{"id":"https://openalex.org/W2154233284","doi":"https://doi.org/10.1093/jac/dkn311","title":"Tigecycline for the treatment of multidrug-resistant Enterobacteriaceae: a systematic review of the evidence from microbiological and clinical studies","display_name":"Tigecycline for the treatment of multidrug-resistant Enterobacteriaceae: a systematic review of the evidence from microbiological and clinical studies","publication_year":2008,"publication_date":"2008-08-01","ids":{"openalex":"https://openalex.org/W2154233284","doi":"https://doi.org/10.1093/jac/dkn311","mag":"2154233284","pmid":"https://pubmed.ncbi.nlm.nih.gov/18676620","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8445635"},"language":"en","primary_location":{"id":"doi:10.1093/jac/dkn311","doi":"https://doi.org/10.1093/jac/dkn311","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkn311","pdf_url":"https://academic.oup.com/jac/article-pdf/62/5/895/39742878/jac_62_5_895.pdf","source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jac/article-pdf/62/5/895/39742878/jac_62_5_895.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085723076","display_name":"Theodoros Kelesidis","orcid":"https://orcid.org/0000-0002-8463-3811","observed_orcids":["https://orcid.org/0000-0002-8463-3811"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I3018163063","display_name":"St. Elizabeth's Medical Center","ror":"https://ror.org/00cr15z55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3018163063"]},{"id":"https://openalex.org/I4210167199","display_name":"Alfa Institute of Biomedical Sciences","ror":"https://ror.org/05pkanq60","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210167199"]}],"countries":["GR","US"],"is_corresponding":false,"raw_author_name":"Theodoros Kelesidis","raw_affiliation_strings":["\u00a0Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece","\u00a0Department of Medicine, Caritas St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a0Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece","institution_ids":["https://openalex.org/I4210167199"]},{"raw_affiliation_string":"\u00a0Department of Medicine, Caritas St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I3018163063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066664805","display_name":"Drosos E. Karageorgopoulos","orcid":"https://orcid.org/0000-0002-9959-9978","observed_orcids":["https://orcid.org/0000-0002-9959-9978"]},"institutions":[{"id":"https://openalex.org/I4210167199","display_name":"Alfa Institute of Biomedical Sciences","ror":"https://ror.org/05pkanq60","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210167199"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Drosos E. Karageorgopoulos","raw_affiliation_strings":["\u00a0Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a0Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece","institution_ids":["https://openalex.org/I4210167199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041957734","display_name":"Iosif Kelesidis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I4210167199","display_name":"Alfa Institute of Biomedical Sciences","ror":"https://ror.org/05pkanq60","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210167199"]}],"countries":["GR","US"],"is_corresponding":false,"raw_author_name":"Iosif Kelesidis","raw_affiliation_strings":["\u00a0Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece","\u00a0Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a0Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece","institution_ids":["https://openalex.org/I4210167199"]},{"raw_affiliation_string":"\u00a0Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, NY, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047582800","display_name":"Matthew E. Falagas","orcid":"https://orcid.org/0000-0002-5905-2695","observed_orcids":["https://orcid.org/0000-0002-5905-2695","https://orcid.org/0000-0002-8068-8575"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210153759","display_name":"Henry Dunant Hospital","ror":"https://ror.org/05n7t4h40","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210153759"]},{"id":"https://openalex.org/I4210167199","display_name":"Alfa Institute of Biomedical Sciences","ror":"https://ror.org/05pkanq60","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210167199"]}],"countries":["GR","US"],"is_corresponding":true,"raw_author_name":"Matthew E. Falagas","raw_affiliation_strings":["\u00a0Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece","\u00a0Department of Medicine, Henry Dunant Hospital, Athens, Greece","\u00a0Department of Medicine, Tufts University School of Medicine, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a0Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece","institution_ids":["https://openalex.org/I4210167199"]},{"raw_affiliation_string":"\u00a0Department of Medicine, Henry Dunant Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210153759"]},{"raw_affiliation_string":"\u00a0Department of Medicine, Tufts University School of Medicine, Boston, MA, USA","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5047582800"],"corresponding_institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210153759","https://openalex.org/I4210167199"],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":null,"fwci":1.1657,"has_fulltext":true,"cited_by_count":184,"citation_normalized_percentile":{"value":0.74774775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"62","issue":"5","first_page":"895","last_page":"904"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tigecycline","display_name":"tigecycline","score":1.0},{"id":"https://openalex.org/keywords/multidrug-resistant-enterobacteriaceae","display_name":"multidrug-resistant Enterobacteriaceae","score":0.9990000128746033},{"id":"https://openalex.org/keywords/extended-spectrum-beta-lactamase","display_name":"extended-spectrum beta-lactamase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/carbapenem-resistance","display_name":"carbapenem resistance","score":0.8169999718666077},{"id":"https://openalex.org/keywords/metallo-beta-lactamase","display_name":"metallo-beta-lactamase","score":0.925000011920929},{"id":"https://openalex.org/keywords/ampc-beta-lactamase","display_name":"AmpC beta-lactamase","score":0.8999999761581421},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9919999837875366},{"id":"https://openalex.org/keywords/klebsiella","display_name":"Klebsiella","score":0.9940000176429749},{"id":"https://openalex.org/keywords/enterobacter","display_name":"Enterobacter","score":0.8830000162124634},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility-breakpoints","display_name":"antimicrobial susceptibility breakpoints","score":0.8370000123977661},{"id":"https://openalex.org/keywords/clinical-effectiveness","display_name":"clinical effectiveness","score":0.6050000190734863},{"id":"https://openalex.org/keywords/tetracycline","display_name":"tetracycline","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2777027569","wikidata":"https://www.wikidata.org/wiki/Q420595","display_name":"Tigecycline","level":3,"score":0.958558201789856},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6812359094619751},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.5774118304252625},{"id":"https://openalex.org/C2778983983","wikidata":"https://www.wikidata.org/wiki/Q134281","display_name":"Enterobacter","level":4,"score":0.5524427890777588},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.5522511005401611},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5427975058555603},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5402460098266602},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5116384625434875},{"id":"https://openalex.org/C2779116282","wikidata":"https://www.wikidata.org/wiki/Q131854","display_name":"Klebsiella","level":4,"score":0.44553518295288086},{"id":"https://openalex.org/C2775992322","wikidata":"https://www.wikidata.org/wiki/Q5037837","display_name":"Carbapenem-resistant enterobacteriaceae","level":5,"score":0.430570513010025},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.41287389397621155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3225472569465637},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.2393733263015747},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000078304","descriptor_name":"Tigecycline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004755","descriptor_name":"Enterobacteriaceae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004756","descriptor_name":"Enterobacteriaceae Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004756","descriptor_name":"Enterobacteriaceae Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008911","descriptor_name":"Minocycline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008911","descriptor_name":"Minocycline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/jac/dkn311","doi":"https://doi.org/10.1093/jac/dkn311","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkn311","pdf_url":"https://academic.oup.com/jac/article-pdf/62/5/895/39742878/jac_62_5_895.pdf","source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7339096","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8445635","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8445635","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8445635","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Antimicrob Chemother","raw_type":"Text"},{"id":"pmid:18676620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18676620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:jac:dkn311v1","doi":null,"is_oa":false,"landing_page_url":"http://jac.oxfordjournals.org/cgi/content/short/dkn311v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/jac/dkn311","doi":"https://doi.org/10.1093/jac/dkn311","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkn311","pdf_url":"https://academic.oup.com/jac/article-pdf/62/5/895/39742878/jac_62_5_895.pdf","source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.4699999988079071,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[{"id":"https://openalex.org/G7391330224","display_name":"Adipokine physiology","funder_award_id":"K24DK081913","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2154233284.pdf","grobid_xml":"https://content.openalex.org/works/W2154233284.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W24568803","https://openalex.org/W91857667","https://openalex.org/W1522563507","https://openalex.org/W1694222912","https://openalex.org/W1965576612","https://openalex.org/W1966831828","https://openalex.org/W1976898407","https://openalex.org/W1980315730","https://openalex.org/W1983065251","https://openalex.org/W1991758987","https://openalex.org/W1994382682","https://openalex.org/W1998455639","https://openalex.org/W2007703916","https://openalex.org/W2008054915","https://openalex.org/W2009835131","https://openalex.org/W2011770881","https://openalex.org/W2022079465","https://openalex.org/W2023287527","https://openalex.org/W2026377811","https://openalex.org/W2031303083","https://openalex.org/W2032003613","https://openalex.org/W2038572801","https://openalex.org/W2039835012","https://openalex.org/W2043864667","https://openalex.org/W2047299545","https://openalex.org/W2048323938","https://openalex.org/W2050746850","https://openalex.org/W2054016576","https://openalex.org/W2054740361","https://openalex.org/W2069416660","https://openalex.org/W2072175080","https://openalex.org/W2072823726","https://openalex.org/W2074669461","https://openalex.org/W2074799088","https://openalex.org/W2083296033","https://openalex.org/W2087901245","https://openalex.org/W2088785016","https://openalex.org/W2097265290","https://openalex.org/W2097925499","https://openalex.org/W2105154075","https://openalex.org/W2107154370","https://openalex.org/W2115033531","https://openalex.org/W2116492265","https://openalex.org/W2119142507","https://openalex.org/W2121725364","https://openalex.org/W2122097905","https://openalex.org/W2122432936","https://openalex.org/W2124132499","https://openalex.org/W2129071962","https://openalex.org/W2130722011","https://openalex.org/W2133243787","https://openalex.org/W2134154068","https://openalex.org/W2134957876","https://openalex.org/W2135421760","https://openalex.org/W2137408524","https://openalex.org/W2139818499","https://openalex.org/W2140588380","https://openalex.org/W2140980606","https://openalex.org/W2141497319","https://openalex.org/W2142929806","https://openalex.org/W2142980821","https://openalex.org/W2146564864","https://openalex.org/W2147847713","https://openalex.org/W2148134051","https://openalex.org/W2148626913","https://openalex.org/W2156473505","https://openalex.org/W2156509762","https://openalex.org/W2156737450","https://openalex.org/W2157974084","https://openalex.org/W2159058062","https://openalex.org/W2161572091","https://openalex.org/W2162537623","https://openalex.org/W2163435672","https://openalex.org/W2167119990","https://openalex.org/W2167233217","https://openalex.org/W2168849436","https://openalex.org/W2170206890","https://openalex.org/W2170632689","https://openalex.org/W2171421171","https://openalex.org/W2186520794","https://openalex.org/W4211198655","https://openalex.org/W4233550107"],"related_works":["https://openalex.org/W3043410825","https://openalex.org/W2396965461","https://openalex.org/W1985109169","https://openalex.org/W2011742075","https://openalex.org/W4308325008","https://openalex.org/W1994382682","https://openalex.org/W2946318236","https://openalex.org/W2148134051","https://openalex.org/W4223505850","https://openalex.org/W3028894994"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Antimicrobial":[1,120],"drug":[2],"resistance":[3,88,140],"is":[4,219,258],"spreading":[5],"among":[6],"Enterobacteriaceae,":[7,31,253],"limiting":[8],"the":[9,20,40,86,95,116,138,148,157,170,196,226,234],"utility":[10,249],"of":[11,26,42,77,85,103,137,178,181,195,205,225,237,246],"traditionally":[12],"used":[13],"agents.":[14],"We":[15],"sought":[16],"to":[17,35,39],"systematically":[18],"review":[19],"microbiological":[21,63,179],"activity":[22,180],"and":[23,48,64,98,151,163,172,233],"clinical":[24,66,192,248],"effectiveness":[25],"tigecycline":[27,182,202],"for":[28,56,132,144,153,161,165],"multidrug-resistant":[29],"(MDR)":[30],"including":[32,58],"those":[33],"resistant":[34,252],"broad-spectrum":[36],"beta-lactams":[37],"due":[38],"expression":[41],"extended-spectrum":[43],"beta-lactamases":[44],"(ESBLs),":[45],"AmpC":[46],"enzymes":[47],"carbapenemases":[49],"(including":[50,90],"metallo-beta-lactamases).":[51],"METHODS:":[52],"PubMed":[53],"was":[54,71,189],"searched":[55],"articles":[57],"relevant":[59],"data.":[60],"RESULTS:":[61],"Twenty-six":[62],"10":[65],"studies":[67],"were":[68,112,142],"identified.":[69],"Tigecycline":[70,218],"active":[72,221],"against":[73,183,222,250],"more":[74],"than":[75],"99%":[76],"1936":[78],"Escherichia":[79],"coli":[80,231],"isolates":[81,146,155,188,232],"characterized":[82],"by":[83,147,156,169,209],"any":[84,136],"above":[87,139],"patterns":[89,141],"1636":[91],"ESBL-producing":[92,167,213],"isolates)":[93],"using":[94,115],"US":[96],"Food":[97],"Drug":[99],"Administration":[100],"(FDA)":[101],"breakpoint":[102,124],"susceptibility":[104],"(MIC":[105],"<":[106],"or":[107,126,212,214,228,239],"=":[108,127],"2":[109],"mg/L).":[110,129],"Findings":[111],"not":[113],"different":[114],"European":[117],"Committee":[118],"on":[119],"Susceptibility":[121,130],"Testing":[122],"(EUCAST)":[123],"(<":[125],"1":[128],"rates":[131],"Klebsiella":[133,241],"spp.":[134,187,242],"with":[135,201],"91.2%":[143],"2627":[145],"FDA":[149,171],"criteria":[150,159],"72.3%":[152,164],"1504":[154],"EUCAST":[158,173],"(92.3%":[160],"2030":[162],"1284":[166],"isolates,":[168],"criteria,":[174],"respectively).":[175],"The":[176],"degree":[177],"576":[184],"MDR":[185,215,229,240],"Enterobacter":[186],"moderate.":[190],"In":[191],"studies,":[193],"69.7%":[194],"33":[197],"reported":[198],"patients":[199],"treated":[200],"achieved":[203],"resolution":[204],"an":[206],"infection":[207],"caused":[208],"a":[210],"carbapenem-resistant":[211],"Enterobacteriaceae.":[216],"CONCLUSIONS:":[217],"microbiologically":[220],"almost":[223],"all":[224],"ESBL":[227,238],"E.":[230],"great":[235],"majority":[236],"isolates.":[243],"Further":[244],"evaluation":[245],"its":[247],"such":[251],"particularly":[254],"regarding":[255],"non-labelled":[256],"indications,":[257],"warranted.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":14}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
