{"id":"https://openalex.org/W2154381491","doi":"https://doi.org/10.1177/32.4.6200530","title":"Proteoglycans in arterial smooth muscle cell cultures: an ultrastructural histochemical analysis.","display_name":"Proteoglycans in arterial smooth muscle cell cultures: an ultrastructural histochemical analysis.","publication_year":1984,"publication_date":"1984-04-01","ids":{"openalex":"https://openalex.org/W2154381491","doi":"https://doi.org/10.1177/32.4.6200530","mag":"2154381491","pmid":"https://pubmed.ncbi.nlm.nih.gov/6200530"},"language":"en","primary_location":{"id":"doi:10.1177/32.4.6200530","doi":"https://doi.org/10.1177/32.4.6200530","is_oa":false,"landing_page_url":"https://doi.org/10.1177/32.4.6200530","pdf_url":null,"source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry &amp; Cytochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"K Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035268339","display_name":"Thomas N. Wight","orcid":"https://orcid.org/0000-0002-2794-4197","observed_orcids":["https://orcid.org/0000-0002-2794-4197"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T N Wight","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":3.5793,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.92649728,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"32","issue":"4","first_page":"347","last_page":"357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10869","display_name":"Polysaccharides and Plant Cell Walls","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteoglycans","display_name":"proteoglycans","score":0.9959999918937683},{"id":"https://openalex.org/keywords/arterial-smooth-muscle-cells","display_name":"arterial smooth muscle cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cationic-dyes","display_name":"cationic dyes","score":0.9210000038146973},{"id":"https://openalex.org/keywords/ruthenium-red","display_name":"ruthenium red","score":0.9269999861717224},{"id":"https://openalex.org/keywords/alcian-blue","display_name":"alcian blue","score":0.996999979019165},{"id":"https://openalex.org/keywords/acridine-orange","display_name":"acridine orange","score":0.9869999885559082},{"id":"https://openalex.org/keywords/safranin-o","display_name":"safranin O","score":1.0},{"id":"https://openalex.org/keywords/chondroitinase-abc","display_name":"chondroitinase ABC","score":0.9649999737739563},{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":0.8980000019073486},{"id":"https://openalex.org/keywords/proteoglycan-monomers","display_name":"proteoglycan monomers","score":0.7710000276565552},{"id":"https://openalex.org/keywords/fixation-artifacts","display_name":"fixation artifacts","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C2779657890","wikidata":"https://www.wikidata.org/wiki/Q424006","display_name":"Ruthenium red","level":3,"score":0.8359739780426025},{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.8335915803909302},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.6397714614868164},{"id":"https://openalex.org/C2776832592","wikidata":"https://www.wikidata.org/wiki/Q413672","display_name":"Safranin","level":3,"score":0.565642237663269},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5450295805931091},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.5231203436851501},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.48322948813438416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46844035387039185},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4299640953540802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2864637076854706},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.22876134514808655},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.22713986039161682},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.07176071405410767},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000165","descriptor_name":"Acridine Orange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000423","descriptor_name":"Alcian Blue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002810","descriptor_name":"Chondroitinases and Chondroitin Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008254","descriptor_name":"Macaca nemestrina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010619","descriptor_name":"Phenazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012430","descriptor_name":"Ruthenium Red","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/32.4.6200530","doi":"https://doi.org/10.1177/32.4.6200530","is_oa":false,"landing_page_url":"https://doi.org/10.1177/32.4.6200530","pdf_url":null,"source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry &amp; Cytochemistry","raw_type":"journal-article"},{"id":"pmid:6200530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6200530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W271881152","https://openalex.org/W1503565413","https://openalex.org/W1980617596","https://openalex.org/W1980741458","https://openalex.org/W1994185414","https://openalex.org/W1999451938","https://openalex.org/W2003549007","https://openalex.org/W2004487950","https://openalex.org/W2023970316","https://openalex.org/W2044334951","https://openalex.org/W2055366835","https://openalex.org/W2087260385","https://openalex.org/W2092905213","https://openalex.org/W2123636742","https://openalex.org/W2153234567","https://openalex.org/W2158979977","https://openalex.org/W2328624212","https://openalex.org/W2394615800","https://openalex.org/W2399550214","https://openalex.org/W2409904542","https://openalex.org/W2616459409","https://openalex.org/W2887117132"],"related_works":["https://openalex.org/W2060101571","https://openalex.org/W2139607378","https://openalex.org/W2090545085","https://openalex.org/W1979039527","https://openalex.org/W2084390306","https://openalex.org/W2049418321","https://openalex.org/W2053055972","https://openalex.org/W2418951569","https://openalex.org/W2026085974","https://openalex.org/W7100576416"],"abstract_inverted_index":{"The":[0,154],"extracellular":[1,97,195],"matrix":[2,98],"in":[3,106,206,258],"cultures":[4,76,103,175],"of":[5,18,89,95,109,120,138,141,168,237],"arterial":[6],"smooth":[7],"muscle":[8],"cells":[9],"has":[10],"been":[11],"examined":[12],"by":[13,159],"ultrastructural":[14],"histochemistry":[15],"using":[16],"each":[17],"the":[19,75,86,96,107,110,121,142,148,166,173,194,199,202,207,229,247,251,259],"following":[20],"cationic":[21,111,143],"dyes:":[22],"ruthenium":[23,49,208],"red,":[24],"Alcian":[25,52,211],"blue,":[26,53],"acridine":[27,63,163],"orange,":[28],"and":[29,70,162,176,197,210,250,254],"safranin":[30,66,160],"O.":[31,67],"All":[32],"dyes":[33,144,230],"exhibited":[34,232],"an":[35,56,82,233],"affinity":[36,234],"for":[37,130,235],"a":[38,46],"structural":[39,93],"component":[40],"that":[41,84,117,186,201,220,240],"was":[42],"either":[43],"preserved":[44,158],"as":[45,55,189],"granule":[47],"with":[48,62,79,263],"red":[50,209],"or":[51,54,59,65],"extended":[57,155,190],"filament":[58],"bottlebrush":[60,191],"structure":[61,157,167],"orange":[64,164],"Both":[68,246],"granules":[69,243],"filaments":[71],"were":[72,77,99,104,125],"removed":[73],"when":[74,102],"pretreated":[78],"chondroitinase":[80,264],"ABC,":[81],"enzyme":[83],"degrades":[85],"glycosaminoglycan":[87],"moiety":[88],"some":[90],"proteoglycans.":[91],"These":[92,183],"components":[94],"not":[100],"observed":[101,205],"prepared":[105,171],"absence":[108],"dyes.":[112],"Labeling":[113],"experiments":[114],"(35S-sulfate)":[115],"revealed":[116],"approximately":[118],"40%":[119],"total":[122],"labeled":[123],"proteoglycans":[124,170,187],"lost":[126],"during":[127,145,225],"routine":[128],"processing":[129],"electron":[131],"microscopy":[132],"(i.e.,":[133],"fixation":[134,146],"through":[135],"dehydration).":[136],"Inclusion":[137],"any":[139],"one":[140],"reduced":[147],"losses":[149],"to":[150],"less":[151],"than":[152],"1%.":[153],"filamentous":[156,255],"O":[161],"resembled":[165],"purified":[169],"from":[172],"same":[174],"spread":[177],"on":[178],"cytochrome":[179],"c":[180],"monolayer":[181],"films.":[182],"observations":[184],"suggest":[185],"exist":[188],"structures":[192,256],"within":[193],"matrix,":[196],"support":[198],"interpretation":[200],"granular":[203,253],"deposits":[204],"blue":[212],"preparations":[213],"most":[214],"likely":[215],"represent":[216],"individual":[217],"proteoglycan":[218],"monomers":[219],"have":[221],"undergone":[222],"molecular":[223],"collapse":[224],"processing.":[226],"In":[227],"addition,":[228],"also":[231],"chords":[236],"fine":[238],"fibrils":[239,260],"contained":[241],"small":[242],"and/or":[244],"filaments.":[245],"fibrillar":[248],"material":[249],"associated":[252],"enmeshed":[257],"resisted":[261],"digestion":[262],"ABC.":[265]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
