{"id":"https://openalex.org/W2154383333","doi":null,"title":"A subcutaneous tissue reaction in the early stage to a synthetic auditory ossicle (Bioceram) in rats.","display_name":"A subcutaneous tissue reaction in the early stage to a synthetic auditory ossicle (Bioceram) in rats.","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W2154383333","mag":"2154383333","pmid":"https://pubmed.ncbi.nlm.nih.gov/9597805"},"language":"en","primary_location":{"id":"pmid:9597805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9597805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of medical investigation : JMI","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://tokushima-u.repo.nii.ac.jp/records/2003860","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Q Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Q Ye","raw_affiliation_strings":["First Department of Pathology, University Hospital, University of Tokushima School of Medicine, Japan","Tokushima University,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pathology, University Hospital, University of Tokushima School of Medicine, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Tokushima University,","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112096617","display_name":"Katsuichiro Ohsaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Ohsaki","raw_affiliation_strings":["Tokushima University,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima University,","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110758872","display_name":"Kunio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Ii","raw_affiliation_strings":["Tokushima University,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima University,","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111970053","display_name":"Dong Jun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"D J Li","raw_affiliation_strings":["Tokushima University,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima University,","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082160788","display_name":"Hiroshi Matsuoka","orcid":"https://orcid.org/0000-0003-4443-4372","observed_orcids":["https://orcid.org/0000-0003-4443-4372"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Matsuoka","raw_affiliation_strings":["Tokushima University,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima University,","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045991264","display_name":"Satoru Tenshin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Tenshin","raw_affiliation_strings":["Tokushima University,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima University,","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044455122","display_name":"Teruko Takano Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Yamamoto","raw_affiliation_strings":["DEN - Dental Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DEN - Dental Sciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.298,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.58999864,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"44","issue":"3-4","first_page":"173","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.0697999969124794,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alumina","display_name":"alumina","score":0.7300000190734863},{"id":"https://openalex.org/keywords/subcutaneous-implantation","display_name":"subcutaneous implantation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.7590000033378601},{"id":"https://openalex.org/keywords/foreign-body-reaction","display_name":"foreign body reaction","score":0.7730000019073486},{"id":"https://openalex.org/keywords/acute-inflammation","display_name":"acute inflammation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.753000020980835},{"id":"https://openalex.org/keywords/foreign-body-giant-cells","display_name":"foreign body giant cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9850000143051147},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9350000023841858},{"id":"https://openalex.org/keywords/bioimplants","display_name":"bioimplants","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2777038747","wikidata":"https://www.wikidata.org/wiki/Q17151027","display_name":"Ossicle","level":3,"score":0.6982690095901489},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6572396755218506},{"id":"https://openalex.org/C2777300098","wikidata":"https://www.wikidata.org/wiki/Q1164665","display_name":"Subcutaneous tissue","level":2,"score":0.6519635915756226},{"id":"https://openalex.org/C77076574","wikidata":"https://www.wikidata.org/wiki/Q2152526","display_name":"Giant cell","level":2,"score":0.632211446762085},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.6002013683319092},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.44143715500831604},{"id":"https://openalex.org/C2994442579","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"Inflammatory cell","level":3,"score":0.412764310836792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.411994993686676},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.40875792503356934},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39913812279701233},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3788739740848541},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2269258201122284},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.1472185254096985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13412830233573914},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08124515414237976},{"id":"https://openalex.org/C2777846895","wikidata":"https://www.wikidata.org/wiki/Q501553","display_name":"Middle ear","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000537","descriptor_name":"Aluminum Oxide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001705","descriptor_name":"Bioprosthesis","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002516","descriptor_name":"Ceramics","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004429","descriptor_name":"Ear Ossicles","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9597805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9597805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of medical investigation : JMI","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00906:0006775839","doi":null,"is_oa":true,"landing_page_url":"https://tokushima-u.repo.nii.ac.jp/records/2003860","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of medical investigation : JMI","raw_type":"journal article"},{"id":"mag:2154383333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9597805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:00906:0006775839","doi":null,"is_oa":true,"landing_page_url":"https://tokushima-u.repo.nii.ac.jp/records/2003860","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of medical investigation : JMI","raw_type":"journal article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W51309640","https://openalex.org/W168035084","https://openalex.org/W1555954838","https://openalex.org/W1976230888","https://openalex.org/W2036445761","https://openalex.org/W2050592154","https://openalex.org/W2087320214","https://openalex.org/W2095438398","https://openalex.org/W2112499661","https://openalex.org/W2130662310","https://openalex.org/W2132049300","https://openalex.org/W2143699259","https://openalex.org/W2403398073","https://openalex.org/W2403931570"],"related_works":["https://openalex.org/W2107769528","https://openalex.org/W145929233","https://openalex.org/W2107870989","https://openalex.org/W7096808349","https://openalex.org/W2112499661","https://openalex.org/W2330347456","https://openalex.org/W2512233454","https://openalex.org/W2137091356","https://openalex.org/W2081687292","https://openalex.org/W2366891012"],"abstract_inverted_index":{"The":[0,24,38,146],"discs":[1],"of":[2,10,21,122,136,165],"synthetic":[3],"auditory":[4],"ossicle":[5],"(Bioceram),":[6],"which":[7,69],"are":[8],"composed":[9],"aluminium":[11],"oxide":[12],"(Al2O3),":[13],"were":[14,27,44,54,99],"implanted":[15,25],"subcutaneously":[16],"in":[17,68,101,110,114],"the":[18,52,115,119,125,131,144,163],"interscapular":[19],"region":[20],"16":[22],"rats.":[23],"specimens":[26],"removed":[28],"at":[29,65,77,88,105,160],"1,":[30],"3,":[31],"7":[32,79],"and":[33,48,71,74,140],"14":[34],"days":[35,80],"after":[36,81],"implantation.":[37,82],"decalcified":[39],"6":[40],"microns":[41],"thick":[42],"sections":[43],"stained":[45],"with":[46,112],"H.E.":[47],"cell":[49],"types":[50],"around":[51,143],"implants":[53],"counted":[55],"microscopically.":[56],"We":[57],"found":[58,100],"that":[59,118,151],"an":[60],"acute":[61],"inflammatory":[62],"reaction":[63],"occurred":[64],"one":[66,103],"day,":[67],"macrophages":[70],"neutrophiles":[72],"predominated,":[73],"almost":[75],"disappeared":[76],"about":[78],"Fibrosis":[83],"began":[84],"to":[85,124,154],"be":[86,155],"observed":[87],"3":[89,106],"days.":[90,107],"During":[91],"this":[92],"early":[93],"stage,":[94],"foreign":[95],"body":[96],"giant":[97],"cells":[98],"only":[102],"specimen":[104],"These":[108],"findings,":[109],"comparison":[111],"those":[113],"controls,":[116],"showed":[117],"chemical":[120,134],"irritation":[121,135],"Bioceram":[123,137,152],"subcutaneous":[126],"tissue":[127],"is":[128],"slight,":[129],"although":[130],"physical":[132],"and/or":[133],"lasts":[138],"continuously":[139],"induces":[141],"fibrosis":[142],"bioimplant.":[145],"results":[147],"so":[148],"far":[149],"suggest":[150],"seems":[153],"a":[156],"satisfactorily":[157],"biocompatible":[158],"material,":[159],"least":[161],"within":[162],"extent":[164],"2":[166],"weeks.":[167]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}