{"id":"https://openalex.org/W2154473343","doi":"https://doi.org/10.1161/01.atv.12.11.1305","title":"Long-term nicotine exposure increases aortic endothelial cell death and enhances transendothelial macromolecular transport in rats.","display_name":"Long-term nicotine exposure increases aortic endothelial cell death and enhances transendothelial macromolecular transport in rats.","publication_year":1992,"publication_date":"1992-11-01","ids":{"openalex":"https://openalex.org/W2154473343","doi":"https://doi.org/10.1161/01.atv.12.11.1305","mag":"2154473343","pmid":"https://pubmed.ncbi.nlm.nih.gov/1420090"},"language":"en","primary_location":{"id":"doi:10.1161/01.atv.12.11.1305","doi":"https://doi.org/10.1161/01.atv.12.11.1305","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.12.11.1305","pdf_url":null,"source":{"id":"https://openalex.org/S4210240347","display_name":"Arteriosclerosis and Thrombosis A Journal of Vascular Biology","issn_l":"1049-8834","issn":["1049-8834","2330-9199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis and Thrombosis: A Journal of Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111539223","display_name":"S.J Lin","orcid":"https://orcid.org/0000-0003-0470-2184","observed_orcids":["https://orcid.org/0000-0003-0470-2184"]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"S J Lin","raw_affiliation_strings":["Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","S J Lin Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"S J Lin Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","institution_ids":["https://openalex.org/I2803004286"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C Y Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C Y Hong","raw_affiliation_strings":["Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","C Y Hong Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"C Y Hong Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","institution_ids":["https://openalex.org/I2803004286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108404866","display_name":"Mau-Song Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"M S Chang","raw_affiliation_strings":["Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","M S Chang Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"M S Chang Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","institution_ids":["https://openalex.org/I2803004286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111651764","display_name":"Benjamin N. Chiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"B N Chiang","raw_affiliation_strings":["Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","B N Chiang Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"B N Chiang Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","institution_ids":["https://openalex.org/I2803004286"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068335042","display_name":"Shu Chien","orcid":"https://orcid.org/0000-0003-0332-285X","observed_orcids":["https://orcid.org/0000-0003-0332-285X"]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"S Chien","raw_affiliation_strings":["Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","S Chien Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"S Chien Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC","institution_ids":["https://openalex.org/I2803004286"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2803004286"],"apc_list":null,"apc_paid":null,"fwci":1.3466,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.82914279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"12","issue":"11","first_page":"1305","last_page":"1312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.2667999863624573,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.051500000059604645,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.949999988079071},{"id":"https://openalex.org/keywords/endothelial-cell-death","display_name":"endothelial cell death","score":0.9380000233650208},{"id":"https://openalex.org/keywords/aortic-endothelium","display_name":"aortic endothelium","score":0.8190000057220459},{"id":"https://openalex.org/keywords/evans-blue-albumin","display_name":"Evans blue albumin","score":0.8370000123977661},{"id":"https://openalex.org/keywords/atherogenesis","display_name":"atherogenesis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.9279999732971191},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.7770000100135803},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.6986746788024902},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.6661645174026489},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.6016294360160828},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5021002292633057},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4753934144973755},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.44732943177223206},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.44474729895591736},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4249565303325653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38930436968803406},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37679511308670044},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3757449686527252},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34695348143577576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1501060426235199},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1463918387889862},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005070","descriptor_name":"Evans Blue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.atv.12.11.1305","doi":"https://doi.org/10.1161/01.atv.12.11.1305","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.12.11.1305","pdf_url":null,"source":{"id":"https://openalex.org/S4210240347","display_name":"Arteriosclerosis and Thrombosis A Journal of Vascular Biology","issn_l":"1049-8834","issn":["1049-8834","2330-9199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis and Thrombosis: A Journal of Vascular Biology","raw_type":"journal-article"},{"id":"pmid:1420090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1420090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis and thrombosis : a journal of vascular biology","raw_type":"Journal Article"},{"id":"mag:3147362573","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/atv91.12.11.1420090","pdf_url":null,"source":{"id":"https://openalex.org/S4210240347","display_name":"Arteriosclerosis and Thrombosis A Journal of Vascular Biology","issn_l":"1049-8834","issn":["1049-8834","2330-9199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Arteriosclerosis and Thrombosis: A Journal of Vascular Biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W42896681","https://openalex.org/W1520438062","https://openalex.org/W1551251634","https://openalex.org/W1572220130","https://openalex.org/W1869971420","https://openalex.org/W1965447052","https://openalex.org/W1976051084","https://openalex.org/W1977258455","https://openalex.org/W1994360551","https://openalex.org/W2006387884","https://openalex.org/W2013301971","https://openalex.org/W2017704303","https://openalex.org/W2018934550","https://openalex.org/W2019627459","https://openalex.org/W2039446574","https://openalex.org/W2040096371","https://openalex.org/W2047264508","https://openalex.org/W2049889762","https://openalex.org/W2052660608","https://openalex.org/W2061755142","https://openalex.org/W2063685010","https://openalex.org/W2079390866","https://openalex.org/W2085308496","https://openalex.org/W2085477708","https://openalex.org/W2091524925","https://openalex.org/W2102380698","https://openalex.org/W2105257626","https://openalex.org/W2107435066","https://openalex.org/W2114557499","https://openalex.org/W2128175749","https://openalex.org/W2147662671","https://openalex.org/W2151671348","https://openalex.org/W2325040893","https://openalex.org/W2329800128","https://openalex.org/W2333119610","https://openalex.org/W2335212019","https://openalex.org/W2340819127","https://openalex.org/W2397041975","https://openalex.org/W2403691727","https://openalex.org/W3023642540"],"related_works":["https://openalex.org/W1572220130","https://openalex.org/W1520438062","https://openalex.org/W3015301382","https://openalex.org/W1551793060","https://openalex.org/W3129800431","https://openalex.org/W2065957257","https://openalex.org/W2047264508","https://openalex.org/W3101123593","https://openalex.org/W2766418426","https://openalex.org/W4380683419"],"abstract_inverted_index":{"Repeated":[0],"endothelial":[1,16,58,130,140,167,188],"cell":[2,59,189],"injury":[3],"has":[4],"been":[5,19],"suggested":[6],"as":[7,114],"an":[8],"initiating":[9],"factor":[10],"in":[11,84,161,233,237],"atherogenesis.":[12],"Dying":[13],"or":[14,128],"dead":[15,129,166],"cells":[17,131,168],"have":[18],"shown":[20],"to":[21,25,104,142],"make":[22],"significant":[23],"contributions":[24],"the":[26,39,47,55,109,115,135,185,208],"local":[27],"enhancement":[28],"of":[29,38,57,77,91,96,122,165,179,187,211],"transendothelial":[30,63],"macromolecular":[31,64],"transport.":[32,65],"Since":[33],"cigarette":[34],"smoking":[35,50],"is":[36],"one":[37],"major":[40],"risk":[41],"factors":[42],"for":[43,177],"atherosclerosis,":[44],"we":[45],"examined":[46],"hypothesis":[48],"that":[49,160],"accelerates":[51],"atherogenesis":[52],"by":[53,134,154,201,225],"increasing":[54],"frequency":[56,186],"death":[60,190],"and":[61,106,139,207],"hence":[62],"Sixteen":[66],"male":[67,99],"Sprague-Dawley":[68,100],"rats":[69,101,235],"were":[70,132,169,230],"given":[71],"nicotine":[72,105],"at":[73],"a":[74,89],"weight-adjusted":[75],"dose":[76],"5":[78],"mg/kg":[79],"body":[80],"wt":[81],"per":[82],"day":[83],"their":[85],"drinking":[86],"water":[87],"over":[88,108],"period":[90,112],"6":[92],"weeks.":[93],"A":[94],"group":[95],"16":[97],"age-matched":[98],"not":[102],"exposed":[103],"maintained":[107],"same":[110],"time":[111],"served":[113],"control":[116,238],"group.":[117],"In":[118],"en":[119],"face":[120],"preparations":[121],"thoracic":[123],"aorta,":[124],"immunoglobulin":[125],"G-containing":[126],"dying":[127],"identified":[133],"indirect":[136],"immunoperoxidase":[137],"method,":[138],"leakage":[141],"Evans":[143],"blue-albumin":[144],"(EBA)":[145],"complexes":[146],"(5":[147],"minutes":[148],"after":[149],"intravenous":[150],"injection)":[151],"was":[152,175],"visualized":[153],"fluorescence":[155],"microscopy.":[156],"The":[157],"results":[158],"showed":[159],"nicotine-treated":[162,234],"rats,":[163],"51%":[164],"associated":[170],"with":[171],"EBA":[172,181,212],"leakage,":[173],"which":[174],"responsible":[176],"57%":[178],"total":[180],"leaky":[182,213],"foci.":[183],"Both":[184],"(0.94":[191],"+/-":[192,196,216,220],"0.11%":[193],"versus":[194,218],"0.40":[195],"0.04%,":[197],"p":[198,222],"<":[199,223],"0.0001":[200],"two-tailed,":[202,226],"unpaired":[203,227],"Student's":[204],"t":[205,228],"test)":[206,229],"number":[209],"density":[210],"foci":[214],"(6.45":[215],"1.23/mm2":[217],"3.30":[219],"0.49/mm2,":[221],"0.05":[224],"significantly":[231],"greater":[232],"than":[236],"rats.(ABSTRACT":[239],"TRUNCATED":[240],"AT":[241],"250":[242],"WORDS)":[243]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
