{"id":"https://openalex.org/W2154508650","doi":"https://doi.org/10.1073/pnas.97.6.2668","title":"Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice","display_name":"Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice","publication_year":2000,"publication_date":"2000-03-14","ids":{"openalex":"https://openalex.org/W2154508650","doi":"https://doi.org/10.1073/pnas.97.6.2668","mag":"2154508650","pmid":"https://pubmed.ncbi.nlm.nih.gov/10716994","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/15987"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.97.6.2668","doi":"https://doi.org/10.1073/pnas.97.6.2668","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.97.6.2668","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/15987","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109186474","display_name":"Yansong Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yansong Gu","raw_affiliation_strings":["Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103010007","display_name":"JoAnn Sekiguchi","orcid":"https://orcid.org/0000-0002-7178-4258","observed_orcids":["https://orcid.org/0000-0002-7178-4258"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JoAnn Sekiguchi","raw_affiliation_strings":["Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108026850","display_name":"Yijie Gao","orcid":"https://orcid.org/0000-0002-6640-8821","observed_orcids":["https://orcid.org/0000-0002-6640-8821"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yijie Gao","raw_affiliation_strings":["Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041258339","display_name":"Pieter Dikkes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pieter Dikkes","raw_affiliation_strings":["Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018348776","display_name":"Karen M. Frank","orcid":"https://orcid.org/0000-0002-9970-4133","observed_orcids":["https://orcid.org/0000-0002-9970-4133"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Frank","raw_affiliation_strings":["Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020196646","display_name":"David O. Ferguson","orcid":"https://orcid.org/0009-0004-7792-5236","observed_orcids":["https://orcid.org/0009-0004-7792-5236"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Ferguson","raw_affiliation_strings":["Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020966290","display_name":"Paul Hasty","orcid":"https://orcid.org/0000-0003-3046-0131","observed_orcids":["https://orcid.org/0000-0003-3046-0131"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Hasty","raw_affiliation_strings":["Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014799222","display_name":"Jerold J. M. Chun","orcid":"https://orcid.org/0000-0003-3964-0921","observed_orcids":["https://orcid.org/0000-0003-3964-0921"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerold Chun","raw_affiliation_strings":["Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033821931","display_name":"Frederick W. Alt","orcid":"https://orcid.org/0000-0002-0583-1271","observed_orcids":["https://orcid.org/0000-0002-0583-1271"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick W. Alt","raw_affiliation_strings":["Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Children's Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Neurology, The Children's Hospital, Boston, MA 02115; Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381; and Department of Pharmacology, Neuroscience Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.7987,"has_fulltext":false,"cited_by_count":194,"citation_normalized_percentile":{"value":0.9796999,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"97","issue":"6","first_page":"2668","last_page":"2673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.8930000066757202},{"id":"https://openalex.org/keywords/ku70","display_name":"Ku70","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ku80","display_name":"Ku80","score":1.0},{"id":"https://openalex.org/keywords/dna-pkcs","display_name":"DNA-PKcs","score":0.8569999933242798},{"id":"https://openalex.org/keywords/xrcc4","display_name":"XRCC4","score":0.925000011920929},{"id":"https://openalex.org/keywords/dna-ligase-iv","display_name":"DNA ligase IV","score":0.996999979019165},{"id":"https://openalex.org/keywords/embryonic-neurogenesis","display_name":"embryonic neurogenesis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.8360000252723694},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.8349999785423279},{"id":"https://openalex.org/keywords/v-d-j-recombination","display_name":"V(D)J recombination","score":0.9629999995231628},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C193104389","wikidata":"https://www.wikidata.org/wiki/Q18032397","display_name":"Ku80","level":5,"score":0.9533215761184692},{"id":"https://openalex.org/C2780919815","wikidata":"https://www.wikidata.org/wiki/Q6440930","display_name":"Ku70","level":4,"score":0.9449232816696167},{"id":"https://openalex.org/C145803527","wikidata":"https://www.wikidata.org/wiki/Q18032396","display_name":"DNA repair protein XRCC4","level":5,"score":0.7886383533477783},{"id":"https://openalex.org/C122917832","wikidata":"https://www.wikidata.org/wiki/Q2065945","display_name":"Non-homologous end joining","level":4,"score":0.6994266510009766},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.6942003965377808},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6495314836502075},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5628855228424072},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5031668543815613},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48680636286735535},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.470523476600647},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.41414642333984375},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3707369565963745},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2769538164138794},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.14323896169662476},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10010141134262085},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.07881531119346619},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.07014769315719604}],"mesh":[{"descriptor_ui":"D000072200","descriptor_name":"Ku Autoantigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072481","descriptor_name":"DNA Ligase ATP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004027","descriptor_name":"Diencephalon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004027","descriptor_name":"Diencephalon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011088","descriptor_name":"DNA Ligases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034961","descriptor_name":"Antigens, Nuclear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051747","descriptor_name":"DNA-Activated Protein Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.97.6.2668","doi":"https://doi.org/10.1073/pnas.97.6.2668","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.97.6.2668","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1780774","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/15987","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:15987","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/15987","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:10716994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10716994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1780774","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/15987","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3907347489","display_name":null,"funder_award_id":"AI-35714","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G6064730503","display_name":null,"funder_award_id":"A.I.01428","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G7092276000","display_name":"EMBRYONIC CORTICAL APOPTOSIS ROLES AND REGULATIONS","funder_award_id":"R01NS036949","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1538906753","https://openalex.org/W1660787335","https://openalex.org/W1969778579","https://openalex.org/W1976450800","https://openalex.org/W1987850577","https://openalex.org/W1988845313","https://openalex.org/W1992688638","https://openalex.org/W1995284691","https://openalex.org/W1999105804","https://openalex.org/W2001558290","https://openalex.org/W2015090136","https://openalex.org/W2017351036","https://openalex.org/W2018609920","https://openalex.org/W2020791858","https://openalex.org/W2020869819","https://openalex.org/W2025277965","https://openalex.org/W2044385625","https://openalex.org/W2051147717","https://openalex.org/W2056508303","https://openalex.org/W2059956556","https://openalex.org/W2069638671","https://openalex.org/W2075784029","https://openalex.org/W2076083889","https://openalex.org/W2088909687","https://openalex.org/W2106605041","https://openalex.org/W2109456034","https://openalex.org/W2110496051","https://openalex.org/W2112963987","https://openalex.org/W2126464081","https://openalex.org/W2129650777","https://openalex.org/W2140489687","https://openalex.org/W2144133290","https://openalex.org/W2159314125","https://openalex.org/W2163827697","https://openalex.org/W2167700185","https://openalex.org/W2414063588","https://openalex.org/W6635807325"],"related_works":["https://openalex.org/W3111383854","https://openalex.org/W2001558290","https://openalex.org/W4380356871","https://openalex.org/W1660787335","https://openalex.org/W2739256644","https://openalex.org/W2017351036","https://openalex.org/W1992688638","https://openalex.org/W2953525652","https://openalex.org/W2134920248","https://openalex.org/W2138061696"],"abstract_inverted_index":{"Mammalian":[0],"nonhomologous":[1,118],"DNA":[2,16,119],"end":[3,88,100,120],"joining":[4,89,101,121],"employs":[5],"Ku70,":[6],"Ku80,":[7],"DNA-dependent":[8],"protein":[9],"kinase":[10],"catalytic":[11],"subunit":[12],"(DNA-PKcs),":[13],"XRCC4,":[14],"and":[15,25,58,71],"ligase":[17],"IV":[18],"(Lig4).":[19],"Herein,":[20],"we":[21],"show":[22],"that":[23,54,105],"Ku70":[24],"Ku80":[26],"deficiency":[27,31],"but":[28,50],"not":[29],"DNA-PKcs":[30],"results":[32],"in":[33,41,68,90],"dramatically":[34],"increased":[35],"death":[36,66],"of":[37,63,75,86,108],"developing":[38],"embryonic":[39],"neurons":[40],"mice.":[42],"The":[43,61],"Ku-deficient":[44,76],"phenotype":[45,67,74],"is":[46],"qualitatively":[47],"similar":[48],"to,":[49],"less":[51],"severe":[52],"than,":[53],"associated":[55],"with":[56,83],"XRCC4":[57],"Lig4":[59],"deficiency.":[60],"lack":[62],"a":[64,97],"neuronal":[65],"DNA-PKcs-deficient":[69],"embryos":[70,81],"the":[72,109,114],"milder":[73],"versus":[77],"XRCC4-":[78],"or":[79],"Lig4-deficient":[80],"correlate":[82],"relative":[84],"leakiness":[85],"residual":[87],"these":[91],"mutant":[92],"backgrounds":[93],"as":[94],"assayed":[95],"by":[96],"V(D)J":[98],"recombination":[99],"assay.":[102],"We":[103],"conclude":[104],"normal":[106],"development":[107],"nervous":[110],"system":[111],"depends":[112],"on":[113],"four":[115],"evolutionarily":[116],"conserved":[117],"factors.":[122]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}