{"id":"https://openalex.org/W2154381036","doi":"https://doi.org/10.1093/jac/40.1.125","title":"Continuous infusion of ceftazidime in cystic fibrosis patients during home treatment: clinical outcome, microbiology and pharmacokinetics","display_name":"Continuous infusion of ceftazidime in cystic fibrosis patients during home treatment: clinical outcome, microbiology and pharmacokinetics","publication_year":1997,"publication_date":"1997-07-01","ids":{"openalex":"https://openalex.org/W2154381036","doi":"https://doi.org/10.1093/jac/40.1.125","mag":"2154381036","pmid":"https://pubmed.ncbi.nlm.nih.gov/9249216"},"language":"en","primary_location":{"id":"doi:10.1093/jac/40.1.125","doi":"https://doi.org/10.1093/jac/40.1.125","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/40.1.125","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040060343","display_name":"Alexander A. T. M. M. Vinks","orcid":"https://orcid.org/0000-0003-4224-2967","observed_orcids":["https://orcid.org/0000-0003-4224-2967"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A. Vinks","raw_affiliation_strings":["The Hague Hospitals Central Pharmacy, The Hague, The Netherlands. kkgt@rijnhaave.nl","Corresponding author. The Hague Hospitals Central Pharmacy, PO Box 43100, 2504 AC The Hague, The Netherlands","The Hague Hospitals Central Pharmacy, The Hague;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hague Hospitals Central Pharmacy, The Hague, The Netherlands. kkgt@rijnhaave.nl","institution_ids":[]},{"raw_affiliation_string":"Corresponding author. The Hague Hospitals Central Pharmacy, PO Box 43100, 2504 AC The Hague, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"The Hague Hospitals Central Pharmacy, The Hague;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5040060343"],"corresponding_institution_ids":[],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":null,"fwci":3.9282,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.93454791,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"40","issue":"1","first_page":"125","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.08839999884366989,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ceftazidime","display_name":"ceftazidime","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/home-intravenous-antibiotic-therapy","display_name":"home intravenous antibiotic therapy","score":0.9240000247955322},{"id":"https://openalex.org/keywords/continuous-infusion","display_name":"continuous infusion","score":0.8289999961853027},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9440000057220459},{"id":"https://openalex.org/keywords/acute-exacerbation","display_name":"acute exacerbation","score":0.6000000238418579},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9010000228881836},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.824999988079071},{"id":"https://openalex.org/keywords/sputum-drug-concentration","display_name":"sputum drug concentration","score":0.6990000009536743},{"id":"https://openalex.org/keywords/total-body-clearance","display_name":"body clearance","score":0.628000020980835},{"id":"https://openalex.org/keywords/serum-levels","display_name":"serum concentration","score":0.3919999897480011},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2776968632","wikidata":"https://www.wikidata.org/wiki/Q808845","display_name":"Ceftazidime","level":4,"score":0.9686691164970398},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7760375738143921},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.7541944980621338},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6928293704986572},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6304401159286499},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.47076416015625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4280461370944977},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35621437430381775},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34111979603767395},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.1381770670413971},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08442628383636475},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.05997386574745178},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002442","descriptor_name":"Ceftazidime","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002442","descriptor_name":"Ceftazidime","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002442","descriptor_name":"Ceftazidime","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013183","descriptor_name":"Sputum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018718","descriptor_name":"Home Infusion Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/jac/40.1.125","doi":"https://doi.org/10.1093/jac/40.1.125","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/40.1.125","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmid:9249216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9249216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1542521825","https://openalex.org/W1699591744","https://openalex.org/W1896681111","https://openalex.org/W1941476297","https://openalex.org/W1963504970","https://openalex.org/W1965100538","https://openalex.org/W1969464314","https://openalex.org/W1973665755","https://openalex.org/W1979861216","https://openalex.org/W2001709173","https://openalex.org/W2009720606","https://openalex.org/W2023174165","https://openalex.org/W2024804660","https://openalex.org/W2030543317","https://openalex.org/W2035691011","https://openalex.org/W2042916674","https://openalex.org/W2047373466","https://openalex.org/W2063374918","https://openalex.org/W2074158230","https://openalex.org/W2106269225","https://openalex.org/W2158308518","https://openalex.org/W2164974390","https://openalex.org/W2167588580","https://openalex.org/W2170823371","https://openalex.org/W2172247411","https://openalex.org/W4249707471"],"related_works":["https://openalex.org/W2412660470","https://openalex.org/W2063508460","https://openalex.org/W2041092399","https://openalex.org/W2047451436","https://openalex.org/W2065424609","https://openalex.org/W2164974390","https://openalex.org/W2037321268","https://openalex.org/W2400522709","https://openalex.org/W2006894520","https://openalex.org/W1990147973"],"abstract_inverted_index":{"Acute":[0],"exacerbations":[1],"of":[2,33,72,75,96,135,151,176,189,196,219,229,260],"Pseudomonas":[3],"aeruginosa":[4,201],"lung":[5],"infections":[6],"were":[7,42,83,107,256],"treated":[8],"with":[9,18,51,270],"ceftazidime":[10,77,220,243,271],"by":[11,116,273],"continuous":[12,76,105,247,274],"infusion":[13,28,106,248,275],"in":[14,98,127,149,174,192,225,257,283,286],"17":[15],"adult":[16],"patients":[17,129],"cystic":[19,52],"fibrosis":[20,53],"at":[21,85,147,181],"home.":[22],"Ceftazidime":[23,101],"was":[24,114,138,145,157,172,236,249],"delivered":[25],"via":[26],"an":[27,163,284],"pump":[29],"and":[30,56,90,179,279],"the":[31,86,88,94,117,136,152,177,187,190,258],"effects":[32],"this":[34],"3":[35],"week":[36],"home":[37,120,148],"intravenous":[38],"antibiotic":[39,143,205],"treatment":[40,97,113,191],"(HIVAT)":[41],"prospectively":[43],"studied":[44],"over":[45],"a":[46,70,226],"2":[47],"year":[48],"period.":[49],"Patients":[50],"(eight":[54],"male":[55],"nine":[57],"female":[58],"patients;":[59],"mean":[60,133],"age":[61],"26.9":[62],"+/-":[63,238,251,264],"7.6":[64],"years,":[65],"range":[66,259],"15-52":[67],"years),":[68],"received":[69],"total":[71],"33":[73],"courses":[74,126,137,218],"(100":[78],"mg/kg/24":[79],"h).":[80],"Clinical":[81,170],"data":[82,103],"collected":[84],"start,":[87],"end":[89,95,188],"4-6":[91,184,213],"weeks":[92,185,214],"after":[93,186,215],"12":[99,128],"patients.":[100,111],"pharmacokinetic":[102],"during":[104,204,246],"obtained":[108],"from":[109],"ten":[110],"The":[112,132,141,154,194,241],"supervised":[115],"clinician":[118],"without":[119],"visits.":[121],"All":[122],"25":[123],"clinically":[124,277],"evaluable":[125],"proved":[130,276],"efficacious.":[131],"duration":[134],"21":[139],"days.":[140],"entire":[142],"course":[144],"administered":[146,272],"88%":[150],"courses.":[153],"other":[155],"12%":[156],"started":[158],"for":[159,199],"2-3":[160],"days":[161],"as":[162],"inpatient.":[164],"Objective":[165],"clinical":[166],"parameters":[167],"significantly":[168,203],"improved.":[169],"improvement":[171],"noted":[173],"91%":[175],"patients,":[178],"lasted":[180],"least":[182],"until":[183],"70%.":[193],"number":[195],"cultures":[197],"positive":[198],"P.":[200],"decreased":[202],"treatment.":[206,216],"Bacterial":[207],"count":[208],"returned":[209],"to":[210],"pretreatment":[211],"values":[212],"Multiple":[217],"monotherapy":[221],"did":[222,280],"not":[223,281],"result":[224,282],"lasting":[227,287],"increase":[228,285],"ceftazidime-resistant":[230],"pseudomonas":[231],"strains.":[232],"Total":[233],"body":[234],"clearance":[235],"9.1":[237],"1.3":[239],"L/h.":[240],"steady-state":[242],"serum":[244],"concentration":[245],"28.4":[250],"5.0":[252],"mg/L.":[253],"Sputum":[254],"concentrations":[255],"0.5-13":[261],"mg/L":[262],"(3.9":[263],"4.0":[265],"mg/L).":[266],"In":[267],"conclusion,":[268],"HIVAT":[269],"effective":[278],"resistance.":[288]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}