{"id":"https://openalex.org/W2154353670","doi":"https://doi.org/10.1128/jcm.39.7.2719-2721.2001","title":"Fluoroquinolone Resistance Is a Poor Surrogate Marker for Type II Topoisomerase Mutations in Clinical Isolates of Streptococcus pneumoniae","display_name":"Fluoroquinolone Resistance Is a Poor Surrogate Marker for Type II Topoisomerase Mutations in Clinical Isolates of Streptococcus pneumoniae","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W2154353670","doi":"https://doi.org/10.1128/jcm.39.7.2719-2721.2001","mag":"2154353670","pmid":"https://pubmed.ncbi.nlm.nih.gov/11427605","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/88221"},"language":"en","primary_location":{"id":"doi:10.1128/jcm.39.7.2719-2721.2001","doi":"https://doi.org/10.1128/jcm.39.7.2719-2721.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jcm.39.7.2719-2721.2001","pdf_url":null,"source":{"id":"https://openalex.org/S53087977","display_name":"Journal of Clinical Microbiology","issn_l":"0095-1137","issn":["0095-1137","1070-633X","1098-660X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC88221","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010695820","display_name":"J Gordon Millichap","orcid":"https://orcid.org/0000-0002-0798-0131","observed_orcids":["https://orcid.org/0000-0002-0798-0131"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210089162","display_name":"Northwestern Memorial Hospital","ror":"https://ror.org/009543z50","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210089162","https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Millichap","raw_affiliation_strings":["<!--label omitted: 1-->Departments of Pathology and Medicine, Northwestern University Medical School,1 and","<!--label omitted: 2-->Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","Departments of Pathology and Medicine, Northwestern University Medical School,1 and; Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Departments of Pathology and Medicine, Northwestern University Medical School,1 and","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"<!--label omitted: 2-->Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I4210089162"]},{"raw_affiliation_string":"Departments of Pathology and Medicine, Northwestern University Medical School,1 and; Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4210089162"]},{"raw_affiliation_string":"Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I4210089162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031259595","display_name":"Ekaterina V. Pestova","orcid":"https://orcid.org/0000-0001-8200-2621","observed_orcids":["https://orcid.org/0000-0001-8200-2621"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210089162","display_name":"Northwestern Memorial Hospital","ror":"https://ror.org/009543z50","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210089162","https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ekaterina Pestova","raw_affiliation_strings":["<!--label omitted: 1-->Departments of Pathology and Medicine, Northwestern University Medical School,1 and","<!--label omitted: 2-->Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","Departments of Pathology and Medicine, Northwestern University Medical School,1 and; Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Departments of Pathology and Medicine, Northwestern University Medical School,1 and","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"<!--label omitted: 2-->Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I4210089162"]},{"raw_affiliation_string":"Departments of Pathology and Medicine, Northwestern University Medical School,1 and; Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4210089162"]},{"raw_affiliation_string":"Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I4210089162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011588990","display_name":"Farida Siddiqui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210089162","display_name":"Northwestern Memorial Hospital","ror":"https://ror.org/009543z50","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210089162","https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farida Siddiqui","raw_affiliation_strings":["<!--label omitted: 1-->Departments of Pathology and Medicine, Northwestern University Medical School,1 and","<!--label omitted: 2-->Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","Departments of Pathology and Medicine, Northwestern University Medical School,1 and; Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Departments of Pathology and Medicine, Northwestern University Medical School,1 and","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"<!--label omitted: 2-->Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I4210089162"]},{"raw_affiliation_string":"Departments of Pathology and Medicine, Northwestern University Medical School,1 and; Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4210089162"]},{"raw_affiliation_string":"Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I4210089162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020381958","display_name":"Gary A. Noskin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210089162","display_name":"Northwestern Memorial Hospital","ror":"https://ror.org/009543z50","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210089162","https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary A. Noskin","raw_affiliation_strings":["<!--label omitted: 1-->Departments of Pathology and Medicine, Northwestern University Medical School,1 and","<!--label omitted: 2-->Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","Departments of Pathology and Medicine, Northwestern University Medical School,1 and; Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Departments of Pathology and Medicine, Northwestern University Medical School,1 and","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"<!--label omitted: 2-->Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I4210089162"]},{"raw_affiliation_string":"Departments of Pathology and Medicine, Northwestern University Medical School,1 and; Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4210089162"]},{"raw_affiliation_string":"Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I4210089162"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026183066","display_name":"Lance R. Peterson","orcid":"https://orcid.org/0000-0001-5279-4752","observed_orcids":["https://orcid.org/0000-0001-5279-4752"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210089162","display_name":"Northwestern Memorial Hospital","ror":"https://ror.org/009543z50","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210089162","https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance R. Peterson","raw_affiliation_strings":["<!--label omitted: 1-->Departments of Pathology and Medicine, Northwestern University Medical School,1 and","<!--label omitted: 2-->Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","Departments of Pathology and Medicine, Northwestern University Medical School,1 and; Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Departments of Pathology and Medicine, Northwestern University Medical School,1 and","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"<!--label omitted: 2-->Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I4210089162"]},{"raw_affiliation_string":"Departments of Pathology and Medicine, Northwestern University Medical School,1 and; Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4210089162"]},{"raw_affiliation_string":"Divisions of Microbiology and Infectious Diseases, Northwestern Memorial Hospital,2 Chicago, Illinois 60611","institution_ids":["https://openalex.org/I4210089162"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7067,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.82864343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"7","first_page":"2719","last_page":"2721"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.5942000150680542,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.5942000150680542,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.35179999470710754,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9200000166893005},{"id":"https://openalex.org/keywords/fluoroquinolone-resistance","display_name":"fluoroquinolone resistance","score":0.996999979019165},{"id":"https://openalex.org/keywords/topoisomerase-ii","display_name":"topoisomerase II","score":0.8360000252723694},{"id":"https://openalex.org/keywords/gyra-mutations","display_name":"gyrA mutations","score":0.6420000195503235},{"id":"https://openalex.org/keywords/quinolone-resistance-determining-region","display_name":"quinolone resistance-determining region","score":0.984000027179718},{"id":"https://openalex.org/keywords/ciprofloxacin-susceptibility","display_name":"ciprofloxacin susceptibility","score":0.8669999837875366},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.8019999861717224},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.8270000219345093},{"id":"https://openalex.org/keywords/surrogate-markers","display_name":"surrogate markers","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.8321930170059204},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6584537029266357},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.626771092414856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5485284924507141},{"id":"https://openalex.org/C2778663903","wikidata":"https://www.wikidata.org/wiki/Q140018","display_name":"Streptococcaceae","level":3,"score":0.5462595224380493},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.49793195724487305},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.4532720148563385},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3813282549381256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27556854486465454},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.25566786527633667},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.23862436413764954},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22521904110908508},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09469354152679443}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jcm.39.7.2719-2721.2001","doi":"https://doi.org/10.1128/jcm.39.7.2719-2721.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jcm.39.7.2719-2721.2001","pdf_url":null,"source":{"id":"https://openalex.org/S53087977","display_name":"Journal of Clinical Microbiology","issn_l":"0095-1137","issn":["0095-1137","1070-633X","1098-660X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:203982","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC88221","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:88221","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/88221","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Microbiol","raw_type":"Text"},{"id":"pmid:11427605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11427605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical microbiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:203982","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC88221","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320309974","display_name":"Bayer Corporation","ror":"https://ror.org/034ffbg36"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320333645","display_name":"Pfizer Pharmaceuticals","ror":"https://ror.org/02bzf1224"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1502375514","https://openalex.org/W1505626160","https://openalex.org/W1510883850","https://openalex.org/W1529428852","https://openalex.org/W1581962345","https://openalex.org/W1856542071","https://openalex.org/W1866015860","https://openalex.org/W1965615003","https://openalex.org/W1966311769","https://openalex.org/W1982607879","https://openalex.org/W2009639913","https://openalex.org/W2038800061","https://openalex.org/W2097476058","https://openalex.org/W2100418869","https://openalex.org/W2103395799","https://openalex.org/W2107131874","https://openalex.org/W2114535764","https://openalex.org/W2152166532","https://openalex.org/W2160852967"],"related_works":["https://openalex.org/W2147990519","https://openalex.org/W2965026303","https://openalex.org/W2103395799","https://openalex.org/W2084439217","https://openalex.org/W7100128453","https://openalex.org/W2007328185","https://openalex.org/W2016529067","https://openalex.org/W1998314878","https://openalex.org/W2372157853","https://openalex.org/W2127354229"],"abstract_inverted_index":{"The":[0],"association":[1],"between":[2],"fluoroquinolone":[3],"susceptibility":[4,45],"and":[5],"DNA":[6],"mutations":[7,40],"coding":[8],"for":[9],"amino":[10,33],"acid":[11,34],"substitutions":[12],"in":[13],"the":[14],"quinolone":[15],"resistance-determining":[16],"region":[17],"was":[18],"assessed":[19],"with":[20,39],"44":[21],"clinical":[22],"isolates":[23],"of":[24],"Streptococcus":[25],"pneumoniae.":[26],"Twenty-three":[27],"strains":[28,38],"bore":[29],"at":[30],"least":[31],"one":[32],"substitution.":[35],"Only":[36],"seven":[37],"were":[41],"suggested":[42],"by":[43],"diminished":[44],"to":[46],"ciprofloxacin":[47],"(MIC,":[48],">":[49],"or":[50],"=2":[51],"microg/ml).":[52]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}