{"id":"https://openalex.org/W2154348564","doi":"https://doi.org/10.1016/j.joca.2013.02.633","title":"Nanoparticle system for the local delivery of disease modifying osteoarthritic drugs","display_name":"Nanoparticle system for the local delivery of disease modifying osteoarthritic drugs","publication_year":2013,"publication_date":"2013-03-27","ids":{"openalex":"https://openalex.org/W2154348564","doi":"https://doi.org/10.1016/j.joca.2013.02.633","mag":"2154348564"},"language":"en","primary_location":{"id":"doi:10.1016/j.joca.2013.02.633","doi":"https://doi.org/10.1016/j.joca.2013.02.633","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2013.02.633","pdf_url":"http://www.oarsijournal.com/article/S1063458413006833/pdf","source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.oarsijournal.com/article/S1063458413006833/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046177203","display_name":"Parthiban Periyasamy","orcid":"https://orcid.org/0000-0002-5264-6984","observed_orcids":["https://orcid.org/0000-0002-5264-6984","https://orcid.org/0000-0002-4431-5253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P.C. Periyasamy","raw_affiliation_strings":["MIRA Inst. for BioMed. technology and technical medicine, Enschede, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIRA Inst. for BioMed. technology and technical medicine, Enschede, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004749653","display_name":"Jos W. H. Wennink","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.W. Wennink","raw_affiliation_strings":["MIRA Inst. for BioMed. technology and technical medicine, Enschede, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIRA Inst. for BioMed. technology and technical medicine, Enschede, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009934870","display_name":"R. Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Wang","raw_affiliation_strings":["MIRA Inst. for BioMed. technology and technical medicine, Enschede, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIRA Inst. for BioMed. technology and technical medicine, Enschede, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089225087","display_name":"Marcel Karperien","orcid":"https://orcid.org/0000-0003-0751-0604","observed_orcids":["https://orcid.org/0000-0003-0751-0604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Karperien","raw_affiliation_strings":["MIRA Inst. for BioMed. technology and technical medicine, Enschede, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIRA Inst. for BioMed. technology and technical medicine, Enschede, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015099570","display_name":"Pieter Jelle Dijkstra","orcid":"https://orcid.org/0000-0001-8455-1093","observed_orcids":["https://orcid.org/0000-0001-8455-1093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P.J. Dijkstra","raw_affiliation_strings":["MIRA Inst. for BioMed. technology and technical medicine, Enschede, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIRA Inst. for BioMed. technology and technical medicine, Enschede, The Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061489108","display_name":"Janine N. Post","orcid":"https://orcid.org/0000-0002-6645-6583","observed_orcids":["https://orcid.org/0000-0002-6645-6583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.N. Post","raw_affiliation_strings":["MIRA Inst. for BioMed. technology and technical medicine, Enschede, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIRA Inst. for BioMed. technology and technical medicine, Enschede, The Netherlands","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16838376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":null,"first_page":"S303","last_page":"S304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.6714000105857849,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.6714000105857849,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.16380000114440918,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.15770000219345093,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disease-modifying-osteoarthritis-drugs","display_name":"disease-modifying osteoarthritis drugs","score":0.8399999737739563},{"id":"https://openalex.org/keywords/intra-articular-drug-delivery","display_name":"intra-articular drug delivery","score":0.8190000057220459},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.5270000100135803},{"id":"https://openalex.org/keywords/micelles","display_name":"micelles","score":0.8159999847412109},{"id":"https://openalex.org/keywords/uv-crosslinking","display_name":"UV crosslinking","score":0.7400000095367432},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9440000057220459},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.8460000157356262},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cartilage-repair","display_name":"cartilage repair","score":0.4749999940395355},{"id":"https://openalex.org/keywords/biodegradable-nanocarriers","display_name":"biodegradable nanocarriers","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.7665121555328369},{"id":"https://openalex.org/C2777516009","wikidata":"https://www.wikidata.org/wiki/Q194207","display_name":"Ethylene glycol","level":2,"score":0.6817379593849182},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6814460754394531},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.629200279712677},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5506746172904968},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.5441438555717468},{"id":"https://openalex.org/C45211672","wikidata":"https://www.wikidata.org/wiki/Q4119016","display_name":"Biodegradable polymer","level":3,"score":0.5388903021812439},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.5068193078041077},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4586370885372162},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.38807958364486694},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3876362442970276},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3827865421772003},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3591367304325104},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1653534173965454},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.joca.2013.02.633","doi":"https://doi.org/10.1016/j.joca.2013.02.633","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2013.02.633","pdf_url":"http://www.oarsijournal.com/article/S1063458413006833/pdf","source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},{"id":"pmh:oai:ris.utwente.nl:openaire_cris_publications/285d2d1b-3f00-4bbc-9362-15b9ed096114","doi":null,"is_oa":false,"landing_page_url":"https://research.utwente.nl/en/publications/285d2d1b-3f00-4bbc-9362-15b9ed096114","pdf_url":null,"source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Periyasamy, P C, Wennink, J W H, Wang, R, Karperien, H B J, Dijkstra, P J & Post, J N 2013, 'Nanoparticle system for the local delivery of disease modifying osteoarthritic drugs', Osteoarthritis and cartilage, vol. 21, no. Supplement, pp. S303-S304. https://doi.org/10.1016/j.joca.2013.02.633","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:ut:oai:ris.utwente.nl:publications/285d2d1b-3f00-4bbc-9362-15b9ed096114","doi":null,"is_oa":true,"landing_page_url":"https://research.utwente.nl/en/publications/285d2d1b-3f00-4bbc-9362-15b9ed096114","pdf_url":null,"source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Osteoarthritis and cartilage, 21(Supplement), S303 - S304. W.B. Saunders Ltd","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.joca.2013.02.633","doi":"https://doi.org/10.1016/j.joca.2013.02.633","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2013.02.633","pdf_url":"http://www.oarsijournal.com/article/S1063458413006833/pdf","source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2154348564.pdf","grobid_xml":"https://content.openalex.org/works/W2154348564.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4366721369","https://openalex.org/W2895282589","https://openalex.org/W3126369458","https://openalex.org/W4386456777","https://openalex.org/W4311202961","https://openalex.org/W2902445771","https://openalex.org/W4387534949","https://openalex.org/W2738773938","https://openalex.org/W2330297021","https://openalex.org/W1984246412"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}