{"id":"https://openalex.org/W2154736070","doi":"https://doi.org/10.1152/ajpcell.00168.2009","title":"Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1","display_name":"Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1","publication_year":2009,"publication_date":"2009-12-10","ids":{"openalex":"https://openalex.org/W2154736070","doi":"https://doi.org/10.1152/ajpcell.00168.2009","mag":"2154736070","pmid":"https://pubmed.ncbi.nlm.nih.gov/20007457"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.00168.2009","doi":"https://doi.org/10.1152/ajpcell.00168.2009","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00168.2009","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3232327","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011854092","display_name":"Marco Tulio N\u00fa\u00f1ez","orcid":"https://orcid.org/0000-0002-1967-8570","observed_orcids":["https://orcid.org/0000-0002-1967-8570"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Marco T. N\u00fa\u00f1ez","raw_affiliation_strings":["Cell Dynamics and Biotechnology Institute, Santiago, Chile;","Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Dynamics and Biotechnology Institute, Santiago, Chile;","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile;","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108209631","display_name":"Victoria Tapia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Victoria Tapia","raw_affiliation_strings":["Cell Dynamics and Biotechnology Institute, Santiago, Chile;","Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Dynamics and Biotechnology Institute, Santiago, Chile;","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile;","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019428194","display_name":"Alejandro Rojas\u2010Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-6004-5425","observed_orcids":["https://orcid.org/0000-0002-6004-5425","https://orcid.org/0000-0002-7183-9626"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Alejandro Rojas","raw_affiliation_strings":["Cell Dynamics and Biotechnology Institute, Santiago, Chile;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Dynamics and Biotechnology Institute, Santiago, Chile;","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014238545","display_name":"Pabla Aguirre","orcid":"https://orcid.org/0000-0003-3352-0574","observed_orcids":["https://orcid.org/0000-0003-3352-0574"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Pabla Aguirre","raw_affiliation_strings":["Cell Dynamics and Biotechnology Institute, Santiago, Chile;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Dynamics and Biotechnology Institute, Santiago, Chile;","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043247664","display_name":"Francisco J. G\u00f3mez","orcid":"https://orcid.org/0000-0002-8816-037X","observed_orcids":["https://orcid.org/0000-0002-8816-037X"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Francisco G\u00f3mez","raw_affiliation_strings":["Cell Dynamics and Biotechnology Institute, Santiago, Chile;","Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Dynamics and Biotechnology Institute, Santiago, Chile;","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile;","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030556066","display_name":"Francisco Nualart","orcid":"https://orcid.org/0000-0002-7762-1417","observed_orcids":["https://orcid.org/0000-0002-7762-1417"]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Francisco Nualart","raw_affiliation_strings":["Department of Cell Biology, Faculty of Biological Sciences, Santiago, Chile and Department of Cell Biology, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Faculty of Biological Sciences, Santiago, Chile and Department of Cell Biology, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011854092"],"corresponding_institution_ids":["https://openalex.org/I69737025"],"apc_list":null,"apc_paid":null,"fwci":2.6308,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.9051273,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"298","issue":"3","first_page":"C477","last_page":"C485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11418","display_name":"Plant Micronutrient Interactions and Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-iron-absorption","display_name":"intestinal iron absorption","score":0.9869999885559082},{"id":"https://openalex.org/keywords/divalent-metal-transporter-1","display_name":"DMT1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/ferroportin-1","display_name":"ferroportin 1","score":0.9300000071525574},{"id":"https://openalex.org/keywords/iron-transporters","display_name":"iron transporters","score":0.5199999809265137},{"id":"https://openalex.org/keywords/iron-flux","display_name":"iron flux","score":0.421999990940094},{"id":"https://openalex.org/keywords/duodenum","display_name":"duodenum","score":0.7379999756813049},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/transporter-internalization","display_name":"transporter internalization","score":0.597000002861023},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C2776531687","wikidata":"https://www.wikidata.org/wiki/Q14914133","display_name":"DMT1","level":4,"score":0.9093981981277466},{"id":"https://openalex.org/C3018436504","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Apical membrane","level":3,"score":0.7081311345100403},{"id":"https://openalex.org/C2776710925","wikidata":"https://www.wikidata.org/wiki/Q24777245","display_name":"Ferroportin","level":4,"score":0.6981019973754883},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.6521977186203003},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.6299784779548645},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5726116895675659},{"id":"https://openalex.org/C39587587","wikidata":"https://www.wikidata.org/wiki/Q5383698","display_name":"Epithelial polarity","level":3,"score":0.5586839318275452},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.5030421614646912},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5025248527526855},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4968154728412628},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4954627752304077},{"id":"https://openalex.org/C57947595","wikidata":"https://www.wikidata.org/wiki/Q7886088","display_name":"Membrane transport","level":3,"score":0.46307456493377686},{"id":"https://openalex.org/C188053792","wikidata":"https://www.wikidata.org/wiki/Q3640664","display_name":"Cotransporter","level":3,"score":0.4602334499359131},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.4567308723926544},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4465654194355011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3055255115032196},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2536749839782715},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2392939329147339},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1984178125858307},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.07602760195732117},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2911035656","wikidata":"https://www.wikidata.org/wiki/Q5925744","display_name":"Iron homeostasis","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000098742","descriptor_name":"Ferroportin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099236","descriptor_name":"Solute Carrier Family 11, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004386","descriptor_name":"Duodenum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005296","descriptor_name":"Ferrous Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005296","descriptor_name":"Ferrous Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1152/ajpcell.00168.2009","doi":"https://doi.org/10.1152/ajpcell.00168.2009","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00168.2009","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:20007457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20007457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Cell physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.915.7321","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.915.7321","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajpcell.physiology.org/content/ajpcell/298/3/C477.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.923.4112","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.923.4112","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://repositorio.uchile.cl/bitstream/handle/2250/119057/Nunez_Marco.pdf%3Bjsessionid%3DEB9031437F148F3A3093519998395BFD?sequence%3D1","raw_type":"text"},{"id":"pmh:oai:americanae.aecid.es:3232327","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3232327","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:localhost:10533/141567","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10533/141567","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorio.uchile.cl:2250/119057","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/119057","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo de revista"}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3232327","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3232327","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W127833933","https://openalex.org/W150407156","https://openalex.org/W1489844805","https://openalex.org/W1568628619","https://openalex.org/W1624438716","https://openalex.org/W1673334025","https://openalex.org/W1837842370","https://openalex.org/W1972385829","https://openalex.org/W1972580189","https://openalex.org/W1987873761","https://openalex.org/W1991349275","https://openalex.org/W1994834562","https://openalex.org/W1995921388","https://openalex.org/W1996072260","https://openalex.org/W1998441646","https://openalex.org/W2001984495","https://openalex.org/W2005488179","https://openalex.org/W2011262372","https://openalex.org/W2012669811","https://openalex.org/W2013435298","https://openalex.org/W2018432586","https://openalex.org/W2021399436","https://openalex.org/W2024633506","https://openalex.org/W2032110401","https://openalex.org/W2041420277","https://openalex.org/W2058454611","https://openalex.org/W2064230518","https://openalex.org/W2068345079","https://openalex.org/W2072929727","https://openalex.org/W2078904403","https://openalex.org/W2087390479","https://openalex.org/W2087740522","https://openalex.org/W2088091808","https://openalex.org/W2088926823","https://openalex.org/W2099846729","https://openalex.org/W2099892653","https://openalex.org/W2101748158","https://openalex.org/W2103738048","https://openalex.org/W2111555448","https://openalex.org/W2112030492","https://openalex.org/W2113822522","https://openalex.org/W2115550983","https://openalex.org/W2130662429","https://openalex.org/W2133623572","https://openalex.org/W2142792785","https://openalex.org/W2143900678","https://openalex.org/W2160159937","https://openalex.org/W2416197362"],"related_works":["https://openalex.org/W7095378091","https://openalex.org/W7100136792","https://openalex.org/W2130662429","https://openalex.org/W2053505784","https://openalex.org/W2103738048","https://openalex.org/W2146213816","https://openalex.org/W127833933","https://openalex.org/W2012669811","https://openalex.org/W2053525423","https://openalex.org/W2068358696"],"abstract_inverted_index":{"Intestinal":[0],"iron":[1,40,45,99,126,141,145,164,167,191,218,235],"absorption":[2,192],"comprises":[3],"the":[4,8,17,27,49,57,73,86,102,113,117,149,163,229],"coordinated":[5],"activity":[6],"of":[7,29,39,51,59,76,88,106,116,151,187,189,205,217,234],"influx":[9],"transporter":[10,13,19],"divalent":[11],"metal":[12],"1":[14],"(DMT1)":[15],"and":[16,31,56,108,124,143,153,171,174,178,196,203,207,211],"efflux":[18,173],"ferroportin":[20],"(FPN).":[21],"In":[22,42,70,110],"this":[23],"work,":[24],"we":[25],"studied":[26],"movement":[28,75],"DMT1":[30,52,80,107,136,152,206],"FPN":[32,63,138,154,208],"between":[33,209],"cellular":[34],"compartments":[35,213],"as":[36,214],"a":[37,184,215],"function":[38,216],"supply.":[41,219],"rat":[43],"duodenum,":[44],"gavage":[46],"resulted":[47],"in":[48,67,94,155,228],"relocation":[50],"to":[53,135,225],"basal":[54,172,176],"domains":[55],"internalization":[58],"basolateral":[60,140],"FPN.":[61,109],"Considerable":[62],"was":[64,81],"also":[65],"found":[66],"apical":[68,144,169,179],"domains.":[69,131],"Caco-2":[71,95],"cells,":[72],"apical-to-basal":[74],"cyan":[77],"fluorescent":[78],"protein-tagged":[79],"complete":[82],"90":[83],"min":[84],"after":[85],"addition":[87],"iron.":[89],"Steady-state":[90],"membrane":[91,104,114,130,201,210],"localization":[92],"studies":[93],"cells":[96],"revealed":[97,122],"that":[98],"status":[100],"determined":[101],"apical/basolateral":[103],"distribution":[105,115],"agreement":[111],"with":[112],"transporters,":[118],"(55)Fe":[119],"flux":[120],"experiments":[121],"inward":[123,195],"outward":[125,197],"fluxes":[127,159,198],"at":[128,199],"both":[129,200],"Antisense":[132],"oligonucleotides":[133],"targeted":[134],"or":[137,231],"inhibited":[139],"uptake":[142,170,177],"efflux,":[146],"respectively,":[147],"indicating":[148],"participation":[150],"these":[156],"fluxes.":[157],"The":[158],"were":[160],"regulated":[161],"by":[162],"supply;":[165],"increased":[166,175],"reduced":[168],"efflux.":[180],"These":[181],"findings":[182],"suggest":[183],"novel":[185],"mechanism":[186,221],"regulation":[188,233],"intestinal":[190],"based":[193,227],"on":[194],"domains,":[202],"repositioning":[204],"intracellular":[212],"This":[220],"should":[222],"be":[223],"complementary":[224],"those":[226],"transcriptional":[230],"translational":[232],"transport":[236],"proteins.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}