{"id":"https://openalex.org/W2154388708","doi":"https://doi.org/10.1161/01.cir.0000027109.14149.67","title":"Impaired Nitric Oxide Synthase Pathway in Diabetes Mellitus","display_name":"Impaired Nitric Oxide Synthase Pathway in Diabetes Mellitus","publication_year":2002,"publication_date":"2002-08-20","ids":{"openalex":"https://openalex.org/W2154388708","doi":"https://doi.org/10.1161/01.cir.0000027109.14149.67","mag":"2154388708","pmid":"https://pubmed.ncbi.nlm.nih.gov/12186805"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.0000027109.14149.67","doi":"https://doi.org/10.1161/01.cir.0000027109.14149.67","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.0000027109.14149.67","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085387677","display_name":"Ken Yu Lin","orcid":"https://orcid.org/0000-0002-8516-7971","observed_orcids":["https://orcid.org/0000-0002-8516-7971"]},"institutions":[{"id":"https://openalex.org/I193620225","display_name":"Okayama Prefectural University","ror":"https://ror.org/038bgk418","country_code":"JP","type":"education","lineage":["https://openalex.org/I193620225"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Ken Y. Lin","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","Ken Y. Lin From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Ken Y. Lin From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101521187","display_name":"Akira Ito","orcid":"https://orcid.org/0000-0002-7064-9863","observed_orcids":["https://orcid.org/0000-0002-7064-9863"]},"institutions":[{"id":"https://openalex.org/I193620225","display_name":"Okayama Prefectural University","ror":"https://ror.org/038bgk418","country_code":"JP","type":"education","lineage":["https://openalex.org/I193620225"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Akira Ito","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","Akira Ito From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Akira Ito From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043812180","display_name":"Tomoko Asagami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193620225","display_name":"Okayama Prefectural University","ror":"https://ror.org/038bgk418","country_code":"JP","type":"education","lineage":["https://openalex.org/I193620225"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Tomoko Asagami","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","Tomoko Asagami From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Tomoko Asagami From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058198453","display_name":"Philip S. Tsao","orcid":"https://orcid.org/0000-0001-7274-9318","observed_orcids":["https://orcid.org/0000-0001-7274-9318"]},"institutions":[{"id":"https://openalex.org/I193620225","display_name":"Okayama Prefectural University","ror":"https://ror.org/038bgk418","country_code":"JP","type":"education","lineage":["https://openalex.org/I193620225"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Philip S. Tsao","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","Philip S. Tsao From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Philip S. Tsao From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058002808","display_name":"Shanthi Adimoolam","orcid":"https://orcid.org/0009-0002-6459-4867","observed_orcids":["https://orcid.org/0009-0002-6459-4867"]},"institutions":[{"id":"https://openalex.org/I193620225","display_name":"Okayama Prefectural University","ror":"https://ror.org/038bgk418","country_code":"JP","type":"education","lineage":["https://openalex.org/I193620225"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Shanthi Adimoolam","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","Shanthi Adimoolam From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Shanthi Adimoolam From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070628886","display_name":"Masumi Kimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193620225","display_name":"Okayama Prefectural University","ror":"https://ror.org/038bgk418","country_code":"JP","type":"education","lineage":["https://openalex.org/I193620225"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Masumi Kimoto","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","Masumi Kimoto From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Masumi Kimoto From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020475566","display_name":"Hideaki Tsuji","orcid":"https://orcid.org/0000-0002-2521-246X","observed_orcids":["https://orcid.org/0000-0002-2521-246X"]},"institutions":[{"id":"https://openalex.org/I193620225","display_name":"Okayama Prefectural University","ror":"https://ror.org/038bgk418","country_code":"JP","type":"education","lineage":["https://openalex.org/I193620225"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hideaki Tsuji","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","Hideaki Tsuji From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Hideaki Tsuji From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113596148","display_name":"Gerald M. Reaven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193620225","display_name":"Okayama Prefectural University","ror":"https://ror.org/038bgk418","country_code":"JP","type":"education","lineage":["https://openalex.org/I193620225"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Gerald M. Reaven","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","Gerald M. Reaven From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Gerald M. Reaven From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039670487","display_name":"John P. Cooke","orcid":"https://orcid.org/0000-0003-0033-9138","observed_orcids":["https://orcid.org/0000-0003-0033-9138"]},"institutions":[{"id":"https://openalex.org/I193620225","display_name":"Okayama Prefectural University","ror":"https://ror.org/038bgk418","country_code":"JP","type":"education","lineage":["https://openalex.org/I193620225"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"John P. Cooke","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","John P. Cooke From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"John P. Cooke From the Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif (K.Y.L., A.I., T.A., P.S.T., S.A., G.M.R., J.P.C.), and the Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K., H.T.)","institution_ids":["https://openalex.org/I193620225","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":22.6,"has_fulltext":false,"cited_by_count":653,"citation_normalized_percentile":{"value":0.99785867,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"106","issue":"8","first_page":"987","last_page":"992"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asymmetric-dimethylarginine","display_name":"asymmetric dimethylarginine","score":0.949999988079071},{"id":"https://openalex.org/keywords/dimethylarginine-dimethylaminohydrolase","display_name":"dimethylarginine dimethylaminohydrolase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.7950000166893005},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8029999732971191},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cgmp-synthesis","display_name":"cGMP production","score":0.7080000042915344},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7049999833106995},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C2779877776","wikidata":"https://www.wikidata.org/wiki/Q752685","display_name":"Asymmetric dimethylarginine","level":4,"score":0.886022686958313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8840706944465637},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8563601970672607},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6649483442306519},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6448788642883301},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.6111456155776978},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5901293158531189},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5798084735870361},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.518636167049408},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.43581992387771606},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.43335071206092834},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.42847511172294617},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.34524691104888916},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2092442810535431},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13826745748519897},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.cir.0000027109.14149.67","doi":"https://doi.org/10.1161/01.cir.0000027109.14149.67","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.0000027109.14149.67","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:12186805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12186805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.528.9604","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.528.9604","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/106/8/987.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3070770366","display_name":"Transplant Arteriosclerosis: Viral and Host Mechanism","funder_award_id":"P01AI050153","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7259869434","display_name":"MANIPULATION OF THE NOS PATHWAY IN ARTERIAL DISEASE","funder_award_id":"R01HL063685","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320328054","display_name":"Japan Heart Foundation","ror":"https://ror.org/008qgm855"},{"id":"https://openalex.org/F4320333871","display_name":"Bayer Yakuhin","ror":"https://ror.org/05arv2073"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W117721727","https://openalex.org/W1583601846","https://openalex.org/W1834350010","https://openalex.org/W1952735225","https://openalex.org/W1970798352","https://openalex.org/W1974041941","https://openalex.org/W1990868483","https://openalex.org/W1991763489","https://openalex.org/W2000881220","https://openalex.org/W2008552265","https://openalex.org/W2013529909","https://openalex.org/W2016833774","https://openalex.org/W2026800046","https://openalex.org/W2029094496","https://openalex.org/W2034825883","https://openalex.org/W2054433514","https://openalex.org/W2057116025","https://openalex.org/W2058385357","https://openalex.org/W2065374983","https://openalex.org/W2073133399","https://openalex.org/W2100071011","https://openalex.org/W2101432960","https://openalex.org/W2106478344","https://openalex.org/W2107818859","https://openalex.org/W2109964559","https://openalex.org/W2111787122","https://openalex.org/W2112538182","https://openalex.org/W2117155692","https://openalex.org/W2126795982","https://openalex.org/W2134293572","https://openalex.org/W2141537184","https://openalex.org/W2145899271","https://openalex.org/W2148531805","https://openalex.org/W2151296579","https://openalex.org/W2151554519","https://openalex.org/W2157346067","https://openalex.org/W2161887334","https://openalex.org/W2166969544","https://openalex.org/W2169061609","https://openalex.org/W2231694041","https://openalex.org/W2328664855","https://openalex.org/W2345903479","https://openalex.org/W2413662182","https://openalex.org/W2415194500"],"related_works":["https://openalex.org/W7097169682","https://openalex.org/W2043426107","https://openalex.org/W2016315662","https://openalex.org/W2133335467","https://openalex.org/W2050633476","https://openalex.org/W2418074275","https://openalex.org/W2369345913","https://openalex.org/W2444616321","https://openalex.org/W2365858143","https://openalex.org/W4310486508"],"abstract_inverted_index":{"BACKGROUND:":[0],"An":[1],"endogenous":[2],"inhibitor":[3],"of":[4,76,117,128,135,154,170],"nitric":[5],"oxide":[6],"synthase,":[7],"asymmetric":[8],"dimethylarginine":[9,77],"(ADMA),":[10],"is":[11],"elevated":[12,30,61],"in":[13,31,47,62,82,99,120,133,182],"patients":[14],"with":[15,49,88,125,142],"type":[16,55],"2":[17,56],"diabetes":[18],"mellitus":[19],"(DM).":[20],"This":[21],"study":[22],"explored":[23],"the":[24,74,143,152,155],"mechanisms":[25],"by":[26],"which":[27],"ADMA":[28,59,91,129,161,173],"becomes":[29],"DM.":[32,57,183],"METHODS":[33],"AND":[34],"RESULTS:":[35],"Male":[36],"Sprague-Dawley":[37],"rats":[38,64,84],"were":[39],"fed":[40],"normal":[41],"chow":[42],"or":[43],"high-fat":[44],"diet":[45],"(n=5":[46],"each)":[48],"moderate":[50],"streptozotocin":[51],"injection":[52],"to":[53,110,178],"induce":[54],"Plasma":[58],"was":[60,80,96,123],"diabetic":[63,83],"(1.33+/-0.31":[65],"versus":[66],"0.48+/-0.08":[67],"micromol/L;":[68],"P<0.05).":[69],"The":[70,115],"activity,":[71,160],"but":[72],"not":[73],"expression,":[75],"dimethylaminohydrolase":[78],"(DDAH)":[79],"reduced":[81,98],"and":[85,104,130,163,175],"negatively":[86],"correlated":[87],"their":[89],"plasma":[90],"levels":[92],"(P<0.05).":[93],"DDAH":[94,118,159,171],"activity":[95,119],"significantly":[97],"vascular":[100,121],"smooth":[101],"muscle":[102],"cells":[103,107,122],"human":[105,138],"endothelial":[106,139,179],"(HMEC-1)":[108],"exposed":[109],"high":[111],"glucose":[112],"(25.5":[113],"mmol/L).":[114],"impairment":[116,169],"associated":[124],"an":[126],"accumulation":[127,174],"a":[131],"reduction":[132],"generation":[134],"cGMP.":[136],"In":[137],"cells,":[140],"coincubation":[141],"antioxidant":[144],"polyethylene":[145],"glycol-conjugated":[146],"superoxide":[147],"dismutase":[148],"(22":[149],"U/mL)":[150],"reversed":[151],"effects":[153],"high-glucose":[156],"condition":[157],"on":[158],"accumulation,":[162],"cGMP":[164],"synthesis.":[165],"CONCLUSIONS:":[166],"A":[167],"glucose-induced":[168],"causes":[172],"may":[176],"contribute":[177],"vasodilator":[180],"dysfunction":[181]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":27},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":36},{"year":2012,"cited_by_count":33}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
