{"id":"https://openalex.org/W2154338652","doi":"https://doi.org/10.1111/j.1365-2710.2008.00931.x","title":"Comparison of follitropin- administered by a pen device with conventional syringe in an ART programme a retrospective study","display_name":"Comparison of follitropin- administered by a pen device with conventional syringe in an ART programme a retrospective study","publication_year":2008,"publication_date":"2008-07-09","ids":{"openalex":"https://openalex.org/W2154338652","doi":"https://doi.org/10.1111/j.1365-2710.2008.00931.x","mag":"2154338652","pmid":"https://pubmed.ncbi.nlm.nih.gov/18613858"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2710.2008.00931.x","doi":"https://doi.org/10.1111/j.1365-2710.2008.00931.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2710.2008.00931.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2710.2008.00931.x","source":{"id":"https://openalex.org/S156693432","display_name":"Journal of Clinical Pharmacy and Therapeutics","issn_l":"0269-4727","issn":["0269-4727","1365-2710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pharmacy and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2710.2008.00931.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026024866","display_name":"G. A. Rama Raju","orcid":"https://orcid.org/0000-0002-2126-596X","observed_orcids":["https://orcid.org/0000-0002-2126-596X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. A. Rama Raju","raw_affiliation_strings":["Krishna IVF Clinic, Visakhapatnam, Andhra Pradesh, India. krishnaivf@yahoo.com","Krishna IVF Clinic, Visakhapatnam, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krishna IVF Clinic, Visakhapatnam, Andhra Pradesh, India. krishnaivf@yahoo.com","institution_ids":[]},{"raw_affiliation_string":"Krishna IVF Clinic, Visakhapatnam, Andhra Pradesh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108599027","display_name":"K Suryanarayana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Suryanarayana","raw_affiliation_strings":["Krishna IVF Clinic, Visakhapatnam, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krishna IVF Clinic, Visakhapatnam, Andhra Pradesh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111928890","display_name":"Gomedhikam Jaya Prakash","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Jaya Prakash","raw_affiliation_strings":["Krishna IVF Clinic, Visakhapatnam, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krishna IVF Clinic, Visakhapatnam, Andhra Pradesh, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017616249","display_name":"Kota Murali Krishna","orcid":"https://orcid.org/0000-0001-6127-5671","observed_orcids":["https://orcid.org/0000-0001-6127-5671"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Murali Krishna","raw_affiliation_strings":["Krishna IVF Clinic, Visakhapatnam, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krishna IVF Clinic, Visakhapatnam, Andhra Pradesh, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":1.9309,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.86365773,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"33","issue":"4","first_page":"401","last_page":"407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.7089999914169312,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.7089999914169312,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.22910000383853912,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.02710000053048134,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/follitropin-beta","display_name":"follitropin beta","score":0.9139999747276306},{"id":"https://openalex.org/keywords/subcutaneous-injection","display_name":"subcutaneous injection","score":0.5849999785423279},{"id":"https://openalex.org/keywords/ovulation-induction","display_name":"ovulation induction","score":0.9070000052452087},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.9229999780654907},{"id":"https://openalex.org/keywords/intracytoplasmic-sperm-injection","display_name":"intracytoplasmic sperm injection","score":0.996999979019165},{"id":"https://openalex.org/keywords/gnrh-agonist-down-regulation","display_name":"GnRH agonist down-regulation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/oocyte-retrieval","display_name":"oocyte retrieval","score":0.796999990940094},{"id":"https://openalex.org/keywords/live-birth-rate","display_name":"live birth rate","score":0.9010000228881836},{"id":"https://openalex.org/keywords/patient-tolerance","display_name":"patient tolerance","score":0.718999981880188},{"id":"https://openalex.org/keywords/injection-site-pain","display_name":"injection site pain","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C2778571141","wikidata":"https://www.wikidata.org/wiki/Q273318","display_name":"Syringe","level":2,"score":0.9201556444168091},{"id":"https://openalex.org/C2778278907","wikidata":"https://www.wikidata.org/wiki/Q28700","display_name":"Intracytoplasmic sperm injection","level":4,"score":0.7882266044616699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7126149535179138},{"id":"https://openalex.org/C2775948956","wikidata":"https://www.wikidata.org/wiki/Q407172","display_name":"Human chorionic gonadotropin","level":3,"score":0.5155360698699951},{"id":"https://openalex.org/C512716672","wikidata":"https://www.wikidata.org/wiki/Q200117","display_name":"In vitro fertilisation","level":3,"score":0.473099023103714},{"id":"https://openalex.org/C160099875","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Embryo transfer","level":3,"score":0.4499731957912445},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3670170307159424},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3583563566207886},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3308832049369812},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2812120318412781},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.17820867896080017},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1151997447013855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0755571722984314},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006080","descriptor_name":"Ovarian Follicle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012646","descriptor_name":"Self Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020554","descriptor_name":"Sperm Injections, Intracytoplasmic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D037201","descriptor_name":"Follicle Stimulating Hormone, beta Subunit","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D037201","descriptor_name":"Follicle Stimulating Hormone, beta Subunit","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D050498","descriptor_name":"Live Birth","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2710.2008.00931.x","doi":"https://doi.org/10.1111/j.1365-2710.2008.00931.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2710.2008.00931.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2710.2008.00931.x","source":{"id":"https://openalex.org/S156693432","display_name":"Journal of Clinical Pharmacy and Therapeutics","issn_l":"0269-4727","issn":["0269-4727","1365-2710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pharmacy and Therapeutics","raw_type":"journal-article"},{"id":"pmid:18613858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18613858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pharmacy and therapeutics","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2710.2008.00931.x","doi":"https://doi.org/10.1111/j.1365-2710.2008.00931.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2710.2008.00931.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2710.2008.00931.x","source":{"id":"https://openalex.org/S156693432","display_name":"Journal of Clinical Pharmacy and Therapeutics","issn_l":"0269-4727","issn":["0269-4727","1365-2710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pharmacy and Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6399999856948853}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2154338652.pdf","grobid_xml":"https://content.openalex.org/works/W2154338652.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1891611021","https://openalex.org/W1977828083","https://openalex.org/W1987528268","https://openalex.org/W2004337058","https://openalex.org/W2012570045","https://openalex.org/W2063469176","https://openalex.org/W2087619879","https://openalex.org/W2096544108","https://openalex.org/W2100533841","https://openalex.org/W2100938534","https://openalex.org/W2104971596","https://openalex.org/W2106612967","https://openalex.org/W2114791171","https://openalex.org/W2118065527","https://openalex.org/W2123738882","https://openalex.org/W2143059800","https://openalex.org/W2144601959","https://openalex.org/W2164092270","https://openalex.org/W2301263574"],"related_works":["https://openalex.org/W2104971596","https://openalex.org/W2022896171","https://openalex.org/W2106612967","https://openalex.org/W2147716065","https://openalex.org/W7095852242","https://openalex.org/W1976535007","https://openalex.org/W2133683600","https://openalex.org/W1979798349","https://openalex.org/W2065451923","https://openalex.org/W7042336450"],"abstract_inverted_index":{"OBJECTIVES:":[0],"This":[1],"study":[2],"compares":[3],"the":[4,39,57,76,100,137,158,175,205],"efficacy":[5],"and":[6,50,73,126,155,194],"patient":[7],"tolerance":[8,164],"of":[9,68,83,90,102,109,119,128],"follitropin-beta":[10,69,186],"(recagon)":[11],"administered":[12,70,187],"using":[13],"a":[14],"pen":[15,72,176,189],"device":[16,177,190],"with":[17,47,53,63,71,165,174,188,197,204],"conventional":[18,159,206],"syringe":[19,42,74,144],"in":[20,24,56,142,157],"infertile":[21],"couples":[22],"undergoing":[23],"vitro":[25],"fertilization/intracytoplasmic":[26],"sperm":[27],"injection":[28,170],"treatment.":[29],"METHODS:":[30],"Data":[31],"for":[32,38,131],"481":[33],"patients":[34,46,52],"were":[35,140,153],"retrieved":[36],"retrospectively":[37],"analysis.":[40],"Conventional":[41],"group":[43],"constituted":[44],"204":[45],"217":[48],"cycles":[49,55],"265":[51],"294":[54],"pen-device":[58],"group.":[59],"Down-regulation":[60],"was":[61,172],"achieved":[62],"GnRH":[64],"agonist.":[65],"RESULTS:":[66],"Comparison":[67],"showed":[75],"following":[77],"data,":[78],"respectively.":[79,146,162],"A":[80],"total":[81],"dose":[82],"1909.38/2100.65":[84],"IU":[85],"(P":[86,94,115,123,134,178],"<":[87,95,116,124,135,179],"0.001),":[88],"duration":[89],"stimulation,":[91],"9.70/10.47":[92],"days":[93],"0.05),":[96,117,136],"oestradiol":[97],"levels":[98],"on":[99],"day":[101],"human":[103],"chorionic":[104],"gonadotropin,":[105],"1488.34/1067.63":[106],"pg/ml,":[107],"number":[108,118,127],"follicles":[110],"reaching":[111],">16-mm":[112],"size,":[113],"9.75/7.34":[114],"oocytes":[120],"retrieved,":[121],"13.84/9.55":[122],"0.001)":[125],"embryos":[129],"available":[130],"freezing,":[132],"4.56/1.30":[133],"above":[138],"data":[139,183],"observed":[141],"pen/conventional":[143],"groups,":[145,161],"The":[147,182],"live":[148],"birth":[149],"rates":[150],"per":[151],"cycle":[152],"28.85%":[154],"30.95%":[156],"syringe/pen-device":[160],"Patient":[163],"respect":[166,198],"to":[167,199],"pain":[168],"at":[169],"site":[171],"better":[173],"0.025).":[180],"CONCLUSION:":[181],"show":[184],"that":[185],"is":[191],"well":[192],"tolerated":[193],"more":[195],"efficacious":[196],"ovarian":[200],"stimulation":[201],"outcome":[202],"compared":[203],"syringe.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}