":[59],"mitotic":[60,88],"arrest,":[61],"which":[62],"leads":[63],"cell":[65],"death":[66],"subset":[69],"arrested":[72],"population.":[73],"However,":[74],"recent":[75],"evidence":[76],"demonstrates":[77],"intratumoral":[79],"concentrations":[80],"paclitaxel":[82,120,128],"are":[83],"too":[84],"low":[85],"cause":[87],"arrest":[89],"result":[91],"multipolar":[93],"divisions":[94],"instead.":[95],"hoped":[98],"this":[100],"insight":[101],"can":[102],"now":[103],"be":[104],"develop":[107],"biomarker":[109],"identify":[111],"\u223c50%":[113],"patients":[115],"will":[117],"benefit":[118],"from":[119],"therapy.":[121],"Here":[122],"I":[123],"discuss":[124],"history":[126],"our":[130],"recently":[131],"evolved":[132],"understanding":[133],"its":[135],"mechanism":[136],"action.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":135},{"year":2025,"cited_by_count":175},{"year":2024,"cited_by_count":186},{"year":2023,"cited_by_count":180},{"year":2022,"cited_by_count":192},{"year":2021,"cited_by_count":219},{"year":2020,"cited_by_count":147},{"year":2019,"cited_by_count":130},{"year":2018,"cited_by_count":94},{"year":2017,"cited_by_count":64},{"year":2016,"cited_by_count":34},{"year":2015,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}