{"id":"https://openalex.org/W2154340055","doi":null,"title":"Novel and simple behavioral paradigm for assessing anxiety in rats: effect of diazepam.","display_name":"Novel and simple behavioral paradigm for assessing anxiety in rats: effect of diazepam.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2154340055","mag":"2154340055","pmid":"https://pubmed.ncbi.nlm.nih.gov/19300387"},"language":"en","primary_location":{"id":"pmid:19300387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19300387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lenka Wachsmannova-Matelova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210121077","display_name":"Cancer Research Institute of the Slovak Academy of Sciences","ror":"https://ror.org/02v8wkr26","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210121077","https://openalex.org/I4210123996"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Lenka Wachsmannova-Matelova","raw_affiliation_strings":["Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia. lenka.matelova@savba.sk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia. lenka.matelova@savba.sk","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210121077"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Viola Stevurkova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Viola Stevurkova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Zuzana Adamcikova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zuzana Adamcikova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Vladimir Holec","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vladimir Holec","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061306532","display_name":"Vladim\u00edr Zajac","orcid":"https://orcid.org/0000-0002-0855-2622","observed_orcids":["https://orcid.org/0000-0002-0855-2622"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vladimir Zajac","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"30","issue":"1","first_page":"25","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.2612000107765198,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.2612000107765198,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.2502000033855438,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.21469999849796295,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.6940000057220459},{"id":"https://openalex.org/keywords/anxiety-assessment","display_name":"anxiety assessment","score":0.5440000295639038},{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":0.8640000224113464},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.9390000104904175},{"id":"https://openalex.org/keywords/risk-assessment-behavior","display_name":"risk assessment behavior","score":0.8339999914169312},{"id":"https://openalex.org/keywords/fear","display_name":"fear","score":0.4620000123977661},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.597000002861023},{"id":"https://openalex.org/keywords/behavioral-paradigms","display_name":"behavioral paradigms","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.8387815952301025},{"id":"https://openalex.org/C2780814781","wikidata":"https://www.wikidata.org/wiki/Q1369011","display_name":"Familial adenomatous polyposis","level":4,"score":0.7704929113388062},{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.7447879314422607},{"id":"https://openalex.org/C129219603","wikidata":"https://www.wikidata.org/wiki/Q1788683","display_name":"Single-strand conformation polymorphism","level":4,"score":0.6810762286186218},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6786184310913086},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6747763156890869},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5376208424568176},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5121409893035889},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.46620261669158936},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.45989421010017395},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2928585112094879}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005106","descriptor_name":"Exploratory Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:19300387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19300387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Comparative Study"},{"id":"pmid:20027139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20027139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},{"id":"mag:2154340055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20027139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W161807028","https://openalex.org/W1961324579","https://openalex.org/W1966037459","https://openalex.org/W1966385194","https://openalex.org/W1966781894","https://openalex.org/W1967111731","https://openalex.org/W1971842245","https://openalex.org/W1988918839","https://openalex.org/W1990666576","https://openalex.org/W1991660407","https://openalex.org/W1999317651","https://openalex.org/W2000591716","https://openalex.org/W2006041248","https://openalex.org/W2008293884","https://openalex.org/W2008375950","https://openalex.org/W2014759590","https://openalex.org/W2017436597","https://openalex.org/W2020841767","https://openalex.org/W2033338316","https://openalex.org/W2034517065","https://openalex.org/W2041561931","https://openalex.org/W2051459893","https://openalex.org/W2056635581","https://openalex.org/W2057502020","https://openalex.org/W2063641763","https://openalex.org/W2069860319","https://openalex.org/W2083048709","https://openalex.org/W2095133395","https://openalex.org/W2122062108","https://openalex.org/W2148705571","https://openalex.org/W2157275585"],"related_works":["https://openalex.org/W2082709484","https://openalex.org/W2054092602","https://openalex.org/W4386574172","https://openalex.org/W2152758117","https://openalex.org/W2294819425","https://openalex.org/W2057502020","https://openalex.org/W2006041248","https://openalex.org/W2417193120","https://openalex.org/W7055746866","https://openalex.org/W2460923487"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Anxiety":[1],"is":[2,10,204],"an":[3],"emotional":[4],"state":[5],"experienced":[6],"by":[7,56],"people,":[8],"and":[9,31,65,82,92,126,142,157,175,185,215,224],"not":[11],"readily":[12],"modeled":[13],"in":[14,26,33,48,87,100,131,186,213],"animals.":[15,133],"In":[16,107,134,165],"order":[17],"to":[18,149,163,208],"extend":[19],"till":[20],"now":[21],"ethologically":[22],"derived":[23],"paradigms":[24],"used":[25],"the":[27,49,52,88,95,110,114,117,121,128,147,151,155,183,187,190],"evaluation":[28],"of":[29,43,58,74,97,113,124,153,189,196,222],"anxiety":[30,223],"fear":[32,225],"rodents,":[34],"a":[35,101,205,218],"modified":[36,201],"open-field":[37,104,202],"was":[38,46,54],"designed.":[39],"METHODS:":[40],"Spontaneous":[41],"behavior":[42,212],"male":[44],"rats":[45],"investigated":[47,86],"elevated":[50],"arena;":[51],"bottom":[53],"divided":[55],"inter-space":[57,115,129,156,159],"different":[59],"width":[60],"(2,":[61],"4,":[62],"6,":[63],"8":[64],"10":[66],"cm)":[67],"into":[68],"two":[69],"identical":[70],"parts.":[71],"Anxiolytic":[72],"effects":[73,96],"diazepam":[75],"(DZP)":[76],"at":[77,138,172],"doses":[78,99,139,173],"0.5,":[79],"1.0,":[80,140],"2.5":[81,141],"5.0":[83,143],"mg/kg":[84,144,177],"were":[85],"newly":[89],"designed":[90],"device":[91],"compared":[93,162],"with":[94],"similar":[98],"large":[102],"circular":[103],"arena.":[105],"RESULTS:":[106],"Experiment":[108,135,166],"1":[109],"progressive":[111],"extension":[112],"prolonged":[116],"first":[118],"passing,":[119,125],"decreased":[120,158],"total":[122],"number":[123],"increased":[127,178],"sniffing":[130,160],"intact":[132],"2":[136],"DZP":[137,171],"significantly":[145],"enhanced":[146],"readiness":[148],"cross,":[150],"frequency":[152],"passing":[154],"as":[161],"controls.":[164],"3":[167],"we":[168],"found":[169],"that":[170],"0.1":[174],"0.3":[176],"behavioral":[179],"activity":[180],"both":[181],"along":[182],"perimeter":[184],"center":[188],"arena,":[191],"thus":[192],"indicating":[193],"lower":[194],"level":[195],"anxiety.":[197],"CONCLUSION:":[198],"The":[199],"presented":[200],"test":[203],"useful":[206],"paradigm":[207],"investigate":[209],"risk":[210],"assessment":[211],"rats,":[214],"may":[216],"provide":[217],"sensitive":[219],"novel":[220],"model":[221],"level.":[226]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
